Circulating microRNAs and liquid biopsy:murine xenograft models for technical validation of clinical protocols
作者机构：Department of Life Sciences and BiotechnologyFerrara UniversityFerrara 44121Italy Oncogenomics and EpigeneticsIRCCS Regina Elena National Cancer InstituteRome 00144Italy Interuniversity Consortium for Biotechnology(CIB)Trieste 34149Italy
出 版 物：《Journal of Cancer Metastasis and Treatment》 (癌症转移与治疗（英文版）)
年 卷 期：2019年第4卷第6期
页 面：87-97页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：the European Union(EU)Horizon 2020 Research and Innovation Programme:project ULTRAsensitive PLAsmonic devices for early CAncer Diagnosis(ULTRAPLACAD)(633937) Associazione Italiana per la Ricerca sul Cancro(AIRC)(13575)to Gambari R,(14204,19052)to Giacomini P.Allegretti M is the recipient of a three-year AIRC fellowship(id.19503) the Interuniversity Consortium for the Biotechnology,Italy
主 题：Liquid biopsy circulating tumor RNA microRNA xenograft
摘 要：In oncology,liquid biopsy is applied to detect with high efficiency clinically relevant analytes,such as tumor cells,cell-free nucleic acids,and exosomes in peripheral blood and other body fluids of cancer *** biopsy is considered one of the most advanced non-invasive diagnostic systems useful,in the next future,for enabling personalized treatments in precision *** actions include,but are not limited to,early diagnosis,staging,prognosis,anticipation(lead time)and prediction of therapy responses,as well as follow *** system for validation of the proposed liquid biopsy approaches is highly *** this review article we will discuss the establishment of xenotransplanted mouse model systems for the validation of liquid biopsy protocols aimed to identify changes in the miRNA plasma *** colon cancer HT-29 and LoVo cells have been xenotransplanted and miR-221-3p and miR-222-3p have been comparatively analyzed in cultured HT-29 and LoVo cells,xenotransplants and plasma samples.
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