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Intimal sarcoma of the pulmonary artery with multiple lung metastases: Long-term survival case

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World Journal of Clinical Oncology 2017年第4期8卷 366-370页

作者： Sonia García-Cabezas Macarena Centeno-Haro Simona Espejo-Pérez Elvira Carmona-Asenjo alberto L Moreno-Vega Rosa Ortega-salas Amalia Palacios-Eito Department of Radiation Oncology Reina Sofia University Hospital Department of Pathological Anatomy Reina Sofia University Hospital Department of Radiology Reina Sofia University Hospital Department of Nuclear Medicine Reina Sofia University Hospital Department of Medical Oncology Reina Sofia University Hospital

Pulmonary artery intimal sarcoma(PAIS) is a rare tumor with a very poor prognosis. Clinical and radiological findings usually mimic thromboembolic disease, leading to diagnostic delays. The treatment of choice is surgery, and adjuvant chemotherapy and radiotherapy have limited results. We report the case of a 48-year-old male patient, initially suspected with pulmonary thromboembolism. The angio-CT revealed a filling defect in the pulmonary artery trunk. The patient underwent surgery, resulting in with complete resection of the mass with a diagnosis of PAIS. The tumor progressed rapidly in the lung, requiring surgery of multiple lung metastases. The patient was treated with stereotactic body radiation therapy(SBRT) on two occasions for new pulmonary lesions. In the last follow-up(4 years after initial diagnosis), the patient was disease-free. In conclusion, SBRT proved to be an alternative treatment to metastasectomy, allowing palliative chemotherapy to be delayed or omitted, which may result in improved quality of life.

关键词： Intimal sarcoma of the pulmonary artery Lung metastases Metastasectomy Stereotactic body radiation therapy Treatment

High ownership concentration and exporting of emerging market firms： evidence from Peru

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Frontiers of Business Research in China 2017年第3期11卷 427-451页

作者： William Gonzalo Vega salas Ziliang Deng Renmin Business School Renmin University of China Haidian Beijing China Vega salas Corp Arequipa Peru

Despite the extraordinarily high ownership concentration widely observed in emerging market firms as a result of institutional voids, there is little research on how this high ownership concentration affects the exporting behavior of emerging market firms. From principal-agent and institutional perspectives, we hypothesize that high ownership concentration has a negative relationship with export intensity, because, in emerging markets, highly concentrated ownership bridges the interests of owners （principals） and managers （agents） so that principals must be prudent in exploring risky international markets. Moreover, we hypothesize that export country diversification strengthens the relationship between ownership concentration and export intensity, because broad geographic dispersion increases risk exposure and principal-agent problems. Empirical analysis based on a panel dataset for publicly listed firms in Peru from 2005 to 2014 supports the hypotheses. The study highlights the risk aversion attitude activated by ownership concentration, an attitude that protects emerging market firms from overconfidently exploring international business opportunities. The study extends the conventional literature on the interface between ownership concentration and international business in an emerging market context. We also discuss the generalizability of the findings to other emerging markets, e.g. China.

关键词： Ownership concentration Export Country diversification Agency theory Emerging markets Peru

Expression of miR‑138 in cryopreserved bovine sperm is related to their fertility potential

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Journal of Animal Science and Biotechnology 2023年第6期14卷 2383-2394页

作者： Albert salas‑Huetos Jordi Ribas‑Maynou Yentel Mateo‑Otero Carolina Tamargo Marc Llavanera Marc Yeste Unit of Cell Biology Department of BiologyFaculty of SciencesUniversity of GironaGirona 17003Spain. Biotechnology of Animal and Human Reproduction(TechnoSperm) Institute of Food and Agricultural TechnologyUniversity of GironaGirona 17003Spain. Department of Nutrition Harvard T.H.Chan School of Public HealthHarvard UniversityBostonMA 02115USA. Consorcio CIBER M.P.Fisiopatologia de la Obesidad y Nutricion(CIBERobn)Instituto de Salud Carlos III(ISCIII)Madrid 28029Spain. Present Address:Unit of Preventive Medicine and Public Health Faculty of Medicine and Health SciencesUniversitat Rovira i VirgiliReus 43201Spain. Department of Animal Selection and Reproduction The Regional Agri-Food Research and Development Service of Asturias(SERIDA)Gijon 33394Spain. Catalan Institution for Research and Advanced Studies(ICREA) Barcelona 08010Spain.

Background MicroRNAs(miRNAs)are small,single-stranded,non-coding RNA molecules of 22–24 nucleotides that regulate gene *** the last decade,miRNAs have been described in sperm of several mammals,including *** is known that miRNAs can act as key gene regulators of early embryogenesis in mice and humans;however,little is known about the content,expression,and function of sperm-borne miRNAs in early bovine *** this study,total sperm RNA was isolated from 29 cryopreserved sperm samples(each coming from a separate bull)using a RNeasy kit and treatment with DNase *** concentration and purity were determined through an Epoch spectrophotometer and an Agilent *** expression of 10 candidate miRNAs in bovine sperm(bta-miR-10a,bta-miR-10b,bta-miR-138,bta-miR-146b,bta-miR-19b,bta-miR-26a,bta-miR-34a,bta-miR-449a,bta-miR-495 and btamiR-7),previously identified in testis and/or epididymis,was evaluated with *** cel-miR-39-3p was used as a spike-in exogenous *** Mann–Whitney tests were run to evaluate which miRNAs were differentially expressed between bulls with high fertility[HF;non-return rates(NRR)ranging from 39.5 to 43.5]and those with subfertility(SF;NRR ranging from 33.3 to 39.3).Several sperm functionality parameters(e.g.,viability,membrane stability or oxygen consumption,among others)were measured by multiplexing flow cytometry and oxygen sensing *** RNA concentration and purity(260/280 nm ratio)(mean±SD)from the 29 samples were 99.3±84.6 ng/μL and 1.97±0.72,*** results confirmed the lack of RNA from somatic *** terms of the presence or absence of miRNAs,and after applying the Livak method,8 out of 10 miRNAs(bta-miR-10b,-138,-146b,-19b,-26a,-449a,-495,-7)were consistently detected in bovine sperm,whereas the other two(bta-miR-10a,and-34a)were ***,the relative expression of one miRNA(bta-miR-138)in sperm was significantly lower in the SF than in the HF gr

关键词： Bovine Fertility miRNAs Sperm

Ecology and local knowledge of the Baird’s tapir (Tapirella bairdii) in the Sierra Madre de Oaxaca, Mexico

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Integrative Zoology 2016年第5期11卷 361-374页

作者： Mario César LAVARIEGA NOLASCO Miguel BRIONES-salas Amado MAZAS-TEODOCIO Elvira DURÁN-MEDINA Interdisciplinary Research Center for Integral Development Oaxaca UnitNational Polytechnic InstituteOaxacaMexico

As well as being of global cultural importance(from local tribal folklore to being an iconic species for conservation),the tapir plays an important role in its ecosystem as a herbivore and seed ***,the ecology and ethnozoology of the endangered Baird’s tapir in the north of Oaxaca,Mexico is poorly *** used camera traps to estimate its relative abundance and density and to describe the activity patterns of the northernmost population of Baird’s tapir in the Sierra Madre de *** knowledge concerning the tapir was also documented,along with the conservation strategies undertaken by the 2 indigenous communities that own the land where the study site is *** adult tapirs were photographed,and these were active 14 h per day,but were mainly nocturnal and *** estimated relative abundance(12.99±2.24 events/1000 camera days)and density values(0.07-0.24 individuals/km2)were both similar to those found in another site in Mexico located within a protected ***-structured interviews revealed that people have a basic understanding of the eating habits,activity and main predators of the *** were reports of hunting,although not among those respondents who regularly consume bush ***,the relative abundance and density estimates of tapir at the study site could be related to the favorable condition of the forest and the absence of hunting and consumption of tapir ***,the local people are conducting initiatives promoting the conservation of this ungulate and its habitat that combine to constitute a regional trend of habitat and wildlife protection.

关键词： camera-trapping density estimation random encounter model tapir conservation

Standing-wave spectrometry in silicon nano-waveguides using reflection-based near-field scanning optical microscopy

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Chinese Physics B 2019年第1期28卷 306-312页

作者： Yi-Zhi Sun Wei Ding Bin-Bin Wang Rafael salas-Montiel Sylvain Blaize Renaud Bachelot Zhong-Wei Fan Li-Shuang Feng School of Instrumentation Science and Opto-Electronics Engineering Beihang University Laboratory of Optical Physics Institute of Physics Chinese Academy of Sciences Laboratoire de Nanotechnologie et d’Instrumentation Optique(LNIO)ICD CNRS UMR 6281 Universitéde Technologie de Troyes Academy of Opto-Electronics Chinese Academy of Science

Utilizing reflection-based near-field scanning optical microscopy(NSOM) to image and analyze standing-wave patterns, we present a characterization technique potentially suitable for complex photonic integrated circuits. By raster scanning along the axis of a straight nano-waveguide in tapping mode and sweeping wavelength, detailed information of propagating waves in that waveguide has been extracted from analyses in both space and wavelength domains. Our technique needs no special steps for phase stabilization, thus allowing long-duration and environment-insensitive measurements. As a proof-of-concept test, in a silicon single-mode waveguide with a few of etched holes, the locations and reflection strengths of the inner defects have been quantified. The measurement uncertainty of the reflection amplitude is less than 25% at current stage. Our technique paves the way for non-destructively diagnosing photonic circuits on a chip with sub-wavelength spatial resolution and detailed information extraction.

关键词： near-field scanning optical microscopes integrated optics interferometry

A multidimensional review of the cash management problem

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Financial Innovation 2023年第1期9卷 1840-1874页

作者： Francisco salas‑Molina Juan A.Rodríguez‑Aguilar Montserrat Guillen Universitat Politècnica de València Ferrándiz y Carbonell03801 AlcoySpain IIIA‑CSIC Campus UAB08913 CerdanyolaSpain Universitat de Barcelona Av.Diagonal69008034 BarcelonaSpain

In this paper,we summarize and analyze the relevant research on the cash manage-ment problem appearing in the ***,we identify the main dimensions of the cash management ***,we review the most relevant contributions in this field and present a multidimensional analysis of these contributions,according to the dimensions of the *** this analysis,several open research questions are highlighted.

关键词： Cash management Models Dimensions Review

Empirical Assessment of Bacillus Calmette-Guérin Vaccine to Combat COVID-19

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Computers, Materials & Continua 2022年第1期70卷 213-231页

作者： Nikita Jain Vedika Gupta Chinmay Chakraborty Agam Madan Deepali Virmani Lorenzo salas-Morera Laura Garcia-Hernandez Department of Computer Science&Engineering Bharati Vidyapeeth’s College of EngineeringNew Delhi110063India Department of Electronics&Communication Engineering Birla Institute of TechnologyMesra814142India Department of Computer Science&Engineering Bhagwan Parshuram Institute of TechnologyNew Delhi110063India Area of Project Engineering University of CórdobaCórdoba14071Spain

COVID-19 has become one of the critical health issues globally,which surfaced first in latter part of the year *** is the topmost concern for many nations’governments as the contagious virus started mushrooming over adjacent regions of infected *** 1980,a vaccine called Bacillus Calmette-Guérin(BCG)was introduced for preventing tuberculosis and lung *** that have made the BCG vaccine mandatory have witnessed a lesser COVID-19 fatality rate than the countries that have not made it *** paper’s initial research shows that the countries with a longtermcompulsory BCGvaccination system are less affected by COVID-19 than those without a BCG vaccination *** paper discusses analytical data patterns for medical applications regarding COVID-19 impact on countries with mandatory BCG status on fatality *** paper has tackled numerous analytical challenges to realize the full potential of heterogeneous *** analogy is drawn to demonstrate how other factors can affect fatality and infection rates other than BCG vaccination only,such as age groups affected,other diseases,and stringency *** data of Spain,Portugal,and Germany have been taken for a case study of BCG impact analysis.

关键词： Bacillus Calmette-Guérin COVID-19 fatality rate lockdown gross domestic product vaccine

BK viral infection: A review of management and treatment

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World Journal of Transplantation 2023年第6期13卷 309-320页

作者： June Hayrelle Gorriceta Amy Lopez Otbo Genta Uehara Maria Aurora Posadas salas Department of Medicine St Francis Hospital-BartlettBartlettTN 38133United States Department of Medicine St.Luke’s Medical CenterQuezon 1112Philippines Department of Medicine Division of NephrologyMedical University of South CarolinaCharlestonSC 29425United States

BK viral infection remains to be a challenging post-transplant infection,which can result in kidney *** mainstay approach to BK infection is reduction of *** in immunosuppressive regimen with minimization of calcineurin inhibitors,use of mechanistic target of rapamycin inhibitors,and leflunomide have been attempted with variable *** the past few years,investigators have explored potential therapeutic options for BK *** prophylaxis and treatment was found to have no benefit in kidney transplant *** utility of cidofovir is limited by its *** immunoglobulin is becoming a popular option for treatment and prophylaxis for BK infection,as it increases the neutralizing antibody titers against the most common BK virus ***-specific T cell therapy is an emerging treatment option for BK *** this review,we will explore management and therapeutic options for BK infection and recent evidence available in literature.

关键词： BK infection Kidney transplant Treatment Management

Effect of protease supplementation on apparent ileal crude protein and amino acid digestibility of over-processed soybean meals in broilers

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Journal of Animal Science and Biotechnology 2022年第6期13卷 1810-1817页

作者： Sergio Salazar-Villanea Maikol Astúa-Ureña Allison Masís-Montoya Juan I.Herrera-Muñoz Catalina salas-Durán Escuela de Zootecnia Universidad de Costa RicaSan JoséCosta Rica Centro de Investigación en Nutrición Animal Universidad de Costa RicaSan JoséCosta Rica

Background: Nutritional value of proteins in feed ingredients can be negatively affected by hydrothermal processing, which causes large variation in the bioavailability of amino acids(AA) and negatively affects animal productive performance. Supplementation of exogenous proteases could increase the rate of digestion of damaged proteins, thereby increasing overall AA digestibility and bioavailability. The aim was to determine the effect of exogenous protease supplementation on the apparent ileal digestibility(AID) of crude protein(CP) and AA of soybean meals(SBM) with different degrees of hydrothermal processing in ***: The experiment involved a 3 × 2 factorial arrangement, with SBM processing time(commercial SBM or autoclaved for 30 or 60 min at 120 ℃) and protease supplementation(not supplemented and supplemented) as factors. Protease was included at three times the recommended dose(0.06%) and the experimental diets were fed from 15 to 21 ***: The interaction between the effects of SBM processing and protease supplementation was significant for the AID of CP(P = 0.01), Trp(P = 0.01), Gly(P = 0.03) and Pro(P = 0.03), and also for the average daily gain(P = 0.01)and feed conversion ratio(P = 0.04). Increasing the processing time of SBM decreased(P < 0.0001) the AID of all amino acids, whilst the effect of protease supplementation was only significant for the AID of Phe(P = 0.02) and Tyr(P = 0.01).Conclusions: Exogenous protease supplementation at three times the commercial dose does not seem to offset the negative effects of hydrothermal processing of SBM on the apparent ileal digestibility of CP and amino acids or performance of broilers. Whilst positive numerical improvements of digestibility and performance(ADG and FCR)were noticed with protease supplementation at relatively mild processing levels, negative results were obtained with the harsh-processed meals.

关键词： Amino acids Apparent ileal digestibility Broilers Exogenous protease