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Resective surgery for liver tumor: a multivariate analysis of causes and risk factors linked to postoperative complications

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Hepatobiliary & Pancreatic Diseases International 2006年第4期5卷 526-533页

作者： Enrico Benzoni Dario Lorenzin Umberto Baccarani Gian Luigi Adani alessandro Favero alessandro cojutti Fabrizio Bresadola alessandro Uzzau Department of Surgery University of Udine School of Medicine Udine Italy

BAcKGROUND: In spite of accurate selection of patients eligible for resection, and although advances in surgical techniques and perioperative management have greatly contributed to reducing the rate of perioperative deaths, stress must be placed on reducing the postoperative complication rates reported to be still as high as 50%. This study was designed to analyze the causes and foreseeable risk factors linked to postoperative morbidity on the grounds of data derived from a single-center surgical population. METHODS: From September 1989 to March 2005, 287 consecutive patients, affected either with Hcc or liver metastasis, had liver resection at our department. Among the Hcc series we recorded 98 patients (73.2%) in child- Pugh class A, 32 (23.8%) in class B and 4 in class c (3%). In 104 colorectal metastases, 71% were due to colon cancer, 25% rectal, 3% sigmoid, and 1% anorectal. In 49 non-colorectal metastases, 22.4% were derived from breast cancer, 63.2% gastrointestinal tumors (excluding colon) and 14.4% other cancers. We performed 80 wedge resections, 77 bisegmentectomies and/or left lobectomies, 74 segmentectomies, 22 major hepatectomies, 20 left hepatectomies, and 14 trisegmentectomies. RESULTS: The in-hospital mortality rate in this series was 4.5%, and the morbidity rate was 47.7%, because of pleural effusion (30%), hepatic abscess (25%), hepatic insufficiency (19%), ascites (10%), hemoperitoneum (10%), or biliary fistula (6%). The variables associated with the technical aspects of the surgical procedure thatwere responsible for the complications were: a Pringle maneuver length more than 20 minutes (P=0.001); the type of liver resection procedure, including major hepatectomy (P=0.02), left hepatectomy (P=0.04), trisegmentectomy (P=0.04), bisegmentectomy and/or left lobectomy (P=0,04); and a blood transfusion of more than 600 ml (P=0.04). cONcLUSION: The evaluation of causes and foreseeable risk factors linked to postoperative morbidity during the planning of

关键词： carcinoma, hepatocellular liver metastases liver resection postoperative complications biliary leakage pleural effusion impaired liver function

Prophylactic drains in totally laparoscopic distal gastrectomy:are they always necessary?

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World Journal of Gastroenterology 2022年第3期28卷 399-401页

作者： Tommaso Maria Manzia alessandro Parente Roberta Angelico HPB and Transplant Unit Department of Surgery ScienceUniversity of Rome Tor VergataRome 00133Italy Queen Elizabeth Hospital Liver UnitUniversity of BirminghamBirmingham UK and HPB and Transplant UnitDepartment of Surgery ScienceUniversity of Rome Tor VergataRome 00133Italy

Prophylactic drains have always been a useful tool to detect early complications and prevent postoperative fluid collections,particularly in gastrointestinal ***,the utilization of such drains has been debated,due to mounting evidence that they could be harmful rather than *** on recent published articles,Liu et al reported that the routine use of prophylactic drains in total laparoscopic distal gastrectomy might not be necessary for all ***,we express our opinion regarding this interesting publication.

关键词： Gastric cancer Prophylactic drainage Totally laparoscopic gastrectomy Enhanced recovery after surgery Minimally invasive surgery Early gastric cancer

Effective Force Stabilising Technique for the Immersed Boundary Method

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communications in computational Physics 2023年第1期33卷 349-366页

作者： Arnab Ghosh alessandro Gabbana Herman Wijshoff Federico Toschi Department of Applied Physics and Science Education Eindhoven University of TechnologyPO Box 5135600 MB EindhovenThe Netherlands Department of Mechanical Engineering Eindhoven University of TechnologyP.O.Box 5135600 MB EindhovenThe Netherlands canon Production Printing Netherlands B.V. P.O.Box 1015900 MA VenloThe Netherlands

The immersed boundary method has emerged as an efficient approach for the simulation of finite-sized solid particles in complex fluid ***,one of the well known shortcomings of the method is the limited support for the simulation of light particles,*** with a density lower than that of the surrounding fluid,both in terms of accuracy and numerical *** a broad literature exists,with several authors reporting different approaches for improving the stability of the method,most of these attempts introduce extra complexities and are very costly from a computational point of *** this work,we introduce an effective force stabilizing technique,allowing to extend the stability range of the method by filtering spurious oscillations arising when dealing with light-particles,pushing down the particle-to-fluid density ratio as low as *** thoroughly validate the method comparing with both experimental and numerical data available in literature.

关键词： Immersed boundary method lattice Boltzmann method light particle force stabilization added mass effect

Implication of platelet-derived growth factor receptor alpha in prostate cancer skeletal metastasis

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chinese Journal of cancer 2011年第9期30卷 612-619页

作者： Qingxin Liu Danielle Jernigan Yun Zhang alessandro Fatatis Department of Pharmacology and Physiology Drexel University College of Medicine Philadelphia PA 19102 USA. Department of Pathology and Laboratory Medicine Drexel University College of Medicine Philadelphia PA 19102 USA.

Metastasis represents by far the most feared complication of prostate carcinoma and is the main cause of death for *** skeleton is frequently targeted by disseminated cancer cells and represents the sole site of spread in more than 80% of prostate cancer *** between select malignant phenotypes and the microenvironment of colonized tissues is broadly recognized as the culprit for the organ-tropism of cancer ***,we review our recent studies showing that the expression of platelet-derived growth factor receptor alpha(PDGFR a) supports the survival and growth of prostate cancer cells in the skeleton and that the soluble fraction of bone marrow activates PDGFR a in a ligand-independent ***,we offer pre-clinical evidence that this receptor is a viable target for therapy.

关键词：前列腺癌细胞生长因子受体血小板衍生并发症兼容性微环境殖民化

The differential benefit of laparoscopic over open minor liver resection for lesions situated in the anterolateral or posterosuperior segments

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Hepatobiliary Surgery and Nutrition 2024年第4期13卷 604-615,I0015-I0021页

作者： Jasper P.Sijberden Guido Fiorentini Jacopo Lanari Davit Aghayan Daniel Osei-Bordom Nadia Russolillo Arjun Takhar Andrea Benedetti cacciaguerra Santi Lopez-Ben Mathieu D’Hondt Felice Giuliante David Fuks Fernando Rotellar Andrea Ruzzenente Adnan Alseidi Mikhail Efanov Burak Görgec Giuseppe Zimmitti Enrico Gringeri Federica cipriani Åsmund Avdem Fretland Ravi Marudanayagam Marco Vivarelli John N.Primrose alessandro Ferrero Robert P.Sutcliffe Bjørn Edwin Umberto cillo Marc G.Besselink Mohammad Abu Hilal Luca A.Aldrighetti Department of Surgery Fondazione Poliambulanza Istituto OspedalieroBresciaItaly Amsterdam UMc location University of Amsterdam Department of SurgeryAmsterdamthe Netherlands cancer center Amsterdam Amsterdamthe Netherlands Hepatobiliary Surgery Division IRCCS San Raffaele HospitalMilanItaly Department of Surgical Oncological and Gastroenterological SciencesGeneral Surgery 2Hepatobiliary Surgery and Liver TransplantationPadua University HospitalPaduaItaly The Intervention centre and Department of HPB Surgery Oslo University Hospital and Institute of Clinical MedicineUniversity of OsloOsloNorway Department of Surgery Ringerike HospitalVestre Viken Hospital TrustDrammenNorway Liver Unit Queen Elizabeth HospitalBirminghamUK Department of General and Oncological Surgery Umberto I Mauriziano HospitalLargo TuratiTurinItaly Department of Surgery University Hospital Southampton NHS Foundation TrustSouthamptonUK Hepatobiliary and Abdominal Transplantation Surgery Department of Experimental and Clinical MedicineRiuniti HospitalPolytechnic University of MarcheAnconaItaly Servei de cirurgia General i Digestiva Hospital Doctor Josep Trueta de GironaGironaCataloniaSpain Department of Digestive and Hepatobiliary/Pancreatic Surgery Groeninge HospitalKortrijkBelgium chirurgia Epatobiliare UniversitàCattolica del Sacro Cuore-IRCCSRomeItaly Department of Digestive Oncologic and Metabolic SurgeryInstitut Mutualiste MontsourisUniversitéParis DescartesParisFrance HPB and Liver Transplantation Unit Department of SurgeryUniversity ClinicUniversidad de NavarraNavarraSpain Institute of Health Research of Navarra(IdisNA) PamplonaSpain Department of Surgery University of VeronaVeronaItaly Department of Surgery Virginia Mason Medical CenterSeattleWAUSA Department of Surgery University of California San FranciscoSan FranciscoCAUSA Department of Hepato-Pancreato-Biliary Surgery Moscow Clinical Research CentreMoscowRussia

Background:It is well known that laparoscopic liver surgery can offer advantages over open liver surgery in selected ***,what type of procedures can benefit most from a laparoscopic approach has been investigated poorly thus *** aim of this study is thus to define the extent of advantages of laparoscopic over open liver surgery for lesions in the anterolateral(AL)and posterosuperior(PS)***:In this international multicentre retrospective cohort study,laparoscopic and open minor liver resections for lesions in the AL and PS segments were compared after propensity score *** differential benefit of laparoscopy over open liver surgery,calculated using bootstrap sampling,was compared between AL and PS resections and expressed as a Delta of the ***:After matching,3,040 AL and 2,336 PS resections were compared,encompassing open and laparoscopic procedures in a 1:1 *** and PS laparoscopic liver resections were more advantageous in comparison to open in terms of blood loss,transfusion rate,complications,and length of ***,AL resections benefitted more from laparoscopy than PS in terms of overall and severe complications(D-difference were 4.8%,P=0.046 and 3%,P=0.046)and blood loss(D-difference was 195 mL,Pcentres,while in recent years no significant differences were found in the differential benefit between AL and PS ***:The advantage of laparoscopic over open liver surgery is greater in the AL segments than in the PS segments.

关键词： Liver neoplasms hepatectomy laparoscopic liver resection open liver resection

Experimental evaluation of a real-time GPU-based pose estimation system for autonomous landing of rotary wings UAVs

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control Theory and Technology 2018年第2期16卷 145-159页

作者： alessandro BENINI Matthew J. RUTHERFORD Kimon P. VALAVANIS DU Unmanned Systems Research Institute (DU2SRI) University of Denver (DU) Denver CO 80208 U.S.A.

This paper proposes a real-time system for pose estimation of an unmanned aerial vehicle （UAV） using parallel image processing and a fiducial marker. The system exploits the capabilities of a high-performance cPU/GPU embedded system in order to provide on-board high-frequency pose estimation enabling autonomous takeoff and landing. The system is evaluated extensively with lab and field tests using a custom quadrotor. The autonomous landing is successfully demonstrated, through experimental tests, using the proposed algorithm. The results show that the system is able to provide precise pose estimation with a framerate of at least 30fps and an image resolution of 640x480 pixels. The main advantage of the proposed approach is in the use of the GPU for image filtering and marker detection. The GPU provides an upper bound on the required computation time regardless of the complexity of the image thereby allowing for robust marker detection even in cluttered environments.

关键词： UAV Vision GPU Kalman filter

Effects of Plasmodium falciparum—infected erythrocytes on matrix metalloproteinase-9 regulation in human microvascular endothelial cells

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Asian Pacific Journal of Tropical Medicine 2013年第3期6卷 195-199页

作者： Sarah D' alessandro Nicoletta Basilico Mauro Prato Dipartimento di Sanita Pubblica-Microbiologia-Virologia Universita di MilanoMilanoItaly Dipartimento di Genetica Biologia e BiochimicaFacolta di Medicina e ChirurgiaUniversita di TorinoTorinoItaly

Objective:To investigate the regulation of matrix metalloproteinases(MMPs) and tissue inhibitors of melalloproleinases(TIMPs) in human microvascular endothelium(HMEc-1) exposed to erythrocytes infected by different strains of Plasmodium falciparum(***).Methods: HMEc—1 eells were co—incubated for 72 h with erythrocytes infected by late stage trophozoite of D10(chloroquine-sensilive) or W 2(chloroquine-resistant) *** *** supernatants were then collected and the levels of pro- or active gelatinases MMP-9 and MMP-2 were evaluated by gelatin zymograpln and *** release of pro-MMP-9,***-1 and TIMP-1 proteins was analyzed by western blotting and ***:Infected erythrocytes induced de novo proMMP-9 and MMP-9 *** basal levels of proMMP-2 were altered,nor active MMP-2 was ***-3 and MMP-1 secretion was significant!) enhanced,whereas basal TIMP-1 was *** effects were similar for both strains. conclusions:*** parasites,either chloroquine-sonsitive or -resistant,induce the release of active MMP-9 protein from human microvascular endothelium,by impairing balances between proMMP-9 and its inhibitor,and by enhancing the levels of its *** work provides new evidence on MMP involvement in malaria,pointing at MMP-9 as a possible target in adjuvant therapy.

关键词： Plasmodium falciparum Malaria Endothelial cells Matrix metalloproteinases Tissue inhibitors of metalloproteinases Gelatinases

An ontological modelling of multi-attribute criticality analysis to guide Prognostics and Health Management program development

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Autonomous Intelligent Systems 2022年第1期2卷 16-31页

作者： Adalberto Polenghi Irene Roda Marco Macchi alessandro Pozzetti Department of Management Economics and Industrial EngineeringPolitecnico di MilanoP.zza Leonardo da Vinci 3320133 MilanItaly

Digital technologies are becoming more pervasive and industrial companies are exploiting them to enhance the potentialities related to Prognostics and Health Management(PHM).Indeed,PHM allows to evaluate the health state of the physical assets as well as to predict their future *** be effective in developing PHM programs,the most critical assets should be identified so to direct modelling *** techniques could be adopted to evaluate asset criticality;in industrial practice,criticality analysis is amongst the most *** the advancement of artificial intelligence for data analysis and predictions,the criticality analysis,which is built upon both quantitative and qualitative data,has not been improved *** is the goal of this work to propose an ontological formalisation of a multi-attribute criticality analysis in order to i)fix the semantics behind the terms involved in the analysis,ii)standardize and uniform the way criticality analysis is performed,and iii)take advantage of the reasoning capabilities to automatically evaluate asset criticality and associate a suitable maintenance *** developed ontology,called MOcA,is tested in a food company featuring a global *** application shows that MOcA can accomplish the prefixed goals;specifically,high priority assets towards which direct PHM programs are *** the long run,ontologies could serve as a unique knowledge base that integrate multiple data and information across facilities in a consistent *** such,they will enable advanced analytics to take place,allowing to move towards cognitive cyber Physical Systems that enhance business performance for companies spread worldwide.

关键词： criticality analysis Ontology Artificial intelligence Prognostics and Health Management PHM Maintenance

An experimental model of vitreous motion induced by eye rotations

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Eye and Vision 2015年第1期2卷 85-94页

作者： Andrea Bonfiglio Alberto Lagazzo Rodolfo Repetto alessandro Stocchino Department of civil Chemical and Environmental EngineeringUniversity of GenoaItalyVia Montallegro 116145 GenoaItaly

Background:During eye rotations the vitreous humour moves with respect to the eye *** relative motion has been suggested to possibly have an important role in inducing degradation of the gel structure,which might lead to vitreous liquefaction and/or posterior vitreous *** of the present work is to study the characteristics of vitreous motion induced by eye ***:We use an experimental setup,consisting of a Perspex model of the vitreous chamber that,for simplicity,is taken to have a spherical *** model is filled with an artificial vitreous humour,prepared as a solution of agar powder and hyaluronic acid sodium salt in deionised water,which has viscoelastic mechanical properties similar to those of the real *** model rotates about an axis passing through the centre of the sphere and velocity measurements are taken on the equatorial plane orthogonal to the axis of rotation,using an optical ***:The results show that fluid viscoelasticity has a strong influence on flow *** particular,at certain frequencies of oscillation of the eye model,fluid motion can be resonantly *** means that fluid velocity within the domain can be significantly larger than that of the ***:The frequencies for which resonant excitation occurs are within the range of possible eye rotations ***,the present results suggest that resonant excitation of vitreous motion is likely to occur in ***,in turn,implies that eye rotations produce large stresses on the retina and within the vitreous that may contribute to the disruption of the vitreous gel *** present results also have implications for the choice of the ideal properties for vitreous substitute fluids.

关键词： Vitreous motion Vitreous dynamics Retinal detachment Viscoelasticity