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A critical review of microplastics in aquatic ecosystems: Degradation mechanisms and removing strategies

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Environmental Science and Ecotechnology 2024年第5期21卷 62-76页

作者： Sameh S.ali Tamer Elsamahy Rania al-Tohamy Jianzhong Sun Biofuels Institute School of the Environment and Safety EngineeringJiangsu UniversityZhenjiang212013China Botany Department Faculty of ScienceTanta UniversityTanta31527Egypt

Plastic waste discarded into aquatic environments gradually degrades into smaller fragments,known as microplastics(MPs),which range in size from 0.05 to 5 *** ubiquity of MPs poses a significant threat to aquatic ecosystems and,by extension,human health,as these particles are ingested by various marine organisms including zooplankton,crustaceans,and fish,eventually entering the human food *** contamination threatens the entire ecological balance,encompassing food safety and the health of aquatic ***,developing effective MP removal technologies has emerged as a critical area of ***,we summarize the mechanisms and recently reported strategies for removing MPs from aquatic *** combining physical and chemical pretreatments with microbial degradation have shown promise in decomposing *** such as bacteria,fungi,algae,and specific enzymes are being leveraged in MP remediation *** advancements have focused on innovative methods such as membrane bioreactors,synthetic biology,organosilane-based techniques,biofilm-mediated remediation,and nanomaterial-enabled strategies,with nano-enabled technologies demonstrating substantial potential to enhance MP removal *** review aims to stimulate further innovation in effective MP removal methods,promoting environmental and social well-being.

关键词： Persistent organic pollutants Bioremediation Nanomaterial-enabled strategies Aquatic environment Ecotoxicity of microplastics

Exploring the Contribution of Pharmacists in Addressing the Opioid Crisis through Naloxone Prescriptions and Pharmacist-Led Interventions

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Pharmacology & Pharmacy 2024年第2期15卷 27-38页

作者： Michelle Krey Sophia Villa nadia Gharibyar Haroon Mesdaq Just Health Experts Thornton CO USA

The opioid epidemic in the United States continues to take the lives of many individuals, with overdoses continuing to rise every year. Naloxone is an opioid antagonist that is efficacious in temporarily reversing opioid overdoses. Pharmacists play an important role in the accessibility and education of naloxone in both the community and health system settings. Recent efforts, such as co-dispensing naloxone with opioid prescriptions, naloxone training programs, and approval of naloxone to be over-the-counter, have been implemented in hopes to better control the opioid epidemic. Despite the efforts to make naloxone more accessible, there are still some barriers to overcome such as lack of training, cost, stigma, and patient refusal. This review aims to explore the contributions pharmacists have made thus far and define the barriers that still have to be resolved.

关键词： Naloxone Narcan Opioid Crisis Opioid Epidemic Pharmacy Pharmacist Interventions

Tuberculosis-diabetes comorbidities: Mechanistic insights for clinical considerations and treatment challenges

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World Journal of Diabetes 2024年第5期15卷 853-866页

作者： Md abdul alim al-Bari Nicholas Peake Nabil Eid Department of Pharmacy University of RajshahiRajshahi 6205Bangladesh Biosciences and Chemistry and Biomolecular Research Centre Sheffield Hallam UniversitySheffield S11WBUnited Kingdom Department of Anatomy Division of Human BiologySchool of MedicineInternational Medical UniversityKuala Lumpur 57000Malaysia

Tuberculosis(TB)remains a leading cause of death among infectious diseases,particularly in poor *** infections,multidrug-resistant and ex-tensively drug-resistant TB strains,as well as the coexistence of chronic illnesses such as diabetes mellitus(DM)greatly aggravate TB morbidity and ***[particularly type 2 DM(T2DM)]and TB have converged making their control even more *** contemporary global epidemics,TB-DM behaves like a syndemic,a synergistic confluence of two highly prevalent diseases.T2DM is a risk factor for developing more severe forms of multi-drug resistant-TB and TB recurrence after preventive *** a bidirectional relationship exists between TB and DM,it is necessary to concurrently treat both,and promote recommendations for the joint management of both *** are also some drug-drug interactions resulting in adverse treatment outcomes in TB-DM patients including treatment failure,and *** addition,autophagy may play a role in these ***,the TB-DM comorbidities present several health challenges,requiring a focus on multidisciplinary collaboration and integrated strategies,to effectively deal with this double *** effectively manage the comorbidity,further screening in affected countries,more suitable drugs,and better treatment strategies are required.

关键词： Diabetes mellitus Tuberculosis Coinfections Comorbidity Drug-drug interactions Autophagy Treatment challenges

Coating powder beds with liquids and foams based on viscous formulations using a twin screw mixer:A continuous process study

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Particuology 2024年第10期93卷 364-376页

作者： Mohamed S.Manga Dimitrios Kontziampasis Mustafa al-Maqdad Sean Clifford Serafim Bakalis David W.York School of Chemical and Process Engineering Faculty of Engineering and Physical SciencesUniversity of LeedsLeedsLS29JTUK School of Mechanical Engineering Faculty of Engineering and Physical SciencesUniversity of LeedsLeedsLS29JTUK School of Science and Engineering University of DundeeDD14HNDundeeScotlandUK Dundee International Institute of Central South University Tongzipo RoadCentral South UniversityChangshaHunan410013China Department of Chemical Engineering School of EngineeringUniversity of NewcastleNewcastleNE17RUUK School of Chemical Engineering University of BirminghamBirminghamB152TTUK Department of Chemical Engineering Faculty of EngineeringUniversity of NottinghamNG72RDUK

Coating with viscous formulations has been essential in numerous industries as it can be a means for providing functionalization, additional properties, as well as other benefits. However, there have been scarce studies that have investigated and proposed methodologies in literature. Continuous coating of powders with viscous liquids poses as a promising technology, which has been mentioned in some studies, but has not yet been thoroughly investigated. This paper employs the use of image processing and analysis, in combination with statistical analysis of particles to evaluate the effectiveness of foams and liquids as a means of coating powder beds. Two different sizes of twin screw mixers that are working in continuous operation are employed, and a new continuous foaming device is fabricated and used for the experiments of coating. The effect of materials and process parameters (as for example rotational speed, and flowrate) on the quality of coating are investigated. Image analysis is used to assess the coating quality. The results clearly showcase the potential of using twin screw mixers for coating purposes and not only for mixing. The hypothesis that using large bubble foams to improve the coating of viscous liquids on particles is proven correct, as they provide higher quality coatings compared to their equivalent liquids, when used in the twin screw mixer. Surprisingly, using a larger scale twin screw mixer, does not show a substantial effect on the mixing, regarding quality, however there is still a requirement for mix optimization for achieving scale-up of this process. These results provide a new pathway for coating powders with viscous formulations in industrial applications, requiring less energy and effort in this process, and can pave the way towards introducing more sustainable industrial methodologies for coating.

关键词： Powder coating Continuous processing Viscous liquid Foam Image analysis Positron emission particle traking(PEPT)

Improved Dwarf Mongoose Optimization algorithm for Feature Selection:Application in Software Fault Prediction Datasets

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Journal of Bionic Engineering 2024年第4期21卷 2000-2033页

作者： abdelaziz I.Hammouri Mohammed A.Awadallah Malik Sh.Braik Mohammed Azmi al-Betar Majdi Beseiso Department of Computer Science Al-Balqa Applied UniversityAl-Salt19117Jordan Department of Scientific Research and Graduate Studies University of Prince Mugrin42241MedinaSaudi Arabia Department of Computer Science Al-Aqsa UniversityGaza4051Palestine Artificial Intelligence Research Center(AIRC) Ajman UniversityAjmanUnited Arab Emirates Department of Information Technology Al-Huson University CollegeAl-Balqa Applied UniversityAl-HusonIrbid21110Jordan

Feature selection(FS)plays a crucial role in pre-processing machine learning datasets,as it eliminates redundant features to improve classification accuracy and reduce computational *** paper presents an enhanced approach to FS for software fault prediction,specifically by enhancing the binary dwarf mongoose optimization(BDMO)algorithm with a crossover mechanism and a modified positioning updating *** proposed approach,termed iBDMOcr,aims to fortify exploration capability,promote population diversity,and lastly improve the wrapper-based FS process for software fault prediction *** gained superb performance compared to other well-esteemed optimization methods across 17 benchmark *** ranked first in 11 out of 17 datasets in terms of average classification ***,iBDMOcr outperformed other methods in terms of average fitness values and number of selected features across all *** findings demonstrate the effectiveness of iBDMOcr in addressing FS problems in software fault prediction,leading to more accurate and efficient models.

关键词： Dwarf mongoose optimization algorithm Optimization Feature selection Classification

Progress on early diagnosing alzheimer’s disease

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Frontiers of Medicine 2024年第3期18卷 446-464页

作者： Yixin Chen Murad al-Nusaif Song Li Xiang Tan Huijia Yang Huaibin Cai Weidong Le Liaoning Provincial Key Laboratory for Research on the Pathogenic Mechanisms of Neurological Diseases The First Affiliated Hospital of Dalian Medical UniversityDalian116021China Transgenic Section Laboratory of NeurogeneticsNational Institute on AgingNational Institutes of HealthBethesdaMD20892USA Institute of Neurology Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChinese Academy of Sciences Sichuan Translational Medicine Research HospitalChengdu610072China

alzheimer’s disease(AD)is a progressive neurodegenerative disorder that affects both cognition and non-cognition *** disease follows a continuum,starting with preclinical stages,progressing to mild cognitive and behavioral impairment,ultimately leading to *** detection of AD is crucial for better diagnosis and more effective ***,the current AD diagnostic tests of biomarkers using cerebrospinal fluid and/or brain imaging are invasive or expensive,and mostly are still not able to detect early disease ***,there is an urgent need to develop new diagnostic techniques with higher sensitivity and specificity during the preclinical stages of *** non-cognitive manifestations,including behavioral abnormalities,sleep disturbances,sensory dysfunctions,and physical changes,have been observed in the preclinical AD stage before occurrence of notable cognitive *** research advances have identified several biofluid biomarkers as early indicators of *** review focuses on these non-cognitive changes and newly discovered biomarkers in AD,specifically addressing the preclinical stages of the ***,it is of importance to explore the potential for developing a predictive system or network to forecast disease onset and progression at the early stage of AD.

关键词： alzheimer’s disease early diagnosis non-cognitive symptoms biomarkers

An Integrated Model of Smart Home Applications User Experience Based on Cognitive Dissonance

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Journal of Electronic Research and Application 2024年第5期8卷 89-94页

作者： Lili Wang nadia Binti Mohd Nasir Shuang Yang City University of Malaysia Kuala Lumpur 58000Malaysia Hefei Jinhu Primary School Hefei 230000China

This study constructs an integrated model of user experience in smart home applications(apps)to deeply explore the impact of cognitive dissonance on users’emotional responses,subsequent behaviors,and experiential *** research emphasizes the importance of addressing emotional management in the design and development of smart home *** findings indicate that emotional response plays a critical mediating role in the user experience of these apps,offering new insights for further *** understanding users’emotional reactions and behavioral patterns under cognitive dissonance,developers can more effectively improve interface design and enhance the overall user experience.

关键词： User experience Smart home apps Cognitive dissonance

A Hybrid and Lightweight Device-to-Server Authentication Technique for the Internet of Things

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Computers, Materials & Continua 2024年第3期78卷 3805-3823页

作者： Shaha al-Otaibi Rahim Khan Hashim ali Aftab Ahmed Khan Amir Saeed Jehad ali Department of Information Systems College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Computer Science Abdul Wali Khan University MardanMardan23200Pakistan Department of Computer Science and IT UET PeshawarJalozai Campus PeshawarPeshawar24240Pakistan Department of AI Convergence Network Ajou UniversitySuwon16499South Korea

The Internet of Things(IoT)is a smart networking infrastructure of physical devices,i.e.,things,that are embedded with sensors,actuators,software,and other technologies,to connect and share data with the respective server *** IoTs are cornerstones in different application domains,the device’s authenticity,i.e.,of server(s)and ordinary devices,is the most crucial issue and must be resolved on a priority ***,various field-proven methodologies were presented to streamline the verification process of the communicating devices;however,location-aware authentication has not been reported as per our knowledge,which is a crucial metric,especially in scenarios where devices are *** paper presents a lightweight and location-aware device-to-server authentication technique where the device’s membership with the nearest server is subjected to its location information along with other ***,Media Access Control(MAC)address and Advance Encryption Scheme(AES)along with a secret shared key,i.e.,λ_(i) of 128 bits,have been utilized by Trusted Authority(TA)to generate MaskIDs,which are used instead of the original ID,for every device,i.e.,server and member,and are shared in the offline ***,TA shares a list of authentic devices,i.e.,server S_(j) and members C_(i),with every device in the IoT for the onward verification process,which is required to be executed before the initialization of the actual communication ***,every device should be located such that it lies within the coverage area of a server,and this location information is used in the authentication process.A thorough analytical analysis was carried out to check the susceptibility of the proposed and existing authentication approaches against well-known intruder attacks,i.e.,man-in-the-middle,masquerading,device,and server impersonations,etc.,especially in the IoT ***,proposed authentication and existing state-of-the-art approaches have been s

关键词： Internet of things authenticity security location communication

Bayesian and Non-Bayesian Analysis for the Sine Generalized Linear Exponential Model under Progressively Censored Data

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Computer Modeling in Engineering & Sciences 2024年第9期140卷 2795-2823页

作者： Naif alotaibi A.S.al-Moisheer Ibrahim Elbatal Mohammed Elgarhy Ehab M.almetwally Department of Mathematics and Statistics Faculty of ScienceImam Mohammad Ibn Saud Islamic University(IMSIU)Riyadh11432Saudi Arabia Department of Mathematics College of ScienceJouf UniversityP.O.Box 848Sakaka72351Saudi Arabia Mathematics and Computer Science Department Faculty of ScienceBeni-Suef UniversityBeni-Suef62521Egypt Department of Basic Sciences Higher Institute of Administrative SciencesBelbeisEgypt Faculty of Business Administration Delta University for Science and TechnologyGamasa11152Egypt

This article introduces a novel variant of the generalized linear exponential(GLE)distribution,known as the sine generalized linear exponential(SGLE)*** SGLE distribution utilizes the sine transformation to enhance its *** updated distribution is very adaptable and may be efficiently used in the modeling of survival data and dependability *** suggested model incorporates a hazard rate function(HRF)that may display a rising,J-shaped,or bathtub form,depending on its unique *** model includes many well-known lifespan distributions as separate *** suggested model is accompanied with a range of statistical *** model parameters are examined using the techniques of maximum likelihood and Bayesian estimation using progressively censored *** order to evaluate the effectiveness of these techniques,we provide a set of simulated data for testing *** relevance of the newly presented model is shown via two real-world dataset applications,highlighting its superiority over other respected similar models.

关键词： Sine G family generalized linear failure rate progressively censored data moments maximum likelihood estimation Bayesian estimation simulation