非溃疡性消化不良的跨文化问卷调查表的建立及其调查效能研究:阿雷格里港消化不良症状调查表

作     者：Sander G.B Mazzoleni L.E Fernando C 李翔 

作者机构：RamiroBarcellos 1660 apto. 501 CEP 90035-002Porto Alegre RS Brazil.Dr 

出 版 物：《世界核心医学期刊文摘（胃肠病学分册）》 (Core Journals in Gastroenterology)

年 卷 期：2005年第1卷第8期

页      面：5-6页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：消化不良症状 效能研究 阿雷格里港 消化道疾病 问卷调查 可重复性 双盲控制 标准术语 问卷表 持续时间 

摘      要：Despite its high prevalence, nonulcer dyspepsia is still difficult to study, d ue to the lack of adequate tools to measure significant outcomes. The objective of this study was to develop and validate a symptom-focused, disease- -specific questionnaire to evaluate patients with nonulcer dyspepsia. For tha t, the questionnaire was carefully written following widely accepted terminology , so as to facilitate translation and validation in other languages and cultures . The questionnaire was developed using Rome I terminology for symptoms, which w ere evaluated according to their intensity, duration, and frequency when applica ***-one patients with nonulcer dyspepsia, as well as 31 sex and age-mat ched volunteers without digestive problems were used to assess the internal cons istency, reproducibility,responsiveness, content validity, and discriminant vali dity of the questionnaire. Another 31 functional dyspeptic patients were enrolle d for assessment of criterion validity. Cronbach’s αcoefficient was 0.82. The intraclass correlation coefficient for the scores obtained 7 days apart was 0.86 . The mean score obtained after 3 months of treatment was 16.4, vs. 23.03 at bas eline (P = 0.001). Two blinded gastroenterologists agreed that the questionnaire adequately evaluated nonulcer *** median symptoms score for controls was 0, vs. 22.5 for dyspeptic patients (P = 0.001). An inverse correlation was o bserved between quality of life and dyspeptic symptoms (R=-0.28, P = 0.026). Th e proposed questionnaire has high degrees of both reproducibility and responsive ness. As this questionnaire was based on Rome I International Consensus terminol ogy, it is expected that it will be easy to translate and validate.