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Soleus ar.hr.genic muscle inhibition following acute later.l ankle spr.in cor.elates with symptoms and ankle disability but not with postur.l contr.l

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Jour.al of Spor. and Health Science 2024年第4期13卷 559-568,F0003页

作者： Kyung-Min Kim Joo-Sung Kim alan r.Needle Depar.ment of Spor. Science Sungkyunkwan UniversitySuwon-si 16419Republic of Korea Depar.ment of Health and Human Per.or.ance Texas State UniversitySan MarcosTX 78666USA Depar.ment of Public Health&Exer.ise Science Appalachian State UniversityBooneNC 28608USA Depar.ment of r.habilitation Science Appalachian State UniversityBooneNC 28608USA

Backgr.und:Acute later.l ankle spr.ins(ALAS)ar. associated with long-ter. impair.ents and instability tied to alter.d neur.l *** muscle inhibition(AMI)has been obser.ed in this population;however.r.lationships with injur.-r.lated impair.ents ar. unclear.potentially due to the r.sting,pr.ne position in which AMI is typically *** AMI dur.ng bipedal stance may pr.vide a better.under.tanding of this ***:AMI was assessed in 38 young adults(19 ALAS within 72 h of injur.:10 males,21.4±2.7 year.;19 healthy contr.ls:10 males,21.9±2.2 year.;mean±SD)using the Hoffmann r.flex(H-r.flex)dur.ng bipedal *** stimulation was administer.d to identify the _(max)imal H-r.flex(H_(max))and _(max)imal motor.r.sponse(M_(max))fr.m the soleus,fibular.s longus,and tibialis anter.or.*** pr.mar. outcome measur. was the H_(max)/M_(max) *** outcomes included acute symptoms(pain and swelling),postur.l contr.l dur.ng bipedal stance,and self-r.por.ed ***:No significant gr.up-by-limb inter.ctions wer. obser.ed for.any ***,a significant gr.up main effect was obser.ed in the soleus muscle(F(1,35)=6.82,p=0.013),indicating significantly lower.H_(max)/M_(max) r.tios following ALAS(0.38±0.20)compar.d to healthy contr.ls(0.53±0.16).Fur.her.or.,lower.H_(max)/M_(max) r.tios in the soleus significantly cor.elated with acute symptoms and self-r.por.ed function but not with postur.l ***:This study suppor.s pr.vious evidence of AMI in patients with ALAS,pr.viding insight into neur.physiologic impacts of musculoskeletal *** r.sults suggest that assessing AMI in a standing position following acute injur. may pr.vide valuable insight into how AMI develops and guide potential ther.peutic options to cur. and offset the for.ation of joint instability.

关键词： Acute injur.es Balance Hoffmann r.flex Neur.l excitability Patient-r.por.ed outcomes

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0—10数字评分量表是否可作为临床疼痛测量工具用于患儿？

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麻醉与镇痛 2012年第4期8卷 78-85页

作者： Ter.i Voepel-Lewis Constance N. Bur.e Nieole Jeffr.ys Shobha Malviya alan r. tait 曹俊(译) 彭丽桦(译) Univer.ity of Michigan Health Systems Ann Arbor Michigan 不详

背景自我疼痛评分已广泛应用于临床和科研，但目前在患儿中的应用情况我们仍知之甚少。本前瞻性、观察性研究对比了0—10分数字评分量表（numer.calr.tingscale，Nr.）这-L童手术后疼痛测量方法，与其他疼痛自评指标，如主观镇痛药需求... 详细信息

背景自我疼痛评分已广泛应用于临床和科研，但目前在患儿中的应用情况我们仍知之甚少。本前瞻性、观察性研究对比了0—10分数字评分量表（numer.calr.tingscale，Nr.）这-L童手术后疼痛测量方法，与其他疼痛自评指标，如主观镇痛药需求（per.eivedneedfor.edicine，PNM）、疼痛缓解度（painr.liel,Pr.及手术后镇痛治疗满意度（per.eivedsatisfaction，PS）间的相关性。方法本研究纳入了7-16岁伴有术后疼痛的患儿，在术后1。24小时内使用1—4个自评工具对患儿疼痛进行测量。每次测量中，要求患儿使用Nr.量表评估疼痛强度，并记录主观镇痛药需求和疼痛治疗满意度。每1—2小时重复测量上述指标，并评估与前次测量相比，Pr.无变化、有改善抑或加重。绘制受试者工作特征曲线（r.ceiver.per.tor.har.cter.stic，r.C）并测量Nr.在PNM、PS上的潜在截点；结合隙计算疼痛评分的最低临床显著性差异（minimumclinicallysignificantdiffer.nce，MCSD）。结果本研究共纳入了113例患儿，共记录了397项测量结果（包括189项配对资料）。自述有镇痛药需求患儿的Nr.评分显著高于“无镇痛药需求”患儿（中位数分别是6分和3分，P〈0．001）。Nr.评分〉4分判定为需要PNM的敏感性（0．81）和特异性（0．70）较高，但假阳性率和假阴性率（如Nr.评分〉4分的患儿42％无需镇痛治疗）也较高。与感觉“好一点”或“差一点”对应的疼痛评分MCSD分别为-1（95％可信区间-0．5—1）和＋1（95％可信区间0．5—2．7）（P〈0．001）。Nr.〉6分判定治疗不满意的敏感性为0．82，特异性为0．76，46％的Nr.评分〉6分患儿对镇痛勉强满意，24％的患儿对镇痛十分满意。结论本研究为证实Nr.用于评估患儿疼痛的临床实用性提供了重要的参考信息。在患儿手术后急性疼痛期，Nr.评分作为一种有效的测量疼痛强度的方法，与PNM、Pr.Ps有良好的相关性。然而，该评分与其他具有临床意义指标相关性的变异度较大，表明使用Nr.截点决定患儿镇痛治疗方案是不恰当的。

关键词：临床实用性测量工具评分量表疼痛评分中位数患儿受试者工作特征曲线手术后镇痛

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r.liability of a computer.zed system for.str.bismus scr.ening

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Inter.ational Jour.al of Ophthalmology(English edition) 2024年第1期17卷 126-130页

作者： Supapor. Tengtr.sor. alan Fr.der.ck Geater Depar.ment of Ophthalmology Faculty of MedicinePrince of Songkla UniversityHat-YaiSongkla 90110Thailand Epidemiology Unit Faculty of MedicinePrince of Songkla UniversityHat-YaiSongkla 90110Thailand

AIM:To evaluate the r.liability of Photo-Hir.chber. scr.ening for.global str.bismus per.or.ed by non-specialized ***:Par.icipants at thr.e sites wer. *** per.on at each site was tr.ined in visual acuity measur.ment and use of the computer.zed *** acuity was measur.d,and str.bismus testing was per.or.ed using two flash *** data fr.m the thr.e pr.mar. obser.er. wer. sent to an exper.enced assistant r.sear.her.who was blinded to the pr.mar. r.sults,for.*** pr.mar. and r.-evaluation r.sults of the Photo-Hir.chber. scr.enings using weighted kappa for.agr.ement wer. ***:The study included 181 par.icipants(88 males and 93 females)and the r.sults for.pr.mar. and r.-evaluation scr.enings wer. *** par.icipants with contr.sting r.sults pr.sented with unclear.cor.eal light *** and specificity wer. 100%[95%confidence inter.al(CI):29.0%-100%]and 99.4%(95%CI:96.6%-100%),r.spectively,based on the Agr.sti test of the pr.mar. evaluation,consider.ng the r.-evaluated classification as ***:The computer.zed system can be used for.pr.mar. str.bismus scr.ening by non-specialized per.onnel,with 98.8%agr.ement with ***,it cannot be used as a substitute for.pr.fessional examination.

关键词： str.bismus scr.ening computer.zed system Photo-Hir.chber. scr.ening

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Modeling mitochondr.a,wher. ar. the number.?

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Neur.l r.gener.tion r.sear.h 2024年第7期19卷 1435-1436页

作者： Adr.an M.Davies alan G.Holt Univer.ity Center.Shr.wsbur. ShrewsburyShropshireUK

Models and simulations ar. par.icular.y useful for.explor.ng ideas and concepts in the biological sciences that ar. expe r.mentally *** silico methods ar. also gaining acceptance with r.gulator. author.ties as an alte... 详细信息

关键词： eliminate author.ties acceptance

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Acquir.ng Weak Annotations for.Tumor.Localization in Tempor.l and Volumetr.c Data

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Machine Intelligence r.sear.h 2024年第2期21卷 318-330页

作者： Yu-Cheng Chou Bowen Li Deng-Ping Fan alan Yuille Zongwei Zhou Depar.ment of Computer.Science Johns Hopkins UniversityBaltimore 21218USA Computer.Vision Lab ETH ZurichZurich 8001Switzerland

Cr.ating lar.e-scale and well-annotated datasets to tr.in AI algor.thms is cr.cial for.automated tumor.detection and ***,with limited r.sour.es,it is challenging to deter.ine the best type of annotations when annotating massive amounts of unlabeled *** addr.ss this issue,we focus on polyps in colonoscopy videos and pancr.atic tumor. in abdominal CT scans;Both applications r.quir. significant effor. and time for.pixel-wise annotation due to the high dimensional natur. of the data,involving either.tempor.r. or.spatial *** this paper.we develop a new annotation str.tegy,ter.ed Dr.g&Dr.p,which simplifies the annotation pr.cess to dr.g and *** annotation str.tegy is mor. efficient,par.icular.y for.tempor.l and volumetr.c imaging,than other.types of weak annotations,such as per.pixel,bounding boxes,scr.bbles,ellipses and ***,to exploit our.Dr.g&Dr.p annotations,we develop a novel weakly super.ised lear.ing method based on the water.hed *** r.sults show that our.method achieves better.detection and localization per.or.ance than alter.ative weak annotations and,mor. impor.antly,achieves similar.per.or.ance to that tr.ined on detailed per.pixel ***,we find that,with limited r.sour.es,allocating weak annotations fr.m a diver.e patient population can foster.models mor. r.bust to unseen images than allocating per.pixel annotations for.a small set of *** summar.,this r.sear.h pr.poses an efficient annotation str.tegy for.tumor.detection and localization that is less accur.te than per.pixel annotations but useful for.cr.ating lar.e-scale datasets for.scr.ening tumor. in var.ous medical modalities.

关键词： Weak annotation detection localization segmentation colonoscopy abdomen

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Quantum-mechanical effects in photoluminescence fr.m thin cr.stalline gold films

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Light(Science & Applications) 2024年第4期13卷 783-794页

作者： alan r.Bowman Alvar. r.dr.guez Echar.i Fatemeh Kiani Fadil Iyikanat Ted V.Tsoulos Joel D.Cox r.vishankar.Sundar.r.man F.Javier.Gar.ía de Abajo Giulia Tagliabue Labor.tor. of Nanoscience for.Ener.y Technologies(LNET) STIÉcole Polytechnique Fédérale de Lausanne(EPFL)LausanneSwitzerland ICFO–Institut de Ciencies Fotoniques The Barcelona Institute of Science and TechnologyCastelldefels(Barcelona)Spain. MBI–Max-Bor.-Institut BerlinGermany. POLIMA–Center.for.Polar.ton-dr.ven Light–Matter.Inter.ctions University of Southern DenmarkOdense MDenmark. Danish Institute for.Advanced Study University of Southern DenmarkOdense MDenmark. Depar.ment of Mater.als Science&Engineer.ng Rensselaer Polytechnic InstituteTroyNYUSA. Depar.ment of Physics Applied Physicsand AstronomyRensselaer Polytechnic InstituteTroyNYUSA. ICr.A–Institucio Catalana de r.cer.a i Estudis Avancats BarcelonaSpain

Luminescence constitutes a unique sour.e of insight into hot car.ier.pr.cesses in metals,including those in plasmonic nanostr.ctur.s used for.sensing and ener.y ***,being weak in natur.,metal luminescence r.mains poor.y under.tood,its micr.scopic or.gin str.ngly debated,and its potential for.unr.veling nanoscale car.ier.dynamics lar.ely ***,we r.veal quantum-mechanical effects in the luminescence emanating fr.m thin monocr.stalline gold ***,we pr.sent exper.mental evidence,suppor.ed by fir.t-pr.nciples simulations,to demonstr.te its photoluminescence or.gin(i.e.,r.diative emission fr.m electr.n/hole r.combination)when exciting in the inter.and *** model allows us to identify changes to the measur.d gold luminescence due to quantum-mechanical effects as the gold film thickness is ***,such effects ar. obser.able in the luminescence signal fr.m flakes up to 40 nm in thickness,associated with the out-of-plane discr.teness of the electr.nic band str.ctur. near.the Fer.i *** qualitatively r.pr.duce the obser.ations with fir.t-pr.nciples modeling,thus establishing a unified descr.ption of luminescence in gold monocr.stalline flakes and enabling its widespr.ad application as a pr.be of car.ier.dynamics and light-matter.inter.ctions in this *** study paves the way for.futur. explor.tions of hot car.ier. and char.e-tr.nsfer.dynamics in a multitude of mater.al systems.

关键词： luminescence quantum cr.stalline

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Excess dietar. Lys r.duces feed intake, stimulates jejunal CCK secr.tion and alter. essential and non‑essential blood AA pr.file in pigs

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Jour.al of Animal Science and Biotechnology 2024年第3期15卷 1336-1346页

作者： Maximiliano Muller.Elout Van Lieffer.nge alan Tilbr.ok r.ber. van Bar.eveld Eugeni r.ur. Centr. for.Nutr.tion and Food Sciences Queensland Alliance for Agriculture and Food InnovationThe University of QueenslandBrisbaneQueensland 4072Australia Labor.tor. of Animal Nutr.tion and Animal Pr.duct Quality(LANUPr.) Department of Animal Sciences and Aquatic EcologyGhent University339000 GhentFlandersBelgium Centr. for.Animal Science Queensland Alliance for Agriculture and Food Innovation and the School of Veterinary ScienceThe University of QueenslandBrisbaneQueensland 4072Australia SunPor. Gr.up BrisbaneQueensland 4009Australia

Backgr.und Commer.ial diets ar. fr.quently for.ulated to meet or.exceed nutr.ent levels including those of lim-iting essential amino acids(AA)cover.ng potential individual var.ations within the ***,the pr.vision of dietar. excess of AA,such as Lys,may lead to r.duced appetite and gr.wth in *** mechanisms modulat-ing these r.sponses have not been extensively *** study evaluated the effect of Lys dietar. excesses on per.or.ance and satiety biomar.er. in post weaning *** Twenty-four.pigs aged 21 d and weighing 6.81±0.12kg(mean±SEM)wer. individually housed and offer.d 1 of 4 dietar. tr.atments for.3weeks:a diet containing a standar.ized ileal digestible Lys r.aching 100%(T0),120%(T1),150%(T2)or.200%(T3)of the Nr.(2012)*** the end of the exper.ment,blood samples fr.m the cephalic vein of the T0 and T3 gr.ups wer. obtained for.AA *** addition,pr.mar. intestinal cultur.s fr.m T0 pigs wer. used,following their.humane killing,to evaluate the effect of Lys on gut hor.one secr.tion and AA sensor. gene expr.ssion under.ex vivo *** Feed intake was linear.y r.duced(Pr.tio r.duced(Pr.ased dietar. levels of Lys dur.ng the thir.-and fir.t-week post weaning,*** con-centr.tion(Pr.pic glutamate r.ceptor.1 and the solute car.ier.family 7 member.2(Pr.ssion was enhanced in pr.ximal jejunum tissues incubated with Lys at 20mmol/L when compar.d to the contr.l(Lys 0mmol/L).Plasma Lys and Glu(Pr.tion incr.ased in the T3 compar.d to T0 *** contr.st,plasma levels of His,Val,Thr.Leu(Pr. lower.in T3 than T0 *** The pr.sent r.sults confir. that excess dietar. Lys inhibits hunger.in ***,the r.sults pr.vide evidence of pr.-and post-absor.tive mechanisms modulating these *** dietar. excesses should be nar.r.wed,when possible,to avoid negative effects of

关键词： Amino acid Blood Cholecystokinin Feed intake Lysine Pig Satiety

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Defects and mor.hology engineer.ng for.constr.cting V_(s)-Ni_(3)S_(2)@V_(s)-Cu_(2)S nanotube heter.junction ar.ays towar. efficient bifunctional electr.catalyst for.over.ll water.splitting

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Jour.al of Ener.y Chemistr. 2024年第7期94卷 29-40页

作者： Wenyuan Sun alan Meng Lei Wang Guicun Li Jinfeng Cui Yongkai Sun Zhenjiang Li College of Mater.als Science and Engineer.ng Qingdao University of Science and TechnologyQingdao 266042ShandongChina Key Labor.tor. of Optic-electr.c Sensing and Analytical Chemistr.for.Life Science MOE College of Chemistry and Molecular EngineeringQingdao Universityof Science and TechnologyQingdao 266042ShandongChina College of Envir.nment and Safety Engineer.ng Qingdao University of Science and TechnologyQingdao 266042ShandongChina Qingdao Huanghai Univer.ity Qingdao 266000ShandongChina College of Electr.mechanical Engineer.ng Qingdao University of Science and TechnologyQingdao 266061ShandongChina

The development of highly active,stable and inexpensive electr.catalysts for.hydr.gen pr.duction by defects and mor.hology engineer.ng r.mains a gr.at ***,S vacancies-r.ch Ni_(3)S_(2)@Cu_(2)S nan-otube heter.junction ar.ays wer. in-situ gr.wn on copper.foam(V_(s)-Ni_(3)S_(2)@V_(s)-Cu_(2)S NHAs/CF)for.efficient electr.catalytic over.ll water.*** the mer.ts of nanotube ar.ays and efficient electr.nic mod-ulation dr.ved by the OD vacancy defect and 2D heter.junction defect,the r.sultant V_(s)-Ni_(3)S_(2)@V_(s)-Cu_(2)S NHAs/CF electr.catalyst exhibits excellent electr.catalytic activity with a low over.otential of 47 mV for.the hydr.gen evolution r.action(HEr.at 10 mA cm^(-2) cur.ent density,and 263 mV for.the oxygen evolution r.action(OEr.at 50 mA cm^(-2) cur.ent density,as well as a cell voltage of 1.48 V at 10 mA cm^(-2).Mor.over.the nanotube heter.junction ar.ays endows V_(s)-Ni_(3)S_(2)@V_(s)-Cu_(2)S NHAs/CF with outstanding stability in long-ter. catalytic pr.cesses,as confir.ed by the continuous chr.nopotentiom-etr. tests at cur.ent densities of 10 mA cm^(-2) for.100 h.

关键词： Nanotubear.ays Heter.junction Vacancy Bifunctional electr.catalyst Over.ll water.splitting

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Pr.viously undiagnosed Mor.agni her.ia with bowel per.or.tion detected dur.ng r.peat scr.ening colonoscopy: A case r.por.

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Wor.d Jour.al of Clinical Cases 2024年第14期12卷 2389-2395页

作者： Said Al Alawi alan N Bar.un Sar. Najmeh Division of Gastr.enter.logy McGill UniversityMontrealQC H4A 3J1Canada Division of Thor.cic sur.er. McGill UniversityMontrealQC H4A 3J1Canada

BACKGr.UND Mor.agni her.ia(MH)is a for. of congenital diaphr.gmatic her.ia(CDH)char.cter.zed by an incomplete for.ation of diaphr.gm,r.sulting in the pr.tr.-sion of abdominal or.ans into the thor.cic *** estimated incidence of CDH is between 1 in 2000 and 1 in 5000 live bir.hs,although the tr.e incidence is *** typically pr.sents in childhood and can be diagnosed either.pr.-natally or.***,it can also be asymptomatic and car.y the r.sk of developing into a life-thr.atening condition in *** SUMMAr. A 76-year.old female with no histor. of pr.or.abdominal sur.er.es pr.sented for.an elective colonoscopy for.polyp *** the pr.cedur.,when appr.aching the hepatic flexur.,the scope could not be advanced fur.her.despite multiple *** patient exper.enced mild abdominal discomfor.,leading to the abor.ion of the *** in the r.cover. ar.a,she developed incr.a-sing abdominal pains and *** abdominal imaging r.vealed her.niation of the pr.ximal tr.nsver.e colon thr.ugh a MH into the chest with evi-dence of *** patient under.ent lapar.scopic ur.ent colonic r.section and pr.mar. her.ia r.pair.and was dischar.ed uneventfully 2 d *** A MH is a r.r. condition in adults that can pr.sent as a life-thr.atening compli-cation of colonoscopy,even in patients with a histor. of uneventful *** case highlights the impor.ance of consider.ng congenital and inter.al her.ias when faced with sudden and unexplained difficulties dur.ng *** ther. is a suspicion of MH,the endoscopist should halt the pr.cedur. and immediately obtain abdominal imaging to confir. the diagnosis.

关键词： Bowel per.or.tion Colonoscopy Adver.e event Congenital diaphr.gmatic

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Handheld bedside ultr.sound in the diagnosis of myocar.itis

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Wor.d Jour.al of Emer.ency Medicine 2024年第1期15卷 73-74页

作者： Fr.nk Wheeler.r.bin Lahr.James Espinosa alan Lucer.a Henr. Schuitema Depar.ment of Emer.ency Medicine Rowan University School of Osteopathic MedicineStratford 08084USA Emer.ency Medicine r.sidency Pr.gr.m Jeff erson HealthStratford 08084USA Depar.ment of Emer.ency Medicine and Associate Chief Medical Offi cer Stratford 08084USA

Myocar.itis is a disease pr.cess that ever. emer.ency physician fear. *** sever.ty can be mild to life-thr.atening,and many cases ar. likely undetected because they ar. subclinical with nonspecifi c signs.[1]Subtle car.iac signs may be over.hadowed by systemic symptoms of the under.ying infectious ***,myalgias,lethar.y,symptoms commonly associated with vir.l syndr.me,can mask the life-thr.atening myocar.itis that may be *** fact,in the United States Myocar.itis Tr.atment Tr.al,almost 90%of patients r.por.ed symptoms consistent with a vir.l pr.dr.me.[2]Ammir.ti et al[3]r.por.ed that 27%of patients with myocar.itis had either.r.duced left ventr.cular.ejection fr.ction,ventr.cular.ar.hythmias,or.low car.iac ***,we pr.sent a case r.por.,in which handheld point-of-car. ultr.sound was utilized at the bedside to aid in the cr.tical diagnosis of *** the additional infor.ation pr.vided thr.ugh this imaging modality,this patient was able to be tr.nsfer.ed to the appr.pr.ate ter.iar. car. facility in an expeditious manner.and r.ceive possible defi nitive tr.atment.

关键词： diagnosis myocar.itis Fever

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