检索结果-南通市图书馆

Bioactive Materials 2023年第12期30卷 184-199页

作者： Dhavan Sharma Archita Sharma Linghao Hu Te-An Chen Sarah Voon Kayla j.Bayless jeremy Goldman alex j.walsh Feng Zhao Department of Biomedical Engineering Texas A&M UniversityCollege StationTXUnited States School of Medicine Texas A&M UniversityCollege StationTXUnited States Department of Biomedical Engineering Michigan Technological UniversityHoughtonMIUnited States

Vascularization is a key pre-requisite to engineered anatomical scale three dimensional(3-D)constructs to ensure their nutrient and oxygen supply upon ***,engineered pre-vascularized 3-D tissues are limited to only micro-scale hydrogels,which meet neither the anatomical scale needs nor the complexity of natural extracellular matrix(ECM)*** scale perfusable constructs are critically needed for translational *** overcome this challenge,we previously developed pre-vascularized ECM sheets with long and oriented dense microvascular *** present study further evaluated the patency,perfusability and innate immune response toward these pre-vascularized ***-co-cultured prevascularized constructs were evaluated in vitro to confirm micro-vessel patency and perturbations in macrophage *** implanted pre-vascularized constructs remained viable and formed a functional anastomosis with host vasculature within 3 days of *** completely biological pre-vascularized construct holds great potential as a building block to engineer perfusable anatomical scale tissues.

关键词： Pre-vascularization Micro-vasculature Mesenchymal stem cells Extracellular matrix Fluorescence lifetime imaging

Stable diffusion gradients in microfluidic conduits bounded by fluid walls

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Microsystems & Nanoengineering 2024年第3期10卷 357-367页

作者： Federico Nebuloni Cyril Deroy Peter R.Cook Edmond j.walsh Department of Engineering Science Osney Thermo-Fluids InstituteUniversity of OxfordOxford OX20ESUK Sir William Dunn School of Pathology University of OxfordOxford OX13REUK

Assays mimicking in vitro the concentration gradients triggering biological responses like those involved in fighting infections and blood clotting are essential for biomedical *** assays prove especially attractive as they allow precise control of gradient shape allied to a reduction in *** microfluidic devices are fabricated using solid plastics that prevent direct access to responding ***-walled microfluidics allows the manufacture of circuits on standard Petri dishes in seconds,coupled to simple operating methods;cell-culture medium sitting in a standard dish is confined to circuits by fluid walls made of an immiscible *** develop and experimentally validate an analytical model of diffusion between two or more aqueous streams flowing at different rates into a fluid-walled conduit with the cross-section of a circular *** solid walls,fluid walls morph during flows as pressures fall,with wall shape changing down the *** model is validated experimentally for Fourier numbers<0.1 using fluorescein diffusing between laminar *** enables a priori prediction of concentration gradients throughout a conduit,so allowing rapid circuit design as well as providing bioscientists with an accurate way of predicting local concentrations of bioactive molecules around responsive and nonresponsive cells.

关键词： walls diffusion attractive

Dietary supplementation of zinc oxide modulates intestinal functionality during the post-weaning period in clinically healthy piglets

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

journal of Animal Science and Biotechnology 2024年第1期15卷 313-328页

作者： Dirkjan Schokker Soumya K.Kar Els Willems alex Bossers Ruud A.Dekker Alfons j.M.jansman Wageningen Bioveterinary Research LelystadThe Netherlands Wageningen Livestock Research Wageningen University&ResearchWageningenThe Netherlands Royal Agrifirm Group ApeldoornThe Netherlands Institute for Risk Assessment Sciences Utrecht UniversityUtrechtThe Netherlands

Background To improve our understanding of host and intestinal microbiome interaction,this research investigated the effects of a high-level zinc oxide in the diet as model intervention on the intestinal microbiome and small intestinal functionality in clinically healthy post-weaning *** study 1,piglets received either a high concentration of zinc(Zn)as zinc oxide(Zn O,Zn,2,690 mg/kg)or a low Zn concentration(100 mg/kg)in the diet during the post weaning period(d 14–23).The effects on the piglet's small intestinal microbiome and functionality of intestinal tissue were *** study 2,the impact of timing of the dietary zinc intervention was investigated,i.e.,between d 0–14 and/or d 14–23 post weaning,and the consecutive effects on the piglet's intestinal functionality,here referring to microbiota composition and diversity and gene expression *** Differences in the small intestinal functionality were observed during the post weaning period between piglets receiving a diet with a low or high concentration Zn O content.A shift in the microbiota composition in the small intestine was observed that could be characterized as a non-pathological change,where mainly the commensals *** the immediate post weaning period,i.e.,d 0–14,the highest number of differentially expressed genes(DEGs)in intestinal tissue were observed between animals receiving a diet with a low or high concentration Zn O content,i.e.,23 DEGs in jejunal tissue and 11 DEGs in ileal *** genes are involved in biological processes related to immunity and inflammatory *** example,genes CD59 and REG3G were downregulated in the animals receiving a diet with a high concentration Zn O content compared to low Zn O content in both jejunum and ileum *** the second study,a similar result was obtained regarding the expression of genes in intestinal tissue related to immune pathways when comparing piglets receiving a diet with a high concentration Zn O con

关键词： Immune system Intestinal functionality Microbiota Piglets Zinc oxide

Nanotechnology for the management of COVID-19 during the pandemic and in the post-pandemic era

在线全文

学校读者我要写书评

暂无评论

National Science Review 2022年第10期9卷 230-242页

作者： Chun Xu Chang Lei Sepanta Hosseinpour Saso Ivanovski Laurence j.walsh Ali Khademhosseini School of Dentistry The University of Queensland Centre for Orofacial Regeneration Reconstruction and Rehabilitation (COR3) School of Dentistry The University of Queensland Australian Institute for Bioengineering and Nanotechnology The University of Queensland Terasaki Institute for Biomedical Innovation

Following the global COVID-19 pandemic,nanotechnology has been at the forefront of research efforts and enables the fast development of diagnostic tools,vaccines and antiviral treatment for this novel virus(SARS-CoV-2).In this review,we first summarize nanotechnology with regard to the detection of SARS-C oV-2,including nanoparticle-based techniques such as rapid antigen testing,and nanopore-based se quencing and sensing *** we investigate nanote chnology as it applies to the development of COVID-19 vaccines and anti-SARS-CoV-2 *** also highlight nanotechnology for the post-pandemic era,by providing tools for the battle with SARS-C oV-2 variants and for enhancing the global distribution of *** not only contributes to the management of the ongoing COVID-19 pandemic but also provides platforms for the prevention,rapid diagnosis,vaccines and antiviral drugs of possible future virus outbreaks.

关键词： COVID-19 nanotechnology SARS-CoV-2 diagnosis vaccines

Error field penetration in j-TEXT tokamak based on two-fluid drift-MHD model

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics B 2024年第4期33卷 545-551页

作者：王文徐涛张仪 the j-TEXT team State Key Laboratory of Advanced Electromagnetic Technology International Joint Research Laboratory of Magnetic Confinement Fusion and Plasma PhysicsSchool of Electrical and Electronic EngineeringHuazhong University of Science and TechnologyWuhan 430074China

An externally generated resonant magnetic perturbation can induce complex non-ideal MHD responses in their resonant *** have studied the plasma responses using Fitzpatrick's improved two-fluid model and program *** calculated the error field penetration threshold for *** addition,we find that the island width increases slightly as the error field amplitude increases when the error field amplitude is below the critical penetration ***,the island width suddenly jumps to a large value because the shielding effect of the plasma against the error field disappears after the *** scanning the natural mode frequency,we find that the shielding effect of the plasma decreases as the natural mode frequency ***,we obtain the m/n=2/1 penetration threshold scaling on density and temperature.

关键词： plasma responses drift-MHD model error field penetration

The Triple Combination of Meropenem,Avibactam,and a Metallo-b-Lactamase Inhibitor Optimizes Antibacterial Coverage Against Different b-Lactamase Producers

在线全文

学校读者我要写书评

暂无评论

Engineering 2024年第7期38卷 124-132页

作者： Zhuoren Ling Alistair james Macdonald Farley Aditya Lankapalli Yanfang Zhang Shonnette Premchand-Branker Kate Cook Andrei Baran Charlotte Gray-Hammerton Claudia Orbegozo Rubio Edgars Suna jordan Mathias jürgen Brem Kirsty Sands Maria Nieto-Rosado Maria Mykolaivna Trush Nadira Naznin Rakhi Willames Martins Yuqing Zhou Christopher joseph Schofield Timothy walsh Department of Biology&Ineos Oxford Institute for Antimicrobial Research University of OxfordOxford OX13REUK Chemistry Research Laboratory Department of Chemistry and the Ineos Oxford Institute for Antimicrobial ResearchUniversity of OxfordOxford OX13TAUK Latvian Institute of Organic Synthesis Riga LV-1006Latvia Department of Medical Microbiology Division of Infection and ImmunitySchool of MedicineCardiff UniversityCardiff CF144XNUK Enzymology and Applied Biocatalysis Research Center Faculty of Chemistry and Chemical EngineeringBabes-Bolyai UniversityCluj-Napoca 400028Romania

This work explores the potential of a triple combination of meropenem(MEM),a novel metallo-blactamase(MBL)inhibitor(indole-2-carboxylate 58(InC58)),and a serine-b-lactamase(SBL)inhibitor(avibactam(AVI))for broad-spectrum activity against carbapenemase-producing bacteria.A diverse panel comprising MBL-and SBL-producing strains was used for susceptibility testing of the triple combination using the agar dilution *** frequency of resistance(FoR)to MEM combined with InC58 was *** were sequenced and tested for cross resistance,fitness,and the stability of the resistance *** with the double combinations of MEM plus an SBL or MBL inhibitor,the triple combination extended the spectrum of activity to most of the isolates bearing SBLs(oxacillinase-48(OXA-48)and Klebsiella pneumoniae carbapenemase-2(KPC-2))and MBLs(New Delhi metallo-blactamases(NDMs)),although it was not effective against Verona integron-encoded metallo-blactamase(VIM)-carrying Pseudomonas aeruginosa(***)and OXA-23-carrying Acinetobacter baumannii(***).The FoR to MEM plus InC58 ranged from 2.22×10^(-7)to 1.13×10^(-6).The resistance correlated with mutations to ompC and comR,affecting porin C and copper permeability,*** mutants manifested a fitness cost,a decreased level of resistance during passage without antibiotic pressure,and cross resistance to another carbapenem(imipenem)and a b-lactamase inhibitor(taniborbactam).In conclusion,compared with the dual combinations,the triple combination of MEM with InC58 and AVI showed a much wider spectrum of activity against different carbapenemaseproducing bacteria,revealing a new strategy to combat b-lactamase-mediated antimicrobial resistance.

关键词： Carbapenemase Metallo/serine-b-lactamase inhibitor Avibactam Meropenem Antimicrobial resistance

Synthesis of tetraarylmethanes:1897–2022

在线全文

学校读者我要写书评

暂无评论

Green Synthesis and Catalysis 2023年第4期4卷 273-292页

作者： Lai Chen jingqian Huo jinlin Zhang judith N.Currano Haixing Guan Patrick j.walsh jianyou Mao College of Plant Protection Hebei Agricultural UniversityBaoding 071000China Department of Chemistry University of PennsylvaniaPennsylvania 19104-6323United States Experimental Center Shandong Provincial Key Laboratory of Traditional Chinese Medicine for Basic ResearchKey Laboratory of Traditional Chinese Medicine Classical TheoryMinistry of EducationShandong University of Traditional Chinese MedicineJinan 250355China Technical Institute of Fluorochemistry(TIF) State Key Laboratory of Materials Oriented Chemical Engineering(MCE)School of Chemistry and Molecular EngineeringNanjing Tech UniversityNanjing 211816China

Tetraarylmethanes(TAMs)contain a carbon atom bound to four aryl *** have found diverse applications in chemistry,materials science,chemical biology and medicinal chemistry because of their unique 3-dimensional *** a reflection of the high demand for TAMs,over 32,000 unique TAMs have been *** distinct structures of TAMs and the crowded nature of the central carbon atom require different strategies for their *** we present the first review on the synthesis of TAMs,from classical approaches to modern methods,including enantioselective syntheses of *** provide a critical evaluation of methods and highlight important directions for future research into the synthesis of this aesthetically pleasing and very useful class of spherical structures.

关键词： Tetraarylmethane Tetraphenylmethane Cross-coupling Palladium Radicals Fridel-crafts Quaternary carbons

Storing Freshwater Versus Storing Electricity in Power Systems with High Freshwater Electric Demand

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

journal of Modern Power Systems and Clean Energy 2024年第2期12卷 323-333页

作者： Mubarak j.Al-Mubarak Antonio j.Conejo Department of Electrical and Computer Engineering The Ohio State UniversityColumbusOHUSA Department of Electrical Engineering Kuwait UniversityP.O.Box 5969Safat 13060Kuwait Department of Integrated Systems Engineering and the Department of Electrical and Computer Engineering The Ohio State UniversityColumbusOH 43210USA IEEE

We consider a power system whose electric demand pertaining to freshwater production is high(high freshwater electric demand),as in the Middle East,and investigate the tradeoff of storing freshwater in tanks versus storing electricity in batteries at the day-ahead operation *** storing freshwater and storing electricity increase the actual electric demand at valley hours and decrease it at peak hours,which is generally beneficial in term of cost and ***,to what extent?We analyze this question considering three power systems with different generation-mix configurations,i.e.,a thermal-dominated mix,a renewable-dominated one,and a fully renewable *** generation-mix configurations are inspired by how power systems may evolve in different countries in the Middle *** production uncertainty is compactly modeled using chance *** draw conclusions on how both storage facilities(freshwater and electricity)complement each other to render an optimal operation of the power system.

关键词： Power system operation freshwater production and transportation coordination day-ahead scheduling

Analysis of ancient mass extinction recoveries in marine environments: generating strategies for managing outcomes of the current mass extinction

在线全文

学校读者我要写书评

暂无评论

National Science Review 2024年第1期11卷 8-10页

作者： David j.Bottjer Department of Earth Sciences University of Southern California

The defining feature of a mass extinction and its associated recovery is the global amount of extinction that occurred[1]. However, there is finer-scale detail to the story, as seen in the ongoing modern mass extinction(the sixth mass extinction), which exhibits variable effects among marine ecosystems and environments, and hence geographic areas [1].

关键词：

Global weirding at mass extinction horizons

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

National Science Review 2024年第1期11卷 10-12页

作者： Gregory j.Retallack Department of Earth Sciences University of Oregon

A strong motivation for studying mass extinctions is understanding how current climatic and biodiversity crises will affect creatures living on land such as ourselves. Perhaps the question is: how bad can it get? In that case, terrestrial Permian-Triassic mass extinctions are an irresistible worst-case scenario [1].

关键词：