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World Journal of Gastroenterology 2008年第45期14卷 6948-6953页

作者： Emiliano Giangreco Cinzia D'agate Carmelo Barbera Lidia Puzzo Giuseppe Aprile Pietro Naso Giacomo Bonanno alessandra nicoletti Salvatore Incarbone Giuseppe Trama Antonio Russo Francesco Paolo Russo Department of Surgery Gastroenterology and Endoscopy Unit University of Catania Department of Surgical and Gastro-enterological Sciences Gastroenterology Section University of Padova

AIM: To investigate the prevalence of celiac disease (CD) in adult patients referred to an open access gas-troenterology clinic in the south of Italy and submitted to esophago-gastro-duodenoscopy (EGD) for evaluation of refractory functional ***: Seven hundred and twenty six consecutive dyspeptic patients (282 male, 444 female; mean age 39.6 years, range 18-75 years) with unexplained prolonged dyspepsia were prospectively enrolled. Duo-denal biopsies were taken and processed by standard staining. Histological evaluation was carried out according to the Marsh-Oberhuber ***: The endoscopic findings were: normal in 61.2%, peptic lesions in 20.5%, malignancies in 0.5%, miscellaneous in 16.7%. CD was endoscopically diagnosed in 8 patients (1.1%), histologically in 15 patients (2%). The endoscopic features alone showed a sensitivity of 34.8% and specificity of 100%, with a positive predictive value (PPV) of 100% and a negative predictive value (NPP) of 97.9%.CONCLUSION: This prospective study showed that CD has a high prevalence (1:48) in adult dyspeptic patients and suggests the routine use of duodenal biopsy in this type of patient undergoing EGD.

关键词： Celiac disease Endoscopy Biopsy Functional Dyspepsia

AN APPLICATION OF MODELING AND SIMULATION TO SUPPORT INDUSTRIAL PLANTS DESIGN

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International Journal of Modeling, Simulation, and Scientific Computing 2012年第1期3卷 90-115页

作者： FRANCESCO LONGO MARINA MASSEI LETIZIA nicoletti Modeling&Simulation Center—Laboratory of Enterprise Solutions(MSC–LES)M&S Net Center Mechanical EngineeringUniversity of Calabria Via Pietro BucciRende87036Italy MISS-DIPTEM University of GenoaVia Molinero 1–17100 SavonaItaly CAL-TEK Srl Via Spagna 70Rende87036Italy

The focus of the research work presented in this article is the design of an industrial plant devoted to produce different types of hazelnuts-based *** industrial plant design is initially based on a traditional approach(production process flow charts analysis and plant layout study)and it is then supported by a simulation model mainly used to investigate the system behavior in different operative *** industrial plant simulation model(called HAZIMUT,HAZelnuts Industrial plant design and man-agement based on advanced simulation Models Utilization)recreates the entire hazelnuts production process(based on nine different production lines).The HAZIMUT simulation model is used to evaluate the effects—caused by multiple changes in the production lines capacities—on multiple performance measures based on machines levels utilization,work in process and production system *** simulation results show how variations in production lines capacities generate an over-reaction of the system with major changes in some of the performance measures therefore stressing the importance to use the HAZIMUT simulator to tune the system correctly to improve the overall plant performances.

关键词： Industrial plants production capacity design modeling simulation

Evaluation of the anticonvulsant activity of the essential oil of Myrothamnus moschatus in convulsion induced by pentylenetetrazole and picrotoxin

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Asian Pacific Journal of Tropical Biomedicine 2016年第6期6卷 501-505页

作者： Emmanuel Randrianarivo Filippo Maggi Marcello nicoletti Philippe Rasoanaivo Malagasy Institute of Applied Research Rakoto Ratsimamanga Foundation School of Pharmacy University of Camerino Department of Environmental Biology Sapienza University

Objective: To evaluate the anticonvulsant effect of the essential oil of Myrothamnus moschatus(M. moschatus) in convulsion induced by pentylenetetrazole and picrotoxin in rodent ***: The essential oil of the aerial parts of M. moschatus was extracted by steam distillation. Thereafter, it was injected subcutaneously to rats and mice at escalating doses(0.1–0.8 m L/kg). Ten minutes after drug injection, pentylenetetrazole was injected intraperitoneally to rats and picrotoxin was administered to mice by the same *** served as the positive control. Every single animal was placed into transparent cage and observed for convulsive behavior for 30 min by using ordinary security cameras connected to a video recorder. Death occurring for a period of 24 h was also ***: The essential oil at 0.8 m L/kg completely arrested the pentylenetetrazole-induced convulsion without any sedative effect and delayed its appearance at lower doses, but showed moderate activities on picrotoxin-induced convulsion. For the rats treated with pentylenetetrazole alone, the mortality was 100% within 1 h, but for the rats pre-treated with the essential oil, the mortality was 0%. For the mice treated with picrotoxin, the mortality rate was also 100%, while 20%–100% died in those that had been pre-treated with the ***: The results confirmed at least partly the traditional uses of the smoke of M. moschatus for the management of convulsion, and implied that the essential oil may inhibit the convulsion by GABAergic neuromodulation.

关键词： Myrothamnus moschatus Essential oil Convulsions Pentylenetetrazole Picrotoxin

SIMULATION, ANALYSIS AND OPTIMIZATION OF CONTAINER TERMINALS PROCESSES

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International Journal of Modeling, Simulation, and Scientific Computing 2012年第3期3卷 1-20页

作者： AGOSTINO BRUZZONE FRANCESCO LONGO LETIZIA nicoletti ELEONORA BOTTANI ROBERTO MONTANARI Simulation Team University of Genoa Via Magliotto 217100 SavonaItaly MSC-LES Mechanical Department University of CalabriaVia P.Bucci 44C 87036 Rende(CS)Italy Department of Industrial Engineering University of Parma Viale G.P.Usberti 181/A43124 ParmaItaly

The freight logistics includes all the processes needed to supply industry,retailers and wholesalers and final customers with *** processes generate a flow of goods that,in the global supply chain,mainly relies on the activities carried out within worldwide container *** this paper,the authors present a simulation model of a real container *** some preliminary analyses,the simulation model is first used with Design of Experiments and Analysis of Variance to investigate the effects of different resources allocations(i.e.,number of forklifts and tractors)and some parameters(i.e.,inter-arrival times,container unloading time)on the container terminal performances in terms of total number of handled containers per ***,based on the results achieved through the Design of Experiments and Analysis of Variance,the simulation model is used with genetic algorithms to carry out a range allocation optimization on berth assignment to incoming ships and number of tractors serving each quay *** aim of the optimization is the minimization of the average time spent by each ship in the port area(decreasing,as consequence,costs and increasing service level provided to final customers).

关键词： Container terminals supply chain node simulation optimization genetic algorithms analysis of variance.

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Experimental assessment of regenerative properties of platelet rich plasma on the human skin-a review

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Plastic and Aesthetic Research 2022年第1期9卷 387-393页

作者： Marco Mario Tresoldi Angela Faga Giovanni nicoletti Unit of Plastic and Reconstructive Surgery Department of Clinical SurgicalDiagnostic and Pediatric SciencesUniversity of PaviaPavia 27100Italy Department of Surgery Istituti Clinici Scientifici MaugeriPavia 27100Italy Department of Clinical Surgical Diagnostic and Pediatric Sciences and Department of Public Health and Experimental and Forensic MedicineAdvanced Technologies for Regenerative Medicine and Inductive Surgery Research CenterUniversity of PaviaPavia 27100Italy Plastic Surgery Unit Azienda Socio-Sanitaria Territoriale di PaviaPavia 27100Italy

Several studies demonstrated the favorable effects of platelet rich plasma(PRP)on the skin and promoted its wide use in clinical *** growth factors stored in platelet alfa-granules allow for the tissue regeneration and the main fields of application of PRP in current clinical practice are the cartilage and musculoskeletal defects,osteoarthritis and other bone disorders,chronic and difficult to heal wounds,and aesthetic *** relevant number of different PRP preparation protocols may explain the inconsistency of the different clinical outcomes reported in the *** the technological advances in PRP preparation,the objective assessment of the clinical efficacy of PRP from the literature reports still is difficult due to the low homogeneity of the samples in terms of both inclusion criteria and ***,it might be useful to establish standardized and reproducible experimental models to confirm and objectively measure the effectiveness of the available clinical *** experimental investigations have been carried out to objectively assess the effectiveness of PRP and platelet gel on several *** far as the skin is concerned,the studies carried out to date are limited to fibroblasts in in-vitro culture models or to collagen,vascular supply,epithelium,and hair follicle in in-vivo *** skin,however,is a very complex organ,where different cell lines coexist and feature complex mutual interaction.A model that combines the advantages of both in-vitro and in-vivo cultures is the ex-vivo *** demonstration of the platelet derived growth factors effects through the ex-vivo human full-thickness skin culture model is a keystone to support the evidence of the PRP effectiveness,as it represents an objective,fast,reproducible,and ethical investigational method.

关键词： Platelet rich plasma PRP ex-vivo regeneration culture techniques skin

Morphological and molecular diversity of arbuscular mycorrhizal fungi in revegetated iron-mining site has the same magnitude of adjacent pristine ecosystems

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Journal of Environmental Sciences 2018年第5期30卷 330-343页

作者： Caroline Krug Vieira Matheus nicoletti Marascalchi Arthur Vinicius Rodrigues Rafael Dutra de Armas Sidney Luiz Stürmer Universidade Regional de Blumenau(FURB) Programa de Pos-Graduacao em Engenharia Ambiental89030-903 BlumenauSCBrazil Universidade Regional de Blumenau(FURB) Departamento de Ciencias Naturais(DCN)89030-903 BlumenauSCBrazil Uniuersidade Regional de Blumenau(FURB) Programaa de Pos-Graduacao em Engenharia Florestal89030-903 BlumenauSCBrazil Centro Universitario-Catolica de Santa Catarina 89203-005 JoinvilleSCBrazil

Arbuscular mycorrhizal fungi（AMF） are important during revegetation of mining sites, but few studies compared AMF community in revegetated sites with pristine adjacent ecosystems. The aim of this study was to assess AMF species richness in a revegetated iron-mining site and adjacent ecosystems and to relate AMF occurrence to soil chemical parameters. Soil samples were collected in dry and rainy seasons in a revegetated iron-mining site（RA） and compared with pristine ecosystems of forest（FL）, canga（NG）,and Cerrado（CE）. AMF species were identified by spore morphology from field and trap cultures and by LSU r DNA sequencing using Illumina. A total of 62 AMF species were recovered, pertaining to 18 genera and nine families of Glomeromycota. The largest number of species and families were detected in RA, and Acaulospora mellea and Glomus sp1 were the most frequent species. Species belonging to Glomeraceae and Acaulosporaceae accounted for 42%–48% of total species richness. Total number of spores and mycorrhizal inoculum potential tended to be higher in the dry than in the rainy season, except in RA. Sequences of uncultured Glomerales were dominant in all sites and seasons and five species were detected exclusively by DNA-based identification. Redundancy analysis evidenced soil p H,organic matter, aluminum, and iron as main factors influencing AMF presence. In conclusion, revegetation of the iron-mining site seems to be effective in maintaining a diverse AMF community and different approaches are complementary to reveal AMF species, despite the larger number of species being identified by traditional identification of field spores.

关键词： Community structure Glomeromycota Illumina LSU rDNA Spore morphology Taxonomic distinctness index

Going with the gut: probiotics as a novel therapy for hepatocellular carcinoma

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Hepatobiliary Surgery and Nutrition 2019年第3期8卷 295-297页

作者： Alberto nicoletti Maurizio Pompili Antonio Gasbarrini Francesca R.Ponziani Internal Medicine Gastroenterology and HepatologyFondazione Policlinico A Gemelli IRCCSRomeItaly

Hepatocellular carcinoma(HCC)is a leading cause of death worldwide(1).It is the most frequent primary liver tumor and usually occurs in patients affected by liver cirrhosis(1).

关键词： liver death carcinoma

Comparison of Pharmacological Treatment Versus Acupuncture Treatment for Migraine Without Aura——Analysis of Socio-medical Parameters

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Journal of Traditional Chinese Medicine 2000年第3期20卷 231-240页

作者： AldoLiguori FilomenaPetti AlfioBangrazi Domenico Camaioni Gaetano Guccione GiovanniMarioPitari AlfredoBianchi Walter E.nicoletti Istituto Institute of Anaesthesia and Intensive Care Universita Cattolica del Sacro CuoreRomeItaly Institute of Anaesthesia and Intensive Care(dir.Prof.A.Sparacia) University of PalermoItaly Institute of Medical Pharmacology University of CataniaItaly

　　This study was carried out in 120 patients affected by migraine without aura, treated in 4 public health centers and randomly divided into acupuncture group (AG) and conventional drug therapy group (CDTG).　　The evaluation of clinical results was made 6 and 12 months after the beginning of treatment and was worked out as well according to socio-medical parameters. Acupuncture was applied to the following points: Touwei (ST 8), Xuanlu (GB 5), Fengchi (GB 20), Dazhui (GV 14), Lieque (LU 7), treated with the reducing method. In AG, the figure scoring the entity and frequency of migraine attacks drops from 9,823 before treatment to 1,990 6 months after and 1,590 12 months after; while in CDTG, it drops from 8,405 before treatment to 3,927 6 months after and 3,084 12 months after. In AG, the total absence from work amounted to 1,120 working days/year, with a total cost (private + social costs) of 186,677,000 Italian liras. In CDTG, the absence from work amounted to 1,404 working days/year, with a total cost of 266,614,000 Italian liras.　　If we consider that in Italy the patients affected by migraine without aura are around 800,000, and that acupuncture therapy is able to save 1,332,000 Italian liras on the total average cost supported for every single patient, the application of acupuncture in the treatment of migraine without aura would allow a saving of the health expenses in Italy of over 1,000 billion liras.

关键词： Analysis of Socio-medical Parameters Comparison of Pharmacological Treatment Versus Acupuncture Treatment for Migraine Without Aura

Fruits and Pseudofruits Can Aid in the Quality of Life of Individuals with Chronic or Other Diseases

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Food and Nutrition Sciences 2024年第11期15卷 1170-1199页

作者： Maria Aparecida nicoletti University Pharmacy-FARMUSP Faculty of Pharmaceutical Sciences University of So Paulo So Paulo Brazil

The article contains a list of 25 structured technical sheets on fruits and pseudo-fruits that will serve as guidance in improving the quality of health of people, whether with chronic diseases or not. The technical sheets contain data related to the composition, active ingredients, interaction with medication, health conditions in which they may be useful in health care by various health professionals and references used to structure the material referring to each fruit or pseudo-fruit.

关键词： Fruit Composition Interactions Nutrients Health Care

Physiologically based microenvironment for in vitro neural differentiation of adipose-derived stem cells

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World Journal of Stem Cells 2018年第3期10卷 23-33页

作者： Adriana Carol Eleonora Graziano Rosanna Avola Vincenzo Perciavalle Ferdinando nicoletti Gianluca Cicala Marinella Coco Venera Cardile Department of Biomedical and Biotechnological Sciences Section of Physiology University of Catania Department of Biomedical and Biotechnological Sciences Section of Pathology and OncologyUniversity of Catania Department of Civil Engineering and Architecture University of Catania

The limited capacity of nervous system to promote a spontaneous regeneration and the high rate of neurodegenerative diseases appearance are keys factors that stimulate researches both for defining the molecular mechanisms of pathophysiology and for evaluating putative strategies to induce neural tissue regeneration. In this latter aspect, the application of stem cells seems to be a promising approach, even if the control of their differentiation and the maintaining of a safe state of proliferation should be troubled. Here, we focus on adipose tissue-derived stem cells and we seek out the recent advances on the promotion of their neural differentiation, performing a critical integration of the basic biology and physiology of adipose tissuederived stem cells with the functional modifications that the biophysical, biomechanical and biochemical microenvironment induces to cell phenotype. The pre-clinical studies showed that the neural differentiation by cell stimulation with growth factors benefits from the integration with biomaterials and biophysical interaction like microgravity. All these elements have been reported as furnisher of microenvironments with desirable biological, physical and mechanical properties. A critical review of current knowledge is here proposed, underscoring that a real advance toward a stable, safe and controllable adipose stem cells clinical application will derive from a synergic multidisciplinary approach that involves material engineer, basic cell biology, cell and tissue physiology.

关键词： Adipose stem cells Biomaterials Neurodegeneration Neural differentiation Physiological microenvironment