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Journal of Cancer Therapy 2024年第4期15卷 179-189页

作者： Bafunyembaka Muka Alain Kitumaini Munyahali John Ciruza Balegana Jean-Claude Lobe Lottin Michel Luhiriri Ndanda Levi Kavira Isse Somo Prisca Amisi Mangaza Emilie Alumeti Munyali Desire Ahuka Ona Longombe albert Department of Surgery H.G.R Panzi/Universit&#233 Evang&#233liqueen Afrique Bukavu DR Congo

A retrospective study was conducted at the HGR de Panzi in eastern DR Congo to determine the profile of colorectal cancer (CRC) management based on 55 cases out of 129 digestive cancers diagnosed in the digestive surgery, endoscopy, and pathology department of the HGR de Panzi from January 2002 to December 2016. The prevalence of CRC was 42.6%. The mean age of patients was 50.8 years, with a range of 20 to 81 years. The male to female ratio was 2.2. In 69.1% of cases, the patients had a low socioeconomic status, and 52.7% had a history of hemorrhoids. Rectorrhagia revealed CCR in 49.1% of cases. The mode of discovery was predominantly emergency in 69.1% of cases, and 58.20% of CRCs were diagnosed by an initial endoscopy of the lower colon. Adenocarcinoma was found in 94.5% of cases, and 45% of cases required abdominoperineal amputation. Various postoperative complications were experienced by 54.5% of patients, and 25.5% of patients died. To decrease the occurrence of these types of cancers, it is necessary to focus on early detection in the population and enhance access to primary healthcare for everyone.

关键词： Assessment Management Colorectal Cancer

Research on Information Architecture Design of Short-Form Video Social Platforms Based on Cognitive Psychology

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Psychology Research 2024年第1期14卷 1-13页

作者： Zhengyang Liu albert Young Choi Hanyang University ERICA AnsanSouth Korea

This study investigates how cognitive psychology principles can be integrated into the information architecture design of short-form video platforms,like TikTok,to enhance user experience,engagement,and *** a questionnaire,it explores TikTok users’habits and preferences,highlighting how social media fatigue(SMF)impacts their interaction with the *** paper offers strategies to optimize TikTok’s *** suggests refining the organizational system using principles like chunking,schema theory,and working memory ***,it proposes incorporating shopping features within TikTok’s interface to personalize product suggestions and enable monetization for influencers and content ***,the study underlines the need to consider gender differences and user preferences in improving TikTok’s sharing features,recommending streamlined and customizable sharing options,collaborative sharing,and a system to acknowledge sharing *** to strengthen social connections and increase sharing likelihood,this research provides insights into enhancing information architecture for short-form video platforms,contributing to their growth and success.

关键词： information architecture design short-form video social cognitive psychology user experience

The Inheritance and Application of Chinese Reverse Contrast Typeface Style

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Psychology Research 2024年第2期14卷 70-80页

作者： Suimeng Qin albert Young Choi Hanyang University ERICA AnsanSouth Korea

This paper discusses the inheritance and application of Chinese character reverse contrast typeface *** begins by analyzing the visual features of Western reverse contrast typeface styles,with a focus on Caslon Italian and French Clarendon,providing a Western perspective reference for subsequent Chinese character reverse contrast typeface style *** paper then traces the origins of the Chinese reverse contrast style,from the calligraphy style"Lacquer Script"to the earliest printing type"フワンテール形",exploring the historical background and cultural significance of the Chinese reverse contrast *** the methodology section of Chinese character reverse contrast typeface style design,the discussion is conducted from two dimensions:inheritance and *** terms of inheritance,through an in-depth analysis of"Lacquer Script"and"フワンテール形"typeface style,the paper summarizes three basic theories for modern Chinese character reverse contrast typeface style *** the application section,it examines in detail the two most influential recent typeface styles,"Ribaasu"and"Basic Artistic",outlining three directions of application:extreme horizontal stroke variations,exaggerated contrast,and diverse decorative strokes,showcasing new directions and possibilities for Chinese character reverse contrast typeface style *** paper not only reviews the developmental history of the Chinese character reverse contrast typeface style but also analyzes the design methodology of Chinese character reverse contrast typeface style through specific case studies.

关键词： reverse contrast fonts Chinese character font design design method

Difficult treatment decisions in autoimmune hepatitis

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World Journal of Gastroenterology 2010年第8期16卷 934-947页

作者： albert J Czaja Division of Gastroenterology and Hepatology Mayo Clinic College of Medicine

Treatment decisions in autoimmune hepatitis are complicated by the diversity of its clinical presentations,uncertainties about its natural history,evolving opinions regarding treatment end points,varied nature of refractory disease,and plethora of alternative immu-nosuppressive agents. The goals of this article are to review the difficult treatment decisions and to provide the bases for making sound therapeutic judgments. The English literature on the treatment problems in au-toimmune hepatitis were identifi ed by Medline search up to October 2009 and 32 years of personal experi-ence. Autoimmune hepatitis may have an acute severe presentation,mild in? ammatory activity,lack autoan-tibodies,exhibit atypical histological changes (centri-lobular zone 3 necrosis or bile duct injury),or have variant features reminiscent of another disease (overlap syndrome). Corticosteroid therapy must be instituted early,applied despite the absence of symptoms,or modified in an individualized fashion. Pursuit of normal liver tests and tissue is the ideal treatment end point,but this objective must be tempered against the risk of side effects. Relapse after treatment withdrawal requires long-term maintenance therapy,preferably with azathioprine. Treatment failure or an incomplete response warrants salvage therapy that can include conventional medications in modified dose or empiricaltherapies with calcineurin inhibitors or mycophenolate mofetil. Liver transplantation supersedes empirical drug therapy in decompensated patients. Elderly and pregnant patients warrant treatment modifications. Difficult treatment decisions in autoimmune hepatitis can be simplified by recognizing its diverse manifestations and individualizing treatment,pursuing realistic goals,applying appropriate salvage regimens,and identifying problematic patients early.

关键词： Autoimmune hepatitis Fulminant hepatitis Salvage therapy Treatment end points

Pedestrian walking speed at un-signalized midblock crosswalk and its impact on urban street segment performance

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Journal of Traffic and Transportation Engineering(English Edition) 2021年第1期8卷 57-69页

作者： albert Forde Janice Daniel Division of Statewide Planning New Jersey Department of TransportationTrentonNJ 08625USA Department of Civil and Environmental Engineering New Jersey Institute of TechnologyNewarkNJ 07102USA

The Urban Street Segment Chapter of the Highway Capacity Manual(HCM)includes a methodology for evaluating the level of service urban street segments provide to automobile *** methodology does not account for pedestrian activity at un-signalized midblock crosswalk on an urban street *** activity at un-signalized midblock crosswalk on urban street segments causes friction conditions between automobiles and *** a consequence,the average time it takes vehicles to travel along the segment is *** segment running time decreases both the travel speed of automobiles and the level of service provided to automobile *** is an inverse relationship between the delay incurred by interrupted vehicles and the speeds at which pedestrians walk while crossing at *** account for this delay,there is a need to investigate pedestrian walking speeds at un-signalized midblock *** study measured pedestrian walking speeds by age-group at two un-signalized midblock crosswalks on urban street *** first objective of this paper is to perform statistical analyses to examine the measured free-flow pedestrian walking *** second objective is to demonstrate how the findings of this study can be incorporated into the Urban Street Segment Analysis Chapter of the *** walking speeds were recorded and analyzed for 2937 *** results show teenagers walk at an average speed of 1.45 m/s,young adults walk at an average speed of 1.55 m/s,middle age pedestrians walk at a speed of 1.45 m/s,older pedestrians walk at speed of 1.09 m/s,and elderly or physically disabled pedestrians walk at a speed of 1.04 m/s.

关键词： Midblock Pedestrian Walking speed HCM Urban Street

Elevated 5-hydroxymethycytosine and cell apoptosis induced by tetrachloro-1,4-benzoquinone in mouse embryonic stem cells

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Journal of Environmental Sciences 2017年第1期29卷 1-4页

作者： albert Zuehlke Hongquan Zhang Division of Analytical and Environmental Toxicology Department of Laboratory Medicine and PathologyUniversity of AlbertaEdmontonAlbertaT6G 2G3Canada

Pentachlorophenol（PCP）has been extensively used as a fungicide,bactericide,herbicide,*** and insecticide worldwide（Ahlborg and Thunberg,1980：Choudhury et al.,1986）.Although PCP is primarily used as a preservative for wood and wood products,it has been also used in a variety of other products,including adhesives,construction materials,leather and paper.

关键词： Tetrachloro-1 4-benzoquinone (TCBQ) DNA methylation 5-hydroxymethylcytosine(5hmC) Apoptosis Stem cells

Regulation of expression of drug-metabolizing enzymes by oncogenic signaling pathways in liver tumors: a review

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Acta Pharmaceutica Sinica B 2020年第1期10卷 113-122页

作者： albert Braeuning Michael Schwarz German Federal Institute for Risk Assessment Dept.Food SafetyBerlin 10589Germany Eberhard Karls University of Tu¨bingen Inst.of Pharmacology and ToxicologyDept.of ToxicologyTu¨bingen 72074Germany

Mutations in genes encoding key players in oncogenic signaling pathways trigger specific downstream gene expression profiles in the respective tumor cell *** regulation of genes related to cell growth,survival,and death has been extensively studied,much less is known on the regulation of drug-metabolizing enzymes(DMEs)by oncogenic ***,a comprehensive review of the available literature is presented summarizing the impact of the most relevant genetic alterations in human and rodent liver tumors on the expression of DMEs with a focus on phasesⅠandⅡof xenobiotic *** few data are available with respect to DME regulation by p53-dependent signaling,telomerase expression or altered chromatin *** contrast,DME regulation by constitutive activation of oncogenic signaling via the RAS/RAF/mitogen-activated protein kinase(MAPK)cascade or via the canonical WNT/β-catenin signaling pathway has been analyzed in greater depth,demonstrating mostly positive-regulatory effects of WNT/β-catenin signaling and negativeregulatory effects of MAPK *** studies have revealed molecular interactions between oncogenic signaling and nuclear xeno-sensing receptors which underlie the observed alterations in DME expression in liver *** of altered DME expression and inducibility in liver tumors with a specific gene expression profile may impact pharmacological treatment options.

关键词： Xenobiotic metabolism Hepatocytes WNT/b-catenin signaling RAS/MAPK signaling Gene mutation Cytochrome P450

ON THE DIFFUSION PHENOMENON OF QUASILINEAR HYPERBOLIC WAVES

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Chinese Annals of Mathematics,Series B 2000年第1期21卷 63-70页

作者： YANG HAN albert MILANI Department of Applied Mathematics South West Jiaotong University610031 ChengduChina Department of Mathematics University of Wisconsin—M ilwaukeeMilwaukeeWisconsin 53201USA

The authors consider the asymptotic behavior of solutions of the quasilinear hyperbolic equation with linear damping u_(tt)+u_(t)-div(a(u)u)=0,and show that,at least when n≥3,they tend,as t-+∞,to those of the nonlinear parabolic equation v_t-div(a(v)v)=0,in the sense that the norm||u(.,t)-v(.,t)||_(L∞(R^n))of the difference u-v decays faster than that of either u or *** provides another example of the diffusion phenomenon of nonlinear hyperbolic waves,first observed by Hsiao,*** Liu Taiping(see[1,2]).

关键词： Asymptotic behavior of solutions Quasilinear hyperbolic and parabolic equations Diffusion phenomenon

On the material dependence of experimental shear fracture orientation

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Science China Earth Sciences 2015年第12期58卷 2357-2362页

作者： Enrique GOMEZ-RIVAS albert GRIERA Department of Geology and Petroleum Geology School of Geosciences King’s College University of Aberdeen Departament de Geologia Universitat Autònoma de Barcelona

It is not uncommon to observe shear fractures in ductile rocks oriented at more than 45° with respect to the maximum compression direction. Since these orientations cannot be explained with the classic Mohr-Coulumb or Tresca yield criteria, Zheng et al.(Journal of Structural Geology, 35: 1394–1405, 2011) proposed the maximum effective moment(MEM) failure criterion. This rule suggests that shear fractures in ductile rocks form at ?55° with the maximum compression axis and that this orientation is material-independent and, therefore, universal. Zheng et al.(Science China: Earth Sciences, 57(11): 2819–2824, 2014) used data from our own experiments as supporting evidence of their failure criterion. In this contribution we discuss why shear fracture formation in ductile rocks indeed strongly depends on the mechanical properties of the deforming medium, and why experimental data should not be taken to prove the validity of the MEM criterion. The formation mechanisms and orientations of shear fractures in our experiments significantly vary depending on the material strength and degree and type of anisotropy(composite and intrinsic). We therefore demonstrate using experimental data that a universal failure angle in ductile and anisotropic rocks does not apply. Additionally, we highlight some inconsistencies of the MEM criterion.

关键词： shear fracture anisotropy fracture orientation material properties failure criteria ductile deformation

Old and new concepts based on coherent structures for understanding sediment transport

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International Journal of Sediment Research 2011年第3期26卷 376-384页

作者： albert GYR Inst.of Hydromechanics and Water Resources Management Swiss Federal Institute of TechnologyCH-8093Swiss

Coherent structures develop due to an instability process on smooth beds under turbulent flow conditions and they are relevant for the incipient motion of fine sand *** flow structures were found to be relevant for the sediment transport under rough wall conditions,but an instability process could not explain *** this article we show that rough walls produce a new class of A-vortices,these vortices develop from separations on the grains,and are new relevant flow structures.

关键词： Sediment transport Incipient motion Coherent structures Turbulence Separations