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Endothelial impairment evaluation by peripheral arterial tonometry in pediatric endocrinopathies:A narrative review

World Journal of Diabetes 2021年第6期12卷 810-826页

作者： alberto la valle Marco Crocco Decimo Silvio Chiarenza Mohamad Maghnie Giuseppe d'Annunzio Pediatric Clinic and Endocrinology IRCCS Istituto Giannina GasliniGenoa16147Italy Pediatric Clinic and Endocrinology IRCCS Giannina Gaslini InstituteDepartment of NeuroscienceRehabilitationOphthalmologyGeneticsMaternal and Child Health University of GenoaGenoa16147Italy

Endothelial dysfunction(ED)is characterized by an imbalance between vasodilator and vasoconstriction *** pathological conditions clinically diagnosed in childhood and adolescence are characterized by ED and increased risk for early development of microangiopathic and macroangiopathic impairment,in particular type 1 diabetes mellitus(T1DM),T2DM,obesity,metabolic syndromeand pituitary dysfunction associated to various *** recently insulin resistance following chemotherapy or radiotherapy for tumors,bone marrow transplantation for hematological malignancies(i.e.,cancer survivors),or immunosuppressive treatment for solid organ transplantation has been *** of ED by means of non-invasive techniques is the gold standard for early ED detection before clinical *** is aimed to recognize patients at risk and to avoid the development and progression of more serious *** hyperemia-peripheral artery tonometry is a noninvasive technique to assess peripheral endothelial function by measuring modifications in digital pulse volume during reactive hyperemia,and represents a non-invasive,reproducible and operator-independent tool able to detect precocious *** narrative review aimed to provide an overview of the most important papers regarding ED detection by EndoPat 2000 in children and adolescents with different endocrine diseases.A comprehensive search of English language articles was performed in the MEDLINE database without using other search filters except the publication interval between 2005 and 2020.

关键词： Pediatric diabetes mellitus Pediatric endocrinopathies Metabolic syndrome Cancer survivors Endothelial dysfunction Peripheral artery tonometry

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Middle Eocene chondrichthyan fauna from Antarctic Peninsula housed in the Museo de la Plata,Argentina

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Advances in Polar Science 2024年第1期35卷 14-47页

作者： Martina CHARNELLI Soledad GOUIRIC-CAVALLI Marcelo A.REGUERO alberto L.CIONE Agencia Nacional de Promoción Científica y Tecnológica(ANPCyT) Godoy Cruz 2370Argentina División Paleontología Vertebrados Museo de La PlataPaseo del Bosque s/nLa Plata B1900FWAArgentina Facultad de Ciencias Naturales y Museo de la Plata(FCNyM) Universidad Nacional de La Plata(UNLP)La Plata CP 1900Argentina Instituto Antártico Argentino(IAA) General San Martín B1650HMKArgentina Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET) Buenos Aires C1425FQBArgentina

In recent years,the taxonomy and systematics of the cartilaginous fish taxa from the Eocene la Meseta Formation of Seymour(Marambio)Island,Antarctica have been extensively discussed in a series of papers,resulting in a complete revision of the Antarctic Eocene ichthyofauna housed in the Vertebrate Paleontology collection of the Museo de la Plata,*** collection constitutes one of the largest and taxonomically most diverse in the world,with approximately 20000 specimens,which provides a solid database used for the analysis of qualitative and quantitative chondrichthyan taxonomic *** information provided herein might be useful to understand the sudden decline in chondrichthyan taxonomic diversity towards the top of la Meseta Formation as well as its potential relationship with environmental changes during the Eocene.

关键词： Gondwana Antarctica Paleogene ichthyofauna Seymour(Marambio)Island

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Stereotactic body radiotherapy in pancreatic adenocarcinoma

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 14-19页

作者： Carolina de la Pinta Radiation Oncology Department Ramón y Cajal University HospitalIRYCISAlcaláUniversity28034 MadridSpain

Background:Stereotactic body radiotherapy(SBRT)in pancreatic cancer allows high delivery of radiation doses on tumors without affecting surrounding *** review aimed at the SBRT application in the treatment of pancreatic *** sources:We retrieved articles published in MEDLINE/PubMed from January 2017 to December *** used in the search included:“pancreatic adenocarcinoma”OR“pancreatic cancer”AND“stereotactic ablative radiotherapy(SABR)”OR“stereotactic body radiotherapy(SBRT)”OR“chemoradiotherapy(CRT)”.English language articles with information on technical characteristics,doses and fractionation,indications,recurrence patterns,local control and toxicities of SBRT in pancreatic tumors were *** articles were assessed for validity and relevant ***:Optimal doses and fractionation have not yet been ***,SBRT could be the standard treatment in patients with pancreatic adenocarcinoma in addition to ***,the combination of SBRT with chemotherapy may have additive or synergic effect on pancreatic ***:SBRT is an effective modality for patients with pancreatic cancer,supported by clinical practice guidelines as it has demonstrated good tolerance and good disease *** opens a possibility of improving outcomes for these patients,both in neoadjuvant treatment and with radical intent.

关键词： Chemoradiotherapy Pancreatic adenocarcinoma Radiotherapy Stereotactic body radiotherapy Stereotactic ablative radiotherapy

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Truly optimal semi-active damping to control free vibration of a single degree of freedom system

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Theoretical & Applied Mechanics Letters 2024年第2期14卷 142-145页

作者： Viet Duc la Ngoc Tuan Nguyen Institute of Mechanics Vietnam Academy of Science and TechnologyHanoi 10000Vietnam Graduate University of Science and Technology Vietnam Academy of Science and TechnologyHanoi 10000Vietnam

This paper studies a single degree of freedom system under free vibration and controlled by a general semiactive damping.A general integral of squared error is considered as the performance index.A one-time switching damping controller is proposed and *** pontryagin maximum principle is used to prove that no other form of semi-active damping can provide the better performance than the proposed one-time switching damping.

关键词： Analytical optimization Quadratic integral Lyapunov equation Pontryagin maximum principle

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A convolutional neural network to detect possible hidden data in spatial domain images

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Cybersecurity 2024年第1期7卷 37-52页

作者： Jean De la Croix Ntivuguruzwa Tohari Ahmad Department of Informatics Institut Teknologi Sepuluh Nopember(ITS)Kampus ITS Keputih SukoliloSurabaya60111Indonesia African Center of Excellence in the Internet of Things College of Science and TechnologyUniversity of Rwanda3900KigaliRwanda

Hiding secret data in digital multimedia has been essential to protect the ***,attackers with a steganalysis technique may break *** steganalysis methods have good results with conventional Machine Learning(ML)techniques;however,the introduction of Convolutional Neural Network(CNN),a deep learning paradigm,achieved better performance over the previously proposed ML-based *** the existing CNN-based approaches yield good results,they present performance issues in classification accuracy and stability in the network training *** research proposes a new method with a CNN architecture to improve the hidden data detection accuracy and the training phase stability in spatial domain *** proposed method comprises three phases:pre-processing,feature extraction,and ***,in the pre-processing phase,we use spatial rich model filters to enhance the noise within images altered by data hiding;secondly,in the feature extraction phase,we use two-dimensional depthwise separable convolutions to improve the signal-to-noise and regular convolutions to model local features;and finally,in the classification,we use multi-scale average pooling for local features aggregation and representability enhancement regardless of the input size variation,followed by three fully connected layers to form the final feature maps that we transform into class probabilities using the softmax *** results identify an improvement in the accuracy of the considered recent scheme ranging between 4.6 and 10.2%with reduced training time up to 30.81%.

关键词： Information security Spatial domain steganalysis Deep learning Convolutional neural network Infrastructure

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Extracorporeal shockwave lithotripsy in the management of urinary stones: New concepts and techniques to improve outcomes

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Asian Journal of Urology 2024年第2期11卷 143-148页

作者： Pilar Bahilo-Mateu alberto Budia-Alba Lithotripsy and Endourology Unit La Fe University and Polytechnic HospitalValenciaSpain Lithotripsy and Endourology Unit Urology DepartmentLa Fe University and Polytechnic HospitalValenciaSpain

Objective: Extracorporeal shockwave lithotripsy (SWL) currently plays an important role in the treatment of urinary tract lithiasis. The purpose of this article was to describe new concepts and procedural strategies that would improve results using SWL as a treatment for urolithiasis, thereby achieving better clinical ***: A systematic review process was carried in PubMed/PMC from January 2003 to March 2023. A narrative synthesis of the most important aspects has been ***: The important recommendations for the adequate selection of the candidate patient for treatment with SWL are summarized, as well as the new strategies for a better application of the technique. Aspects about intraoperative position, stone localization and monitoring, analgesic control, machine and energy settings, and measures aiming at reduced risk of complications are ***: To achieve the therapeutic goal of efficient stone disintegration without increasing the risk of complications, it is necessary to make an adequate selection of patients and to pay special attention to several important factors in the application of treatment. Technological development in later generation devices will help to improve current SWL results.

关键词： Lithotripsy Extracorporeal shockwave Stone disease Treatment Urinary stone

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Erratum to:Tribological behaviour of Ti_(3)C_(2)T_(x)nano-sheets:Substrate-dependent tribo-chemical reactions

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Friction 2024年第7期12卷 1618-1619页

作者： alberto ROTA Nicolas BELLINA Bo WANG Andreas ROSENKRANZ Dipartimento di Scienze Fisiche Informatiche e MatematicheUniversitàdi Modena e Reggio EmiliaModena 41125Italy CNR-Istituto di Nanoscienze Centro S3Modena 41125Italy Centro Interdipartimentale per la Ricerca Applicata e i Servizi nel settore della Meccanica Avanzata e della Motoristica Universitàdi Modena e Reggio EmiliaModena 41125Italy Key laboratory of Marine New Materials and Related Technology Zhejiang Key Laboratory of Marine Materials and Protection TechnologyNingbo Institute of Material Technology&EngineeringChinese Academy of SciencesNingbo 315201China Department of Chemical Engineering Biotechnology and MaterialsUniversity of ChileSantiago 8370456Chile

Erratum to alberto Rota,Nicolas Bellina,Bo Wang&Andreas *** behaviour of Ti_(3)C_(2)T_(x)nano-sheets:Substratedependent tribo-chemical *** 11(8):1522–1533(2023).

关键词： Friction behaviour chemical

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Identification and functional characterization of fish IL‑17 receptors suggest important roles in the response to nodavirus infection

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Marine Life Science & Technology 2024年第2期6卷 252-265页

作者： Carmen González‑Fernández Miguel A.García‑Álvarez alberto Cuesta Department of Cell Biology and Histology Faculty of BiologyUniversity of Murcia30100 MurciaSpain laboratoire d’écotoxicologie Centre de Lyon-VilleurbanneINRAEUR RiverLy69625 VilleurbanneFrance

Th17 is a lymphocyte T helper(Th)subpopulation relevant in the control and regulation of the immune response characterized by the production of interleukin(IL)-*** crucial cytokine family acts through their binding to the IL-17 receptors(IL-17R),having up to six *** the biology of fish Th17 is well-recognized,the molecular and functional characterization of IL-17 and IL-17R has been ***,our aim was to identify and characterize the IL-17R repertory and regulation in the two main Mediterranean cultured fish species,the gilthead seabream(Sparus aurata)and the European sea bass(Dicentrarchus labrax).Our in silico results showed the clear identification of six members in each fish species,from IL-17RA to IL-17RE-like,with well-conserved gene structure and protein domains with their human *** of them showed wide and constitutive transcription in naïve tissues but with highest levels in mucosal tissues,namely skin,gill or *** leucocytes,T mitogens showed the strongest up-regulation in most of the il17 receptors though il17ra resulted in inhibition by most ***,in vivo nodavirus infection resulted in alterations on the transcription of il17 *** nodavirus infection led to some increments in the il17ra,il17rb,il17rc and il17rd transcripts in the susceptible European sea bass,many down-regulations were observed in the resistant gilthead *** data identify the presence and conservation of six coding IL-17R in gilthead seabream and European sea bass as well as their differential regulation in vitro and upon nodavirus infection.

关键词： Th17 cells IL-17 receptors Immunity Teleost fish Nodavirus(NNV) Aquaculture

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ZnSb/Ti_(3)C_(2)T_(x)MXene van der Waals heterojunction for flexible near-infrared photodetector arrays

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Journal of Semiconductors 2024年第5期45卷 99-105页

作者： Chuqiao Hu Ruiqing Chai Zhongming Wei la Li Guozhen Shen State Key laboratory for Superlattices and Microstructures Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China Center of Materials Science and Optoelectronic Engineering University of Chinese Academy of SciencesBeijing 100049China School of Integrated Circuits and Electronics Beijing Institute of TechnologyBeijing 100081China

Two-dimension(2D)van der Waals heterojunction holds essential promise in achieving high-performance flexible near-infrared(NIR)***,we report the successful fabrication of ZnSb/Ti_(3)C_(2)T_(x)MXene based flexible NIR photodetector array via a facile photolithography *** single ZnSb/Ti_(3)C_(2)T_(x)photodetector exhibited a high light-to-dark current ratio of 4.98,fast response/recovery time(2.5/1.3 s)and excellent stability due to the tight connection between 2D ZnSb nanoplates and 2D Ti_(3)C_(2)T_(x)MXene nanoflakes,and the formed 2D van der Waals *** polyethylene terephthalate(PET)substrate enables the ZnSb/Ti_(3)C_(2)T_(x)photodetector withstand bending such that stable photoelectrical properties with non-obvious change were maintained over 5000 bending ***,the ZnSb/Ti_(3)C_(2)T_(x)photodetectors were integrated into a 26×5 device array,realizing a NIR image sensing application.

关键词： ZnSb nanoplates Ti_(3)C_(2)T_(x)MXene van der Waals heterojunction flexible photodetector image sensing

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The Influence of Significant Public Health Events on Offline Consumption and Its Pathways

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Journal of Systems Science and Systems Engineering 2024年第5期33卷 627-648页

作者： Baile Lu Kewei Zhou Shuai Hao la Ta Hongyan Dai Weihua Zhou College of Systems Engineering National University of Defense TechnologyChangsha 410073China Business School Central University of Finance and EconomicsBeijing 100081China Department of Marketing and Operations Management College of BusinessSouthern University of Science and TechnologyShenzhen 518055China School of Management Zhejiang UniversityHangzhou 310058China

In the face of a significant public health event,consumers may either increase their panic buying or decrease their willingness to make *** study focuses on the impact of a significant public health event on offline store sales and consumer consumption,utilizing data from chain convenience stores in Hefei and Wuhu during early 2019 and early 2020 in *** a difference-in-differences model,the study investigates the effect of the significant public health event outbreak on weekly store sales,order numbers,and consumer consumption in terms of product quantities,transaction amount,average amount per order,and transaction *** from prior literature that finds hoarding behavior of consumers online,the findings of this paper indicate a significant reduction in stores’offline weekly sales and order numbers,as well as consumers’offline weekly consumption across the four dimensions,as a result of the significant public health event ***,employing a mediation model,the study explores the pathway of population mobility through which the significant public health event adversely affects offline ***,subset analysis is conducted for stores located in different areas and consumers with varying characteristics,revealing that the aforementioned conclusions predominantly apply to stores situated in office areas and residential areas,as well as consumers with either no apparent preference for different product categories or a noticeable preference for food.

关键词： Significant public health event offline consumption population mobility mediating effect

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