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Tumor irradiation may facilitate the detection of tumor-specific mutations in plasma

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World Journal of Clinical Oncology 2021年第12期12卷 1215-1226页

作者： Ekaterina Kuligina Fedor Moiseyenko Sergey Belukhin Ekaterina Stepanova Maria Zakharova Vera Chernobrivtseva Ikram Aliev Tatiana Sharabura Vladimir Moiseyenko Svetlana Aleksakhina Tatiana Laidus aleksandr Martianov Maksim Kholmatov Aldon Whitehead Grigoriy Yanus Evgeny Imyanitov Department of Tumor Biology N.N.Petrov Institute of OncologySt.-Petersburg 197758Russia Department of Medical Genetics St.-Petersburg Pediatric Medical UniversitySt.-Petersburg 194100Russia Department of Therapy City Cancer CenterSt.-Petersburg 197758Russia Department of Surgery City Cancer CenterSt.-Petersburg 197758Russia Department of Radiology City Cancer CenterSt.-Petersburg 197758Russia Internal Medicine Residency Program The University of Illinois College of MedicineChicagoIL 60612United States Department of Oncology I.I.Mechnikov Northwestern Medical UniversitySt.-Petersburg 191015Russia

BACKGROUND The mutation-based analysis of circulating tumor DNA(ctDNA)is a promising diagnostic tool for clinical ***,it has low success rate because many cancer patients do not have detectable ctDNA in the *** To evaluate whether preoperative tumor irradiation results in a transient increase of plasma ctDNA concentration due to the induction of apoptosis in radiationexposed *** This study focused on patients with locally advanced rectal cancer,because preoperative tumor irradiation is a part of their standard treatment *** subjects,whose tumors contained KRAS,NRAS or BRAF mutations,donated serial blood samples 1 h prior to the first fraction of irradiation(at baseline),immediately after the first fraction(time 0),and 1,3,6,12,24,36,48,72 and 96 h after the first *** amount of mutated gene copies was measured by droplet digital *** Five out of nine patients were mutation-negative by ctDNA test at baseline;two of these subjects demonstrated an emergence of the mutated DNA copies in the bloodstream within the follow-up *** were 4 patients,who had detectable ctDNA in the plasma at the start of the experiment;three of them showed an evident treatment-induced increase of the content of mutated RAS/RAF *** Local tumor irradiation may facilitate the detection of tumor-specific DNA in the *** data justify further assessment of the clinical feasibility of irradiation-assisted liquid biopsy.

关键词： Liquid biopsy Rectal cancer KRAS BRAF Mutations Tumor response Radiotherapy

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诺夫哥罗德之于德米特里·利哈乔夫

俄罗斯文艺 2016年第3期 9-13页

作者：亚·博布罗夫陈玉才(译) 不详东北师范大学人文学院

德米特里·利哈乔夫在1937-1995年间多次到访诺夫哥罗德。从写于1941年的第一篇论文开始,他对于中世纪诺夫哥罗德的历史和文学著述甚丰。此皆源自他与В.Л.科马罗维奇的相识,以及后者对俄罗斯编年史文献的探索。对于А.А.沙赫玛托夫... 详细信息

德米特里·利哈乔夫在1937-1995年间多次到访诺夫哥罗德。从写于1941年的第一篇论文开始,他对于中世纪诺夫哥罗德的历史和文学著述甚丰。此皆源自他与В.Л.科马罗维奇的相识,以及后者对俄罗斯编年史文献的探索。对于А.А.沙赫玛托夫推出的对编年史文献的文本研究方法,科马罗维奇和利哈乔夫也都有着类似的运用。利哈乔夫认为,诺夫哥罗德的编年史是随着这个独立的共和国在12世纪的产生而出现的,且诺夫哥罗德本身就是圣彼得堡的一个前身。

关键词：利哈乔夫诺夫哥罗德编年史文本研究

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To a Question about Forecasting Number of Micromammalia （Rodentia）

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Journal of Life Sciences 2013年第1期7卷 63-68页

作者： Nadezhda Antonets aleksandr B alalayev Margarita Shumkova Dnipro-Orel's Natural Reserve Dnipropetrovs 'k 52030 Ukraine Dnipropetrovs 'k National University Dnipropetrovs 'k 49050 Ukraine Regional Sanitary-Epidemic 'S Station Dnipropetrovs 'k 49006 Ukraine

俄罗斯行政体系的稳定阶段和不稳定阶段（英文）

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跨文化管理 2016年第1期 154-162页

作者：亚历山大·普罗霍罗夫 Yaroslavl State University

俄罗斯在国家稳定和不稳定阶段具有完全不同的行政管理模式。在不稳定阶段,俄罗斯采用高度竞争化的行政系统,其激烈程度超越西方意义上的竞争。本文探究了俄罗斯在不稳定阶段'竞争模式'的表现形式、历史原因和文化内涵。

关键词：俄罗斯不稳定阶段行政系统竞争

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Correction to: Variable retention forestry in European boreal forests in Russia

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Ecological Processes 2019年第1期8卷 484-484页

作者： Ekaterina Shorohova Sergey Sinkevich aleksandr Kryshen Ilkka Vanha-Majamaa Forest Research Institute of the Karelian Research Centre of the Russian Academy of Sciences Pushkinskaya str.11Petrozavodsk 185910Russia Saint-Petersburg State Forest Technical University Institutsky str.5Saint Petersburg 194021Russia Natural Resources Institute Finland(Luke)Latokartanonkaari 9FI-00790 HelsinkiFinland.

Correction to:Ecol Process https://***/10.1186/s13717-019-0183-7 In the original publication of this article(Shorohova et al.,2019),the figure captions of Figs.2,3 and 4 are *** should be changed to:‘Fig.2 The share of different forest management categories in different regions of NW Russia(Regional 2017,2018).Red lines denote the borders between the *** lines denote the borders between vegetation zones(Bonh et al.2000,2003).NB northern boreal zone,MB middle boreal zone,SB southern boreal zone,HB hemiboreal zone.

关键词： states. retention forest

Kinetics of 2-Methylbutene-2 Epoxidation with 2-Methylbutane Hydroperoxide

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Journal of Chemistry and Chemical Engineering 2013年第4期7卷 356-363页

作者： Valentin N. Sapunov aleksandr A. Petukhov Liubov A. Petukhova University of Chemical Technology Moscow Russia National Research Technological University (KNRTU) Kazan Russia

The kinetics of epoxidation of methylbutene with structurally identical methylbutane hydroperoxide was studied in the presence of a molybdenum catalyst. The analysis of the rate curves suggested the most probable scheme of the process. The revealed features of the process and its mathematical description make it possible to more competently design a reactor unit for the commercial production of isoprene according to the developed scheme. The main kinetic constants were calculated.

关键词：动力学常数环氧化反应过氧化氢甲基丁烷丁烯钼催化剂数学描述显示功能

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为声频混合器供电的单电容器电源

电子设计技术 1997年第10期 62-62页

作者： aleksandr Belousov Rego Park NY

微功率、低电压运算放大器允许我们无需用电池或变压器就能构成高性能模拟信号处理器。而且采用一只电容器作为供电电源。图1所示电路是一个为联接电视拍摄器和录像机的音频编辑而设计的模拟混合器,它可以用如

关键词：电源电容器电器混合器声频

On the Biological Regulators of Bloodsucking Blackflies(Diptear:Simuliidae)of Mixed Forests of Belorussian and Ukrainian Woodlands

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Journal of Zoological Research 2021年第2期3卷 18-24页

作者： Valery M.Kaplich Ekaterina B.Sukhomlin aleksandr P.Zinchenko Department of Tourism and Nature Management Belarussian State Technological UniversityMinskBelorussia Department of Zoology Lesya Ukrainka Volyn National UniversityLutskUkraine

This article considers the natural regulators of blood-sucking Simuliidae subzone of mixed forests on the territory of Belarus and *** the mixed forests,the major regulators of preimaginal phases of bloodsucking blackflies are microsporidia(Polidyspirenia simulii,Polidyspirenia sp.,Thelohania fibrata,Amblyospora bracteata,***),fungi and mermithides(Gastromermis boophthorae).Caddisfly larvae(Hydropsyche angustipennis,Neureclipsis bimaculata,Polycentropus flavomaculatus,Cyrnus flavidus,Oligostomis reticulata,Brachycentrus subnubilus and Rhyacophila nubila)and fishes(Scardinius erythrophthalmus,Rutilus rutilus,Carassius carassius,Gobio gobio)significantly reduce the number of blackflies larvae and *** blackflies are eaten by spiders(Araneus diadematus)dragonflies,robberflies,wasps,frogs(Rana temporaria and Rana terrestris),and insectivorous birds(Delichon urbicum,Hirundo rustica,Apus apus).Bactolarvicid and BLP-2477 are among the most effective biological products.

关键词： Blackflies Biological regulators Parasites Predators Biologicals

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为声频混合器供电的单电容器电源

电子设计技术 1997年第9期 59-59页

作者： aleksandr Belousov Rego Park NY

微功率、低电压运算放大器允许我们无需用电池或变压器就能构成高性能模拟信号处理器。而且采用一只电容器作为供电电源。图1所示电路是一个为联接电视拍摄器和录像机的音频编辑而设计的模拟混合器、它可以用如

关键词：电容器电池电器混合器声频电源