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Oropharyngeal acid reflux and motility abnormalities of the proximal esophagus

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World Journal of Gastroenterology 2016年第40期22卷 8991-8998页

作者： Sandro Passaretti Giorgia mazzoleni Cristian Vailati Pier alberto Testoni Gastroenterology and Gastrointestinal Endoscopy Division IRCCS San Raffaele Scientific Institute Vita-Salute San Raffaele University

AIM To investigate the relationship between pathological oropharyngeal(OP) acid exposure and esophageal motility in patients with extra-esophageal *** In this prospective study we enrolled consecutive outpatients with extra-esophageal symptoms suspected to be related to gastroesophageal reflux disease(GERD). We enrolled only patients with a reflux symptom index(RSI) score-higher than 13 and with previous lung, allergy and ear, nose and throat evaluations excluding other specific diagnoses. All patients underwent 24-h OP pH-metry with the Dx probe and esophageal highresolution manometry(HRM). Patients were divided into two groups on the basis of a normal or pathological p H-metric finding(Ryan Score) and all manometric characteristics of the two groups were *** We examined 135 patients with chronic extra-esophageal syndromes. Fifty-one were considered eligible for the study. Of these, 42 decided to participate in the protocol. Patients were divided into two groups on the basis of normal or pathological OP acid exposure. All the HRM parameters were compared for the two groups. Significant differences were found in the median upper esophageal sphincter resting pressure(median 71 mmH g vs 126 mmH g, P = 0.004) and the median proximal contractile integral(median 215.5 cm·mmH g·s vs 313.5 cm·mmH g·s, P = 0.039), both being lower in the group with pathological OP acid exposure, and the number of contractions with small or large breaks, which were more frequent in the same group. This group also had a larger number of peristaltic contractions with breaks in the 20 mm Hg isobaric contour(38.7% vs 15.38%, P < 0.0001).CONCLUSION In patients with suspected GERD-related extraesophageal syndromes pathological OP acid exposure was associated with weaker proximal esophageal motility.

关键词： Esophagus Motility Oropharyngeal reflux Gastroesophageal reflux disease High resolution manometry pH-metry

PCDH19 interplay with GABA(A)receptors:a window to DEE9 pathogenetic mechanisms

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Neural Regeneration Research 2022年第4期17卷 803-805页

作者： Sara mazzoleni Silvia Bassani Institute of Neuroscience CNRMilanItaly Department of Medical Biotechnology and Translational Medicine University of MilanSegrate(MI)Italy NeuroMI Milan Center for Neuroscience University of Milano-BicoccaMilanItaly

Developmental and epileptic encephalopathy 9(DEE9):The gene PCDH19(Xq22.1),which encodes the calcium-dependent cell adhesion protein protocadherin-19(PCDH19),is nowadays considered as one of the most important genes in monogenic epilepsy(Depienne and LeGuern,2012).Mutations in PCDH19 are responsible for DEE9(OMIM#300088),a severe neurodevelopmental disorder characterized by early-onset clustering epilepsy,various degrees of cognitive impairment and neuro psychiatric comorbidities,like autism spectrum disorder(ASD)and behavioural ***9 patients start suffering from seizures around the age of 10 months until adolescence,when seizures tend to reduce or even disappear,while the psychiatric symptoms persist(Depienne and LeGuern,2012;Kolc et al.,2018).

关键词： H19 PCD epilepsy

Screening in liver disease

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World Journal of Gastroenterology 2006年第33期12卷 5272-5280页

作者： Paolo Del Poggio Marzio mazzoleni Hepatology Unit Treviglio Hospital Treviglio (Bergamo) Italy General Practitioner Italian Society of Family Physicians (SIMG) Italy

A disease is suitable for screening if it is common, if the target population can be identifi ed and reached and if both a good screening test and an effective therapy are available. Of the most common liver diseases only viral hepatitis and genetic hemochromatosis partially satisfy these conditions. Hepatitis C is common, the screening test is good and the therapy eliminates the virus in half of the cases, but problems arise in the definition of the target population. In fact generalized population screening is not endorsed by international guidelines, although some recommend screening immigrants from high prevalence countries. Opportunistic screening (case finding) of individuals with classic risk factors, such as transfusion before 1992 and drug addiction, is the most frequently used strategy, but there is disagreement whether prison inmates, individuals with a history of promiscuous or traumatic sex and health care workers should be screened. In a real practice setting the performance of opportunistic screening by general practitioners is low but can be ameliorated by training programs. Screening targeted to segments of the population or mass campaigns are expensive and therefore interventions should be aimed to improve opportunistic screening and the detection skills of general practitioners. Regarding genetic hemochromatosis there is insufficient evidence for population screening, but individual physicians can decide to screen racial groups with a high prevalence of the disease, such as people in early middle age and of northern European origin. In the other cases opportunistic screening of high risk individu-als should be performed, with a high level of suspicion in case of unexplained liver disease, diabetes, juvenile artropathy, sexual dysfunction and skin pigmentation.

关键词： Screening Risk factors Hepatitis C Hepatitis B Genetic hernochromatosis

Surveillance for hepatocellular carcinoma at the community level: Easier said than done

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World Journal of Gastroenterology 2021年第37期27卷 6180-6190页

作者： Paolo Del Poggio Marzio mazzoleni Sergio Lazzaroni Andrea D'Alessio Unitàdi Epatologia Policlinico San Marco Zingonia GSD University and Research Hospital UnitàEpatologiaOsio Sotto 24040BergamoItaly Primary Care Physician ASST BergamoOsio Sotto 24040BergamoItaly Department of Medicine Policlinico San Marco ZingoniaGSD University and Research HospitalOsio Sotto 24040BergamoItaly

Surveillance for hepatocellular carcinoma(HCC)in high-risk patients with semiannual ultrasound examinations is advocated by all international ***,as long as the identification of the population to be screened and the surveillance programs are not well implemented,the real-life impact of HCC surveillance in reducing mortality for HCC cannot be *** propose a new approach that promotes the identification of cirrhotic patients by primary care physicians(PCPs)and referral of patients to the hepatologist for *** should be incorporated,when feasible,in a hub and spoke model of comprehensive hepatology *** PCPs to identify cirrhotic patients and performing surveillance in a subspecialist setting are equally important to improve the effectiveness of real-life surveillance and to decrease HCC mortality over time.

关键词： Hepatocellular carcinoma Cirrhosis Ultrasound surveillance Primary health care

Transoral incisionless fundoplication for gastro-esophageal reflux disease: Techniques and outcomes

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2016年第2期7卷 179-189页

作者： Pier alberto Testoni Giorgia mazzoleni Sabrina Gloria Giulia Testoni Division of Gastroenterology and Gastrointestinal Endoscopy Vita-Salute San Raffaele University San Raffaele Scientific Institute

Gastro-esophageal reflux disease(GERD)is a verycommon disorder that results primarily from the loss of an effective antireflux barrier,which forms a mechanical obstacle to the retrograde movement of gastric *** can be currently treated by medical therapy,surgical or endoscopic transoral *** therapy is the most common approach,though concerns have been increasingly raised in recent years about the potential side effects of continuous longterm medication,drug intolerance or unresponsiveness,and the need for high dosages for long periods to treat symptoms or prevent *** too may in some cases have consequences such as longlasting dysphagia,flatulence,inability to belch or vomit,diarrhea,or functional dyspepsia related to delayed gastric *** the last few years,transoral incisionless fundoplication(TIF)has proved an effective and promising therapeutic option as an alternative to medical and surgical *** review describes the steps of the TIF technique,using the Esophy X®device and the MUSETM *** and their management are described in detail,and the recent literature regarding the outcomes is *** reconfigures the tissue to obtain a full-thickness gastroesophageal valve from inside the stomach,by serosato-serosa plications which include the muscle *** date the procedure has achieved lasting improvement of GERD symptoms(up to six years),cessation or reduction of proton pump inhibitor medication in about 75%of patients,and improvement of functional findings,measured by either p H or impedance monitoring.

关键词： Gastro-esophageal reflux disease Transoral incisionless fundoplication Anterior fundoplication with ultrasonic surgical endostapler Esophy X MUSE Surgical fundoplication

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意大利广播电视法的若干问题

法治湖南与区域治理研究

法治湖南与区域治理研究 2012年第4期9卷 221-247页

作者： Gianpietro mazzoleni Giulio Enea Vigevani 何瑶意大利米兰大学米兰比科卡大学法律系中国传媒大学新媒体研究院

意大利广播电视体系非常有特点,因为有备受争议的政治人物的参与,尤其是国有广播机构———意大利广播电视公司RAI④,它是严格地受控于政府和政党之下的。自从意大利商业电视台在1970年开创以来,在整体无规范的市场环境下,RAI改变了意...

意大利广播电视体系非常有特点,因为有备受争议的政治人物的参与,尤其是国有广播机构———意大利广播电视公司RAI④,它是严格地受控于政府和政党之下的。自从意大利商业电视台在1970年开创以来,在整体无规范的市场环境下,RAI改变了意大利的传媒市场、广告市场以及政治关系。在20世纪中期,一位来自意大利北方、拥有着雄厚的传媒实力的企业家———贝卢斯科尼⑤,在其逐渐成为政治明星以及国家总理的过程中,意大利的商业电视台扮演了非常重要的角色。

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动态质量比较仪

现代计量测试 1996年第6期4卷 54-56,27页

作者： S.Baggia F.mazzoleni 杨如杰

根据质量-弹簧谐振频率、运动量或离心力等,一些作者已提出了几种不同的动态质量比较方法。其中最后一种方法由于不要求固定,因此更适用于非固态样品。

关键词：质量计量仪器动态质量比较仪弹簧

非溃疡性消化不良的跨文化问卷调查表的建立及其调查效能研究:阿雷格里港消化不良症状调查表

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世界核心医学期刊文摘（胃肠病学分册） 2005年第8期1卷 5-6页

作者： Sander G.B mazzoleni L.E Fernando C 李翔 RamiroBarcellos 1660 apto. 501 CEP 90035-002Porto Alegre RS Brazil.Dr

Despite its high prevalence, nonulcer dyspepsia is still difficult to study, d ue to the lack of adequate tools to measure significant outcomes. The objective of this study was to develop and validate a symptom-focused, disease- -specific questionnaire to evaluate patients with nonulcer dyspepsia. For tha t, the questionnaire was carefully written following widely accepted terminology , so as to facilitate translation and validation in other languages and cultures . The questionnaire was developed using Rome I terminology for symptoms, which w ere evaluated according to their intensity, duration, and frequency when applica ***-one patients with nonulcer dyspepsia, as well as 31 sex and age-mat ched volunteers without digestive problems were used to assess the internal cons istency, reproducibility,responsiveness, content validity, and discriminant vali dity of the questionnaire. Another 31 functional dyspeptic patients were enrolle d for assessment of criterion validity. Cronbach’s αcoefficient was 0.82. The intraclass correlation coefficient for the scores obtained 7 days apart was 0.86 . The mean score obtained after 3 months of treatment was 16.4, vs. 23.03 at bas eline (P = 0.001). Two blinded gastroenterologists agreed that the questionnaire adequately evaluated nonulcer *** median symptoms score for controls was 0, vs. 22.5 for dyspeptic patients (P = 0.001). An inverse correlation was o bserved between quality of life and dyspeptic symptoms (R=-0.28, P = 0.026). Th e proposed questionnaire has high degrees of both reproducibility and responsive ness. As this questionnaire was based on Rome I International Consensus terminol ogy, it is expected that it will be easy to translate and validate.

关键词：消化不良症状效能研究阿雷格里港消化道疾病问卷调查可重复性双盲控制标准术语问卷表持续时间

升温后泥炭孔隙水溶解有机碳浓度及其不稳定性:野外贫瘠沼泽地增温试验

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腐植酸 2016年第2期 27-38页

作者： Evan S.Kane Lynn R.mazzoleni Carley J.Kratz John A.Hribljan Christopher P.Johnson Thomas G.Pypker Rodney Chimner 赵旋琪王江静赵红艳刘莎莎美国密歇根科技大学森林资源与环境科学学院霍顿mi49931 东北师范大学地理科学学院长春130024

北欧和北美的研究表明,近几十年来水生生态系统中溶解有机碳(DOC)浓度增加。尽管关于溶解有机碳提高的机制还没有定论,但是一般认为其根本原因在于升温、降水变率增加和大气沉降变化等气候变化因素。本实验历时长达3年,通过在泥炭地上方... 详细信息

北欧和北美的研究表明,近几十年来水生生态系统中溶解有机碳(DOC)浓度增加。尽管关于溶解有机碳提高的机制还没有定论,但是一般认为其根本原因在于升温、降水变率增加和大气沉降变化等气候变化因素。本实验历时长达3年,通过在泥炭地上方1.24 m处安装红外灯积极增温,测试了增温对泥炭孔隙水组成的影响。结果发现在泥炭地下5 c m处,生长季中各处理的平均温度(n=5)比对照处理高1.9±0.4℃(t=5.03,P=0.007)。同时,在泥炭地下25 c m处,生长季中各处理的孔隙水D O C浓度(73.4±3.2 m g/L)比对照处理(63.7±2.1 m g/L)高15%(t=4.69,P<0.001)。此外,升温后的处理中,D O C分解速率是实验室内对照处理的2倍,芳香性比对照组孔隙水更低(增温后泥炭在254 nm处的吸光度降低)。溶解有机氮(DON)浓度变化规律与DOC一致,每单位碳中溶解的氮随着温度升高而下降。以往的研究表明,在这个实验地,增温使净初级生产力增加;同时,几丁质酶和葡萄苷酶的活性增加。本实验观察到,增温条件下DOC浓度增加,可能是因为根际微生物和植物相互作用的结果。在能去质子化生物分子池中,也探测到增温后出现较多的、独特的含有较高双键(DBE)的含氮化合物(在通过超高分辨率离子电喷雾质谱鉴定达到的所有化合物中占16%),这些化合物可能是随着增温引起的植物、微生物和酶活性增加后的产物。随着泥炭地持续升温,相对不稳定的DOC含量升高,这可能导致地表径流中DOC浓度增加,还可能作为有效的电子供体(或者受体)源使陆地和水生环境中的CO2和CH4增加。

关键词：泥炭气候变化细胞外的酶溶解有机氮溶解有机碳杜鹃花科莎草科