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Radiological clinical trials: Proposal of a problem-finding questionnaire to improve study success

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World Journal of Methodology 2016年第4期6卷 214-219页

作者： Francesca Valdora Bianca Bignotti Massimo Calabrese Nehmat Houssami alberto tagliafico Department of Ex-perimental Medicine (DIMES)- Institute of Anatomy University of Genoa Department of Health Sciences (DISSAL) University of Genoa Department of Radiology UOC Seno-logia Diagnostica IRCCS AOU San Martino- IST School of Public Health Sydney Medical School University of Sydney

AIM To develop a survey to help define the main problems in radiological clinical trials. METHODS Since 2006, we have managed seven different radiological clinical trials recruiting patients in academic and non-academic centres. We developed a preliminary questionnaire using a four-round Delphi approach to identify problems occurring in radiological clinical trials run at our centre. We investigated the recruitment experience, involvement of all multi-disciplinary team members and main obstacles to completing the projects. A final round of Delphi processes elucidated solutions to the identified *** Among 19/20(95%) respondents, 10(53%) were young physicians(under 35 years old), and the respondents included non-faculty members, fellows, residents, and undergraduate students. Ninety-four percent(18/19) of respondents showed interest in conducting clinical trials. On a scale of 1 to 10, the problems with higher/worse scores(8-9) were related to technical or communication problems. The most frequent problems across all studies were technical problems related to clinical trial equipment, insufficient willingness to participate, obstacles to understanding the design of electronic-case report form and extra *** The developed questionnaire identified the main recurring problems in radiological clinical trials as perceived by endusers and helped define possible solutions that are mostly related to having dedicated clinical trial research staff.

关键词： Clinical trials Data management Magnetic resonance imaging Mammography Ultrasonography

Peripheral nerve imaging: Not only cross-sectional area

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World Journal of Radiology 2016年第8期8卷 726-728页

作者： alberto Stefano tagliafico Department of Experimental Medicine DIMESInstitute of AnatomyUniversity of Genova

Peripheral nerve imaging is recognized as a complement to clinical and neurophysiological assessment in the evaluation of peripheral nerves with the ability to impact patient management, even for small and difficult nerves. The European Society of Musculoskeletal Radiology,suggest to use ultrasound(US) for nerve evaluation due to the fact that, in sever anatomical area, magnetic resonance imaging is not able to give additional in-formations. US could be considered the first-choice approach for the assessment of peripheral nerves. The relative drawback of peripheral nerve US is the long learning curve and the deep anatomic competence to evaluate even small nerves. In the recent years, the role of US in peripheral nerve evaluation has been widened. In the past, nerve US was mainly used to assess nerve-cross sectional area, but now more advanced mea-surements and considerations are desirable and can boost the role of peripheral nerve US. Nerve echotexture evaluation was defined in 2010: The ratio between the hypoechoic and hyperechoic areas of peripheral nerves on US was called "nerve density". For evaluation of patients who have peripheral neuropathies, the role of peripheral nerve is US wider than simple cross-sectional area evaluation. Quantitative measurements describing the internal fascicular echotexture of peripheral nerves introduce the concept of considering US as a possible quantitative imaging biomarker technique. The potential of nerve US has started to be uncovered. It seems clear that only cross-sectional area measurement is no more sufficient for a comprehensive US evaluation of peripheral nerves.

关键词： Ultrasound Imaging Magnetic resonance Imaging Nerve density Fascicular ratio

Imaging of skeletal muscle in vitamin D deficiency

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World Journal of Radiology 2014年第4期6卷 119-124页

作者： Bianca Bignotti Angela Cadoni Carlo Martinoli alberto tagliafico Radiology Department University of Genoa Institute of Anatomy Department of Experimental MedicineUniversity of Genoa

Elderly people are prone to accidental falls and one of the main risk factor is considered muscle weakness. Several studies focused on muscle weakness and muscle morphology changes in the elderly that may be associated with vitamin D deficiency. The prevalence of vitamin D deficiency is higher than previously though representing an important issue for public health and prevention. There is an increased interest in vitamin D effects in skeletal muscle and imaging modalities are particularly involved in this field. In patients with vitamin D deficiency, ultrasound, computed tomography, densitometry and magnetic resonance imaging(MRI) can efficiently describe changes in muscle morphology and size. Moreover, new imaging modalities, such as MRI spectroscopy, may improve knowledge about the metabolic effects of vitamin D in skeletal muscle. In this narrative review we will discuss the role of skeletal muscle imaging in vitamin D-deficient individuals. The aim of this paper is to improve and encourage the role of radiologists in this field.

关键词： Muscle Vitamin D Vitamin D deficiency Ultrasound Computed tomography Magnetic resonance imaging

Current situation and future perspectives of European natural gas sector

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Frontiers in Energy 2015年第1期9卷 1-6页

作者： Vincenzo BIANCO Federico SCARPA Luca A. tagliafico Division of Thermal Energy and Environmental Conditioning DIME/TEC University of Genoa Via All'OperaPia 15/A 16145 Genova Italy

Gas market in Europe is experiencing a radical change for different reasons, partially determined and accelerated by economic downturn of the last period. In the past few years, many European countries adopted energy policies largely based on the utilization of natural gas. In fact, a sharp increase of the demand was observed and, at the same time, a lot of infrastructures were developed to assure the necessary supply. In the last few years, due to the economic downturn, natural gas demand decreased, causing a consistent oversupply on the market, which altered the consolidated dynamics of the sector. Under- standing the changes currently under development in the European gas market is of paramount importance in order to design future strategies for the sector; in particular, it is necessary to understand if the present situation will cause a reshaping of the sector.

关键词： natural gas natural gas market oil-linkedcontracts supply infrastructures gas hubs

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乳腺癌病人乳腺MRI中的肌肉质量评估:CT腰肌面积与MRI胸肌面积的比较

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国际医学放射学杂志 2019年第2期42卷 248-249页

作者： F.Rossi F.Valdora E.Barabino M.Calabrese A.S.tagliafico 李爽(译) 赵世华(校) Department of Health Sciences DISSAL-University of GenovaVia Pastore116138 GenoaItaly 不详

目的在乳腺癌病人中评价CT成像的腰肌面积(TPA)与MR成像的胸肌面积(PMA)的相关性。方法该回顾性研究经机构伦理委员会批准,参与研究的女性均签署了书面知情同意书。

关键词：乳腺癌肌肉质量 MRI CT

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莫顿神经瘤超声与MR成像的系统性回顾及meta分析

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国际医学放射学杂志 2015年第5期 501-502页

作者： B.Bignotti A.Signori M.P.Sormani L.Molfetta C.Martinoli A.tagliafico 马艳 Institute of Anatomy Department of Experimental MedicineUniversity of Genoa

摘要目的比较US和MRI在莫顿神经瘤中的诊断价值。方法评估US和MRI对莫顿神经瘤诊断准确性的研究是由2人进行回顾分析,检索文献截止至2014年4月1日。采用预定义的纳入和排除标准。结果检索出227项研究,并对14项研究进行了meta分析。在5... 详细信息

摘要目的比较US和MRI在莫顿神经瘤中的诊断价值。方法评估US和MRI对莫顿神经瘤诊断准确性的研究是由2人进行回顾分析,检索文献截止至2014年4月1日。采用预定义的纳入和排除标准。结果检索出227项研究,并对14项研究进行了meta分析。在5项研究中对US的敏感性进行研究,在3项研究中对MRI的敏感性进行了研究,在6项研究中对两者均进行了研究。所有研究均以手术结果为参

关键词：神经瘤 MRI US 神经组织肿瘤 MR 莫顿

超声引导下使用高密度透明质酸行肩峰下间隙黏度补充治疗老年病人肩袖撕裂关节病:前瞻性开放式非随机对照试验

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国际医学放射学杂志 2011年第2期 194-195页

作者： A.tagliafico G.Serafini L.M.Sconfienza F.Lacelli N.Perrone G.Succio 胡娟 Department of Radiology National Institute for Cancer Research

目的评估超声引导下的黏度补充治疗能否减轻肩袖撕裂关节病老年病人的疼痛并改善其功能。病例和方法 93例65岁以上、患有3级以上肩袖撕裂关节病的病人

关键词：黏度补充治疗老年肩袖撕裂关节病透明质酸超声

臂丛神经MR成像:3.0 T MR DTI相关测量与纤维示踪技术的精确性及可重复性

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国际医学放射学杂志 2011年第5期 508-509页

作者： A.tagliafico M.Calabrese M.Puntoni D.Pace G.Baio C.E.Neumaier 蔡兆诚 Department of Radiology National Institute for Cancer Research(IST)

目的对无臂丛神经病理改变的志愿者进行3.0 T MRI检查,评估DTI相关测量与纤维示踪技术(FT)的组内与组间可重复性。方法本研究经机构伦理委员会批准并获得

关键词：扩散张量成像臂丛神经可重复性各向异性分数表观扩散系数 MRI 最小检测差异

乳腺密度评估:使用全自动软件一对一比较数字乳腺X线摄影和数字乳腺体层摄影

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国际医学放射学杂志 2012年第4期 404-404页

作者： A. tagliafico G. tagliafico D. Astengo F. Cavagnetto R. Rosasco G. Rescinito 郭小超秦乃姗 Institute of Anatomy Department of Experimental Medicine University of GenoaLargo Rosanna Benzi 8 16132 Genoa Italy

摘要目的使用全自动化软件比较数字乳腺X线摄影和数字乳腺体层摄影(DBT)的乳腺密度。方法该研究获得机构批准并得到全部参与者的知情同意,每位参与者均进行DBT和全视野乳腺X线摄影(FFDM)。通过软件计算两种检查的乳腺密度百分比。结果5... 详细信息

摘要目的使用全自动化软件比较数字乳腺X线摄影和数字乳腺体层摄影(DBT)的乳腺密度。方法该研究获得机构批准并得到全部参与者的知情同意,每位参与者均进行DBT和全视野乳腺X线摄影(FFDM)。通过软件计算两种检查的乳腺密度百分比。结果50例连续病人(平均51岁,35～83岁)接

关键词：乳腺密度数字乳腺X线摄影体层摄影