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Spatiotemporal variations of ozone exposure and its risks to vegetation and human health in Cyprus:an analysis across a gradient of altitudes

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Journal of Forestry Research 2023年第3期34卷 579-594页

作者： Stefanos Agathokleous Costas JSaitanis Chrysanthos Savvides Pierre Sicard Evgenios Agathokleous alessandra De Marco The Cyprus Institute NicosiaCyprus University of the Aegean MytileneLesvosGreece Agricultural University of Athens AthensGreece Department of Labour Inspection Ministry of Labour and Social InsuranceNicosiaCyprus ARGANS 260 route du Pin MontardBiotFrance School of Applied Meteorology Nanjing University of Information Science and Technology(NUIST)Nanjing 210044People’s Republic of China National Agency for New Technologies Energy and Sustainable Economic DevelopmentRomeItaly

Ground-level ozone(O_(3)) aff ects vegetation and threatens environmental health when levels exceed critical values,above which adverse eff ects are *** is expected to be a hotspot for O_(3)concentrations due to its unique position in the eastern Mediterranean,receiving air masses from Europe,African,and Asian continents,and experiencing a warm Mediterranean *** Cyprus,the spatiotemporal features of O_(3) are poorly understood and the potential risks for forest health have not been *** evaluated O_(3) and nitrogen oxides(NO and NO 2)at four regional background stations at different altitudes over 2014−2016.O_(3) risks to vegetation and human health were estimated by calculating accumulated O_(3)exposure over a threshold of 40 nmol mol^(−1)(AOT40)and cumulative exposure to mixing ratios above 35 nmol mol^(−1)(SOMO35)*** data reveal that mean O_(3)concentrations follow a seasonal pattern,with higher levels in spring(51.8 nmol mol^(−1))and summer(53.2 nmol mol^(−1))and lower levels in autumn(46.9 nmol mol^(−1))and winter(43.3 nmol mol^(−1)).The highest mean O_(3)exposure(59.5 nmol mol^(−1)) in summer occurred at the high elevation station ***(1819 m a.s.l.).Increasing(decreasing)altitudinal gradients were found for O_(3)(NO x),driven by summer–winter diff *** diurnal patterns of O_(3) showed little *** at the lowest altitude O_(3) displayed a typical O_(3) diurnal pattern,with hourly diff erences smaller than 15 nmol mol^(−1).Accumulated O_(3) exposures at all stations and in all years exceeded the European Union’s limits for the protection of vegetation,with average values of 3-month(limit:3000 nmol mol^(−1)h)and 6-month(limit:5000 nmol mol^(−1)h)AOT40 for crops and forests of 16,564 and 31,836 nmol mol^(−1)h,respectively.O_(3) exposures were considerably high for human health,with an average SOMO35 value of 7270 nmol mol^(−1) days across stations and *** results indicate that O_(3) is a major environm

关键词： Air pollution Ozone risk assessment Exposure metrics Vegetation Human health

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Cannabidiol preferentially binds TRPV2: a novel mechanism of action

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Neural Regeneration Research 2022年第12期17卷 2693-2694页

作者： Elisa Landucci Domenico E.Pellegrini-Giampietro alessandra Gianoncelli Giovanni Ribaudo Department of Health Sciences Section of Clinical Pharmacology and OncologyUniversity of FlorenceFirenzeItaly Department of Molecular and Translational Medicine University of BresciaBresciaItaly

Plants from the genus Cannabis,and strains of Cannabis sativa in particular,have been used in medicine since ancient *** Cannabis plant contains more than 500 chemical compounds,with two main phytocannabinoids consisting of Δ9-tetrahydrocannabinol(THC),the psychoactive constituent,and cannabidiol(CBD),which does not bear this *** paper aims at providing a perspective on the potential therapeutic effects of CBD based on its preferential interaction with transient potential receptor V2(TRPV2).Many formulations based on Cannabis extract have been licensed for therapeutic use in some Western *** these,the most relevant are Sativex(THC+CBD,used mainly for the treatment of spasticity in multiple sclerosis)and Epidyolex(purified plant-derived CBD,used for some rare childhood epilepsies).

关键词： effect mechanism formulation

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Solution to Coordination of Transmission and Distribution for Renewable Energy Integration into Power Grids:An Integrated Flexibility Market

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CSEE Journal of Power and Energy Systems 2023年第2期9卷 444-458页

作者： Tao Jiang Zhongwei Shen Xiaolong Jin Rufeng Zhang alessandra Parisio Xue Li Xiao Kou Department of Electrical Engineering Northeast Electric Power UniversityJilin 132012China Key Laboratory of Smart Grid of Ministry of Education Key Laboratory of Smart Energy&Information Technology of Tianjin MunicipalityTianjin UniversityTianjin 300072China Department of Electrical and Electronic Engineering The University of ManchesterManchesterUK Department of Electrical Engineering and Computer Science University of TennesseeKnoxvilleTN37996USA.

Nowadays,transmission system operators(TSOs)encounter the challenges of securely operating power grids with high penetration of *** this context,more flexibility is needed than ever to maintain system *** rapid development of coordinated transmission and distribution technology recently,active distribution networks(ADNs)which have abundant flexible resources,have the potential to provide flexibility to the ***,an integrated transmission-distribution flexibility market is proposed in this *** the proposed framework,the energy market is first cleared to obtain baseline generation *** the baseline generation schedules are treated as inputs to the flexibility ***,the integrated flexibility market is cleared to facilitate flexibility trading between transmission and distribution *** preserve the data privacy of different market participants,an alternating direction method of multipliers(ADMM)based method is utilized to clear the markets in a distributed *** the energy market and flexibility market-clearing model,transmission network market clearing models are linear programming(LP)models,and distribution network market clearing models are second order cone programming(SOCP)*** the proposed method,only limited information is exchanged between TSO and *** studies are conducted on a revised IEEE 30-bus transmission network with two 33-node *** results demonstrate the proposed flexibility market framework can enhance competitiveness of generation companies in the transmission network and distributed generators(DGs)in the ***,flexibility purchasing cost is reduced by 17.7%compared to traditional flexibility supplied by generators according to the case study results,and ADNs can gain additional flexibility profit by providing flexibility.

关键词： ADMM ADN energy market flexibility market TSO-DSO coordination

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Electric field and charge doping induced superconducting transition in 2D freestanding perovskite barium bismuthate

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中国科学:物理学、力学、天文学英文版 2023年第7期66卷 102-111页

作者： Yaning Cui Tianhao Su Lei Qiao Zongquan Gu Gianni Profeta alessandra Continenza Wei Ren Physics Department Materials Genome InstituteInternational Center for Quantum and Molecular StructuresShanghai UniversityShanghai 200444China Shanghai Key Laboratory of High Temperature Superconductors Shanghai UniversityShanghai 200444China Zhejiang Laboratory Hangzhou 311100China School of Microelectronics Fudan UniversityShanghai 200433China Department of Physical and Chemical Sciences Universitàdegli Studi dell'AquilaCoppito(L'Aquila)67100Italy Consiglio Nazionale delle Ricerche CNR-SPIN Coppito(L'Aquila)67100Italy

We present an ab-initio study of monolayer BaBiO_(3) focused on how to harness the insulator-metal transition through suppression of the charge density wave(CDW)phase in this *** the determination of the most stable structure for the freestanding monolayer,we investigate the effects of an applied electric field and of charge doping on the electronic properties of the *** results show that external electric fields of the order of 0.1-0.3 V/A are able to stabilize the metallic phase,destroy the CDW phase and,in addition,lead to a metallic metastable *** this same footing,we show that hole doping could also suppress the CDW phase and drive the system toward a metallic phase with large electron-phonon *** this end,we also study the dependence of the electron-phonon coupling on hole-doping concentration and show that this could drive the onset of ***,low-dimensional BaBiO3 is an extremely flexible material with electronic properties that could be tuned using different and possibly combined external tools such as electric fields and charge doping,paving the way to achieve effective control on the transition from the CDW,to the metallic and then superconducting phase.

关键词： charge wave density phase transition superconductivity 2D material

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Pseudo-discontinuum model to simulate hard-rock mine pillars

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Underground Space 2023年第4期11卷 81-95页

作者： Erick Ro genes alessandra dos Santos Gomes Marcio Muniz de Farias Leandro Lima Rasmussen Faculty of Technology University of BrasiliaDF 70910-900BrasiliaBrazil

In this study,the pseudo-discontinuum modeling technique,called continuum Voronoi block model(CVBM),was applied to repre-sent the behavior of hard-rock pillars from underground mines subjected to high field *** CVBM’s ability to produce numerical results consistent with the observed behavior of pillars is demonstrated through the numerical analysis of a hypothetical case and a back analysis of the Creighton mine *** results show that the model can capture convergence displacements and explicitly show the formation of macro-fractures parallel to excavation walls,intact rock slabs,and V-shaped *** components are characteristics of brittle failure induced by highly stressed ground *** studies presented in this work confirm the CVBM as a convenient tool for the numerical modeling of intact rock pillars excavated in deep underground mines.

关键词： Brittle failure Spalling Bulking Voronoi tessellation

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Haemodynamic management in brain death donors:Influence of aetiology of brain death

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World Journal of Transplantation 2023年第4期13卷 183-189页

作者： Chiara Lazzeri Manuela Bonizzoli Stefano Batacchi Cristiana Guetti Walter Vessella alessandra Valletta alessandra Ottaviano Adriano Peris Department of Emergency Intensive Care Unit and Extracorporeal Membrane Oxygenation CenterFlorence 50134Italy

BACKGROUND In brain death donors(BDDs),donor management is the key in the complex donation *** management goals,which are standards of care or clinical parameters,have been considered an acceptable barometer of successful donor *** To test the hypothesis that aetiology of brain death could influence haemodynamic management in *** Haemodynamic data(blood pressure,heart rate,central venous pressure,lactate,urine output,and vasoactive drugs)of BDDs were recorded on intensive care unit(ICU)admission and during the 6-h observation period(Time 1 at the beginning;Time 2 at the end).RESULTS The study population was divided into three groups according to the aetiology of brain death:Stroke(n=71),traumatic brain injury(n=48),and postanoxic encephalopathy(n=19).On ICU admission,BDDs with postanoxic encephalopathy showed the lowest values of systolic and diastolic blood pressure associated with higher values of heart rate and lactate and a higher need of norepinephrine and other vasoactive *** the beginning of the 6-h period(Time 1),BDDs with postanoxic encephalopathy showed higher values of heart rate,lactate,and central venous pressure together with a higher need of other vasoactive *** According to our data,haemodynamic management of BDDs is affected by the aetiology of brain *** with postanoxic encephalopathy have higher requirements for norepinephrine and other vasoactive drugs.

关键词： Brain death donor Postanoxic encephalopathy Stroke Acute traumatic injury Haemodynamic management Utilization rate

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Which are the most favourable conditions for reducing soil CO_(2)emissions with no-tillage?Results from a meta-analysis

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International Soil and Water Conservation Research 2022年第3期10卷 497-506页

作者： Simone Bregaglio Gabriele Mongiano Rossana M.Ferrara Fabrizio Ginaldi alessandra Lagomarsino Gianfranco Rana CREA-Council for Agricultural Research and Economics Research Centre for Agriculture and EnvironmentI-40128BolognaItaly CREA-Council for Agricultural Research and Economics Research Centre for Plant Protection and CertificationSS 11 km 2500I-13100VercelliItaly CREA-Council for Agricultural Research and Economics Research Centre for Agriculture and EnvironmentI-70125BariItaly CREA-Council for Agricultural Research and Economics Research Centre for Agriculture and EnvironmentI-50125FirenzeItaly

No-tillage practices have a recognised beneficial impact on soil and water conservation while reducing erosion processes and enhancing soil organic matter ***,scientists continue to debate the effectiveness of no-tillage in reducing soil carbon dioxide(CO_(2))emissions from *** the same line of inquiry pursued by the authors who reviewed the impact of conservative practices on direct CO_(2)emissions,we applied meta-analytic and machine learning techniques to unravel the effect of no-tillage under contrasting pedo-environmental conditions and agricultural *** analysed fifty-six experimental studies investigating direct soil CO_(2)emissions from no-tillage and conventional tillage practices(102 paired observations),considering pedological(soil texture,soil organic carbon content),environmental(climate type),and management(crop rotation,experiment duration)*** estimated the effect of different practices on the daily amount of soil CO_(2)emissions,and the impact of tillage in the period immediately following the *** main insights of this study are:(i)the conditions leading to the highest reduction of CO_(2)emissions due to no-tillage were long-term experiments(standardised mean differenceβ=0.64)conducted in arid environments(β=0.76)and clay soils(β=0.81),with low organic carbon content(β=0.79)where crop rotations(β=0.65)were performed;(ii)the same conditions were associated with the lowest absolute CO_(2)emissions,irrespective of soil management;(iii)the highest contribution to the variability of absolute soil CO_(2)emissions was associated with soil texture(mean decrease in accuracy of Random Forest models,MDA=4.57),rotation(MDA=3.07),experiment duration(MDA=2.93)and soil organic carbon content(MDA=2.24),rather than to tillage practices;(iv)soil CO_(2)emissions almost doubled in the first day after a tillage event,consistently across studies(p=0.001).This meta-analysis offers quantitative figures on the impact of tillage

关键词： Agricultural soils Greenhouse gases Global warming Net-zero agriculture

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Feeding broiler chickens with arginine above recommended levels:effects on growth performance,metabolism,and intestinal microbiota

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Journal of Animal Science and Biotechnology 2023年第4期14卷 1528-1541页

作者： Giorgio Brugaletta Marco Zampiga Luca Laghi Valentina Indio Chiara Oliveri alessandra De Cesare Federico Sirri Department of Agricultural and Food Sciences Alma Mater Studiorum-University of BolognaOzzano Dell’Emilia40064 BolognaItaly Department of Veterinary Medical Sciences Alma Mater Studiorum-University of BolognaOzzano Dell’Emilia40064 BolognaItaly Department of Physics and Astronomy Alma Mater Studiorum-University of Bologna40127 BolognaItaly

Background Arginine is an essential amino acid for chickens and feeding diets with arginine beyond the recommended levels has been shown to influence the growth performance of broiler chickens in a positive ***,further research is required to understand how arginine supplementation above the widely adopted dosages affects metabolism and intestinal health of ***,this study was designed to assess the effects of arginine supplementation(i.e.,total arginine to total lysine ratio of 1.20 instead of 1.06-1.08 recommended by the breeding company) on growth performance of broiler chickens and to explore its impacts on the hepatic and blood metabolic profiles,as well as on the intestinal *** this purpose,630 one-day-old male Ross 308 broiler chicks were assigned to 2 treatments(7 replicates each) fed a control diet or a crystalline L-arginine-supplemented diet for 49 *** Compared to control birds,those supplemented with arginine performed significantly better exhibiting greater final body weight at D49(3778 vs.3937 g;P < 0.001),higher growth rate(76.15 vs.79.46 g of body weight gained daily;P < 0.001),and lower cumulative feed conversion ratio(1.808 vs.1.732;P < 0.05).Plasma concentrations of arginine,betaine,histidine,and creatine were greater in supplemented birds than in their control counterparts,as were those of creatine,leucine and other essential amino acids at the hepatic *** contrast,leucine concentration was lower in the caecal content of supplemented *** alpha diversity and relative abundance of Firmicutes and Proteobacteria(specifically Escherichia coli),as well as increased abundance of Bacteroidetes and Lactobacillus salivarius were found in the caecal content of supplemented *** The improvement in growth performance corroborates the advantages of supplementing arginine in broiler *** can be hypothesized that the performance enhancement found in this study is associated with the i

关键词： Arginine Broiler chicken Growth performance Metabolism Microbiota

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Clinicopathological Description of a Chronic Lymphocytic Leukemia in a Dog

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Open Journal of Veterinary Medicine 2024年第7期14卷 155-162页

作者： Maria Clara Boni Raffi Giovanna Valverde Magalhães Barbosa Alana Carolina Capais Rodrigues Sheila Canevese Rahal John P. Kastelic Luíz Guilherme Dercore Benevenuto Iolanda Simões Braga Beatriz Poloni Batista Felipe César Da Silva Brasileiro Fernanda Barthelson Carvalho de Moura Priscylla Tatiana Chalfun Guimarães Okamoto Regina Kiomi Takahira alessandra Melchert Noeme Sousa Rocha Department of Veterinary Clinics School of Veterinary Medicine and Animal Science So Paulo State UniversityUNESP Botucatu SP Brazil Independent Veterinary Practitioner Department of Veterinary Surgery and Animal Reproduction School of Veterinary Medicine and Animal Science So Paulo State UniversityUNESP Botucatu SP Brazil Faculty of Veterinary Medicine University of Calgary Calgary Canada

Hematopoietic tumors are associated with diagnostic and therapeutic challenges and a poor prognosis. Furthermore, their pathophysiology in dogs is not well understood. Chronic lymphocytic leukemia has been rarely reported in golden retrievers, perhaps due to difficulties in diagnosis and care. An 8-year-old spayed female golden retriever was referred to our hospital with a 2-month history of fatigue, weakness, and selective appetite. The dog was diagnosed with chronic lymphocytic leukemia based on blood smear evaluation. Despite treatment, the dog deteriorated and the owners opted for euthanasia. Histopathological examination revealed atypical lymphocytes in the spleen, extramedullary hematopoiesis in the spleen and liver, bone marrow depletion, moderate neutrophilic myocarditis, and acute renal tubular necrosis. In an immunohistochemical panel, cells in the spleen and bone marrow were positive for anti-CD20, anti-CD45, anti-CD3, anti-IBA-1, anti-Ki67, anti-MUM-1, and anti-PAX-5. In conclusion, the leukemia diagnosis was confirmed through reactive histiocytosis, marked extramedullary hematopoiesis, and other clinical and laboratory findings. Herein, we report a case of chronic lymphocytic leukemia in a female dog with clinical, laboratory, and necroscopy findings.

关键词： Canine Cancer Neoplasia Therapeutics

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To metabolomics and beyond:a technological portfolio to investigate cancer metabolism

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Signal Transduction and Targeted Therapy 2023年第4期8卷 1721-1742页

作者： Federica Danzi Raffaella Pacchiana Andrea Mafficini Maria TScupoli Aldo Scarpa Massimo Donadelli alessandra Fiore Department of Neurosciences Biomedicine and Movement SciencesSection of BiochemistryUniversity of VeronaVeronaItaly Department of Diagnostics and Public Health University of VeronaVeronaItaly Department of Neurosciences Biomedicine and Movement SciencesBiology and Genetics SectionUniversity of VeronaVeronaItaly ARC-NET Research Centre University and Hospital Trust of VeronaVeronaItaly

Tumour cells have exquisite flexibility in reprogramming their metabolism in order to support tumour initiation, progression,metastasis and resistance to therapies. These reprogrammed activities include a complete rewiring of the bioenergetic, biosyntheticand redox status to sustain the increased energetic demand of the cells. Over the last decades, the cancer metabolism field hasseen an explosion of new biochemical technologies giving more tools than ever before to navigate this complexity. Within a cell ora tissue, the metabolites constitute the direct signature of the molecular phenotype and thus their profiling has concrete clinicalapplications in oncology. Metabolomics and fluxomics, are key technological approaches that mainly revolutionized the fieldenabling researchers to have both a qualitative and mechanistic model of the biochemical activities in cancer. Furthermore, theupgrade from bulk to single-cell analysis technologies provided unprecedented opportunity to investigate cancer biology at cellularresolution allowing an in depth quantitative analysis of complex and heterogenous diseases. More recently, the advent offunctional genomic screening allowed the identification of molecular pathways, cellular processes, biomarkers and noveltherapeutic targets that in concert with other technologies allow patient stratification and identification of new treatmentregimens. This review is intended to be a guide for researchers to cancer metabolism, highlighting current and emergingtechnologies, emphasizing advantages, disadvantages and applications with the potential of leading the development ofinnovative anti-cancer therapies.

关键词： metabolism qualitative beyond

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