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JASMONATE-ZIM DOMAIN proteins engage polycomb chromatin modifiers to modulate Jasmonate signaling in Arabidopsis

Molecular plant 2021年第5期14卷 732-747页

作者： Zicong Li Xiao Luo Yang Ou Huijun Jiao Li peng Xing Fu alberto p.macho Renyi Liu Yuehui He Shanghai Center for plant Stress Biology Chinese Academy of Sciences Center for Excellence in Molecular Plant SciencesShanghai 201602China Ministry of Education Key Laboratory of plant Development and Environmental Adaption Biology School of Life SciencesShandong UniversityQingdao 266237China Department of Biological Sciences National University of SingaporeSingapore 117543Singapore peking University Institute of Advanced Agricultural Sciences WeifangShandong 261000China Center for Agroforestry Mega Data Sciences Haixia Institute of Science and TechnologyFujian Agriculture and Forestry UniversityFuzhou 350002China State Key Laboratory of protein and plant Gene Research Peking-Tsinghua Center for Life SciencesSchool of Advanced Agriculture SciencesPeking UniversityBeijing 100871China

Jasmonate(JA)regulates various aspects of plant growth and development and stress responses,with prominent roles in male reproductive development and defenses against herbivores and necrotrophic ***-ZIM DOMAIN(JAZ)proteins are key regulators in the JA signaling pathway and function to repress the expression of JA-responsive ***,we show that JAZ proteins directly interact with several chromatin-associated polycomb proteins to mediate repressive chromatin modifications at JA-responsive genes and,thus,their transcriptional repression in *** analyses revealed that the developmental defects,including anther and pollen abnormalities,resulting from loss or block of JA signaling were partially rescued by loss of polycomb protein-mediated chromatin silencing(polycomb repression).We further found that JAZ-mediated transcriptional repression during anther and pollen development requires polycomb proteins at four key Regulatory *** of genome-wide occupancy of a polycomb factor and transcriptome reprogramming in response to JA revealed that polycomb repression is involved in the repression of various JA-responsive *** together,our study reveals an important chromatin-based mechanism for JAZ-mediated transcriptional repression and JA signaling in plants.

关键词： jasmonate JA response polycomb proteins JAZ proteins anther development H3K27me3

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Intra-strain Elicitation and Suppression of plant Immunity by Ralstonia solanacearum Type-III Effectors in Nicotiana benthamiana

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plant Communications 2020年第4期1卷 87-100页

作者： Yuying Sang Wenjia Yu Haiyan Zhuang Yali Wei Lida Derevnina Gang Yu Jiamin Luo alberto p.macho Shanghai Center for plant Stress Biology CAS Center for Excellence in Molecular Plant SciencesShanghai Institutes of Biological SciencesChinese Academy of SciencesShanghai 201602China University of Chinese Academy of Sciences BeijingChina The Sainsbury Laboratory University of East AngliaNorwich Research ParkNorwich NR47UHUK

Effector proteins delivered inside plant cells are powerful weapons for bacterial pathogens,but this exposes the pathogen to potential recognition by the plant immune ***,the effector repertoire of a given pathogen must be balanced for a successful *** solanacearum is an aggressive pathogen with a large repertoire of secreted *** of these effectors,RipE1,is conserved in most *** strains sequenced to *** this work,we found that RipE1 triggers immunity in ***,which requires the immune regulator SGT1,but not EDS1 or ***,RipE1-triggered immunity induces the accumulation of salicylic acid(SA)and the overexpression of several genes encoding phenylalanine-ammonia lyases(pALs),suggesting that the unconventional pALmediated pathway is responsible for the observed SA ***,RipE1 recognition also induces the expression of jasmonic acid(JA)-responsive genes and JA biosynthesis,suggesting that both SA and JA may act cooperatively in response to *** further found that RipE1 expression leads to the accumulation of glutathione in plant cells,which precedes the activation of immune *** secretes another effector,RipAY,which is known to inhibit immune responses by degrading cellular ***,RipAY inhibits RipE1-triggered immune *** work shows a strategy employed by *** to counteract the perception of its effector proteins by plant immune system.

关键词： ETI SGT1 effector immunity Ralstonia pAL

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A bacterial effector protein uncovers a plant metabolic pathway involved in tolerance to bacterial wilt disease

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Molecular plant 2021年第8期14卷 1281-1296页

作者： Yaru Wang Achen Zhao Rafael J.L.Morcillo Gang Yu Hao Xue Jose S.Rufian Yuying Sang alberto p.macho Shanghai Center for plant Stress Biology CAS Center for Excellence in Molecular Plant Sciences/Chinese Academy of SciencesShanghai 201602China University of Chinese Academy of Sciences BeijingChina

Bacterial wilt caused by the soil-borne plant pathogen Ralstonia solanacearum is a devastating disease *** plant colonization,*** replicates massively,causing plant wilting and death;collapsed infected tissues then serve as a source of *** this work,we show that the plant metabolic pathway mediated by pyruvate decarboxylases(pDCs)contributes to plant tolerance to bacterial wilt *** and tomato plants resp ond to *** infection by in creasing pDC activity,and plants with deficient pDC activity are more susceptible to bacterial *** with either pyruvic acid or acetic acid(substrate and product of the pDC pathway,respectively)enhances plant tolerance to bacterial wilt *** effector protein secreted by ***,RipAK,interacts with pDCs and inhibits their oligomerization and enzymatic ***,our work reveals a metabolic pathway involved in plant resistance to biotic and abiotic stresses,and a bacterial virulence strategy to promote disease and the completion of the pathogenic life cycle.

关键词： pyruvate decarboxylase pyruvic acid acetic acid bacterial wilt Ralstonia solanacearum type-Ⅲeffector

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The transcriptional regulator JAZ8 interacts with the C2 protein from geminiviruses and limits the geminiviral infection in Arabidopsis

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Journal of Integrative plant Biology 2023年第7期65卷 1826-1840页

作者： Tabata Rosas-Diaz pepe Cana-Quijada Mengshi Wu Du Hui Gemma Fernandez-Barbero alberto pmacho Roberto Solano Araceli GCastillo Xiao-Wei Wang Rosa Lozano-Duran Eduardo R.Bejarano Departamento de Biología Celular Genética y FisiologíaFacultad de CienciasInstituto de Hortofruticultura Subtropical y Mediterránea“La Mayora”(IHSM‐UMA‐CSIC)Universidad de MálagaMálagaSpain Shanghai Center for plant Stress Biology CAS Center for Excellence in Molecular Plant SciencesChinese Academy of SciencesShanghai 201602China Institute of Insect Sciences Zhejiang UniversityHangzhou 310058China Departamento de Genética Molecular de plantas Centro Nacional de Biotecnología‐Consejo Superior de Investigaciones CientíficasMadrid 28049Spain Department of plant Biochemistry Centre for Plant Molecular BiologyEberhard Karls UniversityTübingen D‐72076Germany

Jasmonates(JAs) are phytohormones that finely regulate critical biological processes, including plant development and defense. JASMONATE ZIM-DOMAIN(JAZ) proteins are crucial transcriptional regulators that keep JA-responsive genes in a repressed state. In the presence of JA-Ile, JAZ repressors are ubiquitinated and targeted for degradation by the ubiquitin/proteasome system,allowing the activation of downstream transcription factors and, consequently, the induction of JA-responsive genes. A growing body of evidence has shown that JA signaling is crucial in defending against plant viruses and their insect vectors. Here, we describe the interaction of C2proteins from two tomato-infecting geminiviruses from the genus Begomovirus, tomato yellow leaf curl virus(TYLCV) and tomato yellow curl Sardinia virus(TYLCSaV), with the transcriptional repressor JAZ8 from Arabidopsis thaliana and its closest orthologue in tomato, SlJAZ9. Both JAZ and C2proteins colocalize in the nucleus, forming discrete nuclear speckles. Overexpression of JAZ8did not lead to altered responses to TYLCV infection in Arabidopsis;however, knock-down of JAZ8 favors geminiviral infection. Low levels of JAZ8 likely affect the viral infection specifically,since JAZ8-silenced plants neither display obvious developmental phenotypes nor present differences in their interaction with the viral insect vector. In summary, our results show that the geminivirus-encoded C2 interacts with JAZ8 in the nucleus, and suggest that this plant protein exerts an anti-geminiviral effect.

关键词： C2 protein geminivirus jasmonates JAZ8 transcriptional repressor TYLCV

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Mapping proteome-Wide Targets of protein Kinases in plant Stress Responses

Mapping Proteome-Wide Targets of Protein Kinases in Plant St...

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2018全国植物生物学大会

作者： pengcheng Wang Chuan-Chih Hsu Yanyan Du peipei Zhu Chunzhao Zhao Xing Fu Chunguang Zhang Juan Sebastian paez alberto p.macho W.Andy Tao Jian-Kang Zhu Shanghai Center for plant Stress Biology CASCenter for Excellence in Molecular Plant SciencesChinese Academy of Sciences Department of Biochemistry Purdue University Department of Horticulture and Landscape Architecture Purdue University

protein kinases are major regulatory components in almost all cellular processes in eukaryotic *** adding phosphate groups,protein kinases regulate the activity,localization,protein-protein interactions,and other features of their target *** is known that protein kinases,such as SNF1-related protein kinases 2 and 3(SnRK2 and SnRK3),calcium dependent protein kinases(CDpKs),and mitogen activated protein kinases(MApKs) are central components in plant response to environmental stresses,such as drought,high salinity,cold,and pathogen *** phosphorylationdependent signaling plays critical roles in plant stress biology,only a small number of targets of these protein kinases have been identified,and consequently how these protein kinases regulate downstream biological processes and mediate stress responses are still largely *** this study,we developed an isotope labeled protein kinase assay-based approach with enriched phosphoproteomes as kinase-substrate pools to identify the putative substrates of eight protein kinases that function in plant abiotic and biotic stress *** a result,we identified more than five thousand putative targets from 11 protein kinase-stimuli *** also analyzed the conserved motif and functional ontology of these putative kinase *** results provide comprehensive information on the role of these protein kinases in controlling cellular activities and constitute a valuable resource for further studies on the mechanisms underlying plant response to environmental stresses.

关键词： stress phosphoproteomics kinase substrate MpK6 SnRK2 CDpK

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Astrocytes, reactive astrogliosis, and glial scar formation in traumatic brain injury

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Neural Regeneration Research 2025年第4期20卷 973-989页

作者： María Belén Cieri alberto Javier Ramos Laboratorio de Neuropatología Molecular IBCN UBA-CONICETFacultad de MedicinaUniversidad de Buenos AiresBuenos AiresArgentina

Traumatic brain injury is a global health crisis,causing significant death and disability *** that follows traumatic brain injury has serious consequences for neuronal survival and cognitive impairments,with astrocytes involved in this *** traumatic brain injury,astrocytes rapidly become reactive,and astrogliosis propagates from the injury core to distant brain *** astroglial proteins are downregulated near the traumatic brain injury core,while pro-inflammatory astroglial genes are *** altered gene expression is considered a pathological remodeling of astrocytes that produces serious consequences for neuronal survival and cognitive *** addition,glial scar formed by reactive astrocytes is initially necessary to limit immune cell infiltration,but in the long term impedes axonal reconnection and functional *** therapeutic strategies for traumatic brain injury are focused on preventing acute ***,cannabinoids,progesterone,beta-blockers,and cerebrolysin demonstrate neuroprotective benefits but most of them have not been studied in the context of *** this review,we discuss the cell signaling pathways activated in reactive astrocytes following traumatic brain injury and we discuss some of the potential new strategies aimed to modulate astroglial responses in traumatic brain injury,especially using cell-targeted strategies with miRNAs or lncRNA,viral vectors,and repurposed drugs.

关键词： astrocyte glial scar innate immunity neuroinflammation stab injury Toll-like receptors

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拟南芥ABA受体pYL的十二重突变体揭示了pYL对ABA不依赖的渗透胁迫应答的抑制

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科学新闻 2019年第2期 124-124页

作者：赵杨 Zhengjing Zhang 高景慧王鹏程胡涛 Zegang Wang Yueh-Ju Hou Yizhen Wan Wenshan Liu Shaojun Xie Tianjiao Lu Liang Xue Yajie Liu alberto p.macho W.Andy Tao Ray A.Bressan 朱健康中国科学院上海植物逆境生物学研究中心西北农林科技大学中科院上海植物逆境生物学研究中心中科院武汉植物园

文章简介ABA促进气孔关闭、生长抑制、休眠等胁迫应答,被称为"胁迫激素"。除胁迫应答之外,ABA信号是否参与调控其他生理过程尚不清楚。本研究构建了敲除所有ABA受体的pYL的十四重突变体,发现它极矮小且不育,表明ABA信号途径是植物的生长

关键词： ABA 胁迫应答突变体 pYL 拟南芥

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Modification of the susceptibility gene TapsIpK1‑a win‑win for wheat disease resistance and yield

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Stress Biology 2022年第1期2卷 193-196页

作者： alberto macho pengcheng Wang Jian‑Kang Zhu Shanghai Center for plant Stress Biology CAS Center for Excellence in Molecular Plant SciencesChinese Academy of SciencesShanghai 200032China Institute of Advanced Biotechnology and School of Life Sciences Southern University of Science and TechnologyShenzhen 518055China Center for Advanced Bioindustry Technologies Chinese Academy of Agricultural SciencesBeijing 100081China

Wheat is one of the most important cereal crops,and it is essential for worldwide food ***,wheat production is threatened by various diseases,including wheat stripe rust caused by the fungus puccinia striiformis ***(pst).The development of plant resistance against disease is usually challenged by potential reduction in crop yield due to the enhancement of plant *** a recent article,Wang et *** that TapsIpK1 is a susceptibil-ity gene targeted by rust *** of TapsIpK1 increases resistance to stripe rust without any developmental effects or yield penalty,providing an exceptional resource for developing disease resistance in wheat.

关键词： Wheat Wheat stripe rust TapsIpK1 Resistance genes

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Nanomechanical hydrodynamic force sensing using suspended microfluidic channels

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Microsystems & Nanoengineering 2023年第3期9卷 95-102页

作者： alberto Martín-pérez Daniel Ramos Optomechanics Lab Instituto de Ciencia de Materiales de Madrid(ICMMCSIC)3 Sor Juana Inés de la Cruz(Madrid)E-28049 MadridSpain

Microfluidics has demonstrated high versatility in the analysis of in-flow particles and can even achieve mechanical properties measurements of biological cells by applying hydrodynamic ***,there is currently no available technique that enables the direct measurement and tracking of these hydrodynamic forces acting on a flowing *** this work,we introduce a novel method for the direct measurement of the hydrodynamic force actuating on an in-flow particle based on the analysis of the induced resonance changes of suspended microchannel resonators(SMRs).This hydrodynamic force sensitivity depends on the device used;therefore,we considered the geometry and materials to advance this dependency on the SMR resonance frequency.

关键词： hydrodynamic applying flow

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The reversed intra- and extracellular pH in tumors as a unified strategy to chemotherapeutic delivery using targeted nanocarriers

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Acta pharmaceutica Sinica B 2021年第8期11卷 2243-2264页

作者： Edgar pérez-Herrero alberto Fernández-Medarde Departamento de Ingeniería Química y Tecnología Farmacéutica Universidad de La LagunaLa Laguna 38206TenerifeSpain Instituto Universitario de Bio-Orgánica Antonio González Universidad de La LagunaLa Laguna 38206TenerifeSpain Instituto Universitario de Tecnologías Biomédicas Universidad de La LagunaLa Laguna 38200TenerifeSpain Instituto de Biología Molecular y Celular Del Cáncer Centro de Investigación Del Cáncer(USAL-CSIC)Salamanca 37007Spain

Solid tumors are complex entities,comprising a wide variety of malignancies with very different molecular *** this,they share a set of characteristics known as"hallmarks of cancer"that can be used as common therapeutic ***,every tumor needs to change its metabolism in order to obtain the energy levels required for its high proliferative rates,and these adaptations lead to alterations in extra-and intracellular *** changes in p H are common to all solid tumors,and can be used either as therapeutic targets,blocking the cell proton transporters and reversing the pH changes,or as means to specifically deliver anticancer *** this review we will describe how proton transport inhibitors in association with nanocarriers have been designed to block the pH changes that are needed for cancer cells to survive after their metabolic *** will also describe studies aiming to decrease intracellular pH in cancer using nanoparticles as molecular cages for protons which will be released upon UV or IR light ***,we will comment on several studies that have used the extracellular pH in cancer for an enhanced cell internalization and tumor penetration of nanocarriers and a controlled drug delivery,describing how nanocarriers are being used to increase drug stability and specificity.

关键词： pH-Gradient inversion Metabolism of glucose proton transport inhibitors proton-caged carriers Chemotherapy Targeted drug delivery pH-Sensitive nanocarriers Warburg effect Cancer

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