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Peptide nucleic acid-based targeting of microRNAs:possible therapeutic applications for glioblastoma

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Journal of Cancer Metastasis and Treatment 2019年第7期4卷 28-40页

作者： Roberto Gambari Jessica Gasparello alessia finotti Department of Life Sciences and Biotechnology University of FerraraFerrara 44121Italy Interuniversity Consortium for Biotechnology(CIB) Trieste 34149Italy.

A large and incremental number of non-coding RNAs, including microRNAs (miRNAs) have been recently demonstrated to play a very important role in human pathologies, including cancer. Therefore, microRNAs have been proposed as therapeutic targets and molecules exhibiting anti-miRNA activity or mimicking functional miRNAs have been developed. Among biomolecules proposed in anti-miRNA therapy, peptide nucleic acids (PNAs) are appealing, in consideration of their stability and efficacy in recognizing RNA targets. PNAs against tumor associated miRNAs have proven to be efficient in inducing anti-tumor effects both in vitro and in vivo. For instance, PNAs targeting miR-155-5p are able to induce apoptosis in glioma cell lines and to enhance the sensitivity to temozolomide (TMZ) in TMZ resistant glioma cells. In vivo, PNAs anti-miR-21 were found to exhibit anti-tumor effects associated with improved survival when administered to animals with intracranial gliomas.

关键词： Peptide nucleic acids glioma microRNAs miRNA targeting delivery apoptosis temozolomide

A narrative review of the current and future role of robotic surgery in liver surgery and transplantation

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Hepatobiliary Surgery and Nutrition 2023年第1期12卷 56-68页

作者： Michele finotti Francesco D’Amico David Mulligan Giuliano Testa Simmons Transplant Institute Baylor University Medical CenterDallasTXUSA Transplantation and Hepatobiliary Surgery University of PadovaPadovaItaly Department of Surgery Yale University School of MedicineNew HavenCTUSA

Background:Minimally invasive surgery(MIS)is the technique of choice in selected patients for the treatment of liver *** robotic approach is considered today the natural evolution of *** application of the robotic technique in liver transplantation(LT)has been recently evaluated,especially in the living *** aim of this paper is to review the current role of the MIS and robotic donor hepatectomy in the literature and to evaluate the possible future implication in the transplant ***:We conducted a narrative review using PubMed and Google Scholar for reports published so far,using the following keywords:minimally invasive liver surgery,laparoscopic liver surgery,robotic liver surgery,robotic living donation,laparoscopic donor hepatectomy and robotic donor ***:Several advantages have been claimed in favor of robotic surgery:three-dimensional(3-D)imaging with stable and high-definition view;a more rapid learning curve than the laparoscopic one;the lack of hand tremors and the freedom of *** to open surgery,the benefits showed in the studies evaluating the robotic approach in the living donation are:less postoperative pain,the shorter period before returning to normal activity despite sustaining longer operation ***,the 3-D and magnification view makes the technique excellent in distinguishing the right plane of transection,vascular and biliary anatomy,associated with high precision of the movements and a better bleeding control(essential for donor safety)and lower rate of vascular ***:The current literature does not fully support the superiority of the robotic approach versus laparoscopic or open method in living donor *** donor hepatectomy performed by teams with high expertise and in properly selected living donors is safe and ***,further data are necessary to evaluate properly the role of robotic surgery in the field of living donation.

关键词： Minimally invasive liver surgery robotic living donation laparoscopic donor hepatectomy robotic donor hepatectomy

Comment on:“A review on radiofrequency,microwave and high-intensity focused ultrasound ablations for hepatocellular carcinoma with cirrhosis”

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Hepatobiliary Surgery and Nutrition 2022年第4期11卷 640-642页

作者： Michele finotti Maurizio Romano Marco Brizzolari Michele Scopelliti Giacomo Zanus 4th Surgery Unit Regional Hospital TrevisoUniversity of PaduaDipartimento di Scienze Chirurgiche Oncologiche e Gastroenterologiche(DISCOG)PaduaItaly Baylor Scott&White Annette C.and Harold C.Simmons Transplant Institute Baylor University MedicalDallasTXUSA

We read with great interest the published article of Cheung et al.(1)on Hepatobiliary Surgery and *** authors provided a comprehensive review and critical evaluation of the three main locoregional ablation(LRA)techniques for liver cancer:radiofrequency(RFA),microwave(MWA),and high-intensity focused ultrasound ablations(HIFU).The focus of the paper is on their application to patients affected by hepatocellular carcinoma(HCC)in the context of end-stage liver disease.

关键词： hepatocellular Surgery al.

Antarctic Sea Ice Concentration in the Brazilian Earth System Model Simulations

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Journal of Geoscience and Environment Protection 2023年第9期11卷 1-19页

作者： Fernanda Casagrande Elisângela finotti Ronald Buss de Souza Regiane Moura Noeli Franchi Leonardo Earth System Numerical Modeling Division (DIMNT) National Institute for Space Research (INPE) Cachoeira Paulista Brazil School of Meteorology Santa Maria Federal University (UFSM) Santa Maria Brazil Nuclear and Energy Research Institute (IPEN) S&#227o Paulo Brazil

Sea ice is an important and complex component of the Earth’s system, acting as both an indicator and an amplifier of climate change. Here, we investigated the ability of the Brazilian Earth System Model (BESM-OA2.5) and four state-of-the-art climate models participating in the fifth phase of the Coupled Model Intercomparison Project, Version 5 (CMIP5) to represent the Antarctic Sea Ice Concentration (SIC) seasonal cycle. We validated the sea ice model’s performance using satellite data from 1980 to 2005 and calculated the skill and RMSE of each model. BESM-OA2.5 results for melt-freeze transitions in the Southern Ocean are consistent with CMIP5 models and satellite data. In February, when the sea ice reaches its annual minimum, the BESM-OA2.5 has the best fit among the models. However, in September, when the Antarctic sea ice reaches its annual maximum, the SIC simulated by BESM-OA2.5 indicated the largest area covered by ice compared to satellite, particularly on the Polar Front. Similar results were found in the CMIP5 models evaluated here. We suggest that the large bias simulated in the Polar Front is related to the inability of the sea ice model to represent the complex ocean-atmosphere-sea ice interactions. The subject is considered a hot topic in climate change studies and lacks conclusive answers.

关键词： Southern Ocean Climate Models Satellite CMIP5 Simulations Climate Validation

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深圳宝安国际机场中国深圳

世界建筑导报 2019年第5期34卷 34-37页

作者： Leonardo finotti Fuksas Architects Speirs + Major

深圳新航站楼的照明设计旨在实现一种平衡之美:光照勾勒出建筑的外形,优化标志性设计的形象,并极具实用性:灯光帮助乘客在陆空之间往返。在机场的持续运行过程中,我们格外留意24小时一周期内照明对乘客乘坐体验的影响。航站楼长度为1.5... 详细信息

深圳新航站楼的照明设计旨在实现一种平衡之美:光照勾勒出建筑的外形,优化标志性设计的形象,并极具实用性:灯光帮助乘客在陆空之间往返。在机场的持续运行过程中,我们格外留意24小时一周期内照明对乘客乘坐体验的影响。航站楼长度为1.5公里,双层屋顶如波浪般延绵起伏,设计独特,点缀着数千个六角天窗。六角天窗引入自然光,创造出动态的光影图案,在多变的设计中,我们有意使人造光与其交相辉映,从而使白日至黑夜过渡自然。我们进行了几项研究,评估并控制光线分散和统一的影响,并在窗户和玻璃墙上逐渐减少光照,让人们可以看到窗外的景色。

关键词：国际机场深圳照明设计运行过程航站楼自然光标志性人造光

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极简与纯净

建筑实践 2010年第8期 34-39页

作者：尹丹 Leonardo finotti Guiheme Machado Voz

在欧洲的足球版图上,葡萄牙的卡斯托雅斯俱乐部算不上声名显赫。甚至在葡萄牙,与波尔图或里斯本竞技等大俱乐部比起来,这个建立于1942年的俱乐部也拿不出像样的历史战绩。不过,如今他们投资150万欧元重建的俱乐部建筑却赢得了人们的关... 详细信息

在欧洲的足球版图上,葡萄牙的卡斯托雅斯俱乐部算不上声名显赫。甚至在葡萄牙,与波尔图或里斯本竞技等大俱乐部比起来,这个建立于1942年的俱乐部也拿不出像样的历史战绩。不过,如今他们投资150万欧元重建的俱乐部建筑却赢得了人们的关注与好评。

关键词：极简建筑足球场卫生间

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巴西圣保罗Garoa服装店

现代装饰 2011年第5期 62-65页

作者： Mateus Ribeiro 肖俊 Leonardo finotti

Garoa服装店位于圣保罗一条最为繁华的商业街——Oscar Freire大街上，虽然该服装店只占据一小块地，但其独特的建筑和室内设计足以令其成为该条街的焦点之一。在两条街道交汇的拐角处，一个三角形的缺口赫然显现在该建筑外立面上，就... 详细信息

Garoa服装店位于圣保罗一条最为繁华的商业街——Oscar Freire大街上，虽然该服装店只占据一小块地，但其独特的建筑和室内设计足以令其成为该条街的焦点之一。在两条街道交汇的拐角处，一个三角形的缺口赫然显现在该建筑外立面上，就如同建筑的一部分被掏空一般，从而定义了缺口处两块透明的玻璃板面，同时也定义了整体室内结构。

关键词：服装店巴西室内设计 Oscar 商业街建筑外立面三角形

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异形空间

设计 2012年第5期25卷 92-95页

作者： Leeble Leonardo finotti（图）

对于设计师来说,经常希望拥有充分的发挥空间,来施展自己的创意,然而在很多情况下都要受到诸多限制,在一些极端情况下,客观条件极为苛刻,留给设计师的空间微乎其微。如何在一处形状怪异、结构反常、空间狭窄的建筑中进行设计?这个案例... 详细信息

对于设计师来说,经常希望拥有充分的发挥空间,来施展自己的创意,然而在很多情况下都要受到诸多限制,在一些极端情况下,客观条件极为苛刻,留给设计师的空间微乎其微。如何在一处形状怪异、结构反常、空间狭窄的建筑中进行设计?这个案例给出了巧妙而又经典的回答。

关键词：空间异形设计师客观条件狭窄

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无限大厦巴西圣保罗

世界建筑导报 2018年第6期33卷 54-57页

作者： H.G. Esch(摄影) Leonard finotti(摄影) 无不详 aflalo & gasperini(合作建筑设计顾问)

塔楼的动态体量本质上来源于航海元素—使人联想到一艘全面扬帆行驶的纵帆船—而在底层,大堂应用了各类巴西本土材料。无限大厦的“帆”采用两片大面积的曲状玻璃包覆各个楼层,设有控制日光和炫光的外部遮阳肋板。设计团队的严谨的设计... 详细信息

塔楼的动态体量本质上来源于航海元素—使人联想到一艘全面扬帆行驶的纵帆船—而在底层,大堂应用了各类巴西本土材料。无限大厦的“帆”采用两片大面积的曲状玻璃包覆各个楼层,设有控制日光和炫光的外部遮阳肋板。设计团队的严谨的设计流程也考虑到了当地材料的可行性。与圣保罗本地承包商Aflalo&Gasperini合作,设计将创新与质量控制相结合。

关键词：巴西大厦设计流程本土材料玻璃包覆控制相帆船承包商