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Long term follow-up after liver transplantation from a JAK2 mutation positive donor

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Hepatobiliary Surgery and Nutrition 2019年第2期8卷 189-191页

作者： alejandro Lazo-Langner Peter Ainsworth Vivian McAlister Department of Medicine Division of HematologyWestern UniversityLondonONCanada Department of Epidemiology and Biostatistics Western UniversityLondonONCanada Department of Oncology Western UniversityLondonONCanada Department of Pathology and Laboratory Medicine Western UniversityLondonONCanada Department of Surgery Western UniversityLondonONCanada

Introduction Philadelphia-negative myeloproliferative neoplasms(MPN),including polycythemia vera(PV),essential thrombocythemia(ET),and primary myelofibrosis(PMF),are characterized by the presence of mutations involving the Janus Kinase 2(JAK2),calreticulin(CALR)or myeloproliferative leukemia virus oncogene(MPL)genes(1).Of these,the JAK2 V617F gain-of-function mutation is the most frequently found and is present in>95%of patients with PV and in about 60%of those with ET or PMF whereas JAK2 exon 12 mutations are found in the remaining PV patients(2).JAK2 V617F somatic mutations have been detected in granulocytes and platelets and therefore they could potentially be transmitted to recipients of solid organ transplants(3)and in fact the presence of the JAK2 V617F mutation has been detected in otherwise healthy blood donors(4,5).

关键词： JAK2 neoplasms patients

Autoimmune hepatitis:Towards a personalized treatment

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World Journal of Hepatology 2024年第11期16卷 1225-1242页

作者： alejandro Costaguta Guillermo Costaguta FernandoÁlvarez Department of Hepatology and Liver Transplant Unit Sanatorio de Niños de RosarioRosario 2000Santa FeArgentina Department of Gastroenterology Hepatologyand NutritionCHU Sainte-JustineMontreal H3T 1C5QuebecCanada of Pediatrics CHU Sainte-JustineMontreal H3T 1C5QuebecCanada

Autoimmune hepatitis is an uncommon condition that affects both adults and children and is characterized by chronic and recurrent inflammatory activity in the *** inflammation is accompanied by elevated IgG and autoantibody ***,treatment consists of steroids with the addition of azathioprine,which results in remission in approximately 80%of *** significant advancements in our understanding of the immune system over the past two decades,few modifications have been made to treatment algorithms,which have remained largely unchanged since they were first proposed more than 40 years *** review summarized the various treatment options currently available as well as our experiences using *** steroids are the standard treatment for induction therapy,other medications may be *** A,a calcineurin inhibitor that decreases T cell activation,has proven effective for induction of remission,but its long-term side effects limit its appeal for ***,a drug belonging to the same family,has been used in patients with refractory diseases with fewer side *** and everolimus have interesting effects on regulatory T cell populations and may become viable options in the *** mofetil is not effective for induction but is a valid alternative for patients who are intolerant to azathioprine.B celldepleting drugs,such as rituximab and belimumab,have been successfully used in refractory cases and are useful in both the short and long *** promising treatments include anti-tumor necrosis factors,Janus kinases inhibitors,and chimeric antigen receptor T cell *** growing armamentarium allows us to imagine a more tailored approach to the treatment of autoimmune hepatitis in the near future.

关键词： Novel therapies Immunosuppressors Treatment tailoring Personalization Special populations

Don´t give up on mitochondria as a target for the treatment of diabetes and its complications

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World Journal of Diabetes 2024年第10期15卷 2015-2021页

作者： Christian Cortés-Rojo Manuel alejandro Vargas-Vargas Instituto de Investigaciones Químico-Biológicas Universidad Michoacana de San Nicolás de HidalgoMorelia 58030MichoacánMexico

In this editorial,we discuss an article by Wang et al,focusing on the role of mitochondria in peripheral insulin resistance and insulin *** numerous in vitro and pre-clinical studies supporting the involvement of mitochondrial dysfunction and oxidative stress in the pathogenesis of diabetes and its complications,efforts to target mitochondria for glycemic control in diabetes using mitochondria-targeted antioxidants have produced inconsistent *** intricate functionality of mitochondria is summarized to underscore the challenges it poses as a therapeutic *** mitochondria-targeted antioxidants have demonstrated improvement in mitochondrial function and oxidative stress in pre-clinical diabetes models,the results regarding glycemic control have been mixed,and no studies have evaluated their hypoglycemic effects in diabetic ***,pre-clinical trials have shown promising outcomes in ameliorating diabetes-related ***,we review some reasons why mitochondria-targeted antioxidants may not function effectively in the context of mitochondrial *** also highlight several alternative approaches under development that may enhance the targeting of mitochondria for diabetes treatment.

关键词： Diabetes mellitus Insulin resistance Mitochondrion Mitochondrial dysfunction MitoQ MitoTEMPO SkQ Elamipretide Mitochondria transplantation Glycemic control

Experimental and Data Fitting Guidelines for the Determination of Polymer Crystallization Kinetics

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Chinese Journal of Polymer Science 2022年第6期40卷 658-691页

作者： Ricardo Arpad Perez-Camargo Guo-Ming Liu Du-Jin Wang alejandro J.Muller Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Engineering PlasticsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China POLYMAT and Department of Polymers and Advanced Materials:Physics Chemistry and TechnologyFaculty of ChemistryUniversity of the Basque Country UPV/EHUDonostia-San Sebastián 20018Spain IKERBASQUE Basque Foundation for ScienceBilbao 48013Spain

The crystallization kinetics of semicrystalline polymers is often studied with isothermal experiments and analyzed by fitting the data with analytical expressions of the Avrami and Lauritzen and Hoffman(LH)*** correctly carry out the analysis,precautions in both experiments and data fitting should be ***,we systematically discussed the factors that influence the validity of the crystallization kinetics *** basic concepts and fundamentals of the Avrami and LH theories were introduced at ***,experimental protocols were discussed in *** clarify the impact of various experimental parameters,selected common polymers,i.e.,polypropylene and polylactide,were studied using various experimental techniques(i.e.,differential scanning calorimetry and polarized light optical microscopy).Common mistakes were simulated under conditions when non-ideal experimental parameters were ***,from a practical point of view,we show how to fit the experimental data to the Avrami and the LH theories,using an Origin■App developed by us.

关键词： Isothermal crystallization Avrami equation Lauritzen and Hoffman theory Thermal analysis Step-crystallization

TangiWheel: A Widget for Manipulating Collections on Tabletop Displays Supporting Hybrid Input Modality

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Journal of Computer Science & Technology 2012年第4期27卷 811-829页

作者： alejandro Catalá Fernando Garcia-Sanjuan Javier Jaen Jose A.Mocholi Software Engineering and Information Systems Research Group Department of Information Systems and Computation Universitat Politècnica de ValènciaCamí de Vera s/n46022ValenciaSpain ACM IEEE

In this paper we present TangiWheel, a collection manipulation widget for tabletop displays. Our implementation is flexible, allowing either multi-touch or interaction, or even a hybrid scheme to better suit user choice and convenience. Different TangiWheel aspects and features are compared with other existing widgets for collection manipulation. The study reveals that TangiWheel is the first proposal to support a hybrid input modality with large resemblance levels between touch and tangible interaction styles. Several experiments were conducted to evaluate the techniques used in each input scheme for a better understanding of tangible surface interfaces in complex tasks performed by a single user （e.g., involving a typical master-slave exploration pattern）. The results show that tangibles perform significantly better than fingers, despite dealing with a greater number of interactions, in situations that require a large number of acquisitions and basic manipulation tasks such as establishing location and orientation. However, when users have to perform multiple exploration and selection operations that do not require previous basic manipulation tasks, for instance when collections are fixed in the interface layout, touch input is significantly better in terms of required time and number of actions. Finally, when a more elastic collection layout or more complex additional insertion or displacement operations are needed, the hybrid and tangible approaches clearly outperform finger-based interactions.

关键词： interactive surface multi-touch tangible user interface tabletop display experimentation

Unmanned Aerial Vehicle Multi-Access Edge Computing as Security Enabler for Next-Gen 5G Security Frameworks

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Intelligent Automation & Soft Computing 2023年第8期37卷 2307-2333页

作者： Jaime Ortiz Córdoba alejandro Molina Zarca Antonio Skármeta Department of Information and Communications Engineering University of MurciaMurcia30003Spain

5G/Beyond 5G(B5G)networks provide connectivity to many heterogeneous devices,raising significant security and operational issues and making traditional infrastructure management increasingly *** this regard,new frameworks such as Anastacia-H2020 or INSPIRE-5GPlus automate the management of next-generation infrastructures,especially regarding policy-based security,abstraction,flexibility,and *** paper presents the design,workflow,and implementation of a security solution based on Unmanned Aerial Vehicles(UAVs),able to extend 5G/B5G security framework capabilities with UAV features like dynamic service provisioning in specific geographic *** proposed solution allows enforcing UAV security policies in proactive and reactive ways to automate UAV dynamic deployments and provisioning security Virtual Network Functions(VNFs)in the onboard Multi-access Edge Computing(MEC)node.A UAV has been ensembled from scratch to validate the proposal,and a raspberry-pi has been onboarded as compute *** implementation provides a VNF for dynamic UAV management,capable of dynamically loading waypoints into the flight controller to address reactive autonomous flights,and anMLbased VNF capable of detecting image *** to the security policies,the onboard VNFs can be dynamically configured to generate alerts to the framework and apply local reactions depending on the detection *** our experiments,we measured the time it takes for the solution to be ready after receiving a security policy for detecting patterns in a specific geographical *** time it takes for the solution to react automatically was also *** results show that the proactive flow configuration considering ten waypoints can be enforced in less than 3 s,and a local reactive flow can be enforced in around 1 *** consider that the results are promising and aligned with other security enabler solutions as part of existing 5G/6G security frameworks.

关键词： UAV 5G AI NFV security

Adsorption and affinity of Escherichia coli to different aggregate sizes of a silty clay soil

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International Journal of Sediment Research 2013年第4期28卷 535-543页

作者： Filipe BEHRENDS KRAEMER Celio Ignacio CHAGAS Diego Julian COSENTINO Lucas alejandro GARIBALDI Department of Soil Use and Management School of Agronomy Buenos Aires University National University of Rio Negro Andina branch 4. Argentina and National Scientificand Technical Research Council(CONICET) Department of Edaphology School of Agronomy Buenos Aires University

The sediments produced by water erosion are the main source of pollution of agricultural origin of surface water *** sediments may be associated to bacteria,compromising the quality of nearby water ***,to understand this biological contamination,it is necessary to find out the adsorption capacity and bacterial affinity to aggregate sizes that may result in a differential *** this end,in the present work,the distribution,adsorption capacity and affinity to different aggregate sizes of two strains of Escherichia coli in two liquid media of contrasting ionic strength were evaluated in a silty clay *** 2 μm,the 20—50um fraction was the one that showed the highest bacterial adsorption in both liquid media(37.9%).On the other hand,the highest values of bacterial affinity were found in the 20 to 50 μm fraction(coarse silt) in the low ionic strength media and 20—50 and >50 μm in the high ionic strength ***,the bacterial strains used revealed only some trends in the modification of these *** work contributes to the development and implementation of strategies to mitigate pollution,such as control of sediment generation and its subsequent capture in filter strips.

关键词： Biological contamination Surface transport Water quality

Optimized Convolutional Neural Network Models for Skin Lesion Classification

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Computers, Materials & Continua 2022年第2期70卷 2131-2148页

作者： Juan Pablo Villa-Pulgarin Anderson Alberto Ruales-Torres Daniel Arias-GarzónMario alejandro Bravo-Ortiz Harold Brayan Arteaga-Arteaga alejandro Mora-RubioJesus alejandro Alzate-Grisales Esteban Mercado-Ruiz M.Hassaballah Simon Orozco-Arias Oscar Cardona-Morales Reinel Tabares-Soto Department of Electronics and Automation Universidad Autónoma deManizalesManizales170001Colombia SEDMATEC Corporación Universitaria Autónoma de Nari駉Pasto520002Colombia Department of Computer Science Faculty of Computers and InformationSouth Valley UniversityQena83523Egypt Department of Computer Science Universidad Autónoma de ManizalesManizales170001Colombia Department of Systems and Informatics Universidad de CaldasManizales170001Colombia

Skin cancer is one of themost severe diseases,andmedical imaging is among themain tools for cancer *** images provide information on the evolutionary stage,size,and location of tumor *** paper focuses on the classification of skin lesion images considering a framework of four experiments to analyze the classification performance of Convolutional Neural Networks(CNNs)in distinguishing different skin *** CNNs are based on transfer learning,taking advantage of ImageNet ***,in each experiment,different workflow stages are tested,including data augmentation and fine-tuning *** CNN models based on DenseNet-201,Inception-ResNet-V2,and Inception-V3 are proposed and compared using the HAM10000 *** results obtained by the three models demonstrate accuracies of 98%,97%,and 96%,***,the best model is tested on the ISIC 2019 dataset showing an accuracy of 93%.The proposed methodology using CNN represents a helpful tool to accurately diagnose skin cancer disease.

关键词： Deep learning skin lesion convolutional neural network data augmentation transfer learning

A RESTful proxy and data model for linked sensor data

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International Journal of Digital Earth 2013年第3期6卷 233-254页

作者： Krzysztof Janowicz Arne Broring Christoph Stasch Sven Schade Thomas Everding alejandro Llaves Department of Geography University of CaliforniaSanta BarbaraCAUSA North Initiative for Geospatial Open Source Software MunsterGermany Faculty ITC University of TwenteEnschedeTheNetherlands Institute for Geoinformatics University of MunsterMunsterGermany Joint Research Centre Institute for Environment and SustainabilityIspraItaly

The vision of a Digital Earth calls for more dynamic information systems,new sources of information,and stronger capabilities for their *** networks have been identified as a major information source for the Digital Earth,while Semantic Web technologies have been proposed to facilitate *** far,sensor data are stored and published using the Observations&Measurements standard of the Open Geospatial Consortium(OGC)as data *** the advent of Volunteered Geographic Information and the Semantic Sensor Web,work on an ontological model gained importance within Sensor Web Enablement(SWE).In contrast to data models,an ontological approach abstracts from implementation details by focusing on modeling the physical world from the perspective of a particular *** restrict the interpretation of vocabularies toward their intended *** ongoing paradigm shift to Linked Sensor Data complements this *** questions have to be addressed:(1)how to refer to changing and frequently updated data sets using Uniform Resource Identifiers,and(2)how to establish meaningful links between those data sets,that is,observations,sensors,features of interest,and observed properties?In this paper,we present a Linked Data model and a RESTful proxy for OGC’s Sensor Observation Service to improve integration and inter-linkage of observation data for the Digital Earth.

关键词： Digital Earth geospatial data integration spatial data infrastructure earth observation data exchange models linked data semantic enablement