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Experimental Results of the Fibrin Clot Use to Accelerate the Regeneration of Damaged Bone in the Rat Lower Jaw

Surgical Science 2010年第1期1卷 1-6页

作者： Igor Maiborodin Andrey shevela Tatyana Perrin Ivan Kolesnikov Vera Matveeva alexander shevela Boris Sheplev Irina Kolmakova 不详

Morphological and radiological methods were used to study regeneration of the damaged bone of rat mandibles after application of plateletenriched fibrin clot. A bone hole was artificially created, and in the natural course of regeneration, the hole was immediately filled with blood and there a blood clot formed. After one week of healing, separate islands of young bone tissue appeared. After two to three weeks, the opening in the mandible was completely replaced by the young bone tissue. When a similar bone hole was filled with autological fibrin clot, the blood clot did not form. But after one week the entire hole was filed with newlyformed fused bone tissue. By the second week after the use of fibrin clot, the bone hole had further healed and bone callus was formed.

关键词： Fibrin Clot Regeneration of Bone Density of Bone Tissue

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The Tissue Reactions and Changes of a Surface of Various Metal Implants after Their Introduction in a Bone Tissue in Experiment

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Surgical Science 2016年第2期7卷 100-106页

作者： Michael S. Toder Andrew I. shevela alexander A. shevela Paul A. Zheleznyi Anna P. Zheleznaia Igor V. Mayborodin International Center of Implantology of iDent Novosibirsk Russia Center of New Medical Technologies Institute of Chemical Biology and Fundamental Medicine Russian Academy of Science Siberian Branch Novosibirsk Russia Novosibirsk State Medical University Novosibirsk Russia

Screw metal implants (3S, Israel) with rough or smooth polished surface were introduced in a tibial proximal condyle of not purebred rabbits. The condition of surrounding tissues in 2 and 6 months after implantation was compared by light microscopy and X-ray methods. Within 6 months after operation the considerable distinctions of radiological and morphological data were revealed not. 2 months later after introduction of implants with a rough surface the effort enclosed for its twisting is, much more, than for removal of the polished product. However, stability of fixing of implants was practically made even at 6 months. On remote rough implants there is a set of tissue scraps whereas on products with a smooth surface the tissue remains were much less. Surrounding tissues strongly join a rough surface, grow into cavities, and during removal of such products there is a considerable trauma of tissues round an implantation place. Smooth implants have the smaller area of contact with organism tissues, they are fixed due to bicortical implantation, during removal easily get out and don’t break off surrounding tissues. The signs of inflammation and formation of merged multinuclear macrophages were not found at all cases, which give evidence to the inertness of material of the mentioned articles for living organism. In some observations however and by implantation of the rough article and by introduction of polished implants, metal particles were found, but after use of the foreign body with grit-blasted treatment of surface metal was found more frequently, and its fragments had larger volume.

关键词： Implantation of Metals Intra Bone Durability of Implant Fixing Isolation of Foreign Bodies Metal Fragments in Tissues Features of Implant Removal

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