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从无力到无畏

经营者(汽车商业评论) 2015年第1期 45-47页

作者： alex taylor iii

尽管全球汽车销量在去年保持强劲增长势头,但召回事件却此起彼伏,对于美国汽车业意味着什么?2014年,尽管美国汽车销量自2007年以来首次超过1600万辆,但占据媒体头条的还是各类召回事故。在召回舞台上最活跃的是通用汽车公司,由于不断曝... 详细信息

尽管全球汽车销量在去年保持强劲增长势头,但召回事件却此起彼伏,对于美国汽车业意味着什么?2014年,尽管美国汽车销量自2007年以来首次超过1600万辆,但占据媒体头条的还是各类召回事故。在召回舞台上最活跃的是通用汽车公司,由于不断曝出点火开关故障,通用去年已经召回了几百万辆汽车。这家汽车制造商选择勇敢曝光自

关键词：汽车销量底特律油价下跌汽车厂商

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福特公司寻求建议

国际经济合作 2007年第6期 95-95页

作者： alex taylor iii 王赟外交学院

如果你的家族财产在仅仅5年半的时间里就蒸发了5．81亿美元，你会怎么办？这正是近一段时期以来比尔·福特以及福特汽车王朝另外46位第四代及第五代家族成员设法解决的问题。2001年，当比尔接任福特汽车公司CEO时，福特家族的B股股票市... 详细信息

如果你的家族财产在仅仅5年半的时间里就蒸发了5．81亿美元，你会怎么办？这正是近一段时期以来比尔·福特以及福特汽车王朝另外46位第四代及第五代家族成员设法解决的问题。2001年，当比尔接任福特汽车公司CEO时，福特家族的B股股票市值为11．4亿美元。

关键词：福特公司福特汽车公司家族成员股票市值福特家族第五代第四代 CEO

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Adaptation in brain structure and respiratory and olfactory structures across environmental gradients in African and North American muroid rodents

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Integrative Zoology 2024年第1期19卷 165-181页

作者： Peter J.taylor Aluwani NENGOVHELA Christiane DENYS Graham R.SCOTT Catherine M.IVY Department of Zoology School of Natural and Mathematical SciencesUniversity of VendaThohoyandouSouth Africa Afromontane Unit Department of Zoology and EntomologyUniversity of the Free StatePhuthaditjhabaSouth Africa Department of Mammalogy National MuseumBloemfonteinSouth Africa Institut de Systématique EvolutionBiodiversité(ISYEB)Muséum National d’Histoire NaturelleCNRSSorbonne UniversitéEPHEUniversitéDes AntillesParisFrance Department of Biology McMaster UniversityHamiltonOntarioCanada Guglielmo and Shoemaker Labs Advanced Facility for Avian ResearchUniversity of Western OntarioLondonOntarioCanada

Morphometric studies of 3D micro CT-scanned images can provide insights into the evolution of the brain and sensory structures but such data are still scarce for the most diverse mammalian order of *** reviewed and new data,we tested for convergence to extreme aridity and high elevation in the sensory and brain morphology of rodents,from morphometric data from micro-CT X-ray scans of 174 crania of 16 species of three distantly re-lated African murid(soft-furred mice,Praomyini,laminate-toothed rats,Otomyini,and gerbils,Gerbillinae)clades and one North American cricetid(deer mice and white-footed mice,Peromyscus)*** studies demon-strated convergent evolution acting on the oval window area of the cochlea(enlarged in extremely arid-adapted species of Otomyini and Gerbillinae)and on endocranial volume(reduced in high elevation taxa of Otomyini and Peromyscus).However,contrary to our predictions,we did notfind evidence of convergence in brain struc-ture to aridity,or in the olfactory/respiratory system(turbinate bones)to high *** structure differed,particularly in the petrosal lobules of the cerebellum and the olfactory bulbs,between Otomyini and Gerbillinae,with extreme arid-adapted species in each clade being highly divergent(not convergent)from other species in the same *** observed greater“packing”of the maxillary turbinate bones,which have important respiratory functions,in Peromyscus mice from high and low elevations compared to the high-elevation African Praomyini,but more complex patterns within Peromyscus,probably related to trade-offs in respiratory physiology and heat exchange in the nasal epithelium associated with high-elevation adaptation.

关键词： 3D morphometrics Africa brain size North America Rodentia sensory evolution

Introduction to management science Bernard W. taylor iii. 8th ed.

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Introduction to management science Bernard W. Taylor III.

Introduction to management science / Bernard W. taylor iii. 7th ed.

2004年

作者： Bernard W. taylor iii.

来源：畅想之星图书光盘版（南... 评论

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Natural products as a means of overcoming cisplatin chemoresistance in bladder cancer

2002年

作者： Bernard W. taylor iii.

Includes index.

ISBN: (纸本)0130331902

Includes index.

关键词： Management science.

来源：畅想之星图书光盘版（南... 评论

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Cancer Drug Resistance 2021年第1期4卷 69-84页

作者： Ganeshkumar Rajendran John A.taylor iii Benjamin L.Woolbright Department of Urology University of Kansas Medical CenterKansas CityKS 66160USA

Cisplatin remains an integral part of the treatment for muscle invasive bladder cancer.A large number of patients do not respond to cisplatin-based chemotherapy and efficacious salvage regimens are *** has offered a second line of treatment;however,only approximately 20% of patients respond,and molecular subtyping of tumors indicates there may be significant overlap in those patients that respond to cisplatin and those patients that respond to *** such,restoring sensitivity to cisplatin remains a major hurdle to improving patient *** potential source of compounds for enhancing cisplatin is naturally derived bioactive products such as phytochemicals,flavonoids and *** compounds can activate a diverse array of different pathways,many of which can directly promote or inhibit cisplatin *** purpose of this review is to understand current drug development in the area of natural products and to assess how these compounds may enhance cisplatin treatment in bladder cancer patients.

关键词： Cisplatin bladder cancer natural products apoptosis

Experimental study of friction dissipators for seismic protection of building structures

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Earthquake Engineering and Engineering Vibration 2011年第4期10卷 475-486页

作者： F. López-Almansa S.T. de la Cruz C. taylor Technical University of Catalonia Architecture Structures Department Universidad Autónoma de Ciudad Juárez Civil and Environmental Engineering Department Civil Engineering Department University of Bristol

This paper presents the results from unidirectional shaking table tests of two reduced scale steel models of a building frame, with one and two floors, respectively. These frames incorporate friction dissipators at every floor. The inputs are sine-dwells and artificial and registered earthquakes. This study is part of a larger research project aiming to assess the seismic efficiency of friction dissipators by means of an integrated numerical and experimental approach. Inside this framework, the main objectives of these experiments are to：（i） collect a wide range of results to calibrate a numerical model derived within the project, （ii） clarify some of the most controversial issues about friction dissipators （including behavior for inputs containing pulses, capacity to reduce resonance peaks, introduction of high frequencies in the response, and self- generated eccentricities）, （iii） better understand their dynamic behavior, （iv） provide insight on the feasibility and reliability of using simple friction dissipators for seismic protection of building structures and （v） characterize the hysteretic behavior of these devices. Most of these objectives are satisfactorily reached and relevant conclusions are stated.

关键词： building structures earthquake engineering passive control friction energy dissipators experimentalverification shaking table tests

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Hormone Replacement Therapy for Restoring the HPG Axis in Pain Patients Treated with Long-Term Opioid Analgesics

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Pharmacology & Pharmacy 2018年第11期9卷 473-480页

作者： Srinivas Nalamachu Joseph V. Pergolizzi Jr. Robert taylor Jr. Jo Ann Le Quang Joseph V. Pergolizzi iii Robert B. Raffa International Clinical Research Institute and Pain Management Institute Overland Park KS USA NEMA Research Inc. Naples FL USA LeQ Medical Angleton TX USA College of Pharmacy University of Arizona Tucson AZ USA School of Pharmacy Temple University Philadelphia PA USA

Opioids are a treatment option for a variety of chronic pain conditions. But long-term opioid use can be associated with side effects, including hypogonadism. Opioid-induced hypogonadism (OIhG) is associated with the alteration of the hypothalamic-pituitary-gonadal axis (HPG). In males, hypogonadism can result in erectile dysfunction, reduced libido, fatigue, worsening mood, and increased risk of osteoporosis;in females, it can result in changes in the menstrual cycle and reduced libido, among other effects. A current treatment option for these patients is hormone replacement therapy. In this report, we discuss the problem of opioid-induced hypogonadism, and the therapeutic approach and the potential complications of treating pain patients using hormone replacement therapy.

关键词： Opioid Therapy Chronic Pain HPG Axis Hormone Replacement Therapy

Quantitative Trait Loci Analysis Identifies a Prominent Gene Involved in the Production of Fatty Acid-Derived Flavor Volatiles in Tomato

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Molecular Plant 2018年第9期11卷 1147-1165页

作者： Karolina Garbowicz Zhongyuan Liu Saleh Alseekh Denise Tieman Mark taylor Anastasiya Kuhalskaya Itai Ofner Dani Zamir Harry J. Klee Alisdair R. Fernie Yariv Brotman Max-Planck-lnstitute of Molecular Plant Physiology Potsdam-Golm Germany Horticultural Sciences Plant Innovation Center University of Florida Gainesville FL USA Center of Plant System Biology and Biotechnology 4000 Plovdiv Bulgaria Department of Life Sciences Ben-Gurion University of the Negev Beersheba Israel Robert H. Smith Institute of Plant Sciences and Genetics Faculty of Agriculture Hebrew University of Jerusalem Rehovot 7610001 Israel These authors contributed equally to this article

To gain insight into the genetic regulation of lipid metabolism in tomato, we conducted metabolic trait loci （mQTL） analysis following the lipidomic profiling of fruit pericarp and leaf tissue of the Solanum pennellii introgression lines （IL）. To enhance mapping resolution for selected fruit-specific mQTL, we profiled the lipids in a subset of independently derived S. pennellii backcross inbred lines, as well as in a nearsogenic sub-iL population. We identified a putative lecithin：cholesterol acyltransferase that controls the levels of several lipids, and two members of the class iii lipase family, LIP1 and LIP2, that were associated with decreased levels of diacylglycerols （DAGs） and triacylglycerols （TAGs）. Lipases of this class cleave fatty acids from the glycerol backbone of acylglycerols. The released fatty acids serve as precursors of flavor volatiles. We show that LIP1 expression correlates with fatty acid-derived volatile levels. We further confirm the function of LIP1 in TAG and DAG breakdown and volatile synthesis using transgenic plants. Taken together, our study extensively characterized the genetic architecture of Upophilic compounds in tomato and demonstrated at molecular level that release of free fatty acids from the glycerol backbone can have a major impact on downstream volatile synthesis.

关键词： lipidomics lipids lipase volatile FA-VOC Z-4-decenal