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Sediment balances in the Blue Nile River Basin

International Journal of Sediment Research 2014年第3期29卷 316-328页

作者： Yasir S.A.ALI alessandra crosato Yasir A.MOHAMED Seifeldin H.ABDALLA Nigel G.WRIGHT UNESCO-IHE Westvest 72601 DA Delftthe Netherlands and Hydraulics Research CenterMinistry of Water Resources and ElectricityP.O.Box 318Wad MedaniSudan UNESCO-IHE Westvest 72601 DA Delft and Profat Hydraulics Research CenterMinistry of Water Resources and Electricity School of Civil Engineering University of LeedsFaculty of EngineeringLeeds LS2 9JT.United Kingdom Water Resources Technical Organ Ministry of Water Resources and ElectricityKhartoumSudan UNESCO-IHE Westvest 72601 DA Delft and Research Associate at Civil Engineering and Geosciences Delft University of TechnologyStevin weg 12628 CN Delftthe Netherlands

Rapid population growth in the upper Blue Nile basin has led to fast land-use changes from natural forest to agricultural *** resulted in speeding up the soil erosion process in the highlands and increasing sedimentation further downstream in reservoirs and irrigation *** present,several dams are planned across the Blue Nile River in Ethiopia and the Grand Ethiopian Renaissance Dam is currently under construction near the border with *** will be the largest hydroelectric power plant in *** objective of this paper is to quantify the river flows and sediment loads along the Blue Nile River *** Soil and Water Assessment Tool was used to estimate the water flows from un-gauged *** assess model performance,the estimated sediment loads were compared to the measured ones at selected *** the gauged sub-basins,water flows and sediment loads were derived from the available flow and sediment *** fill in knowledge gaps,this study included a field survey in which new data on suspended solids and flow discharge were collected along the Blue Nile and on a number of *** comparison between the results of this study and previous estimates of the sediment load of the Blue Nile River at El Deim,near the Ethiopian Sudanese border,show that the sediment budgets have the right order of magnitude,although some uncertainties *** gives confidence in the results of this study providing the first sediment balance of the entire Blue Nile catchment at the sub-basin scale.

关键词： Blue Nile basin Sediment balance Field data Rating curve SWAT model

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Central role of altered phosphodiesterase 2-dependent signaling in the pathophysiology of cognition-based brain disorders

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Neural Regeneration Research 2025年第8期20卷 2302-2303页

作者： Asma Boulksibat alessandra Tempio Barbara Bardoni Institut de Pharmacologie Moléculaire et Cellulaire CNRS UMR7275Inserm U1323ValbonneFrance

The second messengers 3',5'-cyclic adenosine monophosphate(cAMP)and 3',5'-cyclic guanosine monophosphate(cGMP)modulate molecular pathways that are involved in a large variety of cellular *** the brain,these processes include neurogenesis,neuronal differentiation,activation and function of microglia,and synaptic plasticity,finally resulting in memory formation.

关键词： formation processes finally

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Phosphodiesterase 9 localization in cytoplasm and nucleus:the gateway to selective targeting in neuroprotection?

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Neural Regeneration Research 2025年第6期20卷 1701-1702页

作者： Giovanni Ribaudo Matteo Giannangeli Margrate Anyanwu alessandra Gianoncelli Department of Molecular and Translational Medicine University of BresciaBresciaItaly

The umbrella term"neurodege ne rative disorders"(NDDs) refers to several conditions characterized by a progressive loss of structure and function of cells belonging to the nervous *** diseases affect more than 50million people *** disorders are characterized by sundry factors and pathophysiological mechanisms that a re challenging to be fully *** of these rely on cell signaling pathways to preserve homeostasis,involving second messengers such as cyclic adenosine monophosphate (cAMP)and cyclic guanosine 3',5'-monophosphate(cGMP).Their ability to control the duration and amplitude of the signaling cascade is given by the presence of several common and uncommon *** kinases A and G (PKA and PKG),phosphodiesterases (PDEs),and scaffold proteins are among them.

关键词： gateway homeostasis preserve

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A novel solution treatment and aging for powder bed fusion–laser beam Ti–6Al–2Sn–4Zr–6Mo alloy: Microstructural and mechanical characterization

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International Journal of Minerals,Metallurgy and Materials 2025年第02期 414-424页

作者： Gianluca Pirro alessandra Martucci Alessandro Morri Mariangela Lombardi Lorella Ceschini Department of Industrial Engineering (DIN) Alma Mater Studiorum–University of Bologna Department of Applied Science and Technology (DISAT) Politecnico di Torino

Ti–6Al–4Zr–2Sn–6Mo alloy is one of the most recent titanium alloys processed using powder bed fusion–laser beam(PBF–LB) technology. This alloy has the potential to replace Ti–6Al–4V in automotive and aerospace applications, given its superior mechanical properties, which are approximately 10% higher in terms of ultimate tensile strength(UTS) and yield strength after appropriate heat treatment. In as-built conditions, the alloy is characterized by the presence of soft orthorhombic α″ martensite, necessitating a postprocessing heat treatment to decompose this phase and enhance the mechanical properties of the alloy. Usually, PBFed Ti6246 components undergo an annealing process that transforms the α″ martensite into an α–β lamellar microstructure. The primary objective of this research was to develop a solution treatment and aging(STA) heat treatment tailored to the unique microstructure produced by the additive manufacturing process to achieve an ultrafine bilamellar microstructure reinforced by precipitation hardening. This study investigated the effects of various solution temperatures in the α–β field(ranging from 800 to 875°C), cooling media(air and water), and aging time to determine the optimal heat treatment parameters for achieving the desired bilamellar microstructure. For each heat treatment condition,different α–β microstructures were found, varying in terms of the α/β ratio and the size of the primary α-phase lamellae. Particular attention was given to how these factors were influenced by increases in solution temperature and how microhardness correlated with the percentage of the metastable β phase present after quenching. Tensile tests were performed on samples subjected to the most promising heat treatment parameters. A comparison with literature data revealed that the optimized STA treatment enhanced hardness and UTS by13% and 23%, respectively, compared with those of the annealed alloy. Fracture surface analyses were conducted to investigate fracture

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Cluster-Based Nearest-Neighbour Classifier and Its Application on the Lightning Classification

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Journal of Computer Science & Technology 2008年第4期23卷 573-581页

作者： Loris Nanni alessandra Lumini DEIS IEIIT-CNRUniversità di BolognaViale Risorgimento 240136 Bologna

The problem addressed in this paper concerns the prototype generation for a cluster-based nearest-neighbour classifier. It considers, to classify a test pattern, the lines that link the patterns of the training set and a set of prototypes. An efficient method based on clustering is here used for finding subgroups of similar patterns with centroid being used as prototype. A learning method is used for iteratively adjusting both position and local-metric of the prototypes. Finally, we show that a simple adaptive distance measure improves the performance of our nearest-neighbour-based classifier. The performance improvement with respect to other nearest-neighbour-based classifiers is validated by testing our method on a lightning classification task using data acquired from the Fast On-orbit Recording of Transient Events （FORTE） satellite, moreover the performance improvement is validated through experiments with several benchmark datasets. The performance of the proposed methods are also validated using the Wilcoxon Signed-Rank test.

关键词： nearest-neighbour classifier clustering adaptive distance

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Pollen Tube Growth: a Delicate Equilibrium Between Secretory and Endocytic Pathways

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Journal of Integrative Plant Biology 2009年第8期51卷 727-739页

作者： alessandra Moscatelli Aurora Irene Idilli Dipartimento di Biologia L. Gorini Università degli Studi di MilanoVia Celoria 26 20133 Milano Italy

Although pollen tube growth is a prerequisite for higher plant fertilization and seed production, the processes leading to pollen tube emission and elongation are crucial for understanding the basic mechanisms of tip growth. It was generally accepted that pollen tube elongation occurs by accumulation and fusion of Golgi-derived secretory vesicles （SVs） in the apical region, or clear zone, where they were thought to fuse with a restricted area of the apical plasma membrane （PM）, defining the apical growth domain. Fusion of SVs at the tip reverses outside cell wall material and provides new segments of PM. However, electron microscopy studies have clearly shown that the PM incorporated at the tip greatly exceeds elongation and a mechanism of PM retrieval was already postulated in the mid-nineteenth century. Recent studies on endocytosis during pollen tube growth showed that different endocytic pathways occurred in distinct zones of the tube, including the apex, and led to a new hypothesis to explain vesicle accumulation at the tip; namely, that endocytic vesicles contribute substantially to V-shaped vesicle accumulation in addition to SVs and that exocytosis does not involve the entire apical domain. New insights suggested the intriguing hypothesis that modulation between exo- and endocytosis in the apex contributes to maintain PM polarity in terms of lipid/protein composition and showed distinct degradation pathways that could have different functions in the physiology of the cell. Pollen tube growth in vivo is closely regulated by interaction with style molecules. The study of endocytosis and membrane recycling in pollen tubes opens new perspectives to studying pollen tube-style interactions in vivo.

关键词： endocytosis exocytosis membrane recycling polarized growth pollen tube

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α-Synuclein oligomers and fibrils:partners in crime in synucleinopathies

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Neural Regeneration Research 2023年第11期18卷 2332-2342页

作者： alessandra Bigi Roberta Cascella Cristina Cecchi Department of Experimental and Clinical Biomedical Sciences Section of BiochemistryUniversity of FlorenceFlorenceItaly

The misfolding and aggregation of a-synuclein is the general hallmark of a group of devastating neurodegenerative pathologies referred to as synucleinopathies,such as Parkinson’s disease,dementia with Lewy bodies,and multiple system *** such conditions,a range of different misfolded aggregates,including oligomers,protofibrils,and fibrils,are present both in neurons and glial *** expe rimental evidence supports the proposition that solu ble oligomeric assemblies,formed during the early phases of the aggregation process,are the major culprits of neuronal toxicity;at the same time,fibrillar confo rmers appear to be the most efficient at propagating among interconnected neurons,thus contributing to the spreading ofα-synuclein ***,α-synuclein fibrils have been recently repo rted to release soluble and highly toxic oligomeric species,responsible for an immediate dysfunction in the recipient *** this review,we discuss the current knowledge about the plethora of mechanisms of cellular dysfunction caused byα-synuclein oligome rs and fibrils,both contributing to neurodegeneration in synucleinopathies.

关键词： amyloid aggregation neurodegeneration Parkinson’s disease protein aggregation protein misfolding

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Novel insights into the pathogenesis of tendon injury:mechanotransduction and neuroplasticity

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Neural Regeneration Research 2022年第10期17卷 2223-2224页

作者： Suellen alessandra Soares de Moraes Faculdade de Fisioterapia e Terapia Ocupacional Universidade Federal do ParáBelémParáBrazil

Tendon pathology is characterized by damage to the tendon structural integrity with disruption of collagen fibers(Nourissat et al.,2015).Acute tendon injuries show a macroscopic discontinuity,ranging from partial to complete tendon *** involve inflammation and lead to loss of *** chronic conditions(or tendinopathy),symptoms include changes in both locomotor and sensorial functions of the tendon(Nourissat et al.,2015;Scott et al.,2020).Inconsistency in terminology for cases of painful tendon disorders is found,but recently the term tendinopathy was established in consensus as preferable for cases with persistent tendon pain and loss of function related to mechanical *** term excludes a problem in clinical practice-i.e.,specification of the presence of a particular pathological or biochemical process(Scott et al.,2020).

关键词： tendon injuries Acute

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Polymerization of 1,3-Butadiene with Catalysts Based on Cobalt Dichloride Complexes with Aminophosphines: Switching the Regioselectivity by Varying the MAO/Co Molar Ratio

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Chinese Journal of Polymer Science 2024年第4期42卷 501-510页

作者： Giovanni Ricci Anna Sommazzi Francesco Masi alessandra Forni CNR-Istituto di Scienze e Tecnologie Molecolari“Giulio Natta”(SCITEC) via A.Corti 1220133MilanoItaly Viale Giovanni XXIII 34 I-28100NovaraNOItaly Via Galvani 7 I-26866Sant’Angelo LodigianoLOItaly CNR-Istituto di Scienze e Tecnologie Molecolari“Giulio Natta”(SCITEC) via C.Golgi 1920133MilanoItaly

Several novel cobalt dichloride complexes with amino-phosphine bidentate ligands were synthesized and *** some of them single crystals were obtained and their molecular structure was determined by X-ray diffraction *** the complexes were then used in combination with MAO for the polymerization of 1,3-butadiene,obtaining polymers with different structures(i.e.,predominantly 1,2 or cis-1,4)mainly depending on the type of ligand and on the MAO/Co molar *** behavior of these novel catalysts was compared with that exhibited,in the polymerization of the same monomer,by the systems CoCl_(2)(PR3)2-MAO and CoCl_(2)(PRPh2)2-MAO(R=alkyl or cycloalkyl group),and by the systems based on cobalt dichloride complexes with various bi-and tridentate ligands(e.g.,diphosphines,bis-imines,pyridyl-imines,bis-iminopyridines).The comparison between the different systems allowed us to make some clarity about the actual and effective role played by the various types of ligands in the polymerization of conjugated dienes with catalytic systems CoCl_(2)(L)-MAO,in which L=mono-,bi-,or tri-dentate ligand.

关键词： 1,3-Butadiene Stereospecific polymerization Cobalt catalysts Regioselectivity Aminophosphine ligands Crystal structures Chelate rings

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Implications of metabolism-driven myeloid dysfunctions in cancer therapy

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Cellular & Molecular Immunology 2021年第4期18卷 829-841页

作者： Laura Strauss Valentina Guarneri alessandra Gennari Antonio Sica Department of Immunopharmacology and Immuno Oncology EMD Serono Research&Development InstituteInc.80119545A Middlesex TurnpikeBillericaMA 01821USA Department of Surgery Oncology and GastroenterologyUniversity of PadovaPadovaItaly Veneto Institute of Oncology-IRCCS PaduaItalyPadovaItaly Division of Oncology Department of Translational MedicineUniversity of Eastern PiedmontNovaraItaly Department of Pharmaceutical Sciences University of Eastern PiedmontA.Avogadrovia Bovio 6NovaraItaly Humanitas Clinical and Research Center IRCCSVia Manzoni 56RozzanoMilanItaly

Immune homeostasis is maintained by an adequate balance of myeloid and lymphoid *** chronic inflammatory states,including cancer,this balance is lost due to dramatic expansion of myeloid progenitors that fail to mature to functional inflammatory neutrophils,macrophages,and dendritic cells(DCs),thus giving rise to a decline in the antitumor effector lymphoid ***-related inflammation orchestrates the production of hematopoietic growth factors and cytokines that perpetuate recruitment and activation of myeloid precursors,resulting in unresolved and chronic *** pathologic inflammation creates profound alterations in the intrinsic cellular metabolism of the myeloid progenitor pool,which is amplified by competition for essential nutrients and by hypoxia-induced metabolic rewiring at the tumor ***,persistent myelopoiesis and metabolic dysfunctions contribute to the development of cancer,as well as to the severity of a broad range of diseases,including metabolic syndrome and autoimmune and infectious *** aims of this review are to(1)define the metabolic networks implicated in aberrant myelopoiesis observed in cancer patients,(2)discuss the mechanisms underlying these clinical manifestations and the impact of metabolic perturbations on clinical outcomes,and(3)explore new biomarkers and therapeutic strategies to restore immunometabolism and differentiation of myeloid cells towards an effector phenotype to increase host antitumor *** propose that the profound metabolic alterations and associated transcriptional changes triggered by chronic and overactivated immune responses in myeloid cells represent critical factors influencing the balance between therapeutic efficacy and immune-related adverse effects(irAEs)for current therapeutic strategies,including immune checkpoint inhibitor(ICI)therapy.

关键词： Myelopoiesis Tumor-associated macrophages Myeloid-derived suppressor cells Metabolism Cancer therapy

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