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Ionic Species Affect the Self-Propulsion of Urease-Powered Micromotors

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Research 2020年第1期2020卷 349-362页

作者： Xavier Arque Xavier Andres Rafael Mestre Bernard Ciraulo Jaime ortega Arroyo Romain Quidant Tania Patino Samuel Sanchez Institute for Bioengineering of Catalonia(IBEC) The Barcelona Institute of Science and Technology(BIST)Baldiri i Reixac 10-1208028 BarcelonaSpain Institute of Photonic Sciences(ICFO) The Barcelona Institute of Science and TechnologyCarl Friedrich Gauss 308860 CastelldefelsBarcelonaSpain InstitucióCatalana de Recerca i Estudis Avançats(ICREA) Pg.Lluís Companys 2308010 BarcelonaSpain Chemistry Department University of RomeTor VergataVia della Ricerca Scientifica00133 RomeItaly

Enzyme-powered motors self-propel through the catalysis of in situ bioavailable fuels,which makes them excellent candidates for biomedical ***,fundamental issues like their motion in biological fluids and the understanding of the propulsion mechanism are critical aspects to be tackled before a future application in ***,we investigated the physicochemical effects of ionic species on the self-propulsion of urease-powered *** showed that the presence of PBS,NaOH,NaCl,and HEPES reduced self-propulsion of urease-powered micromotors pointing towards iondependent mechanisms of *** studied the 3D motion of urease micromotors using digital holographic microscopy to rule out any motor-surface interaction as the cause of motion decay when salts are present in the *** order to protect and minimize the negative effect of ionic species on micromotors’performance,we coated the motors with methoxypolyethylene glycol amine(mPEG)showing higher speed compared to noncoated motors at intermediate ionic *** results provide new insights into the mechanism of urease-powered micromotors,study the effect of ionic media,and contribute with potential solutions to mitigate the reduction of mobility of enzyme-powered micromotors.

关键词： holographic salts catalysis

A novel induction motor control scheme using IDA-PBC

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控制理论与应用（英文版） 2008年第1期6卷 59-68页

作者： Humberto GONZLEZ Manuel A. DUARTE-MERMOUD Ian PELISSIER Juan Carlos TRAVIESO-TORRES Romeo ortega Department of Electrical Engineering University of ChileCasilla 412-3 Santiago Chile Laboratoire des Signaux et Systèmes Plateau de Moulon 91192 Gif-sur-Yvette France

A new control scheme for induction motors is proposed in the present paper, applying the interconnection and damping assignment-passivity based control （IDA-PBC） method. The scheme is based exclusively on passivity based control, without restricting the input frequency as it is done in field oriented control （FOC）. A port-controlled Hamiltonian （PCH） model of the induction motor is deduced to make the interconnection and damping of energy explicit on the scheme. The proposed controller is validated under computational simulations and experimental tests using an inverter prototype.

关键词： Induction motor Passivity based control Energy shaping control Interconnection and damping assignment IDA-PBC Port-controlled Hamiltonian PCH

Carbon isotopes of graphite:Implications on fluid history

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Geoscience Frontiers 2012年第2期3卷 197-207页

作者： F.J.Luque E.Crespo-Feo J.F.Barrenechea L.ortega Departamento de Cristalografía y Mineralogía Facultad de Geología Universidad Complutense de Madrid 28040 MadridSpain Instituto de Geociencias(UCM-CSIC) Jos Antonio Novais 228040 MadridSpain Departamento de Cristalografia y Mineralogia Facultad de Geología Universidad Complutense de Madrid28040 MadridSpain Departamento de Cristalografía y Mineralogía Facultad de Geología Universidad Complutense de Madrid28040 MadridSpain

Stable carbon isotope geochemistry provides important information for the recognition of funda- mental isotope exchange processes related to the movement of carbon in the lithosphere and permits the elab- oration of models for the global carbon cycle. Carbon isotope ratios in fluid-deposited graphite are powerful tools for unravelling the ultimate origin of carbon （organic matter, mantle, or carbonates） and help to constrain the fluid history and the mechanisms involved in graphite deposition. Graphite precipitation in fluid-deposited occurrences results from C02- and/or CH4-bearing aqueous fluids. Fluid flow can be considered as both a closed （without replenishment of the fluid） or an open system （with renewal of the fluid by successive fluid batches）. In closed systems, carbon isotope systematics in graphite is mainly governed by Rayleigh precipi- tation and/or by changes in temperature affecting the fractionation factor between fluid and graphite. Such processes result in zoned graphite crystals or in successive graphite generations showing, in both cases, isotopic variation towards progressive 13C or 12C enrichment （depending upon the dominant carbon phase in the fluid, C02 or CH4, respectively）. In open systems, in which carbon is episodically introduced along the fracture systems, the carbon systematics is more complex and individual graphite crystals may display oscillatory zoning because of Rayleigh precipitation or heterogeneous variations of 613C values when mixing of fluids or changes in the composition of the fluids are the mechanisms responsible for graphite precipitation.

关键词： Graphite Carbon isotopes Crust C-O-H fluids

Study and ICH validation of a reverse-phase liquid chromatographic method for the quantification of the intact monoclonal antibody cetuximab

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Journal of Pharmaceutical Analysis 2016年第2期6卷 117-124页

作者： Antonio Martinez-ortega Agustin Herrera Antonio Salmeron-Garcia Jose Cabeza Luis Cuadros-Rodriguez Natalia Navas Department of Analytical Chemistry University of Granada Faculty of Science Campus Fuentenueva s/n E-18071 Granada Spain UGC intercentro Interniveles Farmacia Granada San Cecilio Hospital Biomedical Research Institute ibs. GRANADA. Hospitales Universitarios de Granada University of Granada E-18012 Granada Spain Department of Analytical Chemistry Science Faculty Biomedical Research Institute ibis. GRANADA University of Granada Campus Fuentenuevo s/n E-18071 Granada Spain

Cetuximab （CTX） is a potent chimeric mouse/human monoclonal antibody （mAb） approved worldwide for treatment of metastatic colorectal cancer. Among the various biological and physical analyses per- formed for full study on this biopharmaceutic, the determination of the concentration preparations throughout manufacturing and subsequent handling in hospital is particularly relevant. In the present work, the study and validation of a method for quantifying intact CTX by reverse-phase high-perfor- mance liquid chromatography with diode array detection （（RP）HPLC/DAD） is presented. With that end, we checked the performance of a chromatographic method for quantifying CTX and conducted a study to validate the method as stability-indicating in accordance with the International Conference on Harmo- nization guidelines （ICH） for biotechnological drugs; therefore, we evaluated linearity, accuracy, preci- sion, detection and quantification limits, robustness and system suitability. The specificity of the method and the robustness of the mAb formulation against external stress factors were estimated by compre- hensive chromatographic analysis by subjecting CTX to several informative stress conditions. As de- monstrated, the method is rapid, accurate, and reproducible for CTX quantification. It was also suc- cessfully used to quantify CTX in a long-term stability study performed under hospital conditions.

关键词： Reverse-phase high performance liquidchromatography Diode detector Stress study Biopharmaceuticals Cetuximab

Towards Innovative Research Approaches to Investigating the Role of Emotional Variables in Promoting Language Teachers’ and Learners’ Mental Health

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International Journal of Mental Health Promotion 2023年第7期25卷 823-832页

作者： Ali Derakhshan Yongliang Wang Yongxiang Wang José Luis ortega-Martín Department of English Language and Literature Faculty of Humanities and Social SciencesGolestan UniversityGorgan15759-49138Iran School of Foreign Languages and Cultures Nanjing Normal UniversityNanjing210023China Department of Didactics of Language and Literature Faculty of EducationUniversity of GranadaGranada18071Spain

The adequacy of language education largely depends on the favorable and unfavorable emotions that teachers and students experience throughout the education *** said,emotional factors play a key role in improving the quality of language teaching and ***,these emotional factors also promote the well-being of language teachers and learners and place them in a suitable mental *** view of the favorable impact of emotional factors on the mental health of language teachers and learners,many educational scholars around the world have studied these factors,their background,and their pedagogical ***,the majority of previous studies have employed traditional research methods in assessing these variables and their inﬂuences on language teachers’and learners’mental *** of the complex and dynamic quality of emotional factors,traditional research approaches often fail to evaluate these factors and their dynamic,non-linear connections with teachers’and learners’mental health and ***,some novel research approaches are required to measure the dynamicity and complexity of emotional factors in language education *** address this call,the current state-of-the-art conceptual article seeks to provide new insights for investigating emotional factors and their potential impact on language teachers’and learners’mental *** study also intends to offer a comprehensive list of emerging methods that take into account the complex and dynamic nature of emotional ***,the study outlines the potential implications of this review for educational researchers.

关键词： Complexity dynamicity emotional factors mental health well-being innovative research approaches second and foreign language education

Effect of interfacial properties on mechanical stability of ash deposit

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Journal of Rock Mechanics and Geotechnical Engineering 2016年第2期8卷 187-197页

作者： A.Ontiveros-ortega J.A.Moleon I.Plaza C.Guillén Department of Physics Campus Universitario de las Lagunillas s/nEdificio A-3University of JaénJaén23071Spain Instituto Andaluz de Geofísica University of GranadaGranada18071Spain Department of Geography Campus Universitario de Guajara s/nUniversity of La LagunaIslas Canarias38071Spain

The paper presents a study on the cohesion of volcanic ash particles using surface free energy determination and zeta potential *** is a subject of great interest in physical volcanology,as many researches on volcanic particle aggregation are frequently *** this case,special attention is paid to the role of structural or hydration forces between hydrophilic surfaces,which are a consequence of the electron-donor/electron-acceptor character of the *** this point of view,the results are potentially interesting as they could give valuable insights into this *** results are presented in terms of the total energy of interaction between dispersed particles,computed from the extended DLVO *** to the total free energy of interaction were determined from the zeta potential and surface free energy of ash,measured under different experimental *** samples of basaltic volcanic ash(black and white)with silica contents of 44% and 63% respectively are *** surface free energy and zeta potential were analysed for ashes immersed in different electrolytes(NaCl,CaCl,FeCl).The presence of electrolytes changes the surface properties of the solid *** analysis of total interaction energy between the ash particles in aqueous medium shows that soil cohesion strongly depends on ash surface properties,chemical nature,the adsorbed cation on the surface,and p H value.

关键词： Zeta potential Surface free energy Volcanic ash Deposits stability El Hierro Island

Hyperthermic intraperitoneal chemotherapy:Rationale and technique

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World Journal of Gastrointestinal Oncology 2010年第2期2卷 68-75页

作者： Santiago González-Moreno Luis A González-Bayón Gloria ortega-Pérez Peritoneal Surface Oncology Program Department of Surgical OncologyCentro Oncológico MD Anderson International Espaa28033 MadridSpain

The combination of complete cytoreductive surgery and perioperative intraperitoneal chemotherapy provides the only chance for long-term survival for selected patients diagnosed with a variety of peritoneal neoplasms,either primary or secondary to digestive or gynecologic *** intraperitoneal chemotherapy (HIPEC) delivered in the operating room once the cytoreductive surgical procedure is fi nalized,constitutes the most common form of administration of perioperative intraperitoneal *** may be complemented in some instances with early postoperative intraperitoneal chemotherapy (EPIC).HIPEC combines the pharmacokinetic advantage inherent to the intracavitary delivery of certain cytotoxic drugs,which results in regional dose intensification,with the direct cytotoxic effect of *** exhibits a selective cell-killing effect in malignant cells by itself,potentiates the cytotoxic effect of certain chemotherapy agents and enhances the tissue penetration of the administered *** chemotherapeutic agents employed in HIPEC need to have a cell cycle nonspecific mechanism of action and should ideally show a heat-synergistic cytotoxic *** of HIPEC requires an apparatus that heats and circulates the chemotherapeutic solution so that a stable temperature is maintained in the peritoneal cavity during the *** open abdomen (Coliseum) or closed abdomen technique may be used,with no signif icant differences in eff icacy proven to *** ic technical training and a solid knowledge of regional chemotherapy management are *** about safety of the procedure for operating room personnel are expected but are manageable if universal precautions and standard chemotherapy handling procedures are *** HIPEC drug regimens and dosages are currently in use.A tendency for concurrent intravenous chemotherapy administration (bidirectional chemotherapy,so-called "HIPEC plus") has been observed in rece

关键词： Hyperthermia Intracavitary chemotherapy Peritoneal neoplasms Peritoneal carcinomatosis Cytoreductive surgery

Progress of the Modeling Approach on Land Change Science： Comments on Modelling the Dynamics and Consequences of Land System Change

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Journal of Geographical Sciences 2012年第3期22卷 575-576页

作者： Maria Victoria ortega Espaldon School of Environmental Science and Management University of the Philippines

Land system change has never been out of human concerns. It is always one of the hottest themes in global environmental change research （Seto et al., 2002; Gutman et al., 2004）. With the development of research on land use change and the Global Land Project, it is necessary to explore the interactions and associations among various factors in the land system from a systematic perspective to recognize the causes and effects of land system change.

关键词：模型方法新进展动力学土地系统简评科学效应模拟

The Development and Application of CISMOD 1.0, a New Computerized Tool for Designing Wildlife Rainwater Cisterns

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Computational Water, Energy, and Environmental Engineering 2021年第2期10卷 71-81页

作者： Ariel ortega Dave Menicucci University of NM Albuquerque NM USA Sandia National Labs (retired) Albuquerque NM USA

This article reports on a case study of the research and development of a new tool to assist in the design of rainwater cisterns. A rainwater cistern is a way to improve wildlife habitat because it can be situated in locations that do not have natural water sources, such as streams or wells that can supply water for storage. However, the design and sizing of such a system can be challenging because a number of constantly varying factors must be considered, such as changing precipitation patterns, the evaporative losses from the cistern and animal water consumption. No standardized sizing methodology currently exists for designing wildlife rainwater cisterns. In this article we present a new method for assisting in optimally sizing a rainwater cistern. We discuss how we implemented the quantitative portion of this methodology into a new Excel? model called CISMOD, which we configured for general use by wildlife professionals. We describe the methodology for designing a rainwater cistern based on standard engineering techniques. We then present and discuss our experience in applying the model to design two rainwater cisterns in an area of the Jemez Mountains in northern New Mexico, USA. The CISMOD model and a user manual are available at no cost for wildlife professionals.

关键词： Cistern Wildlife Design Sizing Construction