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Tumor-induced neurogenesis and immune evasion as targets of innovative anti-cancer therapies

Signal Transduction and Targeted Therapy 2020年第1期5卷 1584-1606页

作者： Rodolfo Daniel cervantes-villagrana Damaris Albores-García alberto rafael cervantes-villagrana Sara Judit García-Acevez Department of Pharmacology Center for Research and Advanced Studies of the National Polytechnic Institute(CINVESTAV-IPN)07360 Mexico CityMexico Department of Environmental Health Sciences Florida International University(FIU)MiamiFlorida 33199USA Laboratorio de investigación en Terapéutica Experimental Unidad Académica de Ciencias QuímicasÁrea de Ciencias de la SaludUniversidad Autónoma de Zacatecas(UAZ)ZacatecasMéxico Dirección de Proyectos e Investigación Grupo Diagnóstico Médico Proa06400 CDMX CuauhtémocMéxico

Normal cells are hijacked by cancer cells forming together heterogeneous tumor masses immersed in aberrant communication circuits that facilitate tumor growth and *** the well characterized angiogenic effect of some tumor-derived factors;others,such as BDNF,recruit peripheral nerves and *** neurogenic switch,activated by tumor-derived neurotrophins and extracellular vesicles,attracts adjacent peripheral fibers(autonomic/sensorial)and neural progenitor ***,tumor-associated nerve fibers can guide cancer cell ***,IL-1β,CCL2,PGE2,among other chemotactic factors,attract natural immunosuppressive cells,including T regulatory(Tregs),myeloid-derived suppressor cells(MDSCs),and M2 macrophages,to the tumor *** leukocytes further exacerbate the aberrant communication circuit releasing factors with neurogenic ***,cancer cells directly evade immune surveillance and the antitumoral actions of natural killer cells by activating immunosuppressive mechanisms elicited by heterophilic complexes,joining cancer and immune cells,formed by PD-L1/PD1 and CD80/CTLA-4 plasma membrane ***,nervous and immune cells,together with fibroblasts,endothelial,and bone-marrow-derived cells,promote tumor growth and enhance the metastatic properties of cancer *** by the demonstrated,but restricted,power of anti-angiogenic and immune cell-based therapies,preclinical studies are focusing on strategies aimed to inhibit tumor-induced *** we discuss the potential of anti-neurogenesis and,considering the interplay between nervous and immune systems,we also focus on anti-immunosuppression-based *** molecules,antibodies and immune cells are being considered as therapeutic agents,aimed to prevent cancer cell communication with neurons and leukocytes,targeting chemotactic and neurotransmitter signaling pathways linked to perineural invasion and metastasis.

关键词： PD1 therapies invasion

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Effect of Senescence Retardants on the Quality of Persian Lime Fruits

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Phyton-International Journal of Experimental Botany 2024年第8期93卷 1805-1818页

作者： rafael Ariza-Flores rafael Ambriz-cervantes Pedro Cadena-Iñiguez Luis A.Gálvez-Marroquín Miguel A.Cano-García National Institute of Forestry Agriculture and Livestock Research(INIFAP)South Pacific Regional CenterSanto Domingo Barrio BajoVilla de EtlaOaxaca68200México National Institute of Forestry Agriculture and Livestock Research(INIFAP)Zacatepec Research StationZacatepecMorelos62780México National Institute of Forestry Agriculture and Livestock Research(INIFAP)Central Chiapas Research StationOcozocoautlaChis29140México National Institute of Forestry Agriculture and Livestock Research(INIFAP)Oaxaca Central Valley Research StationSanto Domingo Barrio BajoVilla de EtlaOaxaca68200México

The objective of this study consisted of evaluating the effect of the application of chitosan(Q),1-methylcyclopropene(1-MCP)under two controlled temperatures on some physical,physiological,and chemical parameters contributing to the quality of Persian lime Citrus latifolia *** treatments were evaluated,resulting from the combination of four senescence retardant applications(Q,1-MCP,1-MCP+Q,and without application)on fruits stored at two temperatures(12/20℃.Epidermis color(luminosity,chromaticity,and hue),fruit appearance,respiration,weight loss,total juice content,total soluble solids,and titratable acidity were registered during the *** results indicate that the 1-MCP and Q combination favored fruit postharvest quality conditions such as reducing respiration rate;maintaining fruit good appearance,turgidity,and brighter fruit chromaticity;fruits treated with chitosan and stored at 12℃,favored total soluble *** the other hand,Variables such as weight loss,juice content,acidity,phenols,flavonoids,antioxidant activity,and hue values were favored by a 12℃ storing temperature regardless of the *** general,the use of modified atmospheres,senescence retardants,and refrigeration as postharvest methods,can increase Persian lime shelf life.

关键词： Citrus latifolia quality conservation organic alternatives

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3′-UTR of the SARS-CoV-2 genome as a possible source of piRNAs

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Genes & Diseases 2023年第3期10卷 668-670页

作者： María Teresa Hernández-Huerta Laura Pérez-Campos Mayoral Carlos alberto Matias-cervantes Carlos Romero Díaz Eli Cruz Parada Eduardo Pérez-Campos Mayoral rafael Baltiérrez-Hoyos Margarito Martínez Cruz Gabriel Mayoral Andrade Eduardo Pérez-Campos CONACyT Faculty of Medicine and SurgeryAutonomous University“Benito Juárez”of Oaxaca(UABJO)Oaxaca 68020Mexico Research Center Faculty of Medicine UNAM-UABJOAutonomous University“Benito Juárez”of Oaxaca(UABJO)Oaxaca 8020Mexico National Technology of Mexico/IT Oaxaca Oaxaca de JuárezOaxaca 68030Mexico

SARS-CoV-2 is the causal agent of the COVID-19 pandemic. This is a single-stranded RNA beta-coronavirus that is comprised of a 5′ and 3′-untranslated region (UTR) in its non-coding RNA (ncRNA) region. The P-element-induced wimpy testis (PIWI)-interacting RNAs (piRNAs) are ncRNA sequences that bind to transposons and interfere with the translation of new genes. Here, we search for short sequences in the non-coding regions, corresponding to 28 nucleotides (nt). These start from a uracil and have a conserved region of at least 10 nt of homology with the previously reported piRNAs. The aim of this work was to identify piRNA-like sequences in the 3′-UTR of SARS-CoV-2 from the reported Wuhan Patient's genome sequence (GenBank: MN908947.3).

关键词： piRNA sequences piRNAs

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Canine Leptospirosis Serology in Southern Mexico City

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Open Journal of Medical Microbiology 2016年第4期6卷 171-180页

作者： Ignacio Martínez-Barbabosa Edubiel Arturo Alpizar-Sosa Dolores Guadalupe Gavaldón-Rosas Luís Pedro Moles-cervantes Marcia Gutiérrez Cárdenas rafael García-González Michael Shea Ana María Fernández-Presas Health Attention Department Human Parasitology Laboratory Universidad Autónoma Metropolitana-Xochimilco México DF México Animal and Agriculture Production Department Universidad Autónoma Metropolitana-Xochimilco México DF México Microbiology and Parasitology Department School of Medicine Universidad Autónoma de México México DF México Education and Communication Department Universidad Autónoma Metropolitana-Xochimilco México DF México

Background: Leptospirosis is an important zooanthroponotic disease spread worldwide which infection is recognized as a re-emergent disease. Leptospirosis is a systemic disease of humans and domestic animals, mainly dogs, cattle and swine, characterized by fever, renal and hepatic insufficiency, pulmonary manifestations and reproductive failure. Objective: To study the seroprevalence of anti-Leptospira antibodies in an urban canine population. Materials and Methods: The study was performed in March 2014 in stray dogs that had been captured in the districts of Coyoacan, Iztapalapa, Iztacalco and Benito Juarez in Mexico City;117 dogs were analyzed, from each of which 5 ml of blood were obtained. Serology was performed using a MAT test (Microscopic Agglutination Test), finding that the antigens corresponded to 13 serotypes of Leptospirainterrogans. Three age groups were formed: Group 1) younger than a year (n = 28), Group 2) 1 to 6 years (n = 75), and Group 3) older than 6 years (n = 14). Results: Of the analyzed sera, 28.2% were seropositive to one or more Leptospira serotypes, 74% of the positive seracoagglutinated with two or more serotypes. The most frequent serotypes were: Canicola, Icterohaemorrhagiae and Portland-vere. Serotypes Canicola, Pyrogenes, and Bratislava resulted statistically significant (p 0.001). The presence of anti-Leptospira antibodies in the blood of animals of 1 to 6 years resulted with a p 0.001. The sera from Iztapalapa reacted to nine serotypes. Conclusion: The 28.2% of seropositivity indicates Leptospira transmission in the canine population that was studied could exhibit a potential public health risk.

关键词： Leptospira Leptospirosis Canicola Icterohaemorrhagiae Dogs

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Method for Signals Detection in Single Crystal Diffraction Patterns through a Diffraction Pattern Indexing Software

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Journal of Mechanics Engineering and Automation 2015年第9期5卷 525-532页

作者： Tania Paola Campos Frias rafael Vazquez Perez Carlos Elias Omelas-Gutierrez Division de Estudios de Posgrado-Departamento de Sistemas y Computacion Instituto Tecnologico de Chihuahua II Chihuahua 31130 Mexico Centro de Investigacion en Materiales Avanzados S.C. Laboratorio Nacional de Nanotecnologia Miguel de Cervantes No. 120 Chihuahua Chih. C.P. 311136 Mexico

The correct use of information in science and technology is very important for its progress. Nowadays, the equipment used for the scientific and technological development provides results that are later interpreted by the researchers, in most of the above mentioned equipment the results are images full of information which has to be analyzed. A powerful stage with multiple benefits in this field is the image pre-processing by means of intelligent systems, which are capable to do image analysis throwing very useful results that enhance the scientific and technological information. There are currently more than 500 functions in the computational vision specialized open source library OpenCV, which associated with the C＋＋ programming language. These functions are used for application development in many areas of computer vision such as products inspection, medical images, safety, user＇s interfaces, camera calibration, stereoscopic vision and robotics. In this development and research work, by using the available functions and modifying the exposed methods, we present a proposal for signal detection in images originated in the transmission electron microscope （known as diffraction patterns）, which are attached to the detailed analysis of crystalline structures used in the study of the materials science, the results show a profit of at least 18% in the detection of signs by means of the method proposed in this work.

关键词： Diffraction pattern OpenCV detection image pre-processing.

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Acceptance of living liver donation among medical students: A multicenter stratified study from Spain

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World Journal of Gastroenterology 2016年第25期22卷 5800-5813页

作者： Antonio Ríos Ana Isabel López-Navas Ana Isabel López-López Francisco Javier Gómez Jorge Iriarte rafael Herruzo Gerardo Blanco Francisco Javier Llorca Angel Asunsolo Pilar Sánchez-Gallegos Pedro Ramón Gutiérrez Ana Fernández María Teresa de Jesús Laura Martínez-Alarcón alberto Lana Lorena Fuentes Juan Ramón Hernández Julio Virseda José Yelamos José Antonio Bondía Antonio Miguel Hernández Marco Antonio Ayala Pablo Ramírez Pascual Parrilla International Collaborative Donor Project ('Proyecto Colaborativo Internacional Donante' 30007 Casillas Murcia Spain Department of Surgery Paediatrics Obstetrics and Gynaecology University of Murcia Avenida de las Fuerzas Armadas 30800 Espinardo Murcia Spain Transplant Unit Surgery Service IMIB - Virgen de la Arrixaca University Hospital Carretera Madrid-Cartagena s/n 30120 El Palmar Murcia Spain Regional Transplant Centre Consejeria de Sanidad y Consumo de la Region de Murcia 30008 Ronda de Levante Murcia Spain Hospital Clinico Universitario Virgen de la Arrixaca Departamento de Cirugia General y del Aparato Digestivo Unidad de Trasplantes 30007 Casillas Murcia Spain Department of Psychology Universidad Catolica San Antonio (UCAM) Avenida de los Jeronimos 30107 Guadalupe Murcia Spain Department of Urology San Juan University Hospital of Alicante 03010 Calle Pintor Baeza Alicante Spain Universidad de Granada Avenida del Hospicio s/n 18010 Granada Spain Universidad de Navarra Campus Universitario 31080 Pamplona Navarra Spain Universidad Autonoma de Madrid Ciudad Universitaria de cantoblanco 28049 Madrid Spain Servicio de Cirugia HBP y Trasplante Hepatico Complejo Hospitalario Universitario de Badajoz Hospital Infanta Cristina Avenida Elvas s/n 06006 Badajoz Spain Universidad de Cantabria Avenida los Castros s/n 39005 Santander Cantabria Spain Departamento de Cirugia Ciencias Medicas y Sociales Facultad de Medicina y Ciencias de la Salud Universidad de Alcala Campus Cientifico-Tecnologico Plaza de San Diego s/n 28801 Alcala de Henares Madrid Spain Facultad de Medicina Universidad de Malaga 29071 Avenida de Cervantes Malaga Spain Servicio de Urologia (Complejo Hospitalario Universitario de Canarias CHUC) y Departamento de Cirugia (Universidad de La Laguna ULL) Calle Molinos de Agua s/n 38207 San Cristobal de La Laguna Santa Cruz de Tenerife Spain Departamento de Ciencias Biomedicas Basicas Facultad de Ciencias Biomedicas Universidad Europea de

AIM: To analyze the attitude of Spanish medical students toward living liver donation (LLD) and to establish which factors have an influence on this ***: Study type: A sociological, interdisciplinary, multicenter and observational study. Study population: Medical students enrolled in Spain (n = 34000) in the university academic year 2010-2011. Sample size: A sample of 9598 students stratified by geographical area and academic year. Instrument used to measure attitude: A validated questionnaire (PCID-DVH RIOS) was self-administered and completed anonymously. Data collection procedure: Randomly selected medical schools. The questionnaire was applied to each academic year at compulsory sessions. Statistical analysis: Student´s t test, χ2 test and logistic regression ***: The completion rate was 95.7% (n = 9275). 89% (n = 8258) were in favor of related LLD, and 32% (n = 2937) supported unrelated LLD. The following variables were associated with having a more favorable attitude: (1) age (P = 0.008); (2) sex (P < 0.001); (3) academic year (P < 0.001); (4) geographical area (P = 0.013); (5) believing in the possibility of needing a transplant oneself in the future (P < 0.001); (6) attitude toward deceased donation (P < 0.001); (7) attitude toward living kidney donation (P < 0.001); (8) acceptance of a donated liver segment from a family member if one were needed (P < 0.001); (9) having discussed the subject with one’s family (P < 0.001) and friends (P < 0.001); (10) a partner’s opinion about the subject (P < 0.001); (11) carrying out activities of an altruistic nature; and (12) fear of the possible mutilation of the body after donation (P < 0.001).CONCLUSION: Spanish medical students have a favorable attitude toward LLD.

关键词： Attitude Living liver donation Medical students Transplantation Organ donation Psychosocial variables Spain

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自体脂肪臀部移植：14年进展及经验

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中国美容整形外科杂志 2013年第9期24卷 I0013-I0013页

作者： Lazaro Cardenas-Camarena rafael Arenas-Quintana Jose-Antonio Robles-cervantes 魏峰(译) 高景恒(译) 袁继龙(译) 张晨(译) 哈利克斯健康部哈利克斯再造外科中心墨西哥哈利斯科州萨波潘《中国美容整形外科杂志》编辑部辽宁省人民医院整形外科大连大学附属新华医院整形外科

背景与目的脂肪浸润用于改善臀部外形的方法正得到越来越多的提倡。其可视应用的技术和脂肪浸润的量随时间而改变。本研究报道了笔者14年中臀部脂肪移植技术的演变过程。方法自1995年4月至2009年3月，对789例患者行脂肪抽吸和臀部脂肪... 详细信息

背景与目的脂肪浸润用于改善臀部外形的方法正得到越来越多的提倡。其可视应用的技术和脂肪浸润的量随时间而改变。本研究报道了笔者14年中臀部脂肪移植技术的演变过程。方法自1995年4月至2009年3月，对789例患者行脂肪抽吸和臀部脂肪移植。根据时间段和脂肪浸润量，将患者分为3个阶段组。

关键词：臀部脂肪移植技术自体脂肪脂肪浸润 2009年脂肪移植脂肪抽吸患者

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自体脂肪臀部移植:14年进展及经验

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中国美容整形外科杂志 2013年第9期 298-298页

作者： Lzaro Crdenas-Camarena rafael Arenas-Quintana Jos-Antonio Robles-cervantes 魏峰高景恒袁继龙张晨辽宁省人民医院整形外科哈利克斯健康部哈利克斯再造外科中心大连大学附属新华医院整形外科《中国美容整形外科杂志》编辑部

背景与目的脂肪浸润用于改善臀部外形的方法正得到越来越多的提倡。其可视应用的技术和脂肪浸润的量随时间而改变。本研究报道了笔者14年中臀部脂肪移植技术的演变过程。方法自1995年4月至2009年3月,对789例患者行脂肪抽吸和臀部脂...

背景与目的脂肪浸润用于改善臀部外形的方法正得到越来越多的提倡。其可视应用的技术和脂肪浸润的量随时间而改变。本研究报道了笔者14年中臀部脂肪移植技术的演变过程。方法自1995年4月至2009年3月,对789例患者行脂肪抽吸和臀部脂肪移植。根据时间段和脂肪浸润量,将患者分为3个阶段组。结果第一阶段(1995年1月至2004年1月),采取上臀部位浸润120320 ml脂肪的方式。第二阶段(2004年2月至2006年2月),采取上臀、下臀部位浸润210460 ml脂肪的方式。第三阶段(2006年3月至2009年3月),采取上臀、下臀部位和大转子处、臀下部注射2201160 ml脂肪的方式。例如脂肪坏死、臀部红斑、感染和脂肪栓塞综合征等并发症更多的出现在第一阶段,尽管此阶段浸润脂肪量较少。结论增加臀部脂肪浸润的量可更好地对整个臀部进行塑形,使脂肪在更广泛的区域内分布更大的量,并使其分布于多个层次,可以减少并发症的发生率。因此,要获得更好的美容效果,需谨记使大量的移植脂肪分布在更广的区域和更多的层次内,以减少术后并发症的发生。(循证医学证据等级:Ⅲ级,疗法)

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