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DNA and RNA oxidative damage in hepatocellular carcinoma patients and mortality during the first year of liver transplantation

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World Journal of Hepatology 2022年第6期14卷 1182-1189页

作者： Leonardo Lorente Sergio T Rodriguez Pablo Sanz Agustín F González-Rivero Antonia Pérez-Cejas Javier Padilla Dácil Díaz Antonio González María M Martín alejandro jiménez Purificación Cerro Julián Portero Manuel A Barrera Department ofIntensive Care Hospital Universitario de CanariasLa Laguna 38320TenerifeSpain Intensive Care Unit Hospital Universitario Nuestra Señora CandelariaSanta Cruz de Tenerife 38010Spain Department of Surgery Hospital Universitario Nuestra Señora de CandelariaSanta Cruz de Tenerife 38010Spain Department of Laboratory Hospital Universitario de CanariasLa Laguna 38320Spain Department of Digestive Hospital Universitario Nuestra Señora de CandelariaSanta Cruz de Tenerife 38010Spain Research Unit Hospital Universitario de CanariasLa Laguna 38320Spain Transplant Unit Hospital Universitario Nuestra Señora CandelariaSanta Cruz de Tenerife 38010Spain Department of Radiology Hospital Universitario Nuestra Señora CandelariaSanta Cruz de Tenerife 38010Spain

BACKGROUND Oxidative damage of DNA and RNA has been associated with mortality of patients with different ***,there is no published data on the potential use of DNA and RNA oxidative damage to predict the prognosis of patients with hepatocellular carcinoma(HCC)undergoing liver transplantation(LT).AIM To determine whether patients with increased DNA and RNA oxidative damage prior to LT for HCC have a poor LT *** Patients with HCC who underwent LT were included in this observational and retrospective *** levels of all three oxidized guanine species(OGS)were measured prior to LT since guanine is the nucleobase that forms DNA and RNA most prone to *** mortality at 1 year was the end-point *** Surviving patients(n=101)showed lower serum OGS levels(P=0.01)and lower age of the liver donor(P=0.03)than non-surviving patients(n=13).An association between serum OGS levels prior to LT and 1-year LT(odds ratio=2.079;95%confidence interval=1.356-3.189;P=0.001)was found in the logistic regression *** The main new finding was that high serum OGS concentration prior to LT was associated with the mortality 1 year after LT in HCC patients.

关键词： DNA oxidative damage Hepatocellular carcinoma Liver transplantation Mortality Oxidized guanine species

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Attaching CFgroups to organic molecules using trifluoroacetates via ion-shielding photoelectrocatalysis

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Science China Chemistry 2024年

作者： Paula Visiedo-jiménez Francisco Juliá-Hernández Departamento de Química Inorgánica Facultad de Química Universidad de MurciaCampus de Espinardo

Fluorinated molecules play a protagonist role in pharmaceuticals, agrochemicals, and materials. The incorporation of fluoroalkyl groups into organic compounds provides them with unique chemical properties that are key...

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Resilience to structural and molecular changes in excitatory synapses in the hippocampus contributes to cognitive function recovery in Tg2576 mice

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Neural Regeneration Research 2024年第9期19卷 2068-2074页

作者： Carolina Aguado Sara Badesso JoséMartínez-Hernández alejandro Martín-Belmonte Rocío Alfaro-Ruiz Miriam Fernández Ana Esther Moreno-Martínez Mar Cuadrado-Tejedor Ana García-Osta Rafael Luján Synaptic Structure Laboratory Instituto de Investigación en Discapacidades Neurológicas(IDINE)Department of Medical SciencesFacultad de MedicinaUniversidad de Castilla-La ManchaCampus BiosanitarioAlbaceteSpain Gene Therapy for Neurological Disease Program Center for Applied Medical Research(CIMA)University of NavarraInstituto de Investigación Sanitaria de Navarra(IdiSNA)PamplonaSpain Pharmacology Unit Department of Pathology and Experimental TherapeuticsFaculty of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaBarcelonaSpain Neuropharmacology and Pain Group Neuroscience ProgramInstitut d’InvestigacióBiomèdica de BellvitgeIDIBELLL’Hospitalet de LlobregatSpain Department of Pathology Anatomy and PhysiologySchool of MedicineUniversity of NavarraPamplonaSpain UniversitéGrenoble Alpes Grenoble Institut des NeurosciencesGrenobleFrance

Plaques of amyloid-β(Aβ)and neurofibrillary tangles are the main pathological characteristics of Alzheimer’s disease(AD).However,some older adult people with AD pathological hallmarks can retain cognitive *** the factors that lead to this cognitive resilience to AD offers promising prospects for identifying new therapeutic *** hypothesis focuses on the contribution of resilience to changes in excitatory synapses at the structural and molecular levels,which may underlie healthy cognitive performance in aged AD *** the Morris Water Maze test,we selected resilient(asymptomatic)and cognitively impaired aged Tg2576 *** the enzyme-linked immunosorbent assay showed similar levels of Aβ42 in both experimental groups,western blot analysis revealed differences in tau pathology in the pre-synaptic supernatant *** further investigate the density of synapses in the hippocampus of 16-18 month-old Tg2576 mice,we employed stereological and electron microscopic *** findings indicated a decrease in the density of excitatory synapses in the stratum radiatum of the hippocampal CA1 in cognitively impaired Tg2576 mice compared with age-matched resilient Tg2576 and non-transgenic ***,through quantitative immunoelectron microscopy in the hippocampus of impaired and resilient Tg2576 transgenic AD mice,we uncovered differences in the subcellular localization of glutamate ***,the density of GluA1,GluA2/3,and mGlu5 in spines and dendritic shafts of CA1 pyramidal cells in impaired Tg2576 mice was significantly reduced compared with age-matched resilient Tg2576 and non-transgenic ***,the density of GluA2/3 in resilient Tg2576 mice was significantly increased in spines but not in dendritic shafts compared with impaired Tg2576 and non-transgenic *** subcellular findings strongly support the hypothesis that dendritic spine plasticity and synaptic machinery in the hippocampus play cr

关键词： aging Alzheimer´s disease cognitive hippocampus immunoelectron microscopy resilience synapse

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The potential of starch-chitosan blends with poloxamer for the preparation of microparticles by spray-drying

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Particuology 2024年第6期89卷 1-10页

作者： Juan Enrique Barranco-García Carolina Caicedo Enrique Javier jiménez-Regalado Carlos Espinoza-González Graciela Morales Rocio Yaneli Aguirre-Loredo Abril Fonseca-García Tecnológico Nacional de México/Instituto Tecnológico de Oaxaca Departamento de Química y BioquímicaAvenida Ing.Víctor Bravo Ahuja No.125Esquina Calzada Tecnológico68030OaxacaMexico Faculty of Engineering Unidad Central del Valle del Cauca(UCEVA)Carrera 17a 48-144763022TuluáColombia Centro de Investigación en Química Aplicada(CIQA) Blvd.Enrique Reyna Hermosillo 14025294SaltilloCoahuilaMexico Investigadoras por México CONAHCYT-CIQA Av.Insurgentes Sur 1562Col.Crédito Constructor03940Alcaldía Benito JuárezCDMXMexico

Using biopolymers as wall materials in spray drying poses challenges,particularly in attaining flowability and thermal stability among their physicochemical *** paper addresses these challenges by preparing microparticles using a blend of starch–chitosan and a poloxamer,commercially named Pluronic®*** aimed to elucidate the effects of varying poloxamer concentrations on the resulting particles through the spray drying *** with a poloxamer concentration of 3%(w/v)demonstrated a notably higher yield,especially when compared to those with 0%and 1%*** with 3%and 5%(w/v)poloxamer displayed a narrower particle size distribution,with the 3%blend showing a superior yield attributed to arrangements of blend components that improve flowability.X-ray diffraction analysis showcased the characteristic peaks of A-type starch form,with shifts suggesting enhanced interactions between *** with increased poloxamer content showed elevated thermal degradation temperatures,with the 3%blend registering a significant rise,opening avenues for encapsulating heat-sensitive *** study primarily focuses on the preparation and basic characterization of *** underscores the potential of blends with optimal poloxamer concentrations in microencapsulation,emphasizing further research to harness their capabilities thoroughly.

关键词： Biopolymer Starch Chitosan Pluronic®F127 Microparticles Spray drying

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Endoscopic submucosal dissection training with pig models in a Western country

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World Journal of Gastroenterology 2010年第23期16卷 2895-2900页

作者： Adolfo Parra-Blanco María Rosa Arnau David Nicolás-Pérez Antonio Z Gimeno-García Nicolás González Juan A Díaz-Acosta alejandro jiménez Enrique Quintero Department of Gastroenterology University Hospital of the Canary Islands Ofra s/n Endoscopy Unit Department of GastroenterologyAsturias Central University HospitalCelestino Villamil s/n Research Animal Laboratory Ofra s/nLa Laguna University Department of Gastroenterology Montevideo Clinic HospitalAvda Italia s/n Research Unit University Hospital of the Canary IslandsOfra s/n

AIM:To test a strategy for endoscopic submucosal dissection(ESD) training in animal models designed to overcome the initial learning ***:ESD was attempted in ex vivo and in vivo pig *** ESD procedures were attempted in the esophagus(n=9) or the stomach(n=21).The ex vivo model was used until initial competence was *** the in vivo model,several ESD procedures were performed in up to 3 *** following variables were analyzed:specimen size,complete and en bloc resection rate,time for circumferential incision,time for submucosal dissection,total ESD duration,and ***:Complete resection was achieved in 28 cases(en bloc 27);2 could not be completed(one perforation,one technical diff iculty).The mean ± SD time for circumferential incision was 36.2±16.8 min(range:8-87 min),and the mean±SD time for submucosal dissection was 45.1±35.7 min(range:9-196 min).The mean±SD size of the resected specimens was 45.2±17.8 *** mean±SD total resection time was signif icantly increased for the gastric cases performed in the f irst half of the study(n=13) than in the second half(n=8)(98.9±62.4 min vs 61.7±17.6 min,P=0.04),although the specimen size did not ***:Training in animal models could help endoscopists overcome the learning curve before starting ESD in humans.

关键词： Endoscopic submucosal dissection Training Animal model

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Validation of Fujinon intelligent chromoendoscopy with high definition endoscopes in colonoscopy

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World Journal of Gastroenterology 2009年第42期15卷 5266-5273页

作者： Adolfo Parra-Blanco alejandro jiménez Bjrn Rembacken Nicolás González David Nicolás-Pérez Antonio Z Gimeno-García Marta Carrillo-Palau Takahisa Matsuda Enrique Quintero Department of Gastroenterology University Hospital of the Canary Islandsc/Ofra s/nLa Laguna 38320TenerifeSpain Department of Gastroenterology Hospital Universitario Central de AsturiasCelestino Villamil s/n33006 OviedoPrincipado de AsturiasSpain Research Unit University Hospital of the Canary Islandsc/Ofra s/nLa Laguna 38320TenerifeSpain Centre for Digestive Diseases The General Infirmary at LeedsGreat George StLeedsLS1 3EXUnited Kingdom Department of Gastroenterology Hospital de Clínicas de MontevideoAvda.Italia s/nMontevideo 11600Uruguay Division of Endoscopy National Cancer Center Hospital5-1-1 TsukijiChuo-kuTokyo 104-0045Japan

AIM:To validate high definition endoscopes with Fujinon intelligent chromoendoscopy(FICE) in ***:The image quality of normal white light endoscopy(WLE),that of the 10 available FICE filters and that of a gold standard(0.2% indigo carmine dye) were ***:FICE-filter 4 [red,green,and blue(RGB) wavelengths of 520,500,and 405 nm,respectively] provided the best images for evaluating the vascular pattern compared to white *** mucosal surface was best assessed using filter ***,the views obtained were not rated significantly better than those observed with white *** "gold standard",indigo carmine(IC) dye,was found to be superior to both white light and filter *** 6(RGB wavelengths of 580,520,and 460 nm,respectively) allowed for exploration of the IC-stained *** assessing mucosal polyps,both FICE with magnification,and magnification following dye spraying were superior to the same techniques without magnification and to white light *** the presence of suboptimal bowel preparation,observation with the FICE mode was possible,and endoscopists considered it to be superior to observation with white ***:FICE-filter 4 with magnification improves the image quality of the colonic vascular patterns obtained with WLE.

关键词：内窥镜结肠镜内镜色素智能检查富士验证

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Pancreatic Pseudocyst Rupture: Cause of Acute Abdomen

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Case Reports in Clinical Medicine 2023年第8期12卷 324-331页

作者： Joel Iván Cruz-González Miguel Ángel Miranda-Del Olmo Benito Antonio García-Ramón Brenda Hernández-García Crystell Guadalupe Guzmán-Priego alejandro jiménez-Sastré Social Security Institute of the State of Tabasco Villahermosa Mexico Cardiometabolism Laboratory Academic Division of Health Sciences Juarez Autonomous University of Tabasco Villahermosa Mexico

Case report of a 23-year-old male patient with a pancreatic pseudocyst, initially was treated by the Interventional Radiology service by placing percutaneous drainage with poor evolution, abruptly presented abdominal pain, Systemic Inflammatory Response Syndrome and peritoneal irritation, so an urgent exploratory laparotomy was performed with a finding of rupture of the pancreatic pseudocyst into the abdominal cavity. He presented septic shock and died in the immediate postoperative period. Computerized Axial Tomography represents the ideal diagnostic method. Spontaneous rupture is extremely rare and requires urgent surgical intervention.

关键词： Rupture Pancreatic Pseudocyst Acute Abdomen

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Metastatic pancreatic and lung cancer patient in complete remission following immunotherapy: A case report and review of literature

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2233-2240页

作者： Joaquina Martínez-Galán Cristina jiménez-Luna Isabel Rodriguez Elisabeth Maza Carlos García-Collado Antonio Rodríguez-Fernández Javier Luis López-Hidalgo Octavio Caba Department of Medical Oncology Virgen de las Nieves University HospitalGranada 18014Spain Instituto de Investigación Biosanitaria Ibs.GranadaGranada 18012Spain Institute of Biopathology and Regenerative Medicine(IBIMER) University of GranadaGranada 18016Spain Pharmacogenetics Unit Virgen de las Nieves University HospitalGranada 18014Spain Department of Medicina Nuclear Virgen de las Nieves University HospitalGranada 18014Spain Department of Anatomía Patológica Virgen de las Nieves University HospitalGranada 18014Spain

BACKGROUND Metastatic pancreatic ductal adenocarcinoma(PDAC)is a lethal malignancy with dispiriting survival *** is a promising approach to many cancer types,but achieves poor outcomes in advanced PDAC due to its immunosuppressive tumor *** describe a case of metastatic PDAC effectively treated with *** SUMMARY We report the case of a 67-year-old woman with unresectable locally advanced PDAC,treated with gemcitabine plus nab-paclitaxel followed by radiotherapy plus *** nine months,pancreatic tumor progression was observed at the level of the hepatic hilum with the appearance of a new pulmonary nodule suggestive of a second primary,confirmed by left lung *** immunotherapy was then initiated with pembrolizumab,an immune checkpoint inhibitor targeting programmed cell death protein-1 that covers the two tumor *** patient showed a complete metabolic response that was maintained throughout the *** patient continues to be disease-free at 5.6 years since the start of *** These results suggest that the administration of pembrolizumab after chemoradiotherapy has a beneficial effect in patients with metastatic *** our knowledge,this is the first reported case of a patient with metastatic PDAC and metastatic lung cancer showing such a long-lasting complete response after pembrolizumab treatment without curative *** studies are required to determine biomarkers that identify PDAC patients most likely to benefit from this immunotherapy.

关键词： Pancreatic ductal adenocarcinoma Lung cancer Immunotherapy Pembrolizumab Programmed cell death protein-1 Case report

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Endovascular Emergency Management of Hepatic Pseudoaneurism with Vascular Plug 4 System with Sacrifice of the Aneurism Nutrient Artery (Report of 2 Cases)

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Case Reports in Clinical Medicine 2022年第8期11卷 321-329页

作者： alejandro jiménez-Sastré Reynaldo Ramírez-Chacón Miguel Ángel Miranda-Del Olmo Humberto Azuara-Forcelledo Fernando Enrique Mayans-Canabal Jesús Maximiliano Granados-Villalpando Crystell Guadalupe Guzmán-Priego Center of Medical Specialties Instituto de Seguridad Social del Estado de Tabasco (ISSET) Villahermosa Mexico Cardiometabolism Laboratory Research Center División Académica de Ciencias de la Salud (DACS) Universidad Juárez Autónoma de Tabasco (UJAT) Villahermosa Mexico

Pseudoaneurisms are arterial wounds that affect all layers of an artery;although very rare they are mostly lethal and most of them are iatrogenic. Herein, we present two different cases of hepatic artery pseudoaneurysms derived from previous surgeries which were assessed by computed tomography angiographies and consequent conservative endovascular approaches with arteriographies, posterior cannulations and the placement of Amplatzer Vascular Plug 4 (AVP 4) systems in order to treat the pseudoaneurysm. Computed control tomographies were conducted showing no later complications. The purpose of this article is to demonstrate the importance and current clinical applications of AVP in the field of interventional radiology.

关键词： Endovascular Hepatic Pseudoaneurysm Interventional Radiology Vascular Plug

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A Tutorial on Federated Learning from Theory to Practice:Foundations,Software Frameworks,Exemplary Use Cases,and Selected Trends

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IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 824-850页

作者： M.Victoria Luzón Nuria Rodríguez-Barroso Alberto Argente-Garrido Daniel jiménez-López Jose M.Moyano Javier Del Ser Weiping Ding Francisco Herrera Department of Software Engineering Andalusian Research Institute in Data Science and Computational Intelligence(DaSCI)University of GranadaGranada 18071Spain Department of Computer Science and Artificial Intelligence Andalusian Research Institute in Data Science and Computational Intelligence(DaSCI)University of GranadaGranada 18071Spain Department of Communications Engineering University of the Basque Country(UPV/EHU)and also with TECNALIABasque Research&Technology Alliance(BRTA)Spain School of Information Science and Technology Nantong UniversityNantong 226019China

When data privacy is imposed as a necessity,Federated learning(FL)emerges as a relevant artificial intelligence field for developing machine learning(ML)models in a distributed and decentralized *** allows ML models to be trained on local devices without any need for centralized data transfer,thereby reducing both the exposure of sensitive data and the possibility of data interception by malicious third *** paradigm has gained momentum in the last few years,spurred by the plethora of real-world applications that have leveraged its ability to improve the efficiency of distributed learning and to accommodate numerous participants with their data *** virtue of FL,models can be learned from all such distributed data sources while preserving data *** aim of this paper is to provide a practical tutorial on FL,including a short methodology and a systematic analysis of existing software ***,our tutorial provides exemplary cases of study from three complementary perspectives:i)Foundations of FL,describing the main components of FL,from key elements to FL categories;ii)Implementation guidelines and exemplary cases of study,by systematically examining the functionalities provided by existing software frameworks for FL deployment,devising a methodology to design a FL scenario,and providing exemplary cases of study with source code for different ML approaches;and iii)Trends,shortly reviewing a non-exhaustive list of research directions that are under active investigation in the current FL *** ultimate purpose of this work is to establish itself as a referential work for researchers,developers,and data scientists willing to explore the capabilities of FL in practical applications.

关键词： Data privacy distributed machine learning federated learning software frameworks

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