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Human health risks associated to trace elements and metals in commercial fish from the Brazilian Amazon

Journal of Environmental Sciences 2025年第2期148卷 230-242页

作者： Andrea V.Waichman Gabriel Silva de Souza Nunes Rhaul de Oliveira Isabel López-heras Andreu Rico Federal University of the Amazon Institute of Biological SciencesAv.Rodrigo Ramos 3000Manaus 69077-000Brazil Federal University of Pernambuco Department of ZoologyAv.Prof Moraes Rego 1235Cidade UniversitáriaRecife 50670-901Brazil University of Campinas School of TechnologyRua Paschoal Marmo 1888-Jd.Nova ItáliaLimeira 13484-332Brazil IMDEA Water Institute Science and Technology Campus of the University of AlcaláAv.Punto Com 2Alcaláde Henares 28805MadridSpain Cavanilles Institute of Biodiversity and Evolutionary Biology University of Valenciac/Catedrático JoséBeltrán 246980PaternaValenciaSpain

Fish constitutes the main protein source for the Amazonian ***,the impact of different anthropogenic activities on trace element and metal accumulation in fish and their risks for human health at a regional scale remain largely *** we assessed exposure levels of 10 trace elements andmetals(Cr,Mn,Fe,Ni,Cu,Zn,As,Cd,Pb,and Hg)in 56 samples belonging to 11 different species of fish from the Brazilian *** studied the relationship between exposure levels,fish origin,and fish feeding habits,and assessed toxicological and carcinogenic risks for the Amazonian *** significant correlation was found between sampling site and exposure levels to the studied elements,but a significant difference was found between the accumulation of some metals and the position of the fish species in the food *** concentrations of Cr and Hg in fish flesh were found to exceed the Brazilian limits for human *** study shows that current fish consumption patterns can lead to estimated daily intakes of Hg,As and Cr that exceed the oral reference dose,thus posing a toxicological ***,carcinogenic risks may be expected due to the continued exposure to Cr and *** results of this study show that the consumption of wild caught fish in the Amazon region should be ***,continued monitoring of trace element and metal contamination in fish and on the health of the Amazonian population is recommended,particularly for riverine and indigenous communities.

关键词： Metals Deforestation Mining Freshwater ecosystems Carcinogenic risks Amazon

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瑞吉欧学校

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现代装饰 2023年第2期 86-91页

作者： Andrés Jaque Roberto Gonzalez Garcia Luis Gonzalez Cabrera alberto heras Ismael Medina Manzano Jesus Meseguer Cortés Paola Pardo-Castillo Rajvi Anandpara Juan David Barreto Ines Barros Ludovica Battista Shubhankar Bhajekar Elise Durand Drishti Gandhi Maria Karagianni Bansi Mehta Alessandro Peja Meeerati Rana Mishti Shah Saumil Shanghavi JoséHevia(摄影) 范嘉苑(编译) 不详

瑞吉欧学校(Reggio School)的设计理念是通过建筑环境来激发孩子们的探索和求知欲。因此,该建筑被视作一个复杂的生态系统,让孩子们在通过自我驱动的集体实验过程中引导自身教育,这也遵循了罗里斯·马拉古奇(Loris Malaguzzi)和意大利... 详细信息

瑞吉欧学校(Reggio School)的设计理念是通过建筑环境来激发孩子们的探索和求知欲。因此,该建筑被视作一个复杂的生态系统,让孩子们在通过自我驱动的集体实验过程中引导自身教育,这也遵循了罗里斯·马拉古奇(Loris Malaguzzi)和意大利吉欧·艾米利亚市当地家长共同提出的教育理念,旨在增强孩子们应对不可预测挑战和潜在风险的能力。从该建筑的设计、建造到使用,都旨在超越可持续的范式,并将生态作为一种路径,继而将环境影响、多种群类别、物质动态化、集体治理以及教学方法通过建筑相交汇。

关键词：瑞吉欧艾米利亚环境影响教学方法生态系统不可预测教育理念自我驱动

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Methodology for the assessment of the friction torque of ball slewing bearings considering preload scatter

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Friction 2024年第8期12卷 1838-1857页

作者： Iñigo ESCANCIANO Iker heras Florian SCHLEICH Josu AGUIRREBEITIA Department of Mechanical Engineering University of the Basque CountryBilbao 48080Spain Fraunhofer-Institute for Wind Energy Systems IWES Hamburg 27572Germany

This manuscript presents an innovative methodology for the assessment of the friction torque of ball slewing *** methodology aims to overcome the limitations of state-of-the-art approaches,especially when the friction torque is conditioned by the preload of the *** this end,the authors propose to simulate the preload scatter when solving the load distribution problem,prior to the friction torque *** preload scatter allows to simulate a progressive transition of the balls from a four-point contact state to a two-point contact *** implementing this capability into an analytical model,the authors achieve a successful correlation with experimental ***,depending on the stiffness of the structures to which the bearing is assembled,it is demonstrated that the rigid ring assumption can lead to inaccurate friction torque results when a tilting moment is *** methodology described in this research work is meant to have a practical ***,the manuscript provides guidelines about how to use and tune the analytical model to get a reliable friction torque prediction tool.

关键词： slewing bearing ball bearing friction torque preload scatter

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Simultaneous Raman and reflection UV/Vis absorption spectroelectrochemistry

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Nano Research 2022年第6期15卷 5340-5346页

作者： Sheila Hernandez Juan V.Perales-Rondon Aranzazu heras Alvaro Colina Department of Chemistry Universidad de BurgosPza.Misael Banuelos s/ñBurgos E-09001Spain Department of Analytical Chemistry Physical Chemistry and Chemical EngineeringUniversity of Alcala.Ctra.Madrid-BarcelonaKm.33.600MadridAlcaláde Henares E-28871Spain

In the present work,a new combination of Raman and ultraviolet and visible(UV/Vis)absorption spectroelectrochemistry in reflection mode is *** new experimental setup allows obtaining the two kinds of spectroscopic data without interferences concomitantly with the electrochemical *** the best of our knowledge,it is the first time to report the simultaneous obtention of electrochemical,electronic,and vibrational information in the same *** new combination provides time-resolved information about the processes that are taking place on the electrode/solution interface which has significant implications in different fields of chemistry,such as modification of electrodes,studies of electrocatalytic reaction mechanisms,development of sensors,among *** different systems were used to demonstrate the advantages and capabilities of the brand-new technique,namely,the oxidation of potassium ferrocyanide,an out-sphere system that is usually employed in the validation of SEC techniques,and the electrochemical-surface enhanced Raman spectroscopy(EC-SERS)detection of crystal violet by in-situ formation of the silver SERS substrate,where the UV/Vis spectra were used to follow the formation of the SERS substrate,whereas the Raman response of a probe molecule was used to confirm either the formation of a nanostructured surface and to obtain the fingerprint of the molecule with a high time *** brand-new experimental setup has shown to be useful,versatile,robust,compact,and easy to use for future applications.

关键词： spectroelectrochemistry surface enhanced Raman spectroscopy(SERS) Raman ultraviolet and visible(UV/Vis)absorption nanoparticles

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CXC family of chemokines as prognostic or predictive biomarkers and possible drug targets in colorectal cancer

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World Journal of Gastroenterology 2018年第42期24卷 4738-4749页

作者： Sara Cabrero-de las heras Eva Martínez-Balibrea Program Against Cancer Therapeutic Resistance Catalan Institute of OncologyGermans Trias i Pujol health research institute Program of Predictive and Personalized Cancer Medicine Germans Trias i Pujol health research institute

Colorectal cancer(CRC) is the third most common cancer in men and the second most common cancer in women,worldwide. In the early stages of the disease, biomarkers predicting early relapse would improve survival *** metastatic patients, the use of predictive biomarkers could potentially result in more personalized treatments and better outcomes. The CXC family of chemokines(CXCL1 to 17) are small(8 to 10 kDa) secreted proteins that attract neutrophils and lymphocytes. These chemokines signal through chemokine receptors(CXCR) 1 to *** studies have reported that these chemokines and receptors have a role in either the promotion or inhibition of cancer, depending on their capacity to suppress or stimulate the action of the immune system, *** general terms, activation of the CXCR1/CXCR2 pathway or the CXCR4/CXCR7 pathway is associated with tumor aggressiveness and poor prognosis; therefore,the specific inhibition of these receptors is a possible therapeutic strategy. On the other hand, the lesser known CXCR3 and CXCR5 axes are generally considered to be tumor suppressor signaling pathways, and their stimulation has been suggested as a way to fight *** pathways have been studied in tumor tissues(using immunohistochemistry or measuring mRNA levels)or serum [using enzyme-linked immuno sorbent assay(ELISA) or multiplexing techniques], among other sample types. Common variants in genes encoding for the CXC chemokines have also been investigated as possible biomarkers of the disease. This review summarizes themost recent findings on the role of CXC chemokines and their receptors in CRC and discusses their possible value as prognostic or predictive biomarkers as well as the possibility of targeting them as a therapeutic strategy.

关键词： Biomarkers Treatment Chemotherapy Oxaliplatin Irinotecan Immunotherapy Colorectal cancer CXC chemokines Immune system Bevacizumab

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Shaken not stirred: A molecular contribution to the systematics of genus Mugil (Teleostei, Mugilidae)

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Integrative Zoology 2016年第4期11卷 263-281页

作者： Sandra heras Ferruccio MALTAGLIATI Maria Victoria FERNÁNDEZ María Inés ROLDÁN Laboratory of Genetic Ichthyology University of GironaGironaSpain Department of Biology University of PisaPisaItaly

With this work we addressed some molecular systematic issues within the Mugil cephalus species ***ticular attention was paid to the debated situations of:(i)Mugil liza,occurring in partial sympatry with Mugil cephalus in the northwestern Atlantic,and(ii)Mugil platanus,considered by some authors a synonymy of the former species and distributed in the southwestern *** sequenced 79 individuals of a 465-bp portion of the mitochondrial control region(CR)from 8 western Atlantic and 2 Mediterranean *** addition,all CR sequences available from GenBank for the studied taxa were added to our dataset,for a total of 323 indi***,229 haplotypes corresponding to 8 divergent monophyletic lineages were *** of phylogenetic analyses were consistent with the occurrence of past speciation events producing the observed lin*** these lineages,7 correspond to cryptic species and one is constituted by *** and *** a matter of fact,these 2 taxa constitute a single lineage within the *** species ***,individuals of ***/*** lineage analyzed by means of the 18 mitochondrial markers available in GenBank exhibited a degree of genetic diversity consistent with highly divergent *** the 8 lineages detected,the Mediterraean one(type locality)corresponds to ***;the lineage ***/*** should be named ***,under the priority principle,and the left 6 lineages need formal description.

关键词： cryptic species historical demography molecular phylogeny Mugil systematics

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Predicting the performance of steam assisted gravity drainage (SAGD) method utilizing artificial neural network (ANN)

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Petroleum 2020年第4期6卷 368-374页

作者： Areeba Ansari Marco heras Julianne Nones Mehdi Mohammadpoor Farshid Torabi Faculty of Engineering and Applied Science University of ReginaReginaSaskatchewanS4S 0A2Canada

As the price of oil decreases,it is becoming increasingly important for oil companies to operate in the most costeffective *** problem is especially apparent in Western Canada,where most oil production is dependent on costly enhanced oil recovery(EOR)techniques such as steam-assisted gravity drainage(SAGD).Therefore,the goal of this study is to create an artificial neural network(ANN)that is capable of accurately predicting the ultimate recovery factor of oil reservoirs by steam-assisted gravity drainage(SAGD).The developed ANN model featured over 250 unique entries for oil viscosity,steam injection rate,horizontal permeability,permeability ratio,porosity,reservoir thickness,and steam injection pressure collected from *** collected data set was entered through a feed-forward back-propagation neural network to train,validate,and test the model to predict the recovery factor of SAGD method as accurate as *** from this study revealed that the neural network was able to accurately predict recovery factors of selected projects with less than 10%*** the neural network was exposed to a new simulation data set of 64 points,the predictions were found to have an accuracy of 82%as measured by linear ***,the feasibility of ANN to predict the recovery performance of one of the most complicated enhanced heavy oil recovery techniques with reasonable accuracy was confirmed.

关键词： Enhanced oil recovery Steam assisted gravity drainage Artificial neural network

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The extractable hydrokinetic power from an oscillating membrane-based harvester

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Theoretical & Applied Mechanics Letters 2019年第2期9卷 66-70页

作者： Francisco J.Arias Salvador De Las heras Department of Fluid Mechanics University of Catalonia

The extractable hydrokinetic power from an oscillating membrane in standing motion and induced by a water flow and its possible significance with regard energy harvesting is *** main attractiveness of such an energy harvester lies in the possibility of an inexpensive technology able to be used in those water flows which either because limitation of space(narrow channels) or a limited differential pressure drop with the surrounding but yet with a non negligible velocity are not well suited to be turbined. Utilizing a simplified geometrical model, an estimate of the extractable output density power per area of membrane was derived. Preliminary experiments were performed using a rectangular thin rubber membrane and for a typical domestic water intake as source. The experimental data quantitatively agree very well with the theoretical prediction where it was found that for water flows around 2 m/s the output power density from the membrane may be around 30 mW/cm^2 of membrane. Additional research and development is required in order to arrive at a reliable practical and commercial design.

关键词： Energy harvesting Residual waters Waste waters

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Metabolism of tissue macrophages in homeostasis and pathology

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Cellular & Molecular Immunology 2022年第3期19卷 384-408页

作者： Stefanie K.Wculek Gillian Dunphy Ignacio heras-Murillo Annalaura Mastrangelo David Sancho Immunobiology Laboratory Centro Nacional de Investigaciones Cardiovasculares(CNIC)Melchor Fernández Almagro 3Madrid28029Spain

Cellular metabolism orchestrates the intricate use of tissue fuels for catabolism and anabolism to generate cellular energy and structural *** emerging field of immunometabolism highlights the importance of cellular metabolism for the maintenance and activities of immune *** are embryo-or adult bone marrow-derived leukocytes that are key for healthy tissue homeostasis but can also contribute to pathologies such as metabolic syndrome,atherosclerosis,fibrosis or *** metabolism has largely been studied in ***,different organs contain diverse macrophage populations that specialize in distinct and often tissue-specific *** context specificity creates diverging metabolic challenges for tissue macrophage populations to fulfill their homeostatic roles in their particular microenvironment and conditions their response in pathological ***,we outline current knowledge on the metabolic requirements and adaptations of macrophages located in tissues during homeostasis and selected diseases.

关键词： Tissue macrophages metabolism homeostasis pathology tissue regeneration

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An optimized high quality male DNA extraction from spermatophores in open thelycum shrimp species

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Integrative Zoology 2017年第5期12卷 421-427页

作者： Laia PLANELLA Sandra heras Manuel VERA José-Luis GARCÍA-MARÍN María Inés ROLDÁN Laboratory of Genetic Ichthyology University of GironaGironaSpain

The crucial step of most of the current genetic studies is the extraction of DNA of sufficient quantity and *** genomic DNA isolation methods have been described to successfully obtain male DNA from shrimp ***,all current protocols require invasive handling methods with males for DNA *** Aristeus antennatus as a model we tested a reliable non-invasive differential DNA extraction method to male DNA isolation from spermatophores attached to female *** present protocol provides high quality and quantity DNA for polymerase chain reaction amplification and male *** new approach could be useful to experimental shrimp culture to select sires with relevant genetic patterns for selective breeding *** importantly,it can be applied to identify the mating pairs and male structure in wild populations of species as ***,where males are often difficult to *** method could be also valuable for biological studies on other spermatophore-using species,such as myriapods,arachnids and insects.

关键词： differential spermatophore DNA extraction high quality DNA male genotyping non-invasive DNA extraction open thelycum shrimp

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