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nucleoside modified mRnA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： Krisztián Pajer Tamás Bellák Antal nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

Spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(Khyeam et al.,2021).

关键词： injured capacity modified

Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： Carina Hromada Patrick Heimel Markus Kerbl lászlóGál Sylvia nürnberger Barbara Schaedl James Ferguson nicole Swiadek Xavier Monforte Johannes C.Heinzel Antal nógrádi Andreas H.Teuschl-Woller David Hercher Department life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cluster for Tissue Regeneration ViennaAustria ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University Clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tnGCs). However, the use of tnGCs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tnGC would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tnGCs and compared the various features of these improved silk^(+) tnGCs with the tubes without holes(silk^(–) tnGCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tnGCs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tnGCs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tnGCs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tnGCs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

Kalman Filter and H_(∞)Filter Based linear Quadratic Regulator for Furuta Pendulum

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Computer Systems Science & Engineering 2022年第11期43卷 605-623页

作者： n.Arulmozhi T.Aruldoss albert Victorie Department of Electronics and Instrumentation Engineering Government College of TechnologyCoimbatoreTamil NaduIndia Department of Electrical and Electronics Engineering Anna UniversityRegional CampusCoimbatoreTamil NaduIndia

This paper deals with Furuta Pendulum(FP)or Rotary Inverted Pendulum(RIP),which is an under-actuated non-minimum unstable non-linear *** process considered along with uncertainties which are unmodelled and analyses the performance of linear Quadratic Regulator(lQR)with Kalman filter and H∞filter as two filter *** lQR is a technique for developing practical feedback,in addition the desired x shows the vector of desirable states and is used as the external input to the closed-loop *** effectiveness of the two filters in FP or RIP are measured and contrasted with rise time,peak time,settling time and maximum peak overshoot for time domain *** filters are also tested with gain margin,phase margin,disk stability margins for frequency domain performance and worst case stability margins for performance due to *** H-infinity filter reduces the estimate error to a minimum,making it resilient in the worst case than the standard Kalman ***,when theβrestriction value lowers,the H∞filter becomes more *** worst case gain performance is also focused for the two filter configurations and tested where H∞filter is found to outperform towards robust stability and *** the switchover between the two filters is dependent upon a user-specified co-efficient that gives the flexibility in the design of non-linear *** non-linear process is tested for set point tracking,disturbance rejection,un-modelled noise dynamics and uncertainties,which records robust performance towards stability.

关键词： Furuta pendulum linear quadratic regulator kalman filter non-linear process two filter configurations

Cardiogenic shock due to left main related myocardial infarction:is revascularization enough?

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Journal of Geriatric Cardiology 2022年第2期19卷 152-157页

作者： Francisco Galván-Román Elena Puerto Roberto Martín-Asenjo albert Ariza-Solé Department of Cardiology Bellvitge University Hospital.Grup de Malalties Cardiovasculars.Institut d´InvestigacióBiomèdica de Bellvitge(IDIBELL).L’Hospitalet de LlobregatBarcelonaSpain Department of Cardiology Doce de Octubre University Hospital.Instituto de Investigación Sanitaria Hospital 12 de Octubre(imas12).MadridSpain*The authors contributed equally to this manuscript

The incidence of cardiogenic shock(CS)complicating acute myocardial infarction(AMI-CS)remains between 3%and 10%and in-hospital mortality is hardly less than 30%.[1-3]In addition,the economic cost of caring for these patients is high.[4]Revascularization in the acute phase is the only measure that has demonstrated to modify the prognosis of AMI-CS.

关键词： infarction acute mortality

Restoration of Motor Function through Delayed Intraspinal Delivery of Human Il-10-Encoding nucleoside-Modified mRnA after Spinal Cord Injury

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Research 2023年第4期2023卷 131-144页

作者： lászlóGál Tamás Bellák Annamária Marton Zoltán Fekécs Drew Weissman Dénes Török Rachana Biju Csaba Vizler Rebeka Kristóf Mitchell B.Beattie Paulo J.C.lin norbert Pardi Antal nógrádi Krisztián Pajer Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary national Biotechnology laboratory Institute of GeneticsBiological Research CentreSzegedHungary Institute of Biochemistry Biological Research CentreSzegedHungary Department of Medicine University of PennsylvaniaPhiladelphiaPA19104USA Acuitas Therapeutics VancouverBCV6T 1Z3Canada

Efficient in vivo delivery of anti-inflammatory proteins to modulate the microenvironment of an injured spinal cord and promote neuroprotection and functional recovery is a great ***-modified messenger RnA(mRnA)has become a promising new modality that can be utilized for the safe and efficient delivery of therapeutic ***,we used lipid nanoparticle(lnP)-encapsulated human interleukin-10(hIl-10)-encoding nucleoside-modified mRnA to induce neuroprotection and functional recovery following rat spinal cord contusion *** administration of hIl-10 mRnA-lnP to rats led to a remarkable reduction of the microglia/macrophage reaction in the injured spinal segment and induced significant functional recovery compared to ***,hIl-10 mRnA treatment induced increased expression in tissue inhibitor of matrix metalloproteinase 1 and ciliary neurotrophic factor levels in the affected spinal segment indicating a time-delayed secondary effect of Il-105 d after *** results suggest that treatment with nucleoside-modified mRnAs encoding neuroprotective factors is an effective strategy for spinal cord injury repair.

关键词： protective Restoration utilized

Evaluation of ligninolytic activity in spent mushroom substrate from four cultivated mushrooms

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Journal of Bioresources and Bioproducts 2022年第4期7卷 288-294页

作者： Ana Marión Pérez-Chávez María Melisa alberti Edgardo albertó laboratory of Mycology and Mushroom Cultivation.Instituto Tecnológico de Chascomús(InTECH) Universidad Nacional de San Martín(UNSAM)-Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)Intendente Marino AveCC 164.7130ChascomúsBuenos AiresArgentina

Spent mushroom substrate(SMS)is an abundant residue generated by the mushroom industry,which is mostly *** this study,the SMS of four cultivated mushrooms were evaluated as potential sources of ligninolytic *** ostreatus,***,*** and Ganoderma lucidum were cultivated in two differen. substrates to determine growth,mushroom yields and ligninolytic activity of laccase(lac)and manganese peroxidase(MnP).Maximum activities in the SMS were 3.731 U/g lac and 0.191 U/g MnP,both for *** mushroom substrates were also analyzed,and higher activities were found in almost all samples.A correlation test between mushroom yields and ligninolytic activities of each culture was made,and we found that high enzymatic activity in the substrate did not result in high mushroom productivity or vice *** SMS was a good source of ligninolytic *** activity depended on the mushroom species and its affinity to the substrate,and it was not influenced by the mushroom *** of mushrooms in diverse lignocellulosic substrates is gaining interest,and ob-taining ligninolytic enzymes from residual SMS is an excellent alternative in the circular economy concept.

关键词： laccase Manganese peroxidase Biological efficiency Pleurotus spp Ganoderma lucidum Circular economy

Performance of statistical and machine learning-based methods for predicting biogeographical patterns of fungal productivity in forest ecosystems

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Forest Ecosystems 2021年第2期8卷 278-291页

作者： albert Morera Juan Martínez de Aragón José Antonio Bonet Jingjing liang Sergio de-Miguel Department of Crop and Forest Sciences University of LleidaAv.Alcalde Rovira Roure 191E-25198 LleidaSpain Joint Research Unit CTFC-AGROTECnIO-CERCA Center Av.Rovira Roure 19125198 LleidaSpain Forest Science and Technology Centre of Catalonia Ctra.Sant Llorençde Morunys km 225280 SolsonaSpain Forest Advanced Computing and Artificial Intelligence laboratory Department of Forestry and Natural ResourcesPurdue UniversityWest LafayetteIN 47907USA

Background:The prediction of biogeographical patterns from a large number of driving factors with complex interactions,correlations and non-linear dependences require advanced analytical methods and modeling *** study compares differen. statistical and machine learning-based models for predicting fungal productivity biogeographical patterns as a case study for the thorough assessment of the performance of alternative modeling approaches to provide accurate and ecologically-consistent ***:We evaluated and compared the performance of two statistical modeling techniques,namely,generalized linear mixed models and geographically weighted regression,and four techniques based on differen. machine learning algorithms,namely,random forest,extreme gradient boosting,support vector machine and artificial neural network to predict fungal *** evaluation was conducted using a systematic methodology combining random,spatial and environmental blocking together with the assessment of the ecological consistency of spatially-explicit model predictions according to scientific ***:Fungal productivity predictions were sensitive to the modeling approach and the number of predictors ***,the importance assigned to differen. predictors varied between machine learning modeling *** tree-based models increased prediction accuracy by more than 10%compared to other machine learning approaches,and by more than 20%compared to statistical models,and resulted in higher ecological consistence of the predicted biogeographical patterns of fungal ***:Decision tree-based models were the best approach for prediction both in sampling-like environments as well as in extrapolation beyond the spatial and climatic range of the modeling *** this study,we show that proper variable selection is crucial to create robust models for extrapolation in biophysically differen.iated *** allows for reducing the dime

关键词： Modeling Regression Biogeography Climate Forest Fungi Mushrooms

In-Situ Annealing Study of Transformation of α and γ Texture of Interstitial-Free Steel Sheet by High-Energy X-Ray Diffraction

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Journal of Iron and Steel Research International 2013年第5期20卷 38-41页

作者： lIU Yan-dong ZHAnG Yu-dong ren.Yang albert Tidu ZUO liang Key laboratory for Anisotropy and Texture of Materials of Ministry of Education Northeastern University lETAM/ISGMP CNRS X-Ray Science Division Argonne national laboratory

High-energy synchrotron diffraction offers great potential for experimental study of recrystallization kinetics. An experimental design to study the recrystallization mechanism of interstitial-free （IF） steel was implemented. The whole annealing process of cold-rolled IF steel with 80% reduction was observed in situ using high-energy X-ray diffraction （HEXRD）. The results show how the main texture component of IF steel change, i.e. the α [∥rolling direction （RD）] fiber texture decreases and the γ [∥normal direction （nD）] fiber texture increases. The important part of the α fiber texture is that both the {100} and {112} texture decrease at the beginning of recrystallization. The γ fiber texture increases at the early stage of recrystallization which stems from the increase of {111}. nevertheless, the {111} does not change after recrystallization. The dynamic evolution of the main texture components {100}, {112}, {111} and {111} is given by in-situ HEXRD.

关键词： IF steel texture recrystallization high-energy X-ray diffraction Debye-Scherrer ring

A Method Based on Thermo-Vibrational Effects for Hydrogen Transportation and Storage

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Fluid Dynamics & Materials Processing 2024年第12期20卷 2775-2788页

作者： Tatyana P.lyubimova Sergey A.Plotnikov albert n.Sharifulin Vladimir Ya.Modorskii S.neshev Stanislav l.Kalyulin Institute of Continuous Media Mechanics Ural Branch of Russian Academy of SciencesPerm614013Russia Aerospace Faculty Perm National Research Polytechnic UniversityPerm614990Russia

Transporting and storing hydrogen is a complex technological task.A typical problem relates to the need to minimize the stren.th of fluid motion and heat transfer near the walls of the *** this work this problem is tackled numerically assuming an infinite cavity of pipe square cross-section,located in a constant external temperature *** particular,a method based on the application of vibrations to suppress the gravitational convection mechanism is explored.A parametric investigation is conducted and the limits of applicability of the method for small Grashof numbers(10e4)are *** is shown that it is possible to minimize the intensity of the vibrogravitational flow for any values of the problem parameters if correction factors are *** results obtained can be applied in technological processes associated with the transportation,storage and use of hydrogen:pumping the working fluid through pipes,storage in tanks,as well as flow processes in the combustion chambers of power plants.

关键词： Thermal vibration convection vibrations vortex structures square pipe cavity hydrogen transportation and storage