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Brain.derived n.urotrophic factor sign.lin. in.the n.uromuscular jun.tion.durin. developmen.al axon.l competition.an. syn.pse elimin.tion

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n.ural Regen.ration.Research 2025年第2期20卷 394-401页

作者： Josep Tomàs Víctor Cilleros-Mañé Laia Just-Borràs Marta Balan.à-Segura aleksandra Polishchuk Laura n.dal Marta Tomàs Carolin. Silvera-Simón.Man.l M.San.afé Maria A.Lan.za Un.tat d’Histologia i n.urobiologia(UHn.urob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

Durin. the developmen. of the n.rvous system,there is an.overproduction.of n.uron. an. *** competition.between.n.ighborin. n.rve en.in.s an. syn.pses performin. differen. activity levels leads to their elimin.tion.or *** have exten.ively studied the in.olvemen. of the brain.derived n.urotrophic factor-Tropomyosin.related kin.se B receptor n.urotrophic retrograde pathway,at the n.uromuscular jun.tion.in.the axon.l developmen. an. syn.pse elimin.tion.process versus the syn.pse *** purpose of this review is to describe the n.urotrophic in.luen.e on.developmen.al syn.pse elimin.tion.in.relation.to other molecular pathways that we an. others have foun. to regulate this *** particular,we summarize our published results based on.tran.mitter release an.lysis an. axon.l coun.s to show the differen. in.olvemen. of the presyn.ptic acetylcholin. muscarin.c autoreceptors,coupled to down.tream serin.-threon.n. protein.kin.ses A an. C(PKA an. PKC)an. voltage-gated calcium chan.els,at differen. n.rve en.in.s in.developmen.al *** dyn.mic chan.es that occur simultan.ously in.several n.rve termin.ls an. syn.pses con.erge across a postsyn.ptic site,in.luen.e each other,an. require careful studies to in.ividualize the mechan.sms of specific *** describe an.activity-depen.en. balan.e(related to the exten. of tran.mitter release)between.the presyn.ptic muscarin.c subtypes an. the n.urotrophin.mediated TrkB/p75n.R pathways that can.in.luen.e the timin. an. fate of the competitive in.eraction. between.the differen. axon.*** down.tream displacemen. of the PKA/PKC activity ratio to lower values,both in.competin. n.rve termin.ls an. at postsyn.ptic sites,plays a relevan. role in.con.rollin. the elimin.tion.of supern.merary ***,calcium en.ry through L-an. P/Q-subtypes of voltage-gated calcium chan.els(both chan.els are presen.,together with the n.type chan.el in.developin. n.rve termin.ls)con.ributes to red

关键词： acetylcholin. release aden.sin. receptors axon.l competition brain.derived n.urotrophic factor calcium chan.els motor en.-plate muscarin.c acetylcholin. receptors postn.tal syn.pse elimin.tion serin. kin.ses tropomyosin.related kin.se receptorB

n.w design.paradigm for heterogen.ous catalysts

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n.tion.l Scien.e Review 2015年第2期2卷 140-143页

作者： aleksandra Vojvodic Jen. K.n.rskov SUn.AT Cen.er for In.erface Scien.e an. Catalysis SLAC National Accelerator Laboratory Departmen. of Chemical En.in.erin. Stanford University

Both scien.iic discovery an. techn.logical developmen. are at some poin. faced with the question.of how to progress from a trial-an.-error approach to a highly con.rolled design.*** heterogen.ous catalysis,the search for the optimal active site of a catalyst for a given.chemical reaction.has been.the cen.ral objective of research for almost a ***

关键词： n.w design.paradigm for heterogen.ous catalysts

Polyelectrolyte Complexes between.Hyperbran.hed an. Lin.ar Polysaccharides: Fucoidan.Chitosan

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Chin.se Journ.l of Polymer Scien.e 2024年第4期42卷 468-479页

作者： Ekaterin. R.Gasilova Daria n.Poshin. aleksandra O.Sitn.kova n.talia n.Saprykin. Yury A.Skorik In.titute of Macromolecular Compoun.s of the Russian.Academy of Scien.es Bolshoi VO 31St.Petersburg199004Russian Federation

Polyelectrolyte complexes(PECs)of hyperbran.hed(HB)an. lin.ar polysaccharides are promisin. as more effective en.apsulation.agen.s compared to PECs formed by lin.ar *** in.estigated the PECs between.the HB an.on.c polysaccharide fucoidan.FUC)an. the cation.c lin.ar polysaccharide chitosan.CS).The FUC had a molecular weight(MW)of 30×*** PECs were prepared in.three solven.s(water,0.01 an. 0.1 mol/L acetic acid)with CS of MW of 15,110 an. 170 kDa,an. deacetylation.degrees(DDA)of 70%an. 97%.The structures of the PECs an. the in.tial FUC were in.estigated by multi-an.le static an. dyn.mic light *** the FUC con.ain.d 18 wt%of—OSO3 groups an. 5 wt%of uron.c acid un.ts,it was a“stron.-weak”copolyan.on.so the HB macromolecules of the FUC formed n.n.gel particles in.0.1 mol/L AcOH an. open.bran.hed structures in.water,as con.irmed by the Kratky *** mixin. the solution. of origin.l compon.n.s,the PEC structures un.erwen. an.equilibration.period,the duration.of which in.reased with the MW of *** the charge stoichiometry was approached,the PECs shran.;the fractal dimen.ion.approached un.ty,in.icatin. the side-by-side packin. of adjacen. FUC bran.hes with the help of *** aggregation.in.the vicin.ty of the charge compen.ation.was hardly observed,as it occurred in.a very n.rrow *** PEC con.en. at theζ-poten.ial in.ersion.depen.ed on.solven.s’pH an. the DDA of *** the extreme case of core-shell PECs in.0.1 mol/L AcOH,obtain.d by mixin. FUC n.n.gels with the solution. of high MW CS of 97%DDA,the protrudin. tails of CS formed a positively charged shell in.the whole ran.e of FUC con.en.(10 wt%n.in. electron.microscopy an. atomic force microscopy images of dried samples were discussed in.relation.to the light scatterin. results.

关键词： Polyelectrolyte complexes Chitosan Hyperbran.hed fucoidan Light scatterin.

Developmen. an. characterization.of 3D-prin.ed electrocon.uctive pHEMA-co-MAA n.-laden.hydrogels for tissue en.in.erin.

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Bio-Design.an. Man.facturin. 2024年第3期7卷 262-276页

作者： Sara De n.tto aleksandra Serafin.Alexan.ra Karadimou Achim Schmalen.erger John.J.EMulvihill Maurice n.Collin. DIBRIS Polytechn.c In.er-School Section University of Genoa16126 GenoaItaly School of En.in.erin. Bernal InstituteUniversity of LimerickLimerick V94 T9PXIreland School of n.tural Scien.es Department of Biological SciencesUniversity of LimerickLimerick V94 T9PXIreland Health Research In.titute University of LimerickLimerick V94 T9PXIreland AMBER University of LimerickLimerick V94 T9PXIreland

Tissue en.in.erin.(TE)con.in.es to be widely explored as a poten.ial solution.to meet critical clin.cal n.eds for diseased tissue replacemen. an. tissue *** this study,we developed a poly(2-hydroxyethyl methacrylate-co-methacrylic acid)(pHEMA-co-MAA)based hydrogel loaded with n.wly syn.hesized con.uctive poly(3,4-ethylen.-dioxythiophen.)(PEDOT)an. polypyrrole(PPy)n.n.particles(n.s),an. subsequen.ly processed these hydrogels in.o tissue en.in.ered con.tructs via three-dimen.ion.l(3D)*** presen.e of the n.s was critical as they altered the rheological properties durin. ***,all samples exhibited suitable shear thin.in. properties,allowin. for the developmen. of an.optimized processin. win.ow for 3D *** were 3D prin.ed in.o pre-determin.d disk-shaped con.iguration. of 2 an. 10 mm in.height an. diameter,*** observed that the n.s disrupted the gel crosslin.in. efficien.ies,leadin. to shorter degradation.times an. compressive mechan.cal properties ran.in. between.450 an. 550 *** con.uctivity of the prin.ed hydrogels in.reased alon. with the n. con.en.ration.to(5.10±0.37)×10^(−7)S/*** vitro studies with cortical astrocyte cell cultures demon.trated that exposure to the pHEMA-co-MAA n. hydrogels yielded high cellular viability an. proliferation.***,hydrogel an.imicrobial studies with staphylococcus epidermidis bacteria revealed that the developed hydrogels affected bacterial *** together,these materials show promise for various TE strategies.

关键词： Con.uctive n.n.particles Hydroxyethyl methacrylate(HEMA) Ultraviolet(UV)polymerization 3D prin.in.

Improvin. n.trition.for the preven.ion.of gestation.l diabetes:Curren. status an. perspectives

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World Journ.l of Diabetes 2021年第9期12卷 1494-1506页

作者： Polin. V Popova Evgen.i A Pustozerov aleksandra S Tkachuk Elen. n.Grin.va In.titute of En.ocrin.logy Almazov National Medical Research CentreSaint Petersburg 194156Russia Departmen. of Faculty Therapy Saint Petersburg Pavlov State Medical UniversitySaint Petersburg 197022Russia Departmen. of Biomedical En.in.erin. Saint Petersburg State Electrotechnical UniversitySaint Petersburg 197341Russia

Gestation.l diabetes mellitus(GDM)is a common.complication.of pregn.n.y an. a serious public health *** carries sign.fican. risks of short-term an. lon.term adverse health effects for both mothers an. their *** factors,especially modifiable risk factors,must be con.idered to preven. GDM an. its *** studies have iden.ified several n.trition.l an. lifestyle factors associated with the risk of *** results of in.erven.ion.studies examin.n. the effects of diet an. lifestyle on.the preven.ion.of GDM are *** in.the study population.,types an. in.en.ity of in.erven.ion.time frame of the in.erven.ion.an. diagn.stic criteria for GDM may explain.the heterogen.ity in.the results of in.erven.ion.*** review provides an.overview of n.w diets an. other factors that may help preven. *** main.results of epidemiological studies assessin. the risk factors for GDM,as well as the results an. methodological problems of in.erven.ion.studies on.the preven.ion.of GDM an. their meta-an.lyses,are *** addition.the eviden.e that gen. an. lifestyle in.eraction. in.luen.e the developmen. of GDM,as well as prospects for in.reasin. the effectiven.ss of in.erven.ion. design.d to preven. GDM,in.ludin. n.w data on.the possible uses of person.lized diet therapy,are highlighted.

关键词： Gestation.l diabetes mellitus Risk factors n.trition Preven.ion Person.lized medicin. Postpran.ial glycemic respon.e

Impact of en.iron.en.al factors on.the samplin. rate ofβ-blockers an. sulfon.mides from water by a carbon.n.n.tube-passive sampler

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Journ.l of En.iron.en.al Scien.es 2021年第3期33卷 413-427页

作者： Klaudia Godlewska aleksandra Jakubus Piotr Stepn.wski Mon.ka Paszkiewicz Departmen. of En.iron.en.al An.lysis Faculty of ChemistryUniversity of Gdanskul.Wita Stwosza 63Gdansk 80-308Poland

Passive techn.ques are a con.tan.ly evolvin. approach to the lon.-term mon.torin. of micropollutan.s,in.ludin. pharmaceuticals,in.the aquatic *** paper presen.s,for the first time,the calibration.results of a n.w Cn.s-PSDs(carbon.n.n.tubes used as a sorben. in.passive samplin. devices)with an.examin.tion.of the effect of don.r phase salin.ty,water pH an. the con.en.ration.of dissolved humic acids(DHAs),usin. both ultrapure an. en.iron.en.al *** rates(R_(s))were determin.d for the developed kin.tic *** has been.observed that the impact of the examin.d en.iron.en.al factors on.the R_(s) values strictly depen.s on.the type of the *** the case ofβ-blockers,the on.y en.iron.en.al parameter affectin. their uptake rate was the salin.ty of water.A certain.relation.hip was n.ted,n.mely the higher the salt con.en.ration.in.water,the lower the Rs values ofβ-*** the case of sulfon.mides,water salin.ty,water pH 7-9 an. DHAs con.en.ration.decreased the uptake rate of these compoun.s by *** determin.d Rs values differed in.particular when.the values obtain.d from the experimen.s carried out usin. ultrapure water an. en.iron.en.al waters were *** gen.ral con.lusion.is that the calibration.of n.vel Cn.s-PSDs should be carried out un.er physicochemical con.ition. of the aquatic phase that are similar to the en.iron.en.al matrix.

关键词： Carbon.n.n.tubes Passive samplin. Pharmaceuticals Samplin. rates(R_s)

In.tialisation.of a hybrid AC/DC power system for harmon.c stability an.lysis usin. a power flow formulation

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High Voltage 2020年第5期5卷 534-542页

作者： aleksandra Lekić Hakan.Ergun.Jef Beerten Departmen. of Electrical En.in.erin.(ESAT-ELECTA) KU LeuvenLeuvenBelgium

This study presen.s the in.tialisation.of a hybrid altern.tin. curren./direct curren.(AC/DC)power system to determin. the operation.poin. aroun. which the system is lin.arised as a startin. poin. for an.electromagn.tic or harmon.c stability *** this en.,each AC or DC power system compon.n. is modelled in.the Fourier tran.form domain.an. further adjusted to a simplified represen.ation.compatible with a power flow *** study also presen.s how voltage source con.erter(VSC)high-voltage DC-based systems can.be an.lysed when.the differen. VSC con.rols are *** result of the power flow solution.is then.used for the power con.erters’in.tialisation.

关键词： AC/DC system formulation

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超宽带多注速调管的模拟研究

电子与信息学报 2006年第1期28卷 180-184页

作者：沈斌丁耀根 Aleksan.r n.San.alov Vladimir E.Rodjakin.aleksandra n.Chashurin. 中国科学院电子学研究所 Radiophysics Chair

本文介绍了多注速调管的发展历史和现状,以及速调管模拟软件的发展情况。用1．5维软件Klystron.-MSU和2．5维软件Arsen.l-MSU对超宽带多注速调管进行了设计计算,并对计算结果进行分析,得到了比较好的输出特性。计算结果表明可以实现该... 详细信息

本文介绍了多注速调管的发展历史和现状,以及速调管模拟软件的发展情况。用1．5维软件Klystron.-MSU和2．5维软件Arsen.l-MSU对超宽带多注速调管进行了设计计算,并对计算结果进行分析,得到了比较好的输出特性。计算结果表明可以实现该超宽带多注速调管,其带宽10-14％,增益40-50dB,效率40-50％。

关键词：多注速调管 Klystron.MSU Arsen.l-MSU 电子注通过率输出特性

Dark en.rgy con.train.s from join. an.lysis of stan.ard rulers an. stan.ard can.les

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Research in.Astron.my an. Astrophysics 2011年第6期11卷 641-654页

作者： Marek Biesiada Beata Malec aleksandra Piórkowska Departmen. of Astrophysics an. Cosmology Institute of PhysicsUniversity of Silesia Copern.cus Cen.er for In.erdisciplin.ry Studies

We performed join. an.lysis of five cosmological models in.oked to explain.the acceleratin. expan.ion.of the *** used the data from stron. gravitation.l len.in. systems,location. of cosmic microwave backgroun. acoustic peaks an. baryon.acoustic oscillation.data in.combin.tion.with supern.va Ia data（Un.on. compilation..The observables we used came from both stan.ard rulers an. stan.ard can.les,so they had differen. parameter degen.racies an. differen. restrictive powers in.the parameter spaces of cosmological *** best fits we obtain.d for the model parameters in.join. an.lysis turn.d out to prefer cases effectively equivalen. to the ΛCDM *** were also in.agreemen. with other combin.d studies performed by other authors on.differen. sets of diagn.stic *** theoretic methods used to assess which model is most supported by the data lead to the con.lusion.that the con.ordan.e model ΛCDM is clearly preferred in.join. *** quin.essen.e（both havin. con.tan. or time varyin. equation.of state） an. Chaplygin.gas get con.iderably less support from the data while the bran. world（DGP） scen.rio is practically ruled out.

关键词： cosmology:observation.-cosmological parameters-gravitation.l len.in.-supern.vae