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Nano Research 2016年第10期9卷 2852-2861页

作者： Gaute Otnes Magnus Heurlin Mariusz Graczyk Jesper Wallentin Daniel Jacobsson alexander berg Ivan Maximov Magnus T. Borgstrom Solid State Physics Lund University Box 118 S-22100 Lund Sweden

Position controlled nanowire growth is important for nanowire-based optoelectronic components which rely on light emission or light absorption. For solar energy harvesting applications, dense arrays of nanowires are needed; however, a major obstacle to obtaining dense nanowire arrays is seed particle displacement and coalescing during the annealing stage prior to nanowire growth. Here, we explore three different strategies to improve pattern preservation of large-area catalyst particle arrays defined by nanoimprint lithography for nanowire growth. First, we see that heat treating the growth substrate prior to nanoimprint lithography improves pattern preservation. Second, we explore the possibility of improving pattern preservation by fixing the seed particles in place prior to annealing by modifying the growth procedure. And third, we show that a SiNx growth mask can fully prevent seed particle displacement. We show how these strategies allow us to greatly improve the pattern fidelity of grown InP nanowire arrays with dimensions suitable for solar cell applications, ultimately achieving 100% pattern preservation over the sampled area. The generic nature of these strategies is supported through the synthesis of GaAs and GaP nanowires.

关键词： semiconductor nanowire nanoimprint lithography metal-organic vaporphase epitaxial (MOVPE) patterning

Growth and optical properties of InxGa1-xP nanowires synthesized by selective-area epitaxy

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Nano Research 2017年第2期10卷 672-682页

作者： alexander berg Philippe Caroff Naeem Shahid Mark N. Lockrey Xiaoming Yuan Magnus T. Borgstrom Hark Hoe Tan Chennupati Jagadish Solid State Physics and NanoLund Lund University Box 118 SE-221 00 Lund Sweden Department of Electronic Materials Engineering Research School of Physics and Engineering The Australian National University Canberra ACT2601 Australia Australian National Fabrication Facility Research School of Physics and Engineering The Australian National University Canberra ACT 2601 Australia

Ternary III-V nanowires （NWs） cover a wide range of wavelengths in the solar spectrum and would greatly benefit from being synthesized as position-controlled arrays for improved vertical yield, reproducibility, and tunable optical absorption. Here, we report on successful selective-area epitaxy of metal-particle-free vertical InxGa1-xP NW arrays using metal-organic vapor phase epitaxy and detail their optical properties. A systematic growth study establishes the range of suitable growth parameters to obtain uniform NW growth over a large array. The optical properties of the NWs were characterized by room-temperature cathodoluminescence spectroscopy. Tunability of the emission wavelength from 870 nm to approximately 800 nm was achieved. Transmission electron microscopy and energy dispersive X-ray measurements performed on cross- section samples revealed a pure wurtzite crystal structure with very few stacking faults and a slight composition gradient along the NW growth axis.

关键词： nanowire InGaP selective-area epitaxy cathodoluminescence energy-dispersive X-ray spectroscopy

A comparison of three surface roughness characterization techniques:photogrammetry,pin profiler,and smartphone-based LiDAR

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International Journal of Digital Earth 2022年第1期15卷 2422-2439页

作者： Zohreh Alijani Julien Meloche alexander McLaren John Lindsay Alexandre Roy Aaron berg Department of Geography Environment and GeomaticsUniversity of GuelphGuelphCanada Département de Géomatique Appliquée Université de SherbrookeSherbrookeCanada Département des Sciences de l’Environment Université du Québec à Trois-RivièresTrois-RivièresCanada

Surface roughness plays an important role in microwave remote *** the agricultural domain,surface roughness is crucial for soil moisture retrieval methods that use electromagnetic surface scattering or microwave radiative transfer ***,improved characterization of Soil Surface Roughness(SSR)is of considerable *** this study,three approaches,including a standard pin profiler,a LiDAR point cloud generated from an iPhone 12 Pro,and a Structure from Motion(SfM)photogrammetric point cloud,were applied over 24 surface profiles with different roughness variations to measure surface *** objective of this study was to evaluate the capability of smartphone-based LiDAR technology to measure surface roughness parameters and compare the results of this technique with the more common *** showed that the iPhone LiDAR technology,when point cloud data is captured in a fine-resolution mode,has a significant correlation with SfM photogrammetry(R2=0.70)and a relatively close agreement with pin profiler(R2=0.60).However,this accuracy tends to be greater for random surfaces and rough profiles with row structure *** results of this study confirm that smartphone-based LiDAR can be used as a cost-effective,fast,and time-efficient alternative tool for measuring surface roughness,especially for rough,wide,and inaccessible areas.

关键词： LiDAR surface roughness structure from motion iPhone pin profiler

Genome-wide Studies Reveal Genetic Risk Factors for Hepatic Fat Content

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Genomics, Proteomics & Bioinformatics 2024年第2期22卷 57-68页

作者： Yanni Li Eline H.van den berg alexander Kurilshikov Dasha V.Zhernakova Ranko Gacesa Shixian Hu Esteban A.Lopera-Maya Alexandra Zhernakova Lifelines Cohort Study Vincent E.de Meijer Serena Sanna Robin P.F.Dullaart Hans Blokzijl Eleonora A.M.Festen Jingyuan Fu Rinse K.Weersma Department of Gastroenterology and Hepatology University of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands Department of Genetics University of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands Department of Gastroenterology and Hepatology Tianjin Medical University General HospitalTianjin Medical UniversityTianjin 300052China Laboratory of Genomic Diversity Center for Computer TechnologiesITMO UniversitySaint Petersburg 199034Russia Institute of Precision Medicine the First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Department of Surgery Section of Hepatobiliary Surgery and Liver TransplantationUniversity of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands Department of Endocrinology University of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands Department of Pediatrics University of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands 不详

Genetic susceptibility to metabolic associated fatty liver disease(MAFLD)is complex and poorly *** characterization of the genetic background of hepatic fat content would provide insights into disease etiology and causality of risk *** performed genome-wide association study(GWAS)on two noninvasive definitions of hepatic fat content:magnetic resonance imaging proton density fat fraction(MRI-PDFF)in 16,050 participants and fatty liver index(FLI)in 388,701 participants from the United Kingdom(UK)Biobank(UKBB).Heritability,genetic overlap,and similarity between hepatic fat content phenotypes were analyzed,and replicated in 10,398 participants from the University Medical Center Groningen(UMCG)Genetics Lifelines Initiative(UGLI).Meta-analysis of GWASs of MRI-PDFF in UKBB revealed five statistically significant loci,including two novel genomic loci harboring CREB3L1(rs72910057-T,P=5.40E−09)and GCM1(rs1491489378-T,P=3.16E−09),respectively,as well as three previously reported loci:PNPLA3,TM6SF2,and *** of FLI in UKBB identified 196 genome-wide significant loci,of which 49 were replicated in UGLI,with top signals in ZPR1(P=3.35E−13)and FTO(P=2.11E−09).Statistically significant genetic correlation(rg)between MRI-PDFF(UKBB)and FLI(UGLI)GWAS results was found(rg=0.5276,P=1.45E−03).Novel MRI-PDFF genetic signals(CREB3L1 and GCM1)were replicated in the FLI *** identified two novel genes for MRI-PDFF and 49 replicable loci for *** a difference in hepatic fat content assessment between MRI-PDFF and FLI,a substantial similar genetic architecture was *** is identified as an easy and reliable approach to study hepatic fat content at the population level.

关键词： Hepatic fat content MAFLD Genome-wide association study Fatty liver index Magnetic resonance imaging proton density fat fraction

No association between Parkinson disease and autoantibodies against NMDA-type glutamate receptors

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Translational Neurodegeneration 2019年第1期8卷 127-133页

作者： Franziska Hopfner Stefanie HMüller Dagmar Steppat Joanna Miller Nele Schmidt Klaus-Peter Wandinger Frank Leypoldt Daniela berg Andre Franke Wolfgang Lieb Lukas Tittmann Monika Balzer-Geldsetzer Simon Baudrexel Richard Dodel Ruediger Hilker-Roggendorf Elke Kalbe Jan Kassubek Thomas Klockgether Inga Liepelt-Scarfone Brit Mollenhauer Petra Neuser Kathrin Reetz Oliver Riedel Claudia Schulte Jörg BSchulz Annika Spottke alexander Storch Claudia Trenkwalder Hans-Ulrich Wittchen Karsten Witt Ullrich Wüllner Günther Deuschl Gregor Kuhlenbäumer Department of Neurology University Hospital Schleswig HolsteinArnold-Heller Str.324105 KielGermany Center of Blood Transfusion University Hospital Schleswig HolsteinKiel&LübeckGermany Department of Clinical Chemistry University Hospital Schleswig-HolsteinKielGermany Institute of Clinical Molecular Biology University Hospital Schleswig-HolsteinKielGermany Institute of Epidemiology University Hospital Schleswig-HolsteinKielGermany Chair of Geriatric Medicine University Hospital EssenEssenGermany Department of Neurology Philipps-University MarburgMarburgGermany Department of Neurology Goethe UniversityFrankfurt/MainGermany Brain Imaging Center Goethe UniversityFrankfurt/MainGermany Department of Medical Psychology|Neuropsychology and Gender Studies&Center for Neuropsychological Diagnostics and Intervention(CeNDI) University Hospital CologneCologneGermany Psychological Gerontology Institute of GerontologyUniversity of VechtaVechtaGermany Department of Neurology University of UlmUlmGermany Department of Neurology University of Bonnand German Center for Neurodegenerative Diseases(DZNE)BonnGermany Center for Neurology Hertie Institute for Clinical Brain ResearchDepartment of Neurodegenerative DiseasesUniversity of TübingenTübingenGermany DZNE German Center for Neurodegenerative DiseasesTübingenGermany Paracelsus-Elena-Klinik KasselGermany Institute of Neuropathology and Department of Neurosurgery University Medical Center GöttingenGöttingenGermany Coordinating Centre for Clinical Trials Philipps-UniversityMarburgGermany Department of Neurology RWTH Aachen UniversityAachenGermany JARA-BRAIN Institute of Molecular Neuroscience and Neuroimaging Forschungszentrum Jülich GmbH and RWTH Aachen UniversityAachenGermany Leibniz Institute for Prevention Research and Epidemiology-BIPS Achterstrasse 3028359 BremenGermany Department of Neurology Technische Universität Dresden01307 DresdenGermany German Center for Neurodegenerative Diseases(DZNE) Research Site Rostock18147 RostockGerma

Background:IgG-class autoantibodies to N-Methyl-D-Aspartate(NMDA)-type glutamate receptors define a novel entity of autoimmune *** examining the prevalence of NMDA IgA/IgM antibodies in patients with Parkinson disease with/without dementia produced conflicting *** measured NMDA antibodies in a large,well phenotyped sample of Parkinson patients without and with cognitive impairment(n=296)and controls(n=295)free of neuropsychiatric *** phenotyping and large numbers allowed statistically meaningful correlation of antibody status with diagnostic subgroups as well as quantitative indicators of disease severity and cognitive ***:NMDA antibodies were analysed in the serum of patients and controls using well established validated *** used anti-NMDA antibody positivity as the main independent variable and correlated it with disease status and phenotypic ***:The frequency of NMDA IgA/IgM antibodies was lower in Parkinson patients(13%)than in controls(22%)and higher than in previous studies in both *** IgA/IgM antibodies were neither significantly associated with diagnostic subclasses of Parkinson disease according to cognitive impairment,nor with quantitative indicators of disease severity and cognitive impairment.A positive NMDA antibody status was positively correlated with age in controls but not in Parkinson ***:It is unlikely albeit not impossible that NMDA antibodies play a significant role in the pathogenesis or progression of Parkinson disease *** Parkinson disease with dementia,while NMDA IgG antibodies define a separate disease of its own.

关键词： NMDA antibody NMDA IgA/IgM antibodies Parkinson disease Cognitive impairment

造影联合光相干断层扫描在眼底病中的应用(英文)

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造影联合光相干断层扫描在眼底病中的应用(英文)

国际糖尿病足工作组和欧洲血管外科学会及美国血管外科学会关于糖尿病合并足溃疡患者周围动脉病变治疗的跨学会指南——《国际糖尿病足工作组:糖尿病相关的足病预防与管理指南(2023)》的一部分

中国眼底病论坛·全国眼底病专题学术研讨会

作者： alexander Walsh

Background Spectral domain OCT systems,such as Heidel- berg Engineering’s Spectralis HRA+OCT,have higher resolu- tion,better sensitivity and higher speeds than conventional time domain OCT ***,it is unclear if this translates into improved clinical sensitivity or patient *** purpose of this study is to determine if features that may be used to guide treatment decisions with anti-VEGF therapy are seen with equal frequency using conventional time-domain OCT(TD-OCT)and

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来源： cnki会议评论

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感染、炎症、修复 2023年第4期24卷 212-238页

作者：方圆史伟浩薛冠华袁良喜殷敏毅(译) 柏骏董智慧许樟荣(审校) 复旦大学附属中山医院上海200032 复旦大学附属华山医院上海200040 上海交通大学医学院附属仁济医院上海200127 海军军医大学第一附属医院上海200438 上海交通大学医学院附属第九人民医院上海200011 海军军医大学第二附属医院上海200001 战略支援部队特色医学中心北京100101

糖尿病相关的足部并发症与大、小截肢有关,已成为全球范围内导致致残率增加的主要原因。大约50%的糖尿病合并足溃疡的患者伴有周围动脉病变(PAD),PAD的存在显著增加了不良肢体疾病和心血管事件的风险。自1999年以来,国际糖尿病足工作组(... 详细信息

糖尿病相关的足部并发症与大、小截肢有关,已成为全球范围内导致致残率增加的主要原因。大约50%的糖尿病合并足溃疡的患者伴有周围动脉病变(PAD),PAD的存在显著增加了不良肢体疾病和心血管事件的风险。自1999年以来,国际糖尿病足工作组(IWGDF)发表了关于糖尿病相关的足部并发症的管理和预防的循证指南。本指南是对2019年IWGDF发布的《糖尿病足溃疡周围动脉病变诊断、预后与管理指南》的更新。IWGDF、欧洲血管外科学会(ESVS)和美国血管外科学会(SVS)决定合作更新这项指南,以制定一套适用于所有国家临床医生的临床推荐。本指南基于3项新的系统性回顾研究,利用推荐、评估、发展和评价分级(grading of recommendations,assessment,develop⁃ment,and evaluation,GRADE)框架,提出了临床相关问题,并对文献进行了系统回顾。在评估证据的可靠性后制定了推荐意见,并根据效益和危害的平衡、患者价值观、可行性、可接受性、公平性、所需资源以及成本进行权衡。通过这一过程,我们提出了5项推荐,用于糖尿病患者的PAD诊断,无论患者是否具有足溃疡或坏疽。同时,我们对糖尿病伴足溃疡或坏疽患者的预后也提出5项推荐,用于评估愈合和截肢的可能性。我们制定了与PAD治疗相关的15项推荐意见,包括对患者进行血管重建手术的优先级、手术方式的选择和术后护理。此外,指南小组还提出了当前证据不足的关键研究问题。指南小组认为,遵循这些推荐将有助于医务人员提供更好的医治,并将减少糖尿病相关的足部并发症的负担。

关键词：糖尿病糖尿病相关的足溃疡周围动脉病变指南国际糖尿病足工作组欧洲血管外科学会美国血管外科学会