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Genomics, Proteomics & Bioinformatics 2024年第2期22卷 57-68页

作者： Yanni li Eline H.van den Berg alexander Kurilshikov Dasha V.Zhernakova Ranko Gacesa Shixian Hu Esteban A.lopera-Maya Alexandra Zhernakova lifelines Cohort Study Vincent E.de Meijer Serena Sanna Robin P.F.Dullaart Hans Blokzijl Eleonora A.M.Festen Jingyuan Fu Rinse K.Weersma Department of Gastroenterology and Hepatology University of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands Department of Genetics University of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands Department of Gastroenterology and Hepatology Tianjin Medical University General HospitalTianjin Medical UniversityTianjin 300052China laboratory of Genomic Diversity Center for Computer TechnologiesITMO UniversitySaint Petersburg 199034Russia Institute of Precision Medicine the First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Department of Surgery Section of Hepatobiliary Surgery and Liver TransplantationUniversity of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands Department of Endocrinology University of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands Department of Pediatrics University of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands 不详

Genetic susceptibility to metabolic associated fatty liver disease(MAFlD)is complex and poorly *** characterization of the genetic background of hepatic fat content would provide insights into disease etiology and causality of risk *** performed genome-wide association study(GWAS)on two noninvasive definitions of hepatic fat content:magnetic resonance imaging proton density fat fraction(MRI-PDFF)in 16,050 participants and fatty liver index(FlI)in 388,701 participants from the United Kingdom(UK)Biobank(UKBB).Heritability,genetic overlap,and similarity between hepatic fat content phenotypes were analyzed,and replicated in 10,398 participants from the University Medical Center Groningen(UMCG)Genetics lifelines Initiative(UGlI).Meta-analysis of GWASs of MRI-PDFF in UKBB revealed five statistically significant loci,including two novel genomic loci harboring CREB3l1(rs72910057-T,P=5.40E−09)and GCM1(rs1491489378-T,P=3.16E−09),respectively,as well as three previously reported loci:PNPlA3,TM6SF2,and *** of FlI in UKBB identified 196 genome-wide significant loci,of which 49 were replicated in UGlI,with top signals in ZPR1(P=3.35E−13)and FTO(P=2.11E−09).Statistically significant genetic correlation(rg)between MRI-PDFF(UKBB)and FlI(UGlI)GWAS results was found(rg=0.5276,P=1.45E−03).Novel MRI-PDFF genetic signals(CREB3l1 and GCM1)were replicated in the FlI *** identified two novel genes for MRI-PDFF and 49 replicable loci for *** a difference in hepatic fat content assessment between MRI-PDFF and FlI,a substantial similar genetic architecture was *** is identified as an easy and reliable approach to study hepatic fat content at the population level.

关键词： Hepatic fat content MAFlD Genome-wide association study Fatty liver index Magnetic resonance imaging proton density fat fraction

3dCAP-Wheat: An Open-Source Comprehensive Computational Framework Precisely Quantifies Wheat Foliar, Nonfoliar, and Canopy Photosynthesis

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Plant Phenomics 2022年第1期4卷 156-174页

作者： Tian-Gen Chang Zai Shi Honglong Zhao Qingfeng Song Zhonghu He Jeroen Van Rie Bart den Boer alexander Galle Xin-Guang Zhu National Key laboratory for Plant Molecular Genetics Center for Excellence in Molecular Plant SciencesChinese Academy of SciencesShanghai 200032China Insitute of Crop Sciences Chinese Academy of Agricultural SciencesBeijing 100081China International Maize and Wheat Improvement Center(CIMMYT)China Office Chinese Academy of Agricultural SciencesBeijing 100081China BASF Belgium Coordination Center-Innovation Center Gent Technologiepark-Zwijnaarde 1019052 GentBelgium

Canopy photosynthesis is the sum of photosynthesis of all above-ground photosynthetic *** roles of nonfoliar tissues in canopy photosynthesis remain elusive due to methodology ***,we develop the first complete canopy photosynthesis model incorporating all above-ground photosynthetic tissues and validate this model on wheat with state-of-the-art gas exchange measurement facilities.

关键词： Wheat Canopy photosynthesis

Theory of superfluidity and drag force in the one-dimensional Bose gas

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Frontiers of physics 2012年第1期7卷 54-71页

作者： alexander Yu. Cherny (1) Jean-Sébastien Caux (2) Joachim Brand (3) 1. Bogoliubov laboratory of Theoretical Physics Joint Institute for Nuclear Research 141980 Dubna Moscow region Russia2. Institute for Theoretical Physics Science Park 904 University of Amsterdam 1090 GL Amsterdam The Netherlands3. Centre for Theoretical Chemistry and Physics and New Zealand Institute for Advanced Study Massey University Private Bag 102904 North Shore Auckland 0745 New Zealand

The one-dimensional Bose gas is an unusual superfluid. In contrast to higher spatial dimensions, the existence of non-classical rotational inertia is not directly linked to the dissipationless motion of infinitesimal impurities. Recently, experimental tests with ultracold atoms have begun and quanti- tative predictions for the drag force experienced by moving obstacles have become available. This topical review discusses the drag force obtained from linear response theory in relation to lan- dau＇s criterion of superfluidity. Based upon improved analytical and numerical understanding of the dynamical structure factor, results for different obstacle potentials are obtained, including single impurities, optical lattices and random potentials generated from speckle patterns. The dynamical breakdown of superfluidity in random potentials is discussed in relation to Anderson localization and the predicted superfluid-insulator transition in these systems.

关键词： lieb-liniger model Tonks-Girardeau gas luttinger liquid drag force superfluidity,dynamical structure factor

Glutamate reduces experimental intestinal hyperpermeability and facilitates glutamine support of gut integrity

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World Journal of Gastroenterology 2011年第12期17卷 1569-1573页

作者： Mechteld AR Vermeulen Jeffrey de Jong Mathijs J Vaessen Paul AM van leeuwen alexander PJ Houdijk Department of Surgery VU University Medical Center1007 MB AmsterdamThe Netherlands Department of Surgery Gemini Hospital1782 GZ Den HelderThe Netherlands Department of Surgery Medical Center Alkmaar1815 JD AlkmaarThe Netherlands

AIM:To assess whether glutamate plays a similar role to glutamine in preserving gut wall ***:The effects of glutamine and glutamate on induced hyperpermeability in intestinal cell lines were *** hyperpermeability was induced in *** and HT-29Cl.19A cell lines by adding phorbol-12,13-dibutyrate(PDB) apically,after which the effects of glutamine and glutamate on horseradish peroxidase(HRP) diffusion were *** inhibitor of glutamate transport(l-trans-pyrrolidine-2,4-dicarboxylic acid:trans-PDC) and an irreversible blocker(acivicin) of the extracellular glutamine to glutamate converting enzyme,γ-glutamyltransferase,were ***:Apical to basolateral HRP flux increased significantly compared to controls not exposed to PDB (n=30,Plutamine application reduced hyperpermeability by 19%and 39%in the respective cell *** application reduced hyperpermeability by 30%and 20%,*** of HT29Cl.19A cells with acivicin and subsequent PDB and glutamine addition increased permeability *** of *** cells with trans-PDC followed by PDB and glutamate addition also resulted in high permeability ***:Apical glutamate-similar to glutaminecan decrease induced paracellular *** conversion of glutamine to glutamate and subsequent uptake of glutamate could be a pivotal step in the mechanism underlying the protective effect of glutamine.

关键词： Apical Basolateral Flux Glutamate Glutamine Gut protection Gut wall integrity Intestine Permeability

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贝叶斯方差分析在JASP中的实现

心理技术与应用 2023年第9期11卷 528-541页

作者：王允宏 Don van den Bergh Frederik Aust alexander ly Eric-Jan Wagenmakers 胡传鹏上海师范大学心理学系上海200234 Department of Psychological Methods University of Amsterdam1018 VZ AmsterdamThe Netherlands Centrum Wiskunde&Informatica 1090 GB AmsterdamThe Netherlands 南京师范大学心理学院南京210024

贝叶斯统计应用于假设检验的方法——贝叶斯因子——在心理学研究中的应用日渐增加。贝叶斯因子能分别量化所支持的相应假设或模型的证据,进而根据其数值大小做出当前数据更支持哪种假设或模型的判断。然而,国内尚缺乏对方差分析的贝叶... 详细信息

贝叶斯统计应用于假设检验的方法——贝叶斯因子——在心理学研究中的应用日渐增加。贝叶斯因子能分别量化所支持的相应假设或模型的证据,进而根据其数值大小做出当前数据更支持哪种假设或模型的判断。然而,国内尚缺乏对方差分析的贝叶斯因子的原理与应用的介绍。基于此,本文首先介绍贝叶斯方差分析的基本思路及计算原理,并结合实例数据,展示如何在JASP中对五种常用的心理学实验设计(单因素组间设计、单因素组内设计、二因素组间设计、二因素组内设计和二因素混合设计)进行贝叶斯方差分析及如何汇报和解读结果。贝叶斯方差分析提供了一个能有效替代传统方差分析的方案,是研究者进行统计推断的有力工具。

关键词：贝叶斯统计贝叶斯因子方差分析 JASP

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Ein liebesversuch

德语人文研究 2011年第3期 9-12+8页

作者： alexander Kluge

Als das billigste Mittel,in den lagern Massensterilisationen durchzuführen,erschien 1943 R*** war,ob die so erzielte Unfruchtbarkeit nachhaltig *** führten einen mnnlichen und einen weiblichen Gefangenen zu eine... 详细信息

关键词： der Ein liebesversuch

Effects of dietary menthol-rich bioactive lipid compounds on zootechnical traits,blood variables and gastrointestinal function in growing sheep

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Journal of Animal Science and Biotechnology 2020年第1期11卷 227-240页

作者： Amlan K.Patra Sebastian Geiger Katharina T.Schrapers Hannah-Sophie Braun Heidrun Gehlen alexander Starke Robert Pieper Adam Cieslak Malgorzata Szumacher-Strabel Jorg R.Aschenbach Institute of Veterinary Physiology Freie Universitat BerlinOertzenweg 19b14163 BerlinGermany Department of Animal Nutrition West Bengal University of Animal and Fishery Sciences37 K.B.SaraniKolkata 700037India PerformaNat GmbH Hohentwielsteig 614163 BerlinGermany Equine Clinic:Surgery and Radiology Freie Universitat BerlinOertzenweg 19b14163 BerlinGermany Clinic for Ruminants and Swine Faculty of Veterinary MedicineUniversity of LeipzigAn den Tierkliniken 1104103 LeipzigGermany Institute of Animal Nutrition Freie Universitat BerlinK?nigin-Luise-Strasse 4914195 BerlinGermany Department of Animal Nutrition Poznan University of Life SciencesWolynska 3360-637 PoznanPoland

Background:The present study aimed at investigating the influence of 90%menthol-containing plant bioactive lipid compounds(PBlC,essential oils)on growth performance,blood haematological and biochemical profile,and nutrient absorption in ***-four growing Suffolk sheep were allotted into three dietary treatments:Control(without PBlC),lower dose of PBlC(PBlC-l;80 mg/d)and higher dose of PBlC(PBlC-H;160 mg/d).Sheep in all groups were fed meadow hay ad libitum plus 600 g/d of concentrate pellets for 28 ***:Average daily gain was not affected by *** of PBlC increased hay and total feed intake per kg body weight(Pl leucocytes,lymphocytes and monocytes were not different among ***,neutrophil count decreased(PlC-H with a similar trend in PBlC-l(Plucose,bilirubin,triglycerides,cholesterol,urea and magnesium in serum were not different among sheep fed different doses of ***,serum calcium concentration tended to increase in PBlC-H(Plutamate&glutamine(Plinearly with increasing PBlC *** ruminal epithelia isolated from the rumen after killing,baseline conductance(Gt;PlC *** uptakes of glucose and methionine in the presence of Na+were not affected by the dietary PBlC *** the absence of Na+,however,glucose and methionine uptakes increased(PlC-H(Pline Gtwas not *** uptakes of glucose and methionine were not influenced by PBlC in the presence or absence of Na+.Conclusion:The results suggest that menthol-rich PBlC increase feed intake,and passive ion and nutrient transport,the latter specifically in the *** also increased serum concentrations of urea precursor amino acids and tended to increase serum calcium

关键词： Electrophysiology Essential oil Feed intake Growth performance Nutrient uptakes

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Photoluminescence of Ag-In-S/ZnS quantum dots: Excitation energy dependence and low-energy electronic structure

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Nano Research 2019年第7期12卷 1595-1603页

作者： Irina V. Martynenko Anvar S. Baimuratov Florian Weigert Jose X. Soares lorena Dhamo Philip Nickl Ilona Doerfel Jutta Pauli Ivan D. Rukhlenko alexander V. Baranov Ute Resch-Genger Federal Institute for Materials Research and Testing (BAM) Unter den Eichen 8712205 BerlinGermany ITMO University 49 Kronverksky Pr.St. Petersburg197101Russia University of Porto Rua de Jorge Viterbo Ferreira2284050-313 PortoPortugal Institute of Photonics and Optical Sciences (IPOS) School of PhysicsThe University of SydneyCamperdown 2006NSWAustralia

Cd-free Ⅰ-Ⅲ-Ⅵ group semiconductor quantum dots (QDs) like Ag-ln-S and Cu-ln-S show unstructured absorption spectra with a pronounced Urbach tail,rendering the determination of their band gap energy (Eg) and the energy structure of the exciton ***,the origin of the broad photoluminescence (Pl) band with lifetimes of several hundred nanoseconds is still *** encouraged us to study the excitation energy dependence (EED) of the Pl maxima,Pl spectral band widths,quantum yields (QYs),and decay kinetics of AlS/ZnS QDs of j different size,composition,and surface capping *** results were then correlated with the second derivatives of the corresponding absorption *** excellent match between the onset of changes in Pl band position and spectral width with the minima found for the second derivatives of the absorption spectra underlines the potential of the EED approach for deriving Eg values of these ternary QDs from Pl *** Pl QY is,however,independent of excitation energy in the energy range *** the EED of the Pl features of the AlS/ZnS QDs we could also derive a mechanism of the formation of the low-energy electronic *** was additionally confirmed by a comparison of the EED of Pl data of as-synthesized and size-selected QD ensembles and the comparison of these Pl data with Pl spectra of single *** results indicate a strong contribution of intrinsic inhomogeneous Pl broadening to the overall emission features of AlS/ZnS QDs originating from radiative transitions from a set of energy states of defects localized at different positions within the quantum dot volume,in addition to contributions from dimensional and chemical *** mechanism was confirmed by numerically modelling the absorption and Pl energies with a simple mass approximation for spherical QDs and a modified donor-acceptor model,thereby utilizing the advantages of previously proposed Pl mechanisms of ternary *** findings will

关键词： core/shell quantum dot silver indium sulfide defect photoluminescence photoluminescence quantum yield single-dot spectroscopy

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美国影像诊断学的进展及其对医疗保障的影响

放射学实践 1989年第1期4卷 41-43页

作者： Von alexander R.Margulis 徐霓霓 Dept.Radiology Univ.of CaliforniaSan FranciscoCA 北京市宣武医院

新的影像诊断方法在过去十多年来取得了非常广泛的突破性进展。这在很大程度上是由于政府考虑到宇宙技术、能源利用和军事价值而对此项发展进行了大量的投资,并且带来了微电脑、电讯和技术性结构部件微型化方面的显著突破。这一进展对... 详细信息

新的影像诊断方法在过去十多年来取得了非常广泛的突破性进展。这在很大程度上是由于政府考虑到宇宙技术、能源利用和军事价值而对此项发展进行了大量的投资,并且带来了微电脑、电讯和技术性结构部件微型化方面的显著突破。这一进展对新的影像系统也相应产生了较大的影响。观察美国医疗经济可发现:1980年至1986年平均每年支出3800亿美元用于卫生事业(Waldo & lazenby,1985年)。

关键词：影像诊断学美国 CT B超磁共振

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