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A human monoclonal antibody neutralizes SARS-CoV-2 Omicron variants bytargeting the upstream region of spike protein HR2 motif

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hLife 2024年第3期2卷 126-140页

作者： Hang Su Jun Zhang Zhenfei Yi Sajid khan Mian Peng Liang Ye alan Bao Han Zhang Guangli Suo Qian Li Housheng Zheng Dandan Wu Thomas J.kipps Lanfeng Wang Zhenghong Lin Suping Zhang Shenzhen key Laboratory of Precision Medicine for Hematological Malignancies Guangdong Key Laboratory for Genome Stability andHuman Disease PreventionDepartment of PharmacologySchool of Basic Medical SciencesBase for International Science and TechnologyCooperation:Carson Cancer Stem Cell Vaccines R&D CenterInternational Cancer CenterShenzhen University Medical SchoolShenzhenUniversityGuangdongChina School of Life Sciences Chongqing UniversityChongqingChina The Center for Microbes Development and HealthCAS Key Laboratory of Molecular Virology&ImmunologyShanghai Institute of Immunityand InfectionChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghaiChina College of Life Sciences University of Chinese Academy of SciencesBeijingChina Department of Critical Care Medicine Shenzhen Luohu People’s HospitalGuangdongChina University of California BerkeleyCaliforniaUSA Xenta Biomedical Science Co. LtdGuangdongChina CAS key Laboratory of Nano-Bio Interface Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesJiangsuChina Center of Novel Therapeutics University of CaliforniaSan DiegoCaliforniaUSA

The continuous emergence of new severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)variants meansthere is a need to explore additional strategies to develop broad-spectrum vaccines or therapeutics for individuals remaining at risk of coronavirus disease 2019(COVID-19).Neutralizing monoclonal antibody(mAb)that binds to theconserved S2 subunit of the SARS-CoV-2 spike(S)protein alone,or in combination with mAb that binds to the receptor-binding domain(RBD)of S protein,might be effective in eliciting protection from infection by a variety of SARS-CoV2 *** high-throughput single-cell immunoglobulin sequencing of B cells from COVID-19-convalescent donors,we identified a high-affinity S2-specific mAb-39,that could inhibit original SARS-CoV-2 strain,Omicron BA.1,BA.2.86,BA.4,BA.5,and EG.5.1 S protein-mediated membrane fusion,leading to the neutralization of these ***,mAb-39 could also improve the neutralizing activity of anti-RBD antibody against the highlyneutralization-resistant Omicron *** docking and point mutation analyses revealed that mAb-39 recognized epitopes within the conserved upstream region of the heptad repeat 2(HR2)motif of the S2 ***,these findings demonstrate that targeting the conserved upstream region of the HR2 motif(e.g.,using mAbs)provides anovel strategy for preventing the infection of SARS-CoV-2 and its variants.

关键词： coronavirus disease 2019(COVID-19) severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)Omicron variants monoclonal antibody upstream region of heptad repeat 2(HR2) immunoglobulin repertoiresequencing

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Physics-based modeling of crowd evacuation in the Unity game engine

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International Journal of Modeling, Simulation, and Scientific Computing 2018年第4期9卷 108-138页

作者： Walter alan Cantrell Mikel D.Petty Samantha L.knight Whitney k.Schueler University of Alabama in Huntsville 301 Sparkman Drive OKT N353Huntsville Alabama 35899United States of America

Crowds of people are often found in enclosed or constricted *** in such situations is usually conducted calmly,but real or perceived danger may trigger *** panicked crowds,the interpersonal distance crowd members normally observe is often overwhelmed by the physical pressure of crowd members pushing against each *** pressure can both slow evacuation and lead to injury or *** have been developed to study crowd evacuation in a range of *** paper describes the implementation,testing,and validation of a crowd evacuation model using Unity,a commercial computer game engine.A realistic physics-based model of crowd movement that calculates and considers the physical pressure crowd members exert on each other was implemented in *** implemented model was tested under both nonpanicked and panicked scenarios;those tests exhibited known qualitative characteristics of such *** model was then quantitatively validated by comparing its results to the outcome of an actual evacuation event,the 2003 fire at The Station nightclub in Rhode *** implementation and validation show that Unity can be an effective tool for evacuation modeling.

关键词： Crowd modeling crowd movement evacuation modeling game engines Unity.

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Confined space entry and emergency response D. alan Veasey ... [et al.].

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2006年

作者： D. alan Veasey ... [et al.].

夲书着重阐述近年来国内外x究开发或应用的新型废水处理与资源化工艺技术，内容包括：废水中有机污染物的好氧生物处理和厌氧生物处理新工艺，废水中氮和磷等营养物质的去除与资源化，低耗节能的废水人工湿地处理系统与新型稳定塘系统... 详细信息

ISBN: (纸本)0471778451

夲书着重阐述近年来国内外x究开发或应用的新型废水处理与资源化工艺技术，内容包括：废水中有机污染物的好氧生物处理和厌氧生物处理新工艺，废水中氮和磷等营养物质的去除与资源化，低耗节能的废水人工湿地处理系统与新型稳定塘系统，微生物強化废水生物处理技术，能有效氧化分解难降解有机化合物的高级氧化处理工艺。处理后废水的回收与再利用技术。夲书配光盘。

关键词： Indoor air pollution

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Remote monitoring of implantable cardioverters defibrillators:a comparison of acceptance between octogenarians and younger patients

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Journal of Geriatric Cardiology 2020年第7期17卷 417-426页

作者： Iva Safarikova alan Bulava Premysl Hajek Faculty of Health and Social Sciences the University of South Bohemia in Ceske BudejoviceCeske BudejoviceCzech Republic Cardiac Center Department of CardiologyCeske Budejovice HospitalCeske BudejoviceCzech Republic Faculty of Medicine and Dentistry of Palacky University Olomouc OlomoucCzech Republic

Background Remote monitoring(RM)is increasingly employed for all types of cardiac implantable devices(CIED).However,there are only limited data on the acceptance of RM by the *** aim of our study was to ascertain how octogenarians assess RM technologies compared to younger,presumably technically more literate patients,and what concerns or technical problems the system presents to both groups of *** The trial was designed as a descriptive,register-based single-center *** study population consisted of all consecutive patients≥80 years of age(group A,n=94)and all consecutive patients aged≤40 years(group B,n=71),who had undergone implantation of an implantable cardioverter-defibrillator(ICD)between the years of 2009 and 2018 and were using a Home Monitoring?(HM,Biotronik,Berlin,Germany)*** patients fulfilling entry criteria were approached with a request to participate in the *** A total of 85(90.4%)and 65(91.5%)valid surveys were obtained for groups A and B,***-two percent of patients in both groups(P=0.903)were satisfied with the limited number of planned ambulatory follow-ups(i.e.,once a year).All patients in both groups(100%)reported that they were satisfied with the HM system,and 97%and 94%of patients in Groups A and B,respectively,ranked it highly beneficial(P=0.68).A significant proportion of patients in both groups were completely unaware of any health-related benefits associated with the use of the HM system(42%in Group A vs.49%in Group B,P=0.4).Among the most frequently reported personal benefits of HM were a sense of safety and security and savings on travel expenses and time.5%and 9%of patients in Groups A and B,respectively,reported that usage of HM caused them some degree of psychological stress(P=0.27).Nearly all patients in both groups reported receiving information on HM from their doctor after ICD *** of Group A reported receiving information from a nurse either before or after

关键词： Education Implantable electronic devices Remote monitoring The elderly

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Microstructural evolution of Mg-Al-Re alloy reinforced with alumina fibers

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Journal of Magnesium and Alloys 2020年第3期8卷 565-577页

作者： Li Li Dejiang Li Xiaoqin Zeng alan A.Luo Bin Hu Anil k.Sachdev Liangliang Gu Wenjiang Ding Shanghai Jiao Tong University ShanghaiChina The Ohio State University ColumbusOHUnited States General Motors China Science Lab ShanghaiChina General Motors Global R&D Center WarrenMIUnited States

Few studies were reported on the phases'relationships of AE44(Mg-4.0Al-4.1RE-0.3Mn,wt.%)and its *** this work,AE44 alloy and Saffil(6-Al2O3)/AE44 Metal matrix composite(MMC)were both prepared by slow shot high pressure die casting(SS-HPDC)technology and their phase constitutions were all studied in detail using experimental techniques combined with CALPHAD(Calculation of Phase Diagram)*** results revealed that the alloy consists of the a-Mg matrix,A1hRE3 intermetallic phase,and one trace phase AI3RE,while the composite contains five major phases:a-Mg,5-AI2O3,AI3RE,MgO and *** two trace phases of A12RE and AI11RE3,respectively.A1hRE3 is partly derived from ALRE,while A13RE is a product of the peritectoid reaction between the two *** presence of MgO and Mg2Si is due to the interfacial reaction between the SiO2 binder in the fiber preforms and the molten magnesium during *** use of SiO2 binder in the preform manufacturing was limited/minimized to reduce the MgO formation in the MMC casting process,which can be detrimental to the fatigue performance of the MMC materials.

关键词： Mg-Al-RE Magnesium composite Slow shot high pressure die casting Microstructure CALPHAD AlxREy

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Optimizing the use of biological therapy in patients with inflammatory bowel disease

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Gastroenterology Report 2015年第1期3卷 63-68页

作者： alan C.Moss Division of Gastroenterology Beth Israel Deaconess Medical Center&Harvard Medical SchoolBostonMAUSA

Biological therapy revolutionized the treatment of inflammatory bowel disease(IBD)during the last *** monoclonal antibodies,which target tumor necrosis factor(TNF),integrins or IL12/23,have been approved—or are in development for—both Crohn’s disease(CD)and ulcerative colitis(UC).Early use of these agents taught clinicians that induction and maintenance therapy,coupled with immunomodulator agents,reduced the immunogenicity of these agents,and led to sustained remission in many *** recent data has demonstrated that,through dose adjustments,optimizing serum drug levels may also provide more durable maintenance of remission,and improved mucosal *** review examines clinical practices that may enhance clinical outcomes from biological therapy in IBD.

关键词： inflammatory bowel disease biological therapy

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Measurement Sensitivity and Estimation Error in Distribution System State Estimation using Augmented Complex kalman Filter

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Journal of Modern Power Systems and Clean Energy 2020年第4期8卷 657-668页

作者： alan Louis Gerard Ledwich Geoff Walker Yateendra Mishra IEEE Queensland University of Technology BrisbaneAustralia

Distribution state estimation(DSE)is an essential part of an active distribution network with high level of distributed energy *** challenges of accurate DSE with limited measurement data is a well-known *** practice,the operation and usability of DSE depend on not only the estimation accuracy but also the ability to predict error *** paper investigates the application of error covariance in DSE by using the augmented complex kalman filter(ACkF).The kalman filter method inherently provides state error covariance *** can be utilized to accurately infer the error covariance of other parameters and provide a method to determine optimal measurement locations based on the sensitivity of error covariance to measurement noise *** paper also proposes a generalized formulation of ACkF to allow scalar measurements to be incorporated into the complex-valued *** proposed method is simulated by using modified IEEE 34-bus and IEEE 123-bus test feeders,and randomly generates the load data of complex-valued Wiener *** ACkF method is compared with an equivalent formulation using the traditional weighted least squares(WLS)method and iterated extended kalman filter(IEkF)method,which shows improved accuracy and computation performance.

关键词： Augmented complex kalman filter direct load flow distribution system state estimation error variance sensitivity analysis

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Phase constitution of the noble metal thin-film complex solid solution system Ag-Ir-Pd-Pt-Ru in dependence of elemental compositions and annealing temperatures

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Nano Research 2022年第6期15卷 4827-4836页

作者： Bin Xiao Xiao Wang alan Savan Alfred Ludwig Materials Discovery and Interfaces Institute for MaterialsRuhr University Bochum44780 BochumGermany Zentrum für Grenzflächendominierte Höchstleistungswerkstoffe(ZGH) Ruhr University Bochum44780 BochumGermany

Multiple-principal element alloys hold great promise for multifunctional material discovery(e.g.,for novel electrocatalysts based on complex solid solutions)in a virtually unlimited compositional ***,the phase constitution of the noble metal system Ag-Ir-Pd-Pt-Ru was investigated over a large compositional range in the quinary composition space and for different annealing temperatures from 600 to 900°C using thin-film materials ***-dependent X-ray diffraction mapping of the asdeposited thin-film materials library indicates different phases being present across the composition space(face-centered cubic(fcc),hexagonal close packed(hcp)and mixed fcc+hcp),which are strongly dependent on the Ru *** general,low Ru contents promote the fcc phase,whereas high Ru contents favor the formation of an hcp solid-solution ***,a temperature-induced phase transformation study was carried out for a selected measurement area of fcc-Ag_(5)Ir_(8)Pd_(56)Pt_(8)Ru_(23).With increasing temperature,the initial fcc phase transforms to an intermediate C14-type Laves phase at 360°C,and then to hcp when the temperature reaches 510°*** formation and disappearance of the hexagonal Laves phase,which covers a wide temperature range,plays a crucial role of bridging the fcc to hcp phase *** obtained composition,phase and temperature data are transformed into phase maps which could be used to guide theoretical studies and lay a basis for tuning the functional properties of these materials.

关键词： noble metal high-entropy alloys phase transformation combinatorial synthesis and high-throughput characterization

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Solar-absorbing metamaterial microencapsulation of phase change materials for thermo-regulating textiles

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International Journal of Smart and Nano Materials 2015年第2期6卷 105-112页

作者： William Tong alan Tong Illinois Mathematics and Science Academy AuroraIL 60506USA Neuqua Valley High School NapervilleIL 60564USA

This paper presents a novel concept for designing solar-absorbing metamaterial microcapsules of phase change materials(PCMs)integrated with thermo-regulating smart textiles intended for coats or garments,especially for wear in space or cold weather on *** metamaterial is a periodically nanostructured metal-dielectric-metal thin film and can acquire surface plasmons to trap or absorb solar energy at subwavelength *** kind of metamaterial microencapsulation is not only able to take advantage of latent heat that can be stored or released from the PCMs over a tunable temperature range,but also has other advantages over conventional polymer microencapsulation of PCMs,such as enhanced thermal conductivity,improved flame-retardant capabilities,and usage as an extra solar power *** thermal analysis for this kind of microencapsulation has been done and can be used as a guideline for designing integrated thermo-regulating smart textiles in the *** metamaterial microcapsules may open up new routes to enhancing thermo-regulating textiles with novel properties and added value.

关键词： metamaterial microencapsulation phase change material thermo-regulating textile

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基于回授式健康教育的延续护理方案对内窥镜下声带息肉摘除术患者嗓音康复的影响

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黑龙江医学 2024年第2期48卷 205-207页

作者：江阿兰李灵郑星福建医科大学附属第一医院耳鼻咽喉头颈外科福建福州350004

目的:探讨基于回授式健康教育的延续护理方案对内窥镜下声带息肉摘除术患者嗓音康复的影响,为临床护理干预提供依据。方法:选取2021年1—12月福建医科大学附属第一医院收治的64例行内窥镜下声带息肉摘除术的患者作为研究对象,采用随机... 详细信息

目的:探讨基于回授式健康教育的延续护理方案对内窥镜下声带息肉摘除术患者嗓音康复的影响,为临床护理干预提供依据。方法:选取2021年1—12月福建医科大学附属第一医院收治的64例行内窥镜下声带息肉摘除术的患者作为研究对象,采用随机数表法分为对照组与回授组,每组各32例。对照组接受常规院外随访,回授组接受基于回授式健康教育的延续护理方案,两组患者均干预1个月。比较两组患者干预前后嗓音障碍程度[中文版嗓音障碍指数(VHI)量表评分]、嗓音声学参数[基频微扰(Jitter)、振幅微扰(Shimmer)、噪谐比(NHR)、最高基频(Fhigh)、最长发声时间(MPT)]情况。结果:干预1个月,回授组患者VHI量表中F、P、E 3个维度评分及T评分均明显低于对照组患者,差异有统计学意义(t=4.567、8.468、6.697、6.577,P<0.05)。干预1个月,回授组患者Jitter、Shimmer、NHR及嗓音障碍严重指数(DSI)显著低于对照组患者,MPT显著长于对照组患者,差异有统计学意义(t=10.219、4.243、5.657、3.628、6.754,P<0.05)。结论:构建并实施基于回授式健康教育的延续护理方案,有利于促进内窥镜下声带息肉摘除术患者的声带功能恢复,提高嗓音质量。

关键词：内窥镜下声带息肉摘除术回授式健康教育延续护理嗓音康复

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