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Antimicrobial approach of abdominal post-surgical infections

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World Journal of Gastrointestinal Surgery 2023年第12期15卷 2674-2692页

作者： Marco fiore Antonio Corrente Sveva Di Franco Aniello Alfieri Maria Caterina Pace Francesca Martora Stephen Petrou Claudio Mauriello Sebastiano Leone Department of Women Child and General and Specialized SurgeryUniversity of Campania“Luigi Vanvitelli”Naples 80138Italy Unit of Virology and Microbiology “Umberto I”HospitalNocera Inferiore 84018Italy Department of Emergency Medicine University of California San FranciscoSan FranciscoCA 94143United States Department of General Surgery “Santa Maria delle Grazie”HospitalPozzuoli 80078Italy Division of Infectious Diseases “San Giuseppe Moscati”HospitalAvellino 83100Italy

Abdominal surgical site infections(SSIs)are infections that occur after abdominal *** can be superficial,involving the skin tissue only,or more profound,involving deeper skin tissues including organs and implanted ***,SSIs are large global health problem with an incidence that varies significantly depending on the United Nations’Human Development *** purpose of this review is to provide a practical update on the latest available literature on SSIs,focusing on causative pathogens and treatment with an overview of the ongoing studies of new therapeutic strategies.

关键词： Surgical site infections Multidrug resistance Carbapenem-resistant Enterobacterales Carbapenem-resistant Klebsiella Abdominal post-operative complications Post-surgical infections

To compute or not to compute?

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Journal of Traffic and Transportation Engineering(English Edition) 2019年第1期6卷 85-93页

作者： Alessandra fiore Ivo Vanzi Camillo Nuti Cristoforo Demartino Rita Greco Bruno Briseghella Department of Engineering and Geology University of Chieti-Pescara "G.d'Annunzio" DICAR Department of Civil Engineering and Architecture Polytechnic University of Bari College of Civil Engineering Fuzhou University Department of Architecture Roma Tre University College of Civil Engineering Nanjing Tech University DICATECH Department of Civil Engineering Environment Territory Building and Chemical Polytechnic University of Bari

In a previous paper "to retrofit or not to retrofit?"(Nuti and Vanzi, 2003) a straightforward procedure able to forecast the economic return of seismic structural upgrading was presented. More recently, the authors realized that the final mathematical results can be much simplified so as to allow back-of-an-envelope computation. The title of this paper tries to highlight precisely this aspect, namely that for many a regular seismic structural upgrading cases, nearly no computation is needed(apart from one subtraction and one multiplication) to assess their economic convenience. These findings are presented and discussed in this paper, together with a state of the art on the cost-studies available in literature and technical codes. The mathematical formulation leading to the proposed approximation is suitably explained, underlining its applicability field and comparing it with the rigorous solution. Also a table and a formula are furnished that alternatively allows to calculate the maximum estimation errors, in order to obtain an upper and lower bound for the maximum amount of money which should be allocated for seismic structural upgrading.

关键词： Seismic retrofitting Structural reliability Safety Optimization Cost minimization

Assessment of cardiac function in infants with transposition of the great arteries after surgery: comparison of two methods

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World Journal of Pediatrics 2018年第4期14卷 373-377页

作者： Fan Yang Roberta Iacobelli Jian-Ming Wang fiore Salvatore Iorio Cardiac Surgery Department Hebei Province Children's HospitalNo.133Jianhua South StreetShijiazhuang 050031China Pediatric Cardiology Center of Ospedale Pediatrico Bambino Gesù Piazza S.Onofrio 400165 RomeItaly

Background Assessment of cardiac function is crucial in pediatric patients undergoing cardiovascular surgery, monitoring cardiac output and changing hemodynamic conditions during surgery accordingly is important to improve post-surgical outcome. We aimed to measure cardiac index (CI) and maximal rate of the increase of left ventricular pressure dp/dt(max) with the pressure recording analytic method (PRAM, MostCare?) and compared it with transthoracic echocardiographic cardiac index estimation in infants with transposition of the great arteries (TGA) undergoing surgical correction. Methods We enrolled 74 infants with TGA consecutively into this study. CI and dp/dt(max) were measured with PRAM and echocardiography at 0, 4, 8, 12, 24 and 48 h postoperatively. Blood brain natriuretic peptide (BNP) and blood lactate (Lac) were measured at baseline and after operation. Results The median age at surgery was 13 days (range 1–25 days) with an average weight of 3.24 kg (range 2.31–4.17 kg). CI esti-mated by PRAM was 1.11 ± 0.12 L/min/m2 (range 0.69–1.36) and by Doppler echocardiography was 1.13 ± 0.13 L/min/m2 (range 0.76–1.40). dp/dt(max) estimated by PRAM was 1.31 ± 0.03 mmHg/s (range 1.23–1.43) and by Doppler echocardiography was 1.31 ± 0.04 L/min/m2 (range 1.25–1.47). CI (r = 0.817,P< 0.001) and dp/dt(max) (r = 0.794,P< 0.001) measured by two meth-ods were highly correlated with a linear relation. Blood BNP and lactate increased to the highest level at 8–12 h post-operatively. Conclusions In the early post-operative period, PRAM provides reliable estimates of cardiac index and dp/dt(max) value compared with echocardiographic measurements. PRAM through mostcare? is a reliable continuous monitoring method for peri-operative management in children with congenital heart disease.

关键词： Cardiac index Doppler echocardiography dp/dt(max) Pressure recording analytic method Transposition of the great arteries

Nonalcoholic fatty liver disease prevalence in an Italian cohort of patients with hidradenitis suppurativa: A multi-center retrospective analysis

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World Journal of Hepatology 2019年第4期11卷 391-401页

作者： Giovanni Damiani Sebastiano Leone Kristen Fajgenbaum Nicola L Bragazzi alessia Pacifico Rosalynn RZ Conic Paolo DM Pigatto Carlo Maiorana Pierpaolo Poli Emilio Berti Maria C Pace Piergiorgio Malagoli Vincenzo Bettoli Marco fiore Department of Dermatology Case Western Reserve University Young Dermatologists Italian Network (YDIN) Centro Studi GISED Clinical Dermatology IRCCS Galeazzi Orthopaedic Institute Department of Biomedical Surgical and Dental SciencesUniversity of Milan Division of Infectious Diseases "San Giuseppe Moscati" Hospital University of North Carolina School of Medicine School of Public Health Department of Health Sciences (DISSAL)University of Genoa San Gallicano Dermatological Institute IRCCS Center for Jawbone Atrophies Policlinico Hospital University of Milan School of Dentistry Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti Università degli Studi di Milano Unità Operativa di Dermatologia IRCCS Fondazione Ca’ GrandaOspedale Maggiore Policlinico Department of Women Child and General and Specialized SurgeryUniversity of Campania "Luigi Vanvitelli" Dermatology Unit Azienda Ospedaliera San Donato Milanese Department of Clinical and Experimental Dermatology O.C. of DermatologyAzienda Ospedaliero-Universitaria di Ferrara

BACKGROUND Nonalcoholic fatty liver disease(NAFLD) includes two distinct conditions, with different histologic features and prognosis: non-alcoholic fatty liver(NAFL) and non-alcoholic steatohepatitis(NASH). Furthermore, NASH is the more aggressive necro-inflammatory form, which may accumulate fibrosis and result in End stage liver disease(ESLD). NAFLD is also linked to systemic inflammatory conditions such as psoriasis. NAFLD is currently the most common cause of ESLD in Western countries, becoming a serious public health *** suppurativa(HS) is a systemic inflammatory/autoinflammatory disease of the terminal follicular epithelium of the apocrine gland with a prevalence of 0.05% to 4.10%. Due to its systemic inflammatory behavior several comorbidities were recently associated, however liver ones were scarcely *** To evaluate the prevalence and characteristics of NASH/NAFL in HS *** This retrospective study is a sub-analysis of a larger study carried out in 4 Italian dermatological centers. In this cohort, there were 83 patients: 51 patients with HS only, 20 patients with HS/NAFL and 12 with HS/*** Inflammatory comorbidities were present in 3.9% of HS only patients, 25% of HS/NAFL patients and 58.3% of HS/NASH patients(P < 0.001). Similarly, mean Autoinflammatory Disease Damage Index(ADDI) was significantly higher among patients with HS/NASH(5.3 ± 2.2, P < 0.001) compared to patients with HS/NAFL or HS only(2.8 ± 1.6 and 2.6 ± 1.4 respectively). Furthermore, ADDI correlates with IHS4 in HS, HS/NAFL and HS/NASH. Diabetic patients have higher Hurley score than not diabetic ones. Ultrasound examination was significantly different in the three *** HS patients displayed a high prevalence of NASH/NAFLD and ultrasound examination should be particularly addressed to patients that display high ADDI scores.

关键词： Non-alcoholic steatohepatitis Non-alcoholic fatty liver Nonalcoholic fatty liver disease End stage liver disease Hidradenitis suppurativa

Classifying Cardiac Anomalies in Right and Left Isomerism:Concordant and Discordant Patterns

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Congenital Heart Disease 2023年第1期18卷 97-111页

作者： Lilia Oreto Giuseppe Mandraffino Paolo Ciliberti Teresa P.Santangelo Placido Romeo Antonio Celona Placido Gitto Lorenzo Galletti fiore S.Iorio Alfredo Di Pino Aurelio Secinaro Paolo Guccione Robert H.Anderson Salvatore Agati Mediterranean Pediatric Cardiology Center Bambino GesùChildren’s HospitalVia SirinaTaorminaItaly Internal Medicine Unit Department of Clinical and Experimental MedicineUniversity of MessinaMessinaItaly Department of Pediatric Cardiology and Cardiac Surgery Bambino GesùChildren’s HospitalRomaItaly Advanced Cardiovascular Imaging Unit Department of ImagingBambino GesùChildren’s HospitalRomaItaly Radiology Department S.Vincenzo HospitalTaorminaItaly Biosciences Institute Newcastle UniversityNewcastle upon TyneUK

Aims:Evidence is emerging that,in the setting of isomerism,the atrial and bronchial arrangement are not always concordant,nor are these patterns always harmonious with the arrangement of the abdominal *** aimed to evaluate the concordance between these features in a cohort of patients with cardiac malformations in the setting of known isomerism,seeking to determine whether it was feasible to assess complexity on this basis,in this regard taking note of the potential value of bronchial as opposed to appendage *** and Results:We studied 78 patients known to have isomerism of the bronchuses,43 with right and 35 with left *** anatomy could be determined in 49 cases(63%),all but one of these being concordant with bronchial *** assessing abdominal features,in only 59 cases(76%)was splenic morphology in keeping with the thoracic *** expected,right isomerism was associated with greater complexity of cardiac malformations,with an odds ratio of 6.53,with confidence intervals from 2.2–19.3(p<0.001).The odds were slightly decreased with thoraco-abdominal disharmony,when lesions shown to carry higher risk were then found in the setting of left ***:Harmony is excellent between bronchial and appendage isomerism,but less so with the arrangement of the abdominal *** isomerism in our cohort,was indicative of a sixfold increase in intracardiac *** discordance was found between the systems,however,the cardiac anomalies were less typical of the anticipated findings for right *** isomerism of the appendages.

关键词： Isomerism asplenia polysplenia congenital heart disease bronchial isomerism atrial appendages

Forecasting directional movement of Forex data using LSTM with technical and macroeconomic indicators

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Financial Innovation 2021年第1期7卷 1-36页

作者： Deniz Can Yıldırım Ismail HakkıToroslu Ugo fiore Department of Computer Engineering Middle East Technical University06800 AnkaraTurkey Department of Management Studies and Quantitative Methods Parthenope University80132 NapoliNAItaly

Forex(foreign exchange)is a special financial market that entails both high risks and high profit opportunities for *** is also a very simple market since traders can profit by just predicting the direction of the exchange rate between two ***,incorrect predictions in Forex may cause much higher losses than in other typical financial *** direction prediction requirement makes the problem quite different from other typical time-series forecasting *** this work,we used a popular deep learning tool called“long short-term memory”(LSTM),which has been shown to be very effective in many time-series forecasting problems,to make direction predictions in *** utilized two different data sets—namely,macroeconomic data and technical indicator data—since in the financial world,fundamental and technical analysis are two main techniques,and they use those two data sets,*** proposed hybrid model,which combines two separate LSTMs corresponding to these two data sets,was found to be quite successful in experiments using real data.

关键词： Time series Forex Directional movement forecasting Technical and macroeconomic indicators LSTM

Taking advantage of the potential of mesenchymal stromal cells in liver regeneration:Cells and extracellular vesicles as therapeutic strategies

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World Journal of Gastroenterology 2018年第23期24卷 2427-2440页

作者： Esteban Juan fiore Luciana María Domínguez Juan Bayo Mariana Gabriela García Guillermo Daniel Mazzolini Laboratory of Gene Therapy Instituto de Investigaciones en Medicina TraslacionalCONICET-Universidad Austral

Cell-based therapies for acute and chronic liver diseases are under continuous progress. Mesenchymal stem/stromal cells(MSCs) are multipotent cells able to migrate selectively to damaged tissue and contribute to its healing and regeneration. The MSC pro-regenerative effect occurs due to their immunomodulatory capacity and their ability to produce factors that promote cell protection and survival. Likewise,it has been observed that part of their paracrine effect is mediated by MSC-derived extracellular vesicles(EVs). EVs contain proteins,lipids and nucleic acids(DNA,m RNA,mi RNA,lnc RNA) from the cell of origin,allowing for intercellular communication. Recently,different studies have demonstrated that MSC-derived EVs could reproduce,at least in part,the biological effects obtained by MSCbased therapies. Moreover,due to EVs' stability for long periods of time and easy isolation methods they have become a therapeutic option to MSCs treatments. This review summarizes the latest results achieved in clinical trials using MSCs as cell therapy for liver regeneration,the role of EVs in liver physiopathology and the potential of MSC-derived EVs as intercellular mediators and therapeutic tools in liver diseases.

关键词： Mesenchymal stem cells Extracellular vesicles Cirrhosis Liver Acute damage Regeneration

月亮暗面:基于月球卫星的容延/容断网络通信(英文)

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China Communications 2013年第10期10卷 12-25页

作者： Pietrofrancesco Apollonio Carlo Caini Vincenzo fiore Department of Electrical Electronics and Information Engineering "Guglielmo Marconi" University of Bologna

Delay/Disruption-Tolerant Networking(DTN) originated from research on Interplanetary Internet and still today space applications are the most important application field and research stimulus. This paper investigates DTN communications between the Earth and the far side of the Moon, by means of a lunar orbiter acting as relay. After an introductory part, the paper presents a comprehensive analysis of the DTN performance that can be achieved on the identified communication scenario. The focus is on the evaluation of the stateof-the-art ability of Interplanetary Overlay Network(ION), the NASA DTN implementation of Bundle Protocol(BP) and Contact Graph Routing(CGR), to meet the many challenges of the space communication scenario investigated(and more generally of a future interplaynetary Internet): intermittent links, network partitioning, scarce bandwidth, long delays, dynamic routing, handling of high priority and emergency traffic, interoperability issues. A study of security threats and Bundle Security Protocol(BSP) countermeasures complete the *** many results provided, confirm the essential role of DTN in future space communications.

关键词：网络通信容错网络月球星际互联网卫星空间通信安全协议美国航天局

Ultrastructural characters of a Physarum melleum on living leaves of Dendrobium candidum in China

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2007年第12期8卷 896-899页

作者： ZHANG Jing-ze LIU Lu-ning fiore-DONNO Anna-Maria XU Tong Biotechnology Institute Zhejiang University Hangzhou 310029 China Department of Biology University of York PO Box 373 York YOIO 5YW UK

A known species, Physarum melleum, was found fruiting on living leaves of Dendrobium candidum, which was collected in China in 2004. Its morphological characters were revealed by light microscopy (LM), environmental scanning elec- tron microscopy (ESEM) and scanning electron microscopy (SEM). Character variations were distinguished by its olive-yellow peridium and its always thinner capillitium containing globulose granular material between the large calcareous nodes. The cal- cium carbonate granules, deposited on stalks, peridium and hypothallus as well as within stalks, were globose and smooth.

关键词：黏菌超微结构菌类包被中国