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Injectable bone cements:What benefits the combination of calcium phosphates and bioactive glasses could bring?

Bioactive Materials 2023年第1期19卷 217-236页

作者： Öznur Demir-Oguz aldo r.boccaccini Dagnija Loca rudolfs Cimdins riga Biomaterials Innovations and Development Centre of rTU Institute of General Chemical EngineeringFaculty of Materials Science and Applied ChemistryRiga Technical UniversityPulka St 3RigaLV-1007Latvia Baltic Biomaterials Centre of Excellence Headquarters at Riga Technical UniversityRigaLatvia Institute of Biomaterials Department of Materials Science and EngineeringUniversity of Erlangen-Nuremberg91058ErlangenGermany

Out of the wide range of calcium phosphate(CaP)biomaterials,calcium phosphate bone cements(CPCs)have attracted increased attention since their discovery in the 1980s due to their valuable properties such as bioactivity,osteoconductivity,injectability,hardening ability through a low-temperature setting reaction and *** numerous researches have been performed to enhance the properties of ***,low mechanical performance of CPCs limits their clinical application in load bearing regions of ***,the in vivo resorption and replacement of CPC with new bone tissue is still controversial,thus further improvements of high clinical importance are *** glasses(BGs)are biocompatible and able to bond to bone,stimulating new bone growth while dissolving over *** the last decades extensive research has been performed analyzing the role of BGs in combination with different ***,the focal point of this review paper is to summarize the available research data on how injectable CPC properties could be improved or affected by the addition of BG as a secondary powder *** was found that despite the variances of setting time and compressive strength results,desirable injectable properties of bone cements can be achieved by the inclusion of BGs into *** published data also revealed that the degradation rate of CPCs is significantly improved by BG ***,the presence of BG in CPCs improves the in vitro osteogenic differentiation and cell response as well as the tissue-material interaction in vivo.

关键词： Calcium phosphate Bioactive glass Injectable bone cements Bone regeneration Calcium phosphate bone cements

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Bioactive glass-based fibrous wound dressings

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Burns & Trauma 2022年第1期10卷 256-271页

作者： Shahin Homaeigohar Meng Li aldo r.boccaccini School of Science and Engineering University of DundeeDundee DD14HNUnited Kingdom Institute of Biomaterials Department of Materials Science and EngineeringUniversity of Erlangen-Nuremberg91058 ErlangenGermany

Since the discovery of silicate bioactive glass(BG)by Larry Hench in 1969,different classes of BGs have been researched over decades mainly for bone *** recently,validating the beneficial influence of BGs with tailored compositions on angiogenesis,immunogenicity and bacterial infection,the applicability of BGs has been extended to soft tissue repair and wound ***,fibrous wound dressings comprising BG particle reinforced polymer nanofibers and cotton-candy-like BG fibers have been proven to be successful for wound healing *** fibrous dressing materials imitate the physical structure of skin’s extracellular matrix and release biologically active ions ***,pro-angiogenic and antibacterial ions,***,copper,zinc,etc.,that can provoke cellular activities to regenerate the lost skin tissue and to induce new vessels formation,while keeping an anti-infection *** the current review,we discuss different BG fibrous materials meant for wound healing applications and cover the relevant literature in the past *** production methods for BG-containing fibers are explained and as fibrous wound dressing materials,their wound healing and bactericidal mechanisms,depending on the ions they release,are *** present gaps in this research area are highlighted and new strategies to address them are suggested.

关键词： Scaffolds Fibers Angiogenesis Wound healing Bioactive glass

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Gallium containing bioactive materials: A review of anticancer, antibacterial, and osteogenic properties

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Bioactive Materials 2022年第11期7卷 125-146页

作者： Fatih Kurtuldu Nurshen Mutlu aldo r.boccaccini Dusan Galusek FunGlass Alexander Dubcek University of TrencínStudentska 291150TrencínSlovakia Institute of Biomaterials Department of Material Science and EngineeringUniversity of Erlangen-Nuremberg91058ErlangenGermany Joint Glass Centre of the IIC SAS TnUAD and FChFT STUStudentska 291150TrencínSlovakia

The incorporation of gallium into bioactive materials has been reported to enhance osteogenesis,to influence blood clotting,and to induce anti-cancer and anti-bacterial ***-doped biomaterials prepared by various techniques include melt-derived and sol-gel-derived bioactive glasses,calcium phosphate bioceramics,metals and *** this review,we summarize the recently reported developments in antibacterial,anti-cancer,osteogenesis,and hemostasis properties of Ga-doped biomaterials and briefly outline the mechanisms leading to Ga biological *** key finding is that gallium addition to biomaterials has great potential for treating bone-related diseases since it can be efficiently transferred to the desired region at a controllable ***,it can be used as a potential substitute for antibiotics for the inhibition of infections during the initial and advanced phases of the wound healing *** is also used as an anticancer agent due to the increased concentration of gallium around excessive cell proliferation(tumor)***,we highlight the possibility to design different therapeutic approaches aimed at increasing the efficiency of the use of gallium containing bioactive materials for multifunctional applications.

关键词： Antibacterial Bioactive materials Cancer treatment Hemostasis Osteogenesis

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Sol-gel derived B_(2)O_(3)-CaO borate bioactive glasses with hemostatic,antibacterial and pro-angiogenic activities

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regenerative Biomaterials 2024年第1期3卷 108-118页

作者： Kai Zheng Faina Bider Mahshid Monavari Zhiyan Xu Christina Janko Christoph Alexiou Ana M.Beltran aldo r.boccaccini Jiangsu Province Engineering research Center of Stomatological Translational Medicine College of StomatologyNanjing Medical UniversityNanjing 210029China Jiangsu Key Laboratory of Oral Diseases Nanjing Medical UniversityNanjing 210029China Institute of Biomaterials University of Erlangen-Nuremberg91058 ErlangenGermany Department of Oto-rhino-Laryngology Head and Neck SurgerySection of Experimental Oncology and Nanomedicine(SEON)Else Kroener-Fresenius-Stiftung ProfessorshipUniversitaetsklinikum Erlangen91058 ErlangenGermany Departamento de Ingenier�ıa y Ciencia de los Materiales y del Transporte Escuela Politecnica

Sol-gel borate bioactive glasses(BGs)are promising ion-releasing biomaterials for wound healing ***,we report the synthesis of a series of binary B_(2)O_(3)-CaO borate BGs(CaO ranging from 50 to 90mol%)using a sol-gel-based *** influence of CaO content in B_(2)O_(3)-CaO borate BG on morphology,structure and ion release behavior was investigated in *** dissolution(ion release)and crystallization could be observed in borate BGs when CaO content increased,while the morphology was not significantly altered by increasing CaO *** results evidenced that the ion release behavior of borate BGs could be tailored by tuning the B_(2)O_(3)/CaO molar *** also evaluated the in vitro cytotoxicity,hemostatic,antibacterial and angiogenic activities of borate *** was validated for all borate ***,borate BGs exhibited composition-dependent hemostatic,antibacterial and angiogenic ***,higher contents of Ca in borate BGs facilitated hemostatic activity,while higher contents of B_(2)O_(3) were beneficial for pro-angiogenic *** synthesized sol-gel-derived borate BGs are promising materials for developing advanced wound healing dressings,given their fast ion release behavior and favorable hemostatic,antibacterial and angiogenic activities.

关键词： borate glasses sol-gel processing glass composition wound healing

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Bioactive glass based scaffolds coated with gelatin for the sustained release of icariin

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Bioactive Materials 2019年第1期4卷 1-7页

作者： Theresa reiter Tanja Panick Katharina Schuhladen Judith A.roether Jasmin Hum aldo r.boccaccini Institute of Biomaterials Department Materials Science and EngineeringUniversity of Erlangen-NurembergCauerstr.691058 ErlangenGermany

Gelatin-coated,3D sponge-like scaffolds based on 45S5 bioactive glass were produced using the foam replication *** strength tests of gelatin-coated samples compared to uncoated scaffolds showed significant strengthening and toughening effects of the gelatin coating with compressive strength values in the range of cortical ***,the crosslinked gelatin network(using either caffeic acid or N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride(EDC)/N-hxdroxysuccinimide(NHS)as crosslinking agent)was shown to be a suitable candidate for the sustained release of the bioactive molecule *** bioactivity of the produced scaffolds,characterization by FTIr and SEM indicated the formation of hydroxyapatite(HA)in all samples after immersion in simulated body fluid(SBF)for 14 days,highlighting the favorable combination of mechanical robustness,bioactivity and drug delivery capability of this new type of scaffolds.

关键词： Bioactive glass Icariin Drug release Gelatin Scaffold

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Nanocomposite electrospun fibers of poly(ε-caprolactone)/bioactive glass with shape memory properties

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Bioactive Materials 2022年第5期7卷 230-239页

作者： Liliana Liverani Anna Liguori Paola Zezza Chiara Gualandi Maurizio Toselli aldo r.boccaccini Maria Letizia Focarete Department of Materials Science and Engineering University of Erlangen-NurembergCauerstr.691058ErlangenGermany Department of Chemistry“Giacomo Ciamician”and INSTM Udr of Bologna University of Bolognavia Selmi 240126BolognaItaly Interdepartmental Center for Industrial research on Advanced Applications in Mechanical Engineering and Materials Technology CIRI-MAMUniversity of BolognaViale Risorgimento240136BolognaItaly Department of Industrial Chemistry“Toso Montanari” University of BolognaViale Risorgimento 440136BolognaItaly Health Sciences and Technologies–Interdepartmental Center for Industrial research(HST-ICIr) Alma Mater Studiorum-Universit`a di Bologna40064Ozzano dell’EmiliaBolognaItaly

Electrospun fibers of shape memory triethoxysilane-terminated poly(epsilon-caprolactone)(PCL-TES)loaded with bioactive glasses(BG)are here *** PCL-TES,as well as PCL/BG nanocomposite fibers,are also considered for *** is proposed that hydrolysis and condensation reactions take place between triethoxysilane groups of the polymer and the silanol groups at the BG particle surface,thus generating additional crosslinking points with respect to those present in the PCL-TES *** as-spun PCL-TES/BG fibers display excellent shape memory properties,in terms of shape fixity and shape recovery ratios,without the need of a thermal crosslinking *** particles confer in vitro bioactivity to PCL-based nanocomposite fibers and favor the precipitation of hydroxycarbonate apatite on the fiber *** cytocompatibility tests demonstrate that the addition of BG particles to PCL-based polymer does not inhibit ST-2 cell *** novel approach of using bioactive glasses not only for their biological properties,but also for the enhancement of shape memory properties of PCL-based polymers,widens the versatility and suitability of the obtained composite fibers for a huge portfolio of biomedical applications.

关键词： PCL-TES Bioactive glasses Bioactivity Shape memory polymers Electrospinning Benign solvents

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Antibacterial,pro-angiogenic and pro-osteointegrative zein-bioactive glass/copper based coatings for implantable stainless steel aimed at bone healing

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Bioactive Materials 2021年第5期6卷 1479-1490页

作者： Laura ramos rivera Andrea Cochis Sarah Biser Elena Canciani Sara Ferraris Lia rimondini aldo r.boccaccini Institute of Biomaterials Department of Materials Science and EngineeringUniversity of Erlangen-NurembergErlangenGermany Department of Health Sciences Universita del Piemonte UPONovaraItaly Center for Translational research on Autoimmune and Allergic Diseases-CAAD NovaraItaly Department of Department of Biomedical Surgical and Dental SciencesThin Section LabUniversity of MilanMilanItaly Department of Applied Science and Technology Politecnico di TorinoTurinItaly

Stainless steel implants are suitable candidates for bone replacement due to their cytocompatibility and mechanical resistance,but they suffer from lack of bioactivity and are prone to bacterial ***,to overcome those limitations,in this study we developed by electrophoretic deposition(EPD),an innovative surface coating made of(i)zein,a natural fibroblast-friendly polymer,(ii)bioactive glass,a pro-osteogenic inorganic material and(iii)copper containing bioactive glass,an antibacterial and pro-angiogenic *** images confirmed that porous,uniform and free of cracks coatings were obtained by EPD;moreover,coatings were resistant to mechanical stress as demonstrated by the tape test,resulting in a 4B classification of adhesion to the *** coatings were cytocompatible as indicated by metabolism evaluation of human fibroblasts,endothelial cells and mature or progenitor osteoblasts cultivated in direct contact with the *** also maintained pro-osteogenic properties towards undifferentiated progenitor cells that expressed osteogenic genes after 15 days of direct *** conferred antibacterial properties as biofilm formation of the joint pathogens Staphylococcus aureus,Staphylococcus epidermidis and Escherichia coli was significantly reduced in comparison with copper-free coatings(preover,this anti-infective activity resulted as targeted towards bacteria while the cells viability was preserved when cells and bacteria were cultivated in the same environment by a co-culture ***,copper ability to recruit blood vessels and to inhibit bacterial infection was confirmed in vivo where the growth of *** biofilm was inhibited and the formation of new(r spread)blood vessels was observed.

关键词： Zein Bioactive glass Copper Bone Antibacterial

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Biomineralization inspired 3D printed bioactive glass nanocomposite scaffolds orchestrate diabetic bone regeneration by remodeling micromilieu

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Bioactive Materials 2023年第7期25卷 239-255页

作者： Zeqian Xu Xuanyu Qi Minyue Bao Tian Zhou Junfeng Shi Zhiyan Xu Mingliang Zhou aldo r.boccaccini Kai Zheng Xinquan Jiang Department of Prosthodontics Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineNo.639 Zhizaoju RoadShanghai200011People’s Republic of China College of Stomatology Shanghai Jiao Tong UniversityNo.639 Zhizaoju RoadShanghai200011People’s Republic of China National Center for Stomatology No.639 Zhizaoju RoadShanghai200011People’s Republic of China National Clinical research Center for Oral Diseases No.639 Zhizaoju RoadShanghai200011People’s Republic of China Shanghai Key Laboratory of Stomatology No.639 Zhizaoju RoadShanghai200011People’s Republic of China Shanghai Engineering research Center of Advanced Dental Technology and Materials No.639 Zhizaoju RoadShanghai200011People’s Republic of China Department of Oral Maxillofacial-Head and Neck Oncology Shanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineShanghai200023People’s Republic of China Institute of Biomaterials University of Erlangen-NurembergCauerstrasse 691058ErlangenGermany Jiangsu Province Engineering research Center of Stomatological Translational Medicine Nanjing Medical UniversityNanjing210029People’s Republic of China Jiangsu Key Laboratory of Oral Diseases Nanjing Medical UniversityNanjing210029People’s Republic of China

TypeⅡdiabetes mellitus(TIIDM)remains a challenging clinical issue for both dentists and *** virtue of persistent hyperglycemia and altered host metabolism,the pathologic diabetic micromilieu with chronic inflammation,advanced glycation end products accumulation,and attenuated biomineralization severely impairs bone regeneration *** to“remodel”the pathologic diabetic micromilieu,we 3D-printed bioscaffolds composed of Sr-containing mesoporous bioactive glass nanoparticles(Sr-MBGNs)and gelatin methacrylate(GelMA).Sr-MBGNs act as a biomineralization precursor embedded in the GelMA-simulated extracellular matrix and release Sr,Ca,and Si ions enhancing osteogenic,angiogenic,and immunomodulatory *** addition to angiogenic and anti-inflammatory outcomes,this innovative design reveals that the nanocomposites can modulate extracellular matrix reconstruction and simulate biomineralization by activating lysyl oxidase to form healthy enzymatic crosslinked collagen,promoting cell focal adhesion,modulating osteoblast differentiation,and boosting the release of OCN,the noncollagenous proteins(intrafibrillar mineralization dependent),and thus orchestrating osteogenesis through the Kindlin-2/PTH1r/OCN *** 3D-printed bioscaffold provides a multifunctional biomineralization-inspired system that remodels the“barren”diabetic microenvironment and sheds light on the new bone regeneration approaches for TIIDM.

关键词： Biomineralization TypeⅡDiabetes mellitus 3D printing Sr-containing mesoporous bioactive glass nanoparticles Enzymatic cross-links

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Incorporation of bioactive glass nanoparticles in electrospun PCL/chitosan fibers by using benign solvents

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Bioactive Materials 2018年第1期3卷 55-63页

作者： Liliana Liverani Jonas Lacina Judith A.roether Elena Boccardi Manuela S.Killian Patrik Schmuki Dirk W.Schubert aldo r.boccaccini Institute of Biomaterials Department of Materials Science and EngineeringUniversity of Erlangen-NurembergCauerstr.691058 ErlangenGermany Institute of Polymeric Materials Department of Materials Science and EngineeringUniversity of Erlangen-NurembergMartensstrasse 791058 ErlangenGermany LKO Department of Materials Science and EngineeringUniversity of Erlangen-NurembergMartensstrasse 791058 ErlangenGermany Department of Chemistry King Abdulaziz UniversityJeddahSaudi Arabia

The use of bioactive glass(BG)particles as a filler for the development of composite electrospun fibers has already been widely reported and *** novelty of the present research work is represented by the use of benign solvents(like acetic acid and formic acid)for electrospinning of composite fibers containing BG particles,by using a blend of PCL and *** this work,different BG particle sizes were investigated,namely nanosized and micron-sized.A preliminary investigation about the possible alteration of BG particles in the electrospinning solvents was performed using SEM *** obtained composite fibers were investigated in terms of morphological,chemical and mechanical *** in vitro mineralization assay in simulated body fluid(SBF)was performed to investigate the capability of the composite electrospun fibers to induce the formation of hydroxycarbonate apatite(HCA).

关键词： Green electrospinning Benign solvents Bioactive glass Composite PCL Chitosan Nanofibers

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Multifunctional zinc ion doped sol-gel derived mesoporous bioactive glass nanoparticles for biomedical applications

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Bioactive Materials 2019年第1期4卷 312-321页

作者： Zuzana Neščáková Kai Zheng Liliana Liverani Qaisar Nawaz Dagmar Galusková Hana Kaňková Martin Michálek Dušan Galusek aldo r.boccaccini Dept.of Biomaterials FunGlass-Centre for Functional and Surface Functionalized GlassAlexander Dubček University of TrenčínSlovakia Central Laboratories FunGlass-Centre for Functional and Surface Functionalized GlassAlexander Dubček University of TrenčínSlovakia Institute of Biomaterials Department of Materials Science and EngineeringUniversity of ErlangenNurembergGermany

Mesoporous bioactive glasses have been widely investigated for applications in bone tissue regeneration and,more recently,in soft tissue repair and wound *** this study we produced mesoporous bioactive glass nanoparticles(MBGNs)based on the SiO2-CaO *** the intention of adding subsidiary biological function,MBGNs were doped with Zn2+***-MBGNs with 8 mol%ZnO content were synthesized via microemulsion assisted sol-gel *** synthesized particles were homogeneous in shape and *** exhibited spherical shape,good dispersity,and a size of 130±10 *** addition of zinc precursors did not affect the morphology of particles,while their specific surface area increased in comparison to *** presence of Zn2+ions inhibited the formation of hydroxycarbonate apatite(HCAp)on the particles after immersion in simulated body fluid(SBF).No formation of HCAp crystals on the surface of Zn-MBGNs could be observed after 14 days of ***,powders containing relatively high amount of zinc released Zn2+ions in low concentration(0.6-1.2 mg L^−1)but in a sustained *** releasing feature enables Zn-MBGNs to avoid potentially toxic levels of Zn2+ions,indeed Zn-MBGNs were seen to improve the differentiation of osteoblast-like cells(MG-63).Additionally,Zn-MBGNs showed higher ability to adsorb proteins in comparison to MBGNs,which could indicate a favourable later attachment of *** to their advantageous morphological and physiochemical properties,Zn-MBGNs show great potential as bioactive fillers or drug delivery systems in a variety of applications including bone regeneration and wound healing.

关键词： Bioactive particles Sol-gel synthesis Zinc Bioactivity Ion release Bioactive glass

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