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Radiological response and inflammation scores predict tumour recurrence in patients treated with transarterial chemoembolization before liver transplantation

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World Journal of Gastroenterology 2017年第20期23卷 3690-3701页

作者： Daniele Nicolini Andrea Agostini Roberto Montalti Federico Mocchegiani Cinzia Mincarelli alessandra mandolesi Nicola L Robertson Roberto Candelari Andrea Giovagnoni Marco Vivarelli Division of Hepatobiliary and Transplant Surgery Department of Experimental and Clinical MedicinePolytechnic University of Marche Division of General and Pediatric Radiology Department of Radiological SciencesPolytechnic University of Marche Division of Interventional Radiology Department of Radiological SciencesPolytechnic University of Marche Division of Pathology Department of PathologyPolytechnic University of Marche Division of Radiology Department of RadiologyMemorial Sloan Kettering Cancer Center

To investigate the prognostic value of the radiological response after transarterial chemoembolization (TACE) and inflammatory markers in patients affected by hepatocellular carcinoma (HCC) awaiting liver transplantation (LT).METHODSWe retrospectively evaluated the preoperative predictors of HCC recurrence in 70 patients treated with conventional (n = 16) or doxorubicin-eluting bead TACE (n = 54) before LT. The patient and tumour characteristics, including the static and dynamic alpha-fetoprotein, neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio (PLR) measurements, were recorded. Treatment response was classified according to the modified Response Evaluation Criteria in Solid Tumours (mRECIST) and the European Association for the Study of the Liver (EASL) criteria as complete response (CR), partial response (PR), stable disease or progressive disease. After examination of the explanted livers, histological necrosis was classified as complete (100% of the cumulative tumour area), partial (50%-99%) or minimal (< 50%) and was correlated with the preoperative radiological *** to the pre-TACE radiological evaluation, 22/70 (31.4%) and 12/70 (17.1%) patients were beyond Milan and University of San Francisco (UCSF) criteria, respectively. After TACE procedures, the objective response (CR + PR) rates were 71.4% and 70.0% according to mRECIST and EASL criteria, respectively. The agreement between the two guidelines in defining the radiological response was rated as very good both for the overall and target lesion response (weighted k-value: 0.98 and 0.93, respectively). Complete and partial histological necrosis were achieved in 14/70 (20.0%) and 28/70 (40.0%) patients, respectively. Using histopathology as the reference standard, mRECIST criteria correctly classified necrosis in 72.9% (51/70) of patients and EASL criteria in 68.6% (48/70) of cases. The mRECIST non-response to TACE [Exp(b) = 9.2, p = 0.012], exceeding UCSF criteria before

关键词： Liver transplantation Recurrence-free survival Hepatocellular carcinoma Radiological response Locoregional therapies Inflammatory markers Selection criteria

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Doxorubicin-eluting bead vs conventional transcatheter arterial chemoembolization for hepatocellular carcinoma before liver transplantation

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World Journal of Gastroenterology 2013年第34期19卷 5622-5632页

作者： Daniele Nicolini Gianluca Svegliati-Baroni Roberto Candelari Cinzia Mincarelli alessandra mandolesi Italo Bearzi Federico Mocchegiani Andrea Vecchi Roberto Montalti Antonio Benedetti Andrea Risaliti Marco Vivarelli Division of Hepatobiliary and Transplant Surgery Department of Gastroenterology and TransplantationPolytechnic University of Marche Division of Gastroenterology Department of Gastroenterology and TransplantationPolytechnic University of Marche Division of Interventional Radiology Department of Radiological SciencesPolytechnic University of Marche Division of Pathology Department of PathologyPolytechnic University of Marche Division of Hepatobiliary and Transplant Surgery Department of Medical and Biological SciencesUniversityof Udine

AIM:To assess the possible effect of two different types of preoperative transcatheter arterial chemoembolization(TACE)on recurrence-free survival after liver transplantation(LT)in patients with hepatocellular carcinoma(HCC)and to analyze the effects of TACE on tumor ***:We retrospectively analyzed the histological features of 130 HCC nodules in 63 native livers removed at *** who received any other type of treatment such as radiofrequency tumor ablation,percutaneous ethanol ablation or who were not treated at all were *** patients in the present study were within the Milan Criteria at the last imaging findings before *** bead TACE(DEB-TACE)was performed in 22patients(38 nodules),and conventional TACE(c-TACE)in 16(25 nodules).Patients’and tumors’characteristics were retrospectively *** performed a pernodule analysis of the explanted livers to establish the mean percentage of necrosis of any nodule treated by TACE(conventional or DEB)and a per-patient analysis to establish the percentage of necrosis in the cumulative tumor area,including 21 nodules not reached by *** and fibrotic changes in the tissue surrounding the tumor nodule were analyzed and categorized as poor/absent,moderate and enhanced ***-and multivariate analysis of risk factors for HCC-recurrence were ***:The number and diameter of the nodules,the time spent on the waiting list and the number of treatments were similar in the two groups.A trend towards higher appropriate response rates(necrosis≥90%)was observed in the DEB-TACE group(44.7%vs32.0%,P=0.2834).The mean percentage of necrosis in the cumulative tumor area was 58.8%±36.6%in the DEB-TACE group and 50.2%±38.1%in the c-TACE group(P=0.4856).Fibrotic and inflammatory reactions surrounding the tumor nodule were markedly more common in the DEB-TACE group(P<0.0001,for both the parameters).The three-year recurrence-free survival was hig

关键词： Liver transplantation Hepatocellular carcinoma Transcatheter arterial chemoembolization Doxorubicin-eluting bead Tumor histology Recurrence-free survival Locoregional therapies

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Are liver nested stromal epithelial tumors always low aggressive?

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World Journal of Gastroenterology 2017年第46期23卷 8248-8255页

作者： Tania Meletani Luca Cantini Andrea Lanese Daniele Nicolini Alessia Cimadamore Andrea Agostini Giulia Ricci Stefania Antognoli alessandra mandolesi Maria Guido Rita Alaggio Gian Marco Giuseppetti Marina Scarpelli Marco Vivarelli Rossana Berardi Medical Oncology University Hospital and Polytechnic University Ancona Hepatobiliary and Trans-plantation Surgery Department of Clinical and Experimental MedicineUniversity Hospital and Polytechnic University Ancona Section of Pathological Anatomy Department of Biomedical Sciences and Public HealthUniversity Hospital and Polytechnic University Ancona Department of Radiology University Hospital and Polytechnic University Ancona Pathology Department Padova University

Nested stromal-epithelial tumor(NSET) is a nonhepatocytic and non-biliary tumor of the liver consisting of nests of epithelial and spindled cells with associated myofibroblastic stroma and variable intra-lesional calcification and ossification, which represents a very rare and challenging disease. Most of the reported cases have been treated with surgery, obtaining a long survival outcome. Here, we report the case of a 31-year-old Caucasian man who underwent surgery at our institution for a large, lobulated, multinodular mass of the right hemi-liver. The histological exam confirmed the diagnosis of NSET. After 6 mo from surgery, a liver recurrence was described and a chemoembolization was performed. After a further disease progression, based on the correlation between the histological features of the disease and those of the hepatoblastoma, a similar chemotherapy regimen(with cisplatin and ifosfamide/mesna chemotherapy, omitting doxorubicin due to liver impairment) was administered. However, infection of the biliary catheter required a dose modification of the treatment. No benefit was noted and a progression of disease was radiologically assessed after only four cycles. The worsening of the clinical status prevented further treatments, and the patient died a few months later. This case report documents how the NSET might have an aggressive and non-preventable behavior. No chemotherapy schedules with a proved efficacy are available, and new data are needed to shed light on this rare neoplasm.

关键词： Nested stromal epithelial tumor Liver Rare Chemotherapy Aggressive Metastatic

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Central role of altered phosphodiesterase 2-dependent signaling in the pathophysiology of cognition-based brain disorders

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Neural Regeneration Research 2025年第8期20卷 2302-2303页

作者： Asma Boulksibat alessandra Tempio Barbara Bardoni Institut de Pharmacologie Moléculaire et Cellulaire CNRS UMR7275Inserm U1323ValbonneFrance

The second messengers 3',5'-cyclic adenosine monophosphate(cAMP)and 3',5'-cyclic guanosine monophosphate(cGMP)modulate molecular pathways that are involved in a large variety of cellular *** the brain,these processes include neurogenesis,neuronal differentiation,activation and function of microglia,and synaptic plasticity,finally resulting in memory formation.

关键词： formation processes finally

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Phosphodiesterase 9 localization in cytoplasm and nucleus:the gateway to selective targeting in neuroprotection?

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Neural Regeneration Research 2025年第6期20卷 1701-1702页

作者： Giovanni Ribaudo Matteo Giannangeli Margrate Anyanwu alessandra Gianoncelli Department of Molecular and Translational Medicine University of BresciaBresciaItaly

The umbrella term"neurodege ne rative disorders"(NDDs) refers to several conditions characterized by a progressive loss of structure and function of cells belonging to the nervous *** diseases affect more than 50million people *** disorders are characterized by sundry factors and pathophysiological mechanisms that a re challenging to be fully *** of these rely on cell signaling pathways to preserve homeostasis,involving second messengers such as cyclic adenosine monophosphate (cAMP)and cyclic guanosine 3',5'-monophosphate(cGMP).Their ability to control the duration and amplitude of the signaling cascade is given by the presence of several common and uncommon *** kinases A and G (PKA and PKG),phosphodiesterases (PDEs),and scaffold proteins are among them.

关键词： gateway homeostasis preserve

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A novel solution treatment and aging for powder bed fusion–laser beam Ti–6Al–2Sn–4Zr–6Mo alloy: Microstructural and mechanical characterization

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International Journal of Minerals,Metallurgy and Materials 2025年第02期 414-424页

作者： Gianluca Pirro alessandra Martucci Alessandro Morri Mariangela Lombardi Lorella Ceschini Department of Industrial Engineering (DIN) Alma Mater Studiorum–University of Bologna Department of Applied Science and Technology (DISAT) Politecnico di Torino

Ti–6Al–4Zr–2Sn–6Mo alloy is one of the most recent titanium alloys processed using powder bed fusion–laser beam(PBF–LB) technology. This alloy has the potential to replace Ti–6Al–4V in automotive and aerospace applications, given its superior mechanical properties, which are approximately 10% higher in terms of ultimate tensile strength(UTS) and yield strength after appropriate heat treatment. In as-built conditions, the alloy is characterized by the presence of soft orthorhombic α″ martensite, necessitating a postprocessing heat treatment to decompose this phase and enhance the mechanical properties of the alloy. Usually, PBFed Ti6246 components undergo an annealing process that transforms the α″ martensite into an α–β lamellar microstructure. The primary objective of this research was to develop a solution treatment and aging(STA) heat treatment tailored to the unique microstructure produced by the additive manufacturing process to achieve an ultrafine bilamellar microstructure reinforced by precipitation hardening. This study investigated the effects of various solution temperatures in the α–β field(ranging from 800 to 875°C), cooling media(air and water), and aging time to determine the optimal heat treatment parameters for achieving the desired bilamellar microstructure. For each heat treatment condition,different α–β microstructures were found, varying in terms of the α/β ratio and the size of the primary α-phase lamellae. Particular attention was given to how these factors were influenced by increases in solution temperature and how microhardness correlated with the percentage of the metastable β phase present after quenching. Tensile tests were performed on samples subjected to the most promising heat treatment parameters. A comparison with literature data revealed that the optimized STA treatment enhanced hardness and UTS by13% and 23%, respectively, compared with those of the annealed alloy. Fracture surface analyses were conducted to investigate fracture

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Cluster-Based Nearest-Neighbour Classifier and Its Application on the Lightning Classification

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Journal of Computer Science & Technology 2008年第4期23卷 573-581页

作者： Loris Nanni alessandra Lumini DEIS IEIIT-CNRUniversità di BolognaViale Risorgimento 240136 Bologna

The problem addressed in this paper concerns the prototype generation for a cluster-based nearest-neighbour classifier. It considers, to classify a test pattern, the lines that link the patterns of the training set and a set of prototypes. An efficient method based on clustering is here used for finding subgroups of similar patterns with centroid being used as prototype. A learning method is used for iteratively adjusting both position and local-metric of the prototypes. Finally, we show that a simple adaptive distance measure improves the performance of our nearest-neighbour-based classifier. The performance improvement with respect to other nearest-neighbour-based classifiers is validated by testing our method on a lightning classification task using data acquired from the Fast On-orbit Recording of Transient Events （FORTE） satellite, moreover the performance improvement is validated through experiments with several benchmark datasets. The performance of the proposed methods are also validated using the Wilcoxon Signed-Rank test.

关键词： nearest-neighbour classifier clustering adaptive distance

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Pollen Tube Growth: a Delicate Equilibrium Between Secretory and Endocytic Pathways

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Journal of Integrative Plant Biology 2009年第8期51卷 727-739页

作者： alessandra Moscatelli Aurora Irene Idilli Dipartimento di Biologia L. Gorini Università degli Studi di MilanoVia Celoria 26 20133 Milano Italy

Although pollen tube growth is a prerequisite for higher plant fertilization and seed production, the processes leading to pollen tube emission and elongation are crucial for understanding the basic mechanisms of tip growth. It was generally accepted that pollen tube elongation occurs by accumulation and fusion of Golgi-derived secretory vesicles （SVs） in the apical region, or clear zone, where they were thought to fuse with a restricted area of the apical plasma membrane （PM）, defining the apical growth domain. Fusion of SVs at the tip reverses outside cell wall material and provides new segments of PM. However, electron microscopy studies have clearly shown that the PM incorporated at the tip greatly exceeds elongation and a mechanism of PM retrieval was already postulated in the mid-nineteenth century. Recent studies on endocytosis during pollen tube growth showed that different endocytic pathways occurred in distinct zones of the tube, including the apex, and led to a new hypothesis to explain vesicle accumulation at the tip; namely, that endocytic vesicles contribute substantially to V-shaped vesicle accumulation in addition to SVs and that exocytosis does not involve the entire apical domain. New insights suggested the intriguing hypothesis that modulation between exo- and endocytosis in the apex contributes to maintain PM polarity in terms of lipid/protein composition and showed distinct degradation pathways that could have different functions in the physiology of the cell. Pollen tube growth in vivo is closely regulated by interaction with style molecules. The study of endocytosis and membrane recycling in pollen tubes opens new perspectives to studying pollen tube-style interactions in vivo.

关键词： endocytosis exocytosis membrane recycling polarized growth pollen tube

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α-Synuclein oligomers and fibrils:partners in crime in synucleinopathies

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Neural Regeneration Research 2023年第11期18卷 2332-2342页

作者： alessandra Bigi Roberta Cascella Cristina Cecchi Department of Experimental and Clinical Biomedical Sciences Section of BiochemistryUniversity of FlorenceFlorenceItaly

The misfolding and aggregation of a-synuclein is the general hallmark of a group of devastating neurodegenerative pathologies referred to as synucleinopathies,such as Parkinson’s disease,dementia with Lewy bodies,and multiple system *** such conditions,a range of different misfolded aggregates,including oligomers,protofibrils,and fibrils,are present both in neurons and glial *** expe rimental evidence supports the proposition that solu ble oligomeric assemblies,formed during the early phases of the aggregation process,are the major culprits of neuronal toxicity;at the same time,fibrillar confo rmers appear to be the most efficient at propagating among interconnected neurons,thus contributing to the spreading ofα-synuclein ***,α-synuclein fibrils have been recently repo rted to release soluble and highly toxic oligomeric species,responsible for an immediate dysfunction in the recipient *** this review,we discuss the current knowledge about the plethora of mechanisms of cellular dysfunction caused byα-synuclein oligome rs and fibrils,both contributing to neurodegeneration in synucleinopathies.

关键词： amyloid aggregation neurodegeneration Parkinson’s disease protein aggregation protein misfolding

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Novel insights into the pathogenesis of tendon injury:mechanotransduction and neuroplasticity

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Neural Regeneration Research 2022年第10期17卷 2223-2224页

作者： Suellen alessandra Soares de Moraes Faculdade de Fisioterapia e Terapia Ocupacional Universidade Federal do ParáBelémParáBrazil

Tendon pathology is characterized by damage to the tendon structural integrity with disruption of collagen fibers(Nourissat et al.,2015).Acute tendon injuries show a macroscopic discontinuity,ranging from partial to complete tendon *** involve inflammation and lead to loss of *** chronic conditions(or tendinopathy),symptoms include changes in both locomotor and sensorial functions of the tendon(Nourissat et al.,2015;Scott et al.,2020).Inconsistency in terminology for cases of painful tendon disorders is found,but recently the term tendinopathy was established in consensus as preferable for cases with persistent tendon pain and loss of function related to mechanical *** term excludes a problem in clinical practice-i.e.,specification of the presence of a particular pathological or biochemical process(Scott et al.,2020).

关键词： tendon injuries Acute

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