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Polyoxidovanadates a new therapeutic alternative for neurodegenerative and aging diseases

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Neural Regeneration Research 2024年第3期19卷 571-577页

作者： Sonia Irais Gonzalez-cano Gonzalo Flores Jorge Guevara Julio Cesar Morales-Medina Samuel Treviño Alfonso Diaz Faculty of Chemical Sciences Benemerita Autonomous University of PueblaPueblaMexico Institute of Physiology Benemerita Autonomous University of PueblaPueblaMexico Department of Biochemistry Faculty of MedicineNational Autonomous University of MexicoMexico CityMexico Animal Reproduction Research Center CINVESTAV-Autonomous University of TlaxcalaTlaxcalaMexico

Aging is a natural phenomenon characterized by a progressive decline in physiological integrity,leading to a deterioration of cognitive function and increasing the risk of suffering from chronic-degenerative diseases,including cardiovascular diseases,osteoporosis,cancer,diabetes,and *** is considered the major risk factor for Parkinson’s and Alzheimer’s disease ***,diabetes and insulin resistance constitute additional risk factors for developing neurodegenerative ***,no treatment can effectively reverse these neurodegenerative ***,some antidiabetic drugs have opened the possibility of being used against neurodegenerative *** the previous framework,Vanadium species have demonstrated a notable antidiabetic *** research group evaluated polyoxidovanadates such as decavanadate and metforminium-decavanadate with preventive and corrective activity on neurodegeneration in brain-specific areas from rats with metabolic *** results suggest that these polyoxidovanadates induce neuronal and cognitive restoration *** review aims to describe the therapeutic potential of polyoxidovanadates as insulin-enhancer agents in the brain,constituting a therapeutic alternative for aging and neurodegenerative diseases.

关键词： Alzheimer’s disease antidiabetic brain cognition diabetes insulin neurodegeneration neuroinflammation oxidative stress Vanadium species

西尔维斯特·雷维尔塔斯的《小提琴与钢琴三曲》的演奏诠释

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西尔维斯特·雷维尔塔斯的《小提琴与钢琴三曲》的演奏诠释

作者： Nadia Citlali cano Casta(?)eda 成都大学

学位级别：硕士

西尔维斯特·雷维尔塔斯于1899年出生在一个艺术家世家。他在墨西哥革命时期长大并接受了那个时期的教育。1917年他被派往美国,在芝加哥音乐学院完成了他的小提琴学习,并且一直在这个国家担任小提琴演奏家,直到1928年。到墨西哥后,他成... 详细信息

西尔维斯特·雷维尔塔斯于1899年出生在一个艺术家世家。他在墨西哥革命时期长大并接受了那个时期的教育。1917年他被派往美国,在芝加哥音乐学院完成了他的小提琴学习,并且一直在这个国家担任小提琴演奏家,直到1928年。到墨西哥后,他成为了这个国家最重要的作曲家之一。尽管他创作的作品曲目有限,但涵盖了重要的作品,如管弦乐作品、电影音乐、室内乐和声乐作品。他的创作美学特点在于融合了他所在的那个时代的现代音乐元素和传统的墨西哥音乐元素,创造出具有创新性的音乐。西尔维斯特·雷维尔塔斯的《小提琴与钢琴三曲》聚集了他作品中最独特的作曲元素。作为他最后的小提琴和钢琴作品,他在他的弦乐四重奏所建立起来的探索基础上继续发展,呈现了他在作曲和表演风格上的重要元素。这份文件提供了产生作曲家作品的历史背景,并对《小提琴与钢琴三曲》中的每一首曲目进行了分析。此外,它根据对作品和小提琴技术分析的技术和解释性建议。

关键词：墨西哥音乐西尔维斯特音乐分析历史背景拼贴画

Interpretations of Globalisation during Late Qing Dynasty in Industrial Museums of China

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Interpretations of Globalisation during Late Qing Dynasty in...

Competencies in Computer Security and Resolution of Technological Problems in Higher Education Students

第二届国家工业遗产峰会学术研讨会

作者： Juan Manuel cano SANCHIZ Ruijie ZHANG Lang LON

This paper discusses how the industrial museums of China represent the international interferences and influences that characterised the first stages of the country's *** terms of methodology,this is a cross-disciplinary exercise that combines museum studies,industrial heritage studies and discourse analysis to examine an ensemble of industrial museums in different sectors and *** investigation is developed on two levels:on one hand,the production and delivery of narratives about foreign elements in Chinese industrialisation during the Late Qing Dynasty;on the other hand,the reception of such narratives by national and international *** study concludes that the museums' narratives of early industrial internationalisation in China are heterogeneous and,in spite of some difficulties to reach the public,play a role in defining and building China as a modern nation.

关键词： colonisation westernisation industrial museums globalisation

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Journal of Computer and Communications 2024年第4期12卷 171-185页

作者： Esteban Pérez Flores Alejandra Aldrette Malacara Sandra R. Murillo cano Vittorio Zanella Palacios Facultad de Ciencias Administrativas Universidad Aut&#243noma de Baja California Mexicali M&#233xico Decanato de Ingenierí as Universidad Popular Aut&#243noma Del Estado de Puebla Puebla M&#233xico

Starting from the importance of preserving our information and protecting our devices against attacks on their vulnerabilities, this article aims to establish the level of knowledge in computer security and problem-solving of students at a university in northwest Mexico. This research has a quantitative approach where the European Framework of Digital Competencies for Citizenship was used as a reference to identify and establish the level of the competencies that were evaluated. The IKANOS Test was used as a data collection tool. The results show that students know the importance of keeping their devices safe and how valuable the information found on them is. On the other hand, the results also show a considerable percentage of students who do not have the knowledge and are at a basic level of knowledge to solve technical problems with their devices.

关键词： Digital Literacy Cybersecurity DigComp Digital Skills Data Protection

The Effect of Brain Gym on Global Cognitive Function of Institutionalized Older People

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International Journal of Mental Health Promotion 2022年第3期24卷 375-383页

作者： Araceli cano-Estrada Araceli jimenez-Mendoza Denny Contreras-Guerrero Mario Hernandes-alejandro Andres Salas-Casas Escuela Superior de Tlahuelilpan Universidad Autónoma del Estado de HidalgoTlahuelilpanHidalgoMéxico Escuela Nacional de Enfermería y Obstetricia.Universidad Nacional Autónoma de México Mexico CityMéxico Departomento de Bioingenieria Unidad Profesional Interdisciplinaria de Biotecnología del Instituto Politecnico Nacional(UPIBIIPN)Mexico CityMexico Instituto de Ciencias de la Salud.Universidad Autónoma del Estado de Hidalgo.Pachuca Hidalgo.México.Scuela Superior de TlahuelilpanUniversidad Autónoma del Estado de HidalgoTlahuelilpanHidalgoMéxico

Cognitive function of older adults is influenced by several factors such as age,sex,education,and physical activity so that it can impact the decrease in progressive cognitive *** is necessary to implement cognitive training in old people’s care to prevent or delay the onset of age-related cognitive *** gym is a series of simple motion exercises and is an alternative therapy that stimulates the *** study aims to evaluate the effect of brain gym as a cognitive training intervention on global cognitive functioning of institutionalized older *** study is a non-randomized quasi-experimental one using pre-and post-test control group *** participants of the study were 65 years old or older who had been part of gerontological centers from a local *** were divided into two groups:control and intervention,each one with 15 ***-Mental State Examination was applied to the sample before and after the cognitive *** brain gym training consists of bi-weekly group meeting for 12 weeks,lasting 50 min *** treated group had a significantly better global cognitive ***(memory),orientation and language skills were the domains with the most significant changes(p<0.05).On the other hand,no significant changes were found in the participants of control groups during post *** results suggest that cognitive training based in brain gym improves global cognitive function of institutionalized older people lease type your abstract *** of a research paper is typically 200 to 400 words in length,and 150 to 300 words for a review *** shall be running continuously(not structured)and shall not include reference *** that appear only once in the abstract should be defined in *** abbreviations appear more than once,the full definitions should be provided first before they can be used elsewhere.

关键词： Cognitive function brain gymnastic older people gerontological center physical activity

Multi-omic study to unmask genes involved in prostate cancer development in amulti-case family

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Cancer Communications 2024年第3期44卷 443-447页

作者： Lucia Chica-Redecillas Sergio Cuenca-Lopez Eduardo Andres-Leon Laura Carmen Terron-Camero Blanca cano-Gutierrez Jose Manuel Cozar Jose Antonio Lorente Fernando Vazquez-Alonso Luis Javier Martinez-Gonzalez Maria Jesus Alvarez-Cubero GENYO Centre for Genomics and Oncological ResearchPfizerUniversity of GranadaAndalusian Regional GovernmentPTS GranadaGranadaGranadaSpain Department of Biochemistry Molecular Biology III and ImmunologyFaculty of MedicineUniversity of GranadaPTS GranadaGranadaGranadaSpain Bioinformatics Unit Institute of Parasitology and Biomedicine“López-Neyra”Spanish National Research CouncilGranadaGranadaSpain Nursery Service.University Hospital Clínico San Cecilio GranadaGranadaSpain Urology Department University Hospital Virgen de las NievesGranadaGranadaSpain Legal Medicine and Toxicology Department Faculty of MedicineUniversity of GranadaPTS GranadaGranadaGranadaSpain Ibs Biosanitary Research InstituteGranadaGranadaSpain

Dear Editor,Hereditary prostate cancer(PC)comprises 5%-10%of all PC *** increased risk of PC in menwith a family his-tory of the disease is well known and is commonly caused by germline mutations,leading to clinical guidelines men-tioning various genes for identifying high-risk ***,the complex inheritance patterns involvingmul-tiple single nucleotide polymorphisms(SNPs)make it a genetically heterogeneous disease,with genetic testing still in its early stages.

关键词： cancer clinical cases

Evaluation of Human Impacts on Bartlett Pond Ecosystem, Laredo, Southern Texas, USA, through Empirical Modeling

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Journal of Environmental Protection 2024年第4期15卷 497-526页

作者： Maya P. Bhatt Amede Rubio Ganesh B. Malla Cristobal Lopez Virginia Morales Erick Vazquez cano David Marquez Orlando Berumen Alvarez Alfred Addo-Mensah Department of Biology and Chemistry Texas A&M International University Laredo USA Department of Mathematics Computer Geology and Physics University of Cincinnati-Clermont College Batavia USA

The trace elements chemistry of Bartlett Pond, a small shallow wetland pond in Laredo, Southern Texas, was sampled to evaluate the dynamics of trace elements impacts on water quality and ecosystems ecology of the pond. Two types of fish (bass and tilapia) were also sampled to see the trace element accumulation in different parts of their body. The concentrations of trace elements in water samples were found in the following order: Fe ≫Sb > Pb > As ≫Co > Tl > Cr > Cd within Bartlett Pond. Overall, the water quality of the pond is unacceptable for drinking and any other purposes as trace element concentrations (e.g. As, Cd, Co, Cr, Pb, Fe, Sb and Tl) are exceedingly higher (several fold) than the WHO and US EPA guidelines. Predictive and correlation analysis shows that most trace elements exhibit a strong positive correlation among them indicating the same anthropogenic sources and biogeochemical processes regulate these trace elements within the pond. Distributions of the trace elements in water exhibit different shapes mostly as positively skewed distribution for As, Cd, Co, Cr, and Tl, symmetrical distribution for Fe and almost symmetrical distribution for Pb and Sb. Concentrations of As, Co and Tl accumulated much higher in different parts of the Bass than Tilapia fish. The concentrations of As, Tl, Co, and Sb appeared significantly higher in different parts of the body of both Bass and Tilapia than the maximum SRM certified values. Accumulation of these contaminants in fish tissues pose increased health risks to humans who consume these contaminated fish although fishing is prohibited. Anthropogenic activities in the region primarily degrade the whole pond ecosystem ecology of the Bartlett Pond and waters of this pond to be not recommended for any use. These findings may be useful for the scientific community and concerned authorities to improve understanding about these precious natural resources and conservation of the ecosystem ecology.

关键词： Trace Elements Bartlett Pond Laredo Southern Texas Wetlands Ecosystem Ecology

Potential distribution of a montane rodent (Cricetidae, Handleyomys chapmani) through time in Mexico: the importance of occurrence data

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Journal of Mountain Science 2021年第8期18卷 2024-2033页

作者： cano Ivonne GUEVARA Lazaro Department of Zoology Institute of BiologyNational Autonomous University of Mexico04510Mexico CityMexico

Ecological Niche Modeling uses the geographic coordinates of species presence records as the primary input to estimate potential geographic *** is little known whether carrying out rigorous data pre-processing is necessary before building niche models to be transferred to different time *** we compared the current,past,and future potential distributions projected by niche models built from two different databases,an open-access database and a database compiled ad hoc,for Handleyomys chapmani,a rodent closely associated with montane cloud forests in *** models predicted different spatial patterns of climatic suitability for the three periods *** on our current knowledge of cloud forest species in Mexico,the distributions predicted by the model built from the ad hoc database are more ecologically realistic than those obtained from the open-access *** models built using the open-access database were particularly inaccurate at the limits of the geographic range,predicting larger,more diffuse distributions for the three *** conclude that pre-processing occurrence data is crucial for mountain species,as the number of localities and even minor inaccuracies in the geographic coordinates can translate into very different climatic conditions due to abrupt altitudinal ***,the predicted shifts in the potential distribution of *** over time indicate that this species is highly susceptible to climate change.

关键词： Cloud forests Ecological Niche Modeling Handleyomys chapmani Maxent Rodentia

CD137 agonist potentiates the abscopal efficacy of nanoparticle-based photothermal therapy for melanoma

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Nano Research 2022年第3期15卷 2300-2314页

作者： Preethi Bala Balakrishnan Debbie KLedezma Juliana cano-Mejia Jaclyn Andricovich Erica Palmer Vishal APatel Patricia SLatham Eric SYvon alejandro Villagra Rohan Fernandes Elizabeth E.Sweeney GW Cancer Center Department of MedicineSchool of Medicine and Health SciencesGeorge Washington UniversityWashingtonDC 20052USA The Institute for Biomedical Sciences School of Medicine and Health SciencesGeorge Washington UniversityWashingtonDC 20052USA GW Cancer Center Department of Biochemistry and Molecular MedicineSchool of Medicine and Health SciencesGeorge Washington UniversityWashingtonDC 20052USA Department of Dermatology&Oncology School of Medicine and Health SciencesGeorge Washington UniversityWashingtonDC 20037USA Department of Pathology School of Medicine and Health SciencesGeorge Washington UniversityWashingtonDC 20037USA ImmunoBlue BethesdaMD 20817USA

Despite the promise of immunotherapy such as the immune checkpoint inhibitors(ICIs)anti-PD-1 and anti-CTLA-4 for advanced melanoma,only 26%–52%of patients respond,and many experience grade III/IV immune-related adverse *** by the need for an effective therapy for patients non-responsive to clinically approved ICIs,we have developed a novel nanoimmunotherapy that combines locally administered Prussian blue nanoparticle-based photothermal therapy(PBNP-PTT)with systemically administered agonistic anti-CD137 monoclonal antibody therapy(aCD137).PBNP-PTT was administered at various thermal doses to melanoma cells in vitro,and was combined with aCD137 in vivo to test treatment effects on melanoma tumor progression,animal survival,immunological protection against tumor rechallenge,and *** administered at a melanoma-specific thermal dose,PBNP-PTT elicits immunogenic cell death(ICD)in melanoma cells and upregulates markers associated with antigen presentation and immune cell co-stimulation in ***,PBNP-PTT eliminates primary melanoma tumors in vivo,yielding long-term tumor-free ***,the antitumor immune effects generated by PBNP-PTT cannot eliminate secondary tumors,despite significantly slowing their *** addition of aCD137 enables significant abscopal efficacy and improvement of survival,functioning through activated dendritic cells and tumor-infiltrating CD8^(+)T cells,and generates CD4^(+)and CD8^(+)T cell memory that manifests in the rejection of tumor rechallenge,with no long-term *** study describes for the first time a novel and effective nanoimmunotherapy combination of PBNP-PTT with aCD137 mAb therapy for melanoma.

关键词： photothermal therapy Prussian blue nanoparticles anti-CD137 melanoma nanoimmunotherapy