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基于DInSAR沉陷区超前影响角计算修正方法

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深圳大学学报（理工版） 2012年第4期29卷 290-294页

作者：阎跃观戴华阳葛林林 alex Hay-ManNg 李晓静中国矿业大学(北京)地球科学与测绘工程学院北京100083 新南威尔士大学测绘与空间信息学院新南威尔士大学土木与环境工程学院

基于澳大利亚West Cilff煤矿开采期间获取的差分干涉合成孔径雷达(DInSAR)数据,以动态开采过程中超前影响角为例,研究对比实际超前影响距与DInSAR实测超前影响距的偏差,提出采用距离影响系数修正沉陷区DInSAR超前影响角的计算方法,实现... 详细信息

基于澳大利亚West Cilff煤矿开采期间获取的差分干涉合成孔径雷达(DInSAR)数据,以动态开采过程中超前影响角为例,研究对比实际超前影响距与DInSAR实测超前影响距的偏差,提出采用距离影响系数修正沉陷区DInSAR超前影响角的计算方法,实现直接利用DInSAR获取数据,研究沉陷区变形规律.

关键词：差分干涉合成孔径雷达超前影响角距离影响系数动态开采计算修正方法地表沉陷监测澳大利亚

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摒弃主义忘记流派——钱慧溟和他的阿福系列

城市漫步（全国英文版） 2015年第2期 74-79页

作者： alex Zheng li Jing 不详

QIAN'S A'FU OIL PAINTING SERIES-CHARACTERISTIC OF HIS FULL-BODIED,MYSTERIOUSLY OOZING FREESTYLE STROKES AND BOLD CHILD-liKE COLOURING-IS PURELY INTUITIONAL.

关键词： HIS 钱慧 ING

Venous thromboembolism in children with acute lymphoblastic leukemia in China:a report from the Chinese Children’s Cancer Group-ALL-2015

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Frontiers of Medicine 2023年第3期17卷 518-526页

作者： Mengmeng Yin Hongsheng Wang Xianmin Guan Ju Gao Minghua Yang Ningling Wang Tianfeng liu Jingyan Tang alex WK Leung Fen Zhou Xuedong Wu Jie Huang Hong li Shaoyan Hu Xin Tian Hua Jiang Jiaoyang Cai Xiaowen Zhai Shuhong Shen Qun Hu Department of Pediatrics Tongji Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Hematology/Oncology Children’s Hospital of Fudan UniversityShanghai 201100China Department of Hematology/Oncology Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityKey Laboratory of Pediatric Hematology&Oncology of China Ministry of HealthShanghai 200120China Department of Hematology/Oncology Chongqing Medical University Affiliated Children’s HospitalChongqing 400015China Department of Pediatrics Key Laboratory of Birth Defects and Related Disease of Women and ChildrenMinistry of EducationWest China Second University HospitalSichuan UniversityChengdu 610041China Department of Pediatrics Xiangya Hospital Central South UniversityChangsha 410008China Department of Pediatrics Anhui Medical University Second Affiliated HospitalHefei 230601China State Key Laboratory of Experimental Hematology and Division of Pediatric Blood Diseases Center Institute of Hematology and Blood Diseases HospitalPeking Union Medical CollegeChinese Academy of Medical SciencesTianjin 300020China Department of Pediatrics Hong Kong Children’s HospitalThe Chinese University of Hong KongHong Kong SAR 999077China Department of Pediatrics Union Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Pediatrics Nanfang HospitalSouthern Medical UniversityGuangzhou 516006China Department of Hematology/Oncology Children’s Hospital of Nanjing Medical UniversityNanjing 210008China Department of Hematology/Oncology Shanghai Children’s HospitalShanghai Jiao Tong UniversityShanghai 200062China Department of Hematology/Oncology Children’s Hospital of Soochow UniversitySuzhou 215002China Department of Hematology/Oncology Kunming Children’s HospitalKunming 650103China Department of Hematology/Oncology Guangzhou Women and Children’s Medical CenterGuangzhou 510620China

Venous thromboembolism(VTE)is a complication in children with acute lymphoblastic leukemia(ALL).The Chinese Children’s Cancer Group-ALL-2015 protocol was carried out in China,and epidemiology,clinical characteristics,and risk factors associated with VTE were *** collected data on VTE in a multiinstitutional clinical study of 7640 patients with ALL diagnosed in 20 hospitals from January 2015 to December ***,VTE occurred in 159(2.08%)patients,including 90(56.6%)during induction therapy and 108(67.92%)in the upper extremities.T-ALL had a 1.74-fold increased risk of VTE(95%CI 1.08–2.8,P=0.022).Septicemia,as an adverse event of ALL treatment,can significantly promote the occurrence of VTE(P<0.001).Catheter-related thrombosis(CRT)accounted for 75.47%(n=120);and,symptomatic VTE,58.49%(n=93),which was more common in patients aged 12–18 years(P=0.023),non-CRT patients(P<0.001),or patients with cerebral thrombosis(P<0.001).Of the patients with VTE treated with anticoagulation therapy(n=147),4.08%(n=6)had *** VTE recurrence rate was 5.03%(n=8).Patients with VTE treated by non-ultrasoundguided venous cannulation(P=0.02),with residual thrombus(P=0.006),or with short anticoagulation period(P=0.026)had high recurrence ***,preventing repeated venous puncture and appropriately prolonged anticoagulation time can reduce the risk of VTE recurrence.

关键词： acute lymphoblastic leukemia child venous thromboembolism epidemiology clinical characteristic risk factor

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Perspective:Societally connected multimedia across cultures

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Journal of Zhejiang University-Science C(Computers and Electronics) 2012年第12期13卷 875-880页

作者： Zhongfei ZHANG Zhengyou ZHANG Ramesh JAIN Yueting ZHUANG Noshir CONTRACTOR alexander G. HAUPTMANN Alejandro (alex) JAIMES Wanqing li alexander C. LOUI Tao MEI Nicu SEBE Yonghong TIAN Vincent S. TSENG Qing WANG Changsheng XU Huimin YU Shiwen YU Department of lnformation Science & Electronic Engineering Zhejiang University Hangzhou 310027 China Microsoft Research Redmond WA USA Department of Computer Science University of California IrvineCA USA College of Computer Science and Technology Zhejiang UniversityHangzhou 310027 China School of Communication Northwestern University Evanston 1LUSA Informedia Group CMU Pittsburgh PA Yahoo.t Research Spain School of Computer Science and Software Engineering Universityof Wollongong NSW Australia Kodak Research Labs USA Microsoft Research Asia China Department of Information Engineering and Computer Science University of Trento Italy Institute of Computational linguistics Peking University Beijing100871 China Institute of Computer Science and Information National ChengKung University Taiwan 701 Tainan School of Computer Science Northwestern Polytechnical UniversityXi'an 710129 China Institute of Automation Chinese Academy of Sciences Beijing100080 China

The advance of the Internet in the past decade has radically changed the way people communicate and col- laborate with each other. Physical distance is no more a barrier in online social networks, but cultural differences （at the individual, community, as well as societal levels） still govern human-human interactions and must be con- sidered and leveraged in the online world. The rapid deployment of high-speed lnternet allows humans to interact using a rich set of multimedia data such as texts, pictures, and videos. This position paper proposes to define a new research area called ＇connected multimedia＇, which is the study of a collection of research issues of the super-area social media that receive little attention in the literature. By connected multimedia, we mean the study of the social and technical interactions among users, multimedia data, and devices across cultures and explicitly exploiting the cultural differences. We justify why it is necessary to bring attention to this new research area and what benefits of this new research area may bring to the broader scientific research community and the humanity.

关键词： Connected multimedia Social media Social-cultural constraint

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走得慢,只要能回家

城市漫步（全国英文版） 2015年第5期 58-59页

作者： alex Zheng li Jing 不详

因为喜爱数字6,张立宪自称老六。他是联想ThinkPad中国思想力人物评选,的十位中国思想力人物之一。平朴风趣的文风、勤慎踏实和非凡的多任务操作能力以及独到的装帧理念,让这个擅长跨界的出版人在中国的图书界独树一帜,完美诠释了和华... 详细信息

因为喜爱数字6,张立宪自称老六。他是联想ThinkPad中国思想力人物评选,的十位中国思想力人物之一。平朴风趣的文风、勤慎踏实和非凡的多任务操作能力以及独到的装帧理念,让这个擅长跨界的出版人在中国的图书界独树一帜,完美诠释了和华而不实的成功对决。

关键词：多任务操作 ThinkPad 人物评选张立宪华而不实

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北京奥运会期间气溶胶光学特性垂直分布特征

气候与环境研究 2010年第5期15卷 602-608页

作者：杨婷李杰王自发张柏王喜全 GBAGUIDI alex 中国科学院东北地理与农业生态研究所地理遥感信息研究中心长春130012 中国科学院大气物理研究所竺可桢-南森国际研究中心北京100029 中国科学院研究生院北京100049

利用激光雷达观测资料,分析了奥运会期间气溶胶消光系数的垂直廓线,并结合后向轨迹方法对北京地区污染来源以及污染控制措施效果进行了初步分析。观测数据表明:1)2008年消光系数较之2007年在不同高度层的降幅并不相同,600m以下的年际降... 详细信息

利用激光雷达观测资料,分析了奥运会期间气溶胶消光系数的垂直廓线,并结合后向轨迹方法对北京地区污染来源以及污染控制措施效果进行了初步分析。观测数据表明:1)2008年消光系数较之2007年在不同高度层的降幅并不相同,600m以下的年际降幅最为显著,1200～4000m高度范围次之。2)各类型消光系数垂直廓线出现频次的统计显示,2008年影响北京的主要廓线类型为边界层上部最高型,而非近地面最高型,说明2008年近地层消光系数有明显的降低。另外,利用后向轨迹法对近地层消光系数降低的原因进行了分析,结果表明,当近地层气团中污染物主要来自于北京周边地区时,400m以下气溶胶消光系数的年际降幅可达18.1%,这说明北京周边区域大气污染控制措施对改善北京近地面层气溶胶污染起到了重要作用。

关键词：激光雷达气溶胶消光系数垂直廓线后向轨迹

人工智能在药物靶点的筛选及验证方面的应用进展

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中国药科大学学报 2023年第3期54卷 269-281页

作者：王超肖辅李妙竹潘颖丁晓任峰 Zhavoronkov alex 王亚洲英矽智能科技(上海)有限公司上海201203

近年来人工智能发展迅速,随着算力的提升、算法的迭代,人工智能极大方便了生物信息、化学信息和临床数据的收集及处理,为新药研发注入了新的活力。本综述对人工智能在制药领域的发展历程及其主要算法进行了简要介绍,随后结合具体实例对... 详细信息

近年来人工智能发展迅速,随着算力的提升、算法的迭代,人工智能极大方便了生物信息、化学信息和临床数据的收集及处理,为新药研发注入了新的活力。本综述对人工智能在制药领域的发展历程及其主要算法进行了简要介绍,随后结合具体实例对人工智能在药物靶点筛选及验证方面的不同阶段进行了详细描述,包括药物靶点发现、蛋白结构预测以及苗头化合物生成与优化等。最后对人工智能平台“端到端”的一次高效应用过程进行了具体讨论。

关键词：人工智能靶点发现蛋白结构预测苗头化合物生成端到端应用

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Glycolysis in the control of blood glucose homeostasis

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Acta Pharmaceutica Sinica B 2012年第4期2卷 358-367页

作者： Xin Guo Honggui li Hang Xu Shihlung Woo Hui Dong Fuer Lu alex J.Lange Chaodong Wu Intercollegiate Faculty of Nutrition Department of Nutrition and Food ScienceTexas A&M UniversityCollege StationTX 77843USA Institute of Integrated Chinese and Western Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430000China Department of Biochemistry Molecular Biology and Biophysicsthe University of MinnesotaMinneapolisMN 55405USA

Glycolysis,a simple pathway of glucose metabolism,critically regulates insulin secretion and metabolic functions of various *** on cell types,rates of glycolysis are determined at various steps of glycolysis that are subjected to the control of key metabolic and regulatory enzyme(S),which include glucokinase,6-phosphofructo-I-kinase,and 6-phosphofructo-2-kinase/fructose-2,*** enzymes are regulated by both nutritional and hormonal signals at the levels of transcription,translation,and post-translational *** hepatocytes,glycolysis is involved in the control of hepatic glucose *** latter,when excessive,contributes to hyperglycemia in *** pancreatic β cells,glycolysis couples glucose-stimulated insulin *** or relatively low levels of circulating insulin causes *** adipocytes,glycolysis generates metabolites for lipogenesis and channels fatty acids from excessive oxidation to triglyceride synthesis,thereby reducing oxidative *** increased proinflammatory status,adipocytes produce pro-hyperglycemic factors and bring about hyperglycemia and insulin *** hypotha lamic neurons,glycolysis conveys nutrient sensing that is related to feeding *** of glycolysis occurs in conditions of insulin deficiency or resistance,and is attributable to inappropriate amount and/or activities of metabolic and regulatory enzymes of *** key metabolic and regulatory enzymes to enhance glycolysis may offer viable approaches for treatment of diabetes.

关键词： Glycolysis Diabetes Insulin resistance liver Pancreatic beta cells Adipose tissue Hypothalamus Inflammatory response

Method for Single Intravenous Anesthetic Infusion in a Rodent Model

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Open Journal of Anesthesiology 2015年第5期5卷 96-104页

作者： Shawn K Puri Jing li Ming Xiong Johan Reyes Pratap R. Nadavaluru Jiang Hong Ye alex Bekker Department of Anesthesiology New Jersey Medical School Rutgers The State University of New Jersey Newark NJ USA

Venous catheterization, endotracheal intubation, and mechanical ventilation are necessary for performing total intravenous general anesthesia in rats. Intubation and IV cannulation of the rat is challenging because of the animals’ small size and the lack of equipment specifically designed for the restricted anatomical dimensions. Here, we present methods for tail venous catheterization and intubation that are quickly learned by the provider with clinical operating room experience but lack experience in the lab. For tail venous catheterization, each rat (n = 20) was gently restrained in a rat chamber;its tail was placed in warm water for 10 minutes, and a 24 gauge intravenous catheter was inserted into the lateral tail vein. The catheter was fixed in place using tape and attached to a T-connector for drug administration. A bolus of propofol (n = 10), ketamine (n = 7), or etomidate (n = 3) was administered to achieve rapid deep anesthesia. Once anesthetized, rats were intubated with the aid of a modified pediatric laryngoscope. The standard miller blade 0 was cut on each side for approximately 2/3 of the total blade length to remove a total of half the width. After the ventilator was properly set, the rats’ vital signs and metabolic status were monitored. Throughout the one-hour infusion, the rats’ physiologic parameters were maintained within normal range. These results indicate that intravenous general anesthesia can be performed effectively and safely in small animals using the refined catheterization and intubation methods tested in this study. These techniques are easily reproducible and learned as they mimic the tools and strategies commonly used in the OR.

关键词： Refinement Venous Catheterization Endotracheal Intubation Intravenous General Anesthesia Rat