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Toward optical coherence tomography on a chip: in vivo three-dimensional human retinal imaging using photonic integrated circuit-based arrayed waveguide gratings

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Light(Science & Applications) 2021年第1期10卷 71-85页

作者： Elisabet A.Rank Ryan Sentosa Danielle J.Harper Matthias Salas Anna Gaugutz Dana Seyringer Stefan Nevlacsil alejandro maese-novo Moritz Eggeling Paul Muellner Rainer Hainberger Martin Sagmeister Jochen Kraft Rainer ALeitgeb Wolfgang Drexler Center for Medical Physics and Biomedical Engineering Medical University of ViennaWaehringer Guertel 18-20/4 L1090 ViennaAustria Research Centre for Microtechnology Vorarlberg University of Applied SciencesHochschulstrasse 16850 DornbirnAustria AIT Austrian Institute of Technology GmbH Gieffinggasse 41210 ViennaAustria ams AG Tobelbader Strasse 308141 PremstaettenAustria

In this work,we present a significant step toward in vivo ophthalmic optical coherence tomography and angiography on a photonic integrated *** diffraction gratings used in spectral-domain optical coherence tomography can be replaced by photonic integrated circuits comprising an arrayed waveguide *** arrayed waveguide grating designs with 256 channels were tested,which enabled the first chip-based optical coherence tomography and angiography in vivo three-dimensional human retinal *** 1 supports a bandwidth of 22nm,with which a sensitivity of up to 91 dB(830μW) and an axial resolution of 10.7 pm was *** 2 supports a bandwidth of 48 nm,with which a sensitivity of 90 dB(480μW) and an axial resolution of 6.5μm was *** silicon nitride-based integrated optical waveguides were fabricated with a fully CMOS-compatible process,which allows their monolithic co-integration on top of an optoelectronic silicon *** a benchmark for chip-based optical coherence tomography,tomograms generated by a commercially available clinical spectral-domain optical coherence tomography system were compared to those acquired with on-chip *** similarities in the tomograms demonstrate the significant clinical potential for further integration of optical coherence tomography on a chip system.

关键词： waveguide arrayed optical

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Amyloid-beta pathology-induced nanoscale synaptic disruption:the case of the GABA_B-GIRK assembly

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Neural Regeneration Research 2025年第5期20卷 1409-1410页

作者： Rafael Lujan alejandro Martín-Belmonte Sergi Ferré Francisco Ciruela Synaptic Structure Laboratory Instituto de Biomedicina de la UCLM(IB-UCLM)Departamento de Ciencias MédicasInstituto de Investigación en Salud de Castilla-La Mancha(IDISCAM)Facultad de MedicinaUniversidad Castilla-La ManchaCampus BiosanitarioC/AlmansaAlbaceteSpain Integrative Neurobiology Section National Institute on Drug AbuseIntramural Research ProgramNational Institutes of HealthBaltimoreMDUSA Pharmacology Unit Department of Pathology and Experimental TherapeuticsSchool of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaNeuropharmacology&Pain GroupNeuroscience ProgramBellvitge Institute for Biomedical ResearchL’Hospitalet de LlobregatSpain

Alzheimer's disease (AD) is characterized by an imbalance between excitatory and inhibitory brain networks,leading to aberrant homeostatic synaptic *** has progressively been recognized as syna ptopathy and syna ptic dysfunction has been identified as a key component of its pathogenesis (Schirinzi et al.,2020).Syna ptic dysfunction is believed to precede synapse loss,a primary biological correlate of cognitive decline in AD,inevita bly associated with neuronal death.

关键词： Alzheimer pathology

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Differential response of injured and healthy retinas to syngeneic and allogeneic transplantation of a clonal cell line of immortalized olfactory ensheathing glia:a double-edged sword

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Neural Regeneration Research 2025年第8期20卷 2395-2407页

作者： María Norte-Muñoz María Portela-Lomba Paloma Sobrado-Calvo Diana Simón Johnny Di Pierdomenico alejandro Gallego-Ortega Mar Pérez JoséMCabrera-Maqueda Javier Sierra Manuel Vidal-Sanz María Teresa Moreno-Flores Marta Agudo-Barriuso Grupo de Investigación Oftalmología Experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaSpain Experimental Sciences Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain Anatomy Histology and Neuroscience DepartmentMedicine FacultyUniversidad Autónoma de MadridMadridSpain Center of Neuroimmunology Service of NeurologyLaboratory of Advanced Imaging in Neuroimmunological DiseasesHospital Clínic of BarcelonaInstitut d’Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)and Universitat de BarcelonaBarcelonaSpain Medicine Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain

Olfactory ensheathing glia promote axonal regeneration in the mammalian central nervous system,including retinal ganglion cell axonal growth through the injured optic ***,it is unknown whether olfactory ensheathing glia also have neuroprotective *** ensheathing glia express brain-derived neurotrophic factor,one of the best neuroprotectants for axotomized retinal ganglion ***,we aimed to investigate the neuroprotective capacity of olfactory ensheating glia after optic nerve *** ensheathing glia cells from an established rat immortalized clonal cell line,TEG3,were intravitreally injected in intact and axotomized retinas in syngeneic and allogeneic mode with or without microglial inhibition or immunosuppressive *** and gene expression analyses were *** bulb-derived primary olfactory ensheathing glia and TEG3 express major histocompatibility complex classⅡ*** and syngenically transplanted TEG3 cells survived in the vitreous for up to 21 days,forming an *** axotomized retinas,only the allogeneic TEG3 transplant rescued retinal ganglion cells at 7 days but not at 21 *** these retinas,microglial anatomical activation was higher than after optic nerve crush *** intact retinas,both transplants activated microglial cells and caused retinal ganglion cell death at 21 days,a loss that was higher after allotransplantation,triggered by pyroptosis and partially rescued by microglial inhibition or ***,neuroprotection of axotomized retinal ganglion cells did not improve with these *** different neuroprotective properties,different toxic effects,and different responses to microglial inhibitory treatments of olfactory ensheathing glia in the retina depending on the type of transplant highlight the importance of thorough preclinical studies to explore these variables.

关键词： cell therapy immune recognition major histocompatibility complex class II(MHCII) neuroprotection olfactory ensheathing glia retinal ganglion cells

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Chemical-Abrasion U-Pb zircon geochronology reveals 150 Myr of partial melting events in the Archean crust of the São Francisco Craton

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Geoscience Frontiers 2022年第5期13卷 169-189页

作者： Lorena Martins Cristiano Lana Ariela Mazoz Tiago novo Applied Isotope Research Group Departamento de GeologiaEscola de MinasUniversidade Federal de Ouro PretoMorro do CruzeiroOuro PretoMG35400-000Brazil Universidade Federal de Minas Gerais Programa de Pós-Graduação em GeologiaIGC-CPMTCCampus PampulhaAv.Antônio Carlos 6627Belo HorizonteMG31270-901Brazil

Field observations and CA-LA-ICP-MS U–Pb zircon ages and Hf isotope compositions obtained from migmatitic orthogneisses and granitoids from the Belo Horizonte Complex,southern São Francisco Craton,indicate a major period of partial melting and production of felsic rocks in the *** observations show that the complex is an important site for studying partial melting processes of Archean crystalline *** of the complex exposes fine-grained stromatic migmatites that are intruded by multiple leucogranitic veins and sheeted *** migmatites and leucogranite sheets are crosscut by several phases of granitoid batholiths and small granitic bodies;both of which are closely associated with the host banded *** abrasion followed by detailed cathodoluminescence imaging revealed a wide variety of zircon textures that are consistent with a long-lived period of partial melting and crustal *** of U-Pb and Hf isotopes disclose the complex as part of a much wider crustal segment,encompassing the entire southern part of the São Francisco *** of available U-Pb ages suggests that this crustal segment was consolidated sometime between 3000 Ma and 2900 Ma and that it experienced three main episodes of partial melting before stabilization at 2600 *** partial melting episodes took place between 2750 Ma and 2600 Ma as a result of tectonic accretion and peeling off the lithospheric mantle and lower *** process is likely responsible for the emplacement of voluminous potassic granitoids across the entire São Francisco *** believe that the partial melting of Meso-Archean crystalline crust and production of potassic granitoids are linked to a fundamental shift in the tectonics of the craton,which was also responsible for the widespread intrusion of large syenitic bodies in the northern part of the craton,and the construction of layered mafic–ultramafic intrusions to the south of the BHC.

关键词： Archean São Francisco Craton Crustal reworking U-Pb geochronology Lu-Hf isotopes

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Stochastic Contrast Measures for SAR Data: A Survey

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雷达学报（中英文） 2019年第6期8卷 758-781页

作者： alejandro C.Frery La CCAN–Laboratório de Computa??o Científica e Análise Numérica Universidade Federal de Alagoas

“Contrast”is an generic denomination for“difference”.Measures of contrast are a powerful tool in image processing and analysis,e.g.,in denoising,edge detection,segmentation,classification,parameter estimation,change detection,and feature *** present a survey on techniques that aim at measuring the contrast between(i)samples of SAR imagery,and(ii)samples and models,with emphasis on those that employ the statistical properties of the data.

关键词： Contrast Divergence Entropy Geodesic distance Statistics Synthetic Aperture Radar(SAR)

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Chronic epididymitis and Grade III varicocele and their associations with semen characteristics in men consulting for couple infertility

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Asian Journal of Andrology 2018年第4期20卷 360-365页

作者： alejandro Oliva Luc Multigner Center for Interdisciplinary Studies National University of Rosario Rosario 2000 Argentina University of Rennes Inserm EHESP Irset (Institut de recherche en sante environnement et travail) UMR_S 1085 Rennes F-35000 France

Chronic epididymitis and varicocele are frequently observed genital disorders in men consulting for couple infertility, but their impact on semen characteristics at the time of infertility consultation is still a matter of debate. We investigated 652 male partners of couples who had their first infertility consultation between 1999 and 2015 in Argentina. Men with chronic epididymitis （n = 253）, Grade III varicocele （n = 106）, and both conditions （n = 125） were compared with a control group （n = 168） composed of men without these disorders or any other recognized causes of male infertility. We showed that men who presented isolated chronic epididymitis were more likely to have high percentages of low sperm motility and abnormal sperm morphology as well as a high number of white blood cells. Men with isolated Grade III varicocele had low sperm production and motility and an increased percentage of abnormal sperm morphology. Finally, men who simultaneously presented chronic epididymitis with Grade III varicocele had a low sperm motility and increased percentage of abnormal sperm morphology as well as a high number of white blood cells. Physical examination of the genital organs may identify common disorders, potentially involved as causal factors of patient＇s infertility. These disorders are associated with specific seminal profiles that should help in identifying the best treatment from the available therapeutic options, effectiveness, safety, and allowing as much as possible natural conception.

关键词： couple subfertility epididymitis male factor infertility semen quality varicocele

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Vee-tail conceptual design criteria for commercial transport aeroplanes

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Chinese Journal of Aeronautics 2019年第3期32卷 595-610页

作者： alejandro SANCHEZ-CARMONA Cristina CUERNO-REJADO Faculty of Aerospace Engineering Department of Aircraft and Spacecraft Technical University of Madrid (Universidad Poltécnica de Madrid)

Vee-tail configuration is an unconventional tail configuration for commercial transport aviation, the use of which could suppose reductions on CO2 emissions. The conceptual design criteria have been selected inspired on the certification requirements established by the aviation regulation in force. They are static stability in cruise, control after Critical Engine Failure(CEF),control in crosswind landing, and trim in these three conditions. The study is carried out through a combination of semi-empirical techniques and Vortex-Lattice Methods(VLM) and thus this analyses the consequences of applying these criteria to a reference aeroplane substituting its conventional tail by a parametrised Vee-tail configuration. The Vee-tail is defined by four parameters:span, root chord, taper ratio and dihedral angle. The results of the study establish a relation between the parameters in order to accomplish the proposed conceptual design criteria. To sum up, minimum and maximum limits are obtained for dihedral angle depending on the combination of the rest of parameters. In addition, a design restriction to the yawing trailing-edge tail control is reached when the results are analysed, demonstrating that its minimum size must be between 60%and 80% of the half-span of the tail, depending on the Vee-tail geometry.

关键词： Commercial transport aeroplane Conceptual aircraft design Tail design requirements Unconventional tail design Vee-tail

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A CONTRIBUTION TO THE SCIENTIFIC FOUNDATIONS OF SYSTEMS ENGINEERING： SOLUTION SPACES AND REQUIREMENTS

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Journal of Systems Science and Systems Engineering 2017年第5期26卷 549-589页

作者： alejandro Salado Roshanak Nilchiani Dinesh Verma Grado Department of Industrial and Systems Engineering Virginia Tech Blacksburg VA 24061 USA School of Systems and Enterprises Stevens Institute of Technology Hoboken N J 07030 USA

Some researchers have suggested that scientific foundations expressed in a mathematical form are needed to thrust the success of systems engineering as a discipline on its own merit. In order to contribute the development of such systems science, this paper investigates from a foundational standpoint the relationships between stakeholder needs, system requirements, and sets of systems. Various theorems and corollaries are proposed and mathematically proven. The theoretical elements are presented as a foundation for the development of a science for requirements engineering. The proposed foundations are finally tested to mathematically describe, in a rigorous and precise manner, qualities of good requirements, which are otherwise traditionally defined using vague narrative. By showcasing practical examples of the theoretical aspects, the paper is intended to serve as a bridge between practitioners and theorists.

关键词： Systems science systems theory requirements engineering mathematical formulation,requirements qualities formal concepts

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’Emulsion locks’ for the containment of hydrocarbons during surfactant flushing

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Journal of Environmental Sciences 2020年第4期32卷 98-109页

作者： Kristine Lamont alejandro GMarangoni Erica Pensini University of Guelph School of Engineering50 Stone Road EastGwelph ONNIG 2W1Canada University of Guelph Food Science Department50 Stone Road EastGuelph ONNIG 2WlCanada

Reversible double water in oil in water(W/O/W)emulsions were developed to contain subsurface hydrocarbon spills during their remediation using surfactant *** emulsions were prepared by emulsifying CaCl2 solutions in canola oil,and subsequently by emulsifying the W/O emulsions in aqueous sodium alginate *** formation of double emulsions was confirmed with confocal and optical *** double emulsions reversed and gelled when mixed with the surfactants sodium dodecyl sulfate(SDS)and cocamidopropyl betaine(CPB).Gels can act as’emulsion locks’to prevent spreading of the hydrocarbon plume from the areas treated with surfactant flushing,as shown in sand column *** rheology was used to quantify the viscoelastic moduli increase(gelation)upon mixing the double emulsion with SDS and *** was more effective than CPB in gelling the double *** and SDS could adsorb at the interface between water and model hydrocarbons(toluene and motor oil),lowering the interfacial tension and rigidifying the interface(as shown with a Langmuir trough).Bottle tests and optical microscopy showed that SDS and CPB produced W/O and O/W emulsions,with either toluene or motor oil and *** emulsification of motor oil and toluene in water with SDS and CPB facilitated their flow through sand columns and their *** recovery from sand columns was quantitated using Gas-Chromatography MassSpectroscopy(GC-MS).The data show that SDS and CPB can be used both for surfactant flushing and to trigger the gelation of’emulsion locks’.Ethanol also gelled the emulsions at100 mL/L.

关键词： Remediation Emulsion Hydrocarbons Surfactant Rheology Langmuir trough

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Germline predisposition to soft tissue sarcoma

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Journal of Cancer Metastasis and Treatment 2022年第1期8卷 265-280页

作者： Jennie Vagher Matthew S.Dietz Joshua D.Schiffman Wendy Kohlmann Luke maese Department of Population Sciences Huntsman Cancer InstituteUniversity of UtahSalt Lake CityUT 84112USA Division of Hematology/Oncology Primary Children’s HospitalUniversity of UtahSalt Lake CityUT 84112USA Peel Therapeutics Inc.Altitude LabSalt Lake CityUT 84108USA

Soft tissue sarcoma(STS)most often occurs sporadically,but can also arise in the setting of a germline cancer predisposition syndrome(CPS).There is significant diversity amongst STS diagnoses as these tumors exhibit a variety of histologies,occur in all age groups,and can occur in any location in the *** diversity is also reflected in the many known associated germline cancer predisposition *** STS diagnoses,such as anaplastic rhabdomyosarcoma,are associated with high heritability and other STS,such as Ewing sarcoma,are notably absent from known *** when a STS is more likely to be hereditary can influence clinical *** diagnosed with STS due to CPS may be at risk for other malignancies and should undergo additional surveillance for early ***,family members should undergo genetic testing as they also may be at risk to develop STS and other CPS-associated *** underlying cancer predisposition diagnoses may have implications for the treatment of a concurrent malignancy as in the case of PARP inhibitor therapy in the setting of homologous recombination *** review summarizes current knowledge of selected STS and their associations with CPS.

关键词： Genetic soft tissue sarcoma Li-Fraumeni syndrome cancer predisposition syndrome

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