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The Essential Oil of Ocimum americanum from Senegal and Gambia as a Source of Methyleugenol for the Control of Bactrocera dorsalis, Fruit Fly

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Journal of Agricultural Chemistry and Environment 2024年第1期13卷 133-141页

作者： Yoro Tine Antonio alain Coffi Sinzogan Ousmane Ndiaye Cebastiana Sambou Alioune Diallo Ismaila Mbenga Kemo Badji El Hadji Omar Dieng Assa Balayara Jeanne Diatta Cheikhouna Gaye Julien Paolini Jean Costa Alassane Wele Saliou Ngom Laboratoire de Chimie Organique et Thérapeutique Faculté de Médecine Pharmacie et Odontologie Université Cheikh Anta Diop Dakar Sénégal Faculte des Sciences Agronomiques Universite d’Abomey Calavi Cotonou Benin Ecole Nationale Supérieure d’Agriculture (ENSA) Université Iba Der Thiam de Thiès Thiès Sénégal Direction de la Protection des Végétaux Rufisque Sénégal Laboratoire de Chimie des Produits Naturels Université de Corse Corte France National Agricultural Research Institute (NARI) Sere Kunda Gambia Institut Sénégalais de Recherches Agricoles (ISRA) Dakar Sénégal

The fruit fly, Bactrocera dorsalis (Diptera: Tephritidae) is one of the most important pests in all mango-producing areas, particularly in West Africa. In Senegal, O. americanum leaves have been used for several years to control this fly. However, to our knowledge, no chemical studies have been carried out. Thus, the aim of this study is to determine the chemical composition of the essential oil of O. americanum leaves collected in Senegal and Gambia. The essential oil obtained by hydrodistillation of these leaves is analyzed by GC/FID and GC/MS. Yields of essential oils from O. americanum leaves are 3.84% and 2.13%, respectively. Analysis of these essential oils by GC/FID and GC/MS allowed the identification of 23 compounds representing almost 100% of the total compositions. These essential oils are mainly dominated by methyleugenol (72.0% and 75.8%, respectively). Other components in significant percent are trans-β-caryophyllene (13.9% and 13.0%, respectively), germacrene D (4.1% and 3.7%, respectively), β-elemene (3.3% and 0.9%, respectively). Due to the high methyleugenol content, this study explains the attractive potential of O. americanum towards B. dorsalis. In perspective, we plan to evaluate the attractive effect of the essential oil and leaf powder of O. americanum against B. dorsalis, a real pest of mango orchards in Senegal.

关键词： Ocimum americanum Essential Oils Methyleugenol Bactrocera dorsalis GC/MS

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Atomic-scale structural signature of dynamic heterogeneities in metallic liquids

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npj Computational Materials 2017年第1期3卷 179-188页

作者： alain Pasturel Noel Jakse University Grenoble Alpes CNRSGrenoble INPSIMaPF-38000 GrenobleFrance

With sufficiently high cooling rates,liquids will cross their equilibrium melting temperatures and can be maintained in a metastable undercooled state before *** of undercooled liquids reveal several intriguing dynamic phenomena and because explicit connections between liquid structure and liquids dynamics are difficult to identify,it remains a major challenge to capture the underlying structural link to these *** initio molecular dynamics(AIMD)simulations are yet especially powerful in providing atomic-scale details otherwise not accessible in *** the AIMD-based study of Cr additions in Al-based liquids,we evidence for the first time a close relationship between the decoupling of component diffusion and the emergence of dynamic heterogeneities in the undercooling *** addition,we demonstrate that the origin of both phenomena is related to a structural heterogeneity caused by a strong interplay between chemical short-range order(CSRO)and local fivefold topology(ISRO)at the short-range scale in the liquid phase that develops into an icosahedral-based medium-range order(IMRO)upon ***,our findings reveal that this structural signature is also captured in the temperature dependence of partial pair-distribution functions which opens up the route to more elaborated experimental studies.

关键词： structural dynamic signature

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Transforming growth factor-β and fibrosis

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World Journal of Gastroenterology 2007年第22期13卷 3056-3062页

作者： Franck Verrecchia alain Mauviel INSERM U697 Paris 75010 France

Transforming growth factor-β （TGF-β）, a prototype of multifunctional cytokine, is a key regulator of extracellular matrix （ECM） assembly and remodeling. Specifically, TGF-β isoforms have the ability to induce the expression of ECM proteins in mesenchymal cells, and to stimulate the production of protease inhibitors that prevent enzymatic breakdown of the ECM. Elevated TGF-β expression in affected organs, and subsequent deregulation of TGF-β functions, correlates with the abnormal connective tissue deposition observed during the onset of fibrotic diseases. During the last few years, tremendous progress has been made in the understanding of the molecular aspects of intracellular signaling downstream of the TGF-β receptors. In particular, Smad proteins, TGF-β receptor kinase substrates that translocate into the cell nucleus to act as transcription factors, have been studied extensively. The role of Smad3 in the transcriptional regulation of type I collagen gene expression and in the development of fibrosis, demonstrated both/n vitro and in animal models with a targeted deletion of Smad3, is of critical importance because it may lead to novel therapeutic strategies against these diseases. This review focuses on the mechanisms underlying Smad modulation of fibrillar collagen expression and how it relates to fibrotic processes.

关键词： Collagen Connective tissue growth factor Fibrosis Smad Transforming growth factor-β

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Vulnerable window of yield strength for swelling-driven fracture of phase-transforming battery materials

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npj Computational Materials 2020年第1期6卷 1162-1171页

作者： Ataollah Mesgarnejad alain Karma Center for Inter-disciplinary Research on Complex Systems Department of PhysicsNortheastern UniversityBostonMA 02115USA

Despite numerous experimental and theoretical investigations of the mechanical behavior of high-capacity Si and Ge Li-ion battery anodes,our basic understanding of swelling-driven fracture in these materials remains *** theoretical studies have provided insights into elasto-plastic deformations caused by large volume change phase transformations,but have not modeled fracture explicitly beyond Griffith’s ***,we use a multi-physics phase-field approach to model self-consistently anisotropic phase transformation,elasto-plastic deformation,and crack initiation and propagation during lithiation of Si *** computational results reveal that fracture occurs within a“vulnerable window”inside the two-dimensional parameter space of yield strength and fracture energy and highlight the importance of taking into account the surface localization of plastic deformation to accurately predict the magnitude of tensile stresses at the onset of *** further demonstrate how the increased robustness of hollow nanopillars can be understood as a direct effect of anode geometry on the size of this vulnerable *** insights provide an improved theoretical basis for designing next-generation mechanically stable phasetransforming battery materials undergoing large volume changes.

关键词： fracture strength deformation

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Direct impacts of recent climate warming on insect populations

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Integrative Zoology 2010年第2期5卷 132-142页

作者： Christelle ROBINET alain ROQUES National Institute for Agricultural Research INRA UR633OrléansFrance

Effects of recent climate change have already been detected in many species,and,in particular,in *** present paper reviews the key impacts of global warming on insect development and *** effects of climate change appear to be much more complex than a simple linear response to an average increase in *** can differ between seasons and bioclimatic *** flight periods,enhanced winter survival and acceleration of development rates are the major insect *** response of insects and hosts to warming up might also lead to disruption of their phenological synchrony,but adaptive genetic processes are likely to quickly restore this *** a number of cases,warming results in removing or relocating the barriers that limit present species’*** is also likely to facilitate the establishment and spread of invasive alien ***,knowledge gaps are identified and future research interests are suggested.

关键词： adaptation alien species climate warming phenology range distribution

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Control and Nash Games with Mean Field Effect

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Chinese Annals of Mathematics,Series B 2013年第2期34卷 161-192页

作者： alain BENSOUSSAN Jens FREHSE International Center for Decision and Risk Analysis School of Management University of Texas-DallasFrance School of Business the Hong Kong Polytechnic University Graduate Department of Financial Engineering Ajou University Institute for Applied Mathematics University of Bonn

Mean field theory has raised a lot of interest in the recent years (see in particular the results of Lasry-Lions in 2006 and 2007,of Gueant-Lasry-Lions in 2011,of HuangCaines-Malham in 2007 and many others).There are a lot of *** general,the applications concern approximating an infinite number of players with common behavior by a representative *** agent has to solve a control problem perturbed by a field equation,representing in some way the behavior of the average infinite number of *** approach does not lead easily to the problems of Nash equilibrium for a finite number of players,perturbed by field equations,unless one considers averaging within different groups,which has not been done in the literature,and seems quite *** this paper,the authors approach similar problems with a different motivation which makes sense for control and also for differential *** the systems of nonlinear partial differential equations with mean field terms,which have not been addressed in the literature so far,are considered here.

关键词： Mean field Dynamic programming Nash games Equilibrium Calculus of variations

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Polysaccharide-based chromatographic adsorbents for virus purification and viral clearance

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Journal of Pharmaceutical Analysis 2020年第4期10卷 291-312页

作者： Guy-alain Junter Laurent Lebrun Normandie Univ UNIROUENINSA RouenCNRSPBS76000RouenFrance

Viruses still pose a significant threat to human and animal health *** the fight against viral infections,high-purity viral stocks are needed for manufacture of safer *** is also a priority to ensure the viral safety of biopharmaceuticals such as blood *** techniques are widely implemented at both academic and industrial levels in the purification of viral particles,whole viruses and virus-like particles to remove viral contaminants from biopharmaceutical *** paper focuses on polysaccharide adsorbents,particulate resins and membrane adsorbers,used in virus purification/removal chromatography *** chromatographic modes are surveyed,with particular attention to ion exchange and affinity/pseudo-affinity adsorbents among which commercially available agarose-based resins(Sepharose®)and cellulose-based membrane adsorbers(Sartobind®)occupy a dominant *** built on the development of new ligands coupled to conventional agarose/cellulose matrices,the development perspectives of polysaccharide-based chromatography media in this antiviral area are stressed in the conclusive part.

关键词： Polysaccharide Chromatography Virus particle Biopharmaceuticals purification Vaccine

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Quantitative assessment on basin-scale hydrological services of wetlands

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Science China Earth Sciences 2020年第2期63卷 279-291页

作者： Yanfeng WU Guangxin ZHANG alain NROUSSEAU Northeast Institute of Geography and Agroecology Chinese Academy of SciencesChangchun 130102China University of Chinese Academy of Sciences Beijing 100049China INRS-ETE/Institut National de la Recherche Scientifique-Eau Terre Environnement Quebec G1K 9A9Canada

Despite recognizing the importance of hydrological function of wetlands, basin-scale wetlands services have rarely been investigated. The PHYSITEL/HYDROTEL modelling platform was used to quantitatively assess the impact of wetlands on quickflow and baseflow with paired simulation scenarios in Duobukuli River Basin, namely with wetlands and without *** results showed that wetlands exert significant impact on basin hydrological processes by decreasing streamflow and altering streamflow regime(magnitude, frequency, duration and time of flow events). The intensity(significant or not) of wetlands influences on quickflow had daily, monthly and annual variation. Wetlands significantly attenuated quickflow during flood season while slightly support daily, monthly and annual baseflow. The average quickflow attenuation and baseflow support of wetlands were 5.89% and 0.83%, respectively. Although the intensity and effect(mitigation or augment) of wetlands on streamflow temporally varied at daily, monthly, seasonal and annual scales, wetland overall mitigated quickflow and augment baseflow in Duobukuli River Basin. Our results could provide insights for future decision-making for rehabilitation and conservation of wetlands as well as integrated basin water resources management.

关键词： Wetlands modules Hydrological processes simulation Baseflow support Quickflow mitigation Hydrological function

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Evaluation of the effect of geometrical parameters on stope probability of failure in the open stoping method using numerical modeling

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International Journal of Mining Science and Technology 2019年第3期29卷 399-408页

作者： Shahriyar Heidarzadeh Ali Saeidi alain Rouleau Department of Applied Sciences University of Quebec at Chicoutimi

Stress-induced failure is among the most common causes of instability in Canadian deep underground *** stoping is the most widely practiced underground excavation method in these mines,and creates large stopes which are subjected to stress-induced *** probability of failure(POF)depends on many factors,of which the geometry of an open stope is especially *** this study,a methodology is proposed to assess the effect of stope geometrical parameters on the POF,using numerical *** ranges for each input parameter are defined according to previous surveys on open stope geometry in a number of Canadian underground mines.A Monte-Carlo simulation technique is combined with the finite difference code FLAC3D,to generate model realizations containing stopes with different geometrical *** probability of failure(POF)for different categories of stope geometry,is calculated by considering two modes of failure;relaxation-related gravity driven(tensile)failure and rock mass brittle *** individual and interactive effects of stope geometrical parameters on the POF,are analyzed using a general multi-level factorial ***,mathematical optimization techniques are employed to estimate the most stable stope conditions,by determining the optimal ranges for each stope’s geometrical parameter.

关键词： Stope stability Stope geometrical parameters Probability of failure General factorial design Numerical modeling Sublevel open stoping

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ON A SECOND ORDER DISSIPATIVE ODE IN HILBERT SPACE WITH AN INTEGRABLE SOURCE TERM

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Acta Mathematica Scientia 2012年第1期32卷 155-163页

作者： alain Haraux Mohamed Ali Jendoubi UPMC Univ Paris 06 UMR 7598Laboratoire Jacques-Louis Lions CNRS UMR 7598Laboratoire Jacques-Louis Lions Facult des Sciences de Bizerte Dpartement de Mathmatiques

Asymptotic behaviour of solutions is studied for some second order equations including the model casex（t）＋γx（t）＋ ↓△φb（x（t）） = h（t） with γ 〉 0 and h ∈ L1（O, ＋∞; H）, φ being continuouly differentiable with locally Lipschitz continuous gradient and bounded from below. In particular when φ is convex, all solutions tend to minimize the potential φ as time tends to infinity and the existence of one bounded trajectory implies the weak convergence of all solutions to equilibrium points.

关键词： dissipative dynamical system asymptotic behaviour gradient system heavyball with friction

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