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Assessment of the Drafting Quality of Request Forms Submitted to the Malaria and Parasitology Units at the Institut Pasteur de Cote d’Ivoire

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Journal of biosciences and Medicines 2024年第5期12卷 330-339页

作者： Yao Serge-Stéphane ako ako bérenger aris.ide Sylvain beourou Ouattara Yacouba N’Guessan Tiacoh Landry N’Dri Kouadio Thierry-borel Toure André Offianan Malaria Unit Institut Pasteur de Cote d&#8217Ivoire Abidjan Cote d&#8217Ivoire Parasitology Unit Institut Pasteur de Cote d&#8217Ivoire Abidjan Cote d&#8217Ivoire

biological tests provide information on the medical analysis requested by both the patient and the prescriber. It is a communication link between the prescriber and the laboratory staff. The lack of some information on request forms not only affects the drafting quality of the test and patient care, but could also make thousands of data produced by healthcare centers unusable. The aim of this study was to assess the drafting quality of request forms submitted to the Malaria and Parasitology Units at the Institut Pasteur de Côte d’Ivoire. Methods: It was a descriptive cross-sectional study to assess the drafting quality of request forms of various prescribers received at the Institut Pasteur de Côte d’Ivoire. This study was conducted at the Malaria and Parasitology Units, department of Parasitology and Mycology (Institut Pasteur de Côte d’Ivoire), from 6th December 2020 to 6th December 2021. The information on each request forms was recorded on a data collection form designed for this purpose. Each data collection form corresponds to a request forms and each test to a patient. Results: Out of a total of 1990 request forms received, the patient’s age and sex were missing on 18% and 26.8% of the tests respectively. More than half (51.80%) of request forms did not indicate the patient’s place of residence. Clinical information was not provided on 45.90% of the tests. Prescribers omitting their signatures were 51%, stamps were 50.3% and contacts were 71.2%. Only 5.4% of request forms were of good drafting quality. Providing all the required information on the forms could facilitate the use and analysis of data and samples.

关键词： Laboratory Quality Request Forms Information

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Management of autoimmune hepatitis induced by hepatitis delta virus

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World Journal of Gastroenterology 2024年第8期30卷 799-805页

作者： Eleni Gigi Vasileios Lagopoulos aris Liakos Hepatology Unit The Second Internal Medicine DepartmentAristotle University Medical SchoolHippokrateio General HospitalThessaloniki 54642Greece Department of Surgical AHEPA General Hospital of ThessalonikiThessaloniki 54636Greece Clinical Research and Evidence-based Medicine Unit Second Medical DepartmentHippokratio General HospitalAristotle University ThessalonikiThessaloniki 54642Greece

Approximately 12-72 million people worldwide are co-infected with hepatitis b virus(HbV)and hepatitis delta virus(HDV).This concurrent infection can lead to several severe outcomes with hepatic disease,such as cirrhosis,fulminant hepatitis,and hepatocellular carcinoma,being the most *** the past few decades,a correlation between viral hepatitis and autoimmune diseases has been ***,autoantibodies have been detected in the serum of patients co-infected with HbV/HDV,and autoimmune features have been ***,to date,very few cases of clinically significant autoimmune hepatitis(AIH)have been reported in patients with HDV infection,mainly in those who have received treatment with pegylated ***,there are some patients with HbV infection and AIH in whom HDV infection is unearthed after receiving treatment with ***,several questions remain unanswered with the challenge to distinguish whether it is autoimmune or“autoimmune-like”hepatitis being the most ***,it remains uncertain whether autoimmunity is induced by HbV or delta ***,we investigated whether the cause of AIH lies in the previous treatment of HDV with pegylated *** pressing issues should be elucidated to clarify whether new antiviral treatments for HDV,such as bulevirtide or immu-nosuppressive drugs,are more appropriate for the management of patients with HDV and AIH.

关键词： Autoimmune hepatitis Hepatitis delta virus bulevirtide Prednisolone

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Prediction of overbreak depth in Ghalaje road tunnel using strength factor

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International Journal of Mining Science and Technology 2018年第4期28卷 671-676页

作者： ako Daraei Shokrollah Zare Civil Engineering Department Soran University School of Mining Petroleum & Geophysics Engineering Shahrood University of Technology

It is well known that the overbreak caused by the blasting damage during tunnel excavation increases costs associated with filling the collapsed area with shotcrete and results in filing of a claim by the contractor. This paper outlines a new approach for prediction the overbreak depth during tunnel construction. Hence, firstly excavation damage zone(EDZ) are determined by average specific charge in each zone. Numerical modelling is used to simulate the EDZ around tunnel boundary and the overbreak depth are calculated by the rock strength factor. The predicted overbreak depth compared with observed field data from a case study. The results show that there exists an approximately up to 40% difference between the prediction and the observed volume of overbreak depth. Therefore, the method can be well used to predict the overbreak depth to estimate more precision of shotcrete and concrete volumes in tunnelling cost during design phase.

关键词： Overbreak blasting Excavation damaged zone Strength factor Tunneling

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Modified criterion for prediction of tunnel deformation in non-squeezing ground conditions

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Journal of Modern Transportation 2019年第1期27卷 11-24页

作者： ako Daraei Shokrollah Zare Faculty of Mining Petroleum and Geophysics EngineeringShahrood University of Technology

The strength factor-based criterion for tunnel deformation prediction proposed by Hoek in 2000 is reckoned to be the most practical criterion among the tunnel deformation criteria since 1980s. In view of the fact that Hoek's criterion was obtained based on case studies under squeezing ground conditions, it has a limited range of applications, applicable mainly in squeezing tunnels. In this work, this criterion was modified by taking into consideration the conditions of eight unstable stations in three non-squeezing tunnels in Iran to amplify its application range. Relative displacements and strength factor(defined as a strength-to-stress ratio) were obtained in unstable stations first. Then, the parametric values were plotted on a Cartesian coordinate's plane. by using the optimal regression line passing through all points, a criterion for prediction of tunnel deformation was proposed finally. A comparison made between the measured values and the ones predicted by the new criterion shows that the variance accounted for was 77% and the root mean square error was 2%, an acceptable accuracy and a small error implying the effectiveness of the new criterion in tunnel deformation prediction. In addition, the results show that the strength factor of 0.38 can be used to determine the boundary between squeezing and non-squeezing conditions; the behavior and type of failure of the tunnel would be predictable by use of the strength factor.

关键词： Strength factor Tunnel deformation Monitoring Failure type Tunneling

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Hidden army within:Harnessing the microbiome to improve cancer treatment outcomes

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World Journal of Clinical Cases 2024年第28期12卷 6159-6164页

作者： Ippokratis Messaritakis Georgios Vougiouklakis Asimina Koulouridi aris P Agouridis Nikolaos Spernovasilis Department of Microbiology German Oncology Center&Yiannoukas Labs LTDBioiatriki GroupLimassol 4108Cyprus Department of Internal Medicine German Oncology CenterLimassol 4108Cyprus Department of Oncology German Oncology CenterLimassol 4108Cyprus School of Medicine European University CyprusNicosia 2404Cyprus Department of Infectious Diseases German Oncology CenterLimassol 4108Cyprus

The gut microbiome has emerged as a critical player in cancer pathogenesis and treatment ***,an imbalance in the gut microbial community,impacts tumor initiation,progression,and therapy *** bacterial species have been associated with either promoting or inhibiting tumor growth,offering potential targets for therapeutic *** gut microbiome in-fluences the efficacy and toxicity of conventional treatments and cutting-edge immunotherapies,highlighting its potential as a therapeutic target in cancer ***,translating microbiome research into clinical practice requires addres-sing challenges such as standardizing methodologies,validating microbial bio-markers,and ensuring ethical ***,we provide a comprehensive overview of the gut microbiome's role in cancer highlighting the need for on-going research,collaboration,and innovation to harness its full potential for im-proving patient outcomes in *** current editorial aims to explore these insights and emphasizes the need for standardized methodologies,validation of microbial biomarkers,and interdisciplinary collaboration to translate microbiome research into clinical ***,it underscores ethical consider-ations and regulatory challenges surrounding the use of microbiome-based ***,this article advocates for ongoing research,collaboration,and innovation to realize the full potential of microbiome-guided oncology in impro-ving patient care and outcomes.

关键词： Gut microbiome Cancer treatment Immunotherapy Microbiome-based interventions Dysbiosis Precision oncology

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靶向白细胞介素1β纳米抗体的制备及其对缺氧小鼠心肌细胞凋亡的影响

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中华医学杂志 2024年第22期104卷 2066-2073页

作者：欧阳情王露 Nasser Moussa ide 邓刚张新奎游婷苏浩滔朱平华南理工大学医学院广州广东省心血管病研究所南方医科大学附属广东省人民医院(广东省医学科学院)广东省心脏病发病机制与精准防治重点实验室广州市心脏发病机制与重点防治重点实验室广州

目的制备抗白细胞介素1β(IL-1β)纳米抗体, 并观察其对缺氧小鼠心肌细胞凋亡的影响。方法利用DNA重组技术, 使用pET-16b和pHEN1表达载体构建抗IL-1β纳米抗体的重组质粒(pET-16b-4G6M-VHH、pET-16b-5bVP-VHH、pET-16b-5MVZ-VHH和pHEN1-... 详细信息

目的制备抗白细胞介素1β(IL-1β)纳米抗体, 并观察其对缺氧小鼠心肌细胞凋亡的影响。方法利用DNA重组技术, 使用pET-16b和pHEN1表达载体构建抗IL-1β纳米抗体的重组质粒(pET-16b-4G6M-VHH、pET-16b-5bVP-VHH、pET-16b-5MVZ-VHH和pHEN1-4G6M-VHH、pHEN1-5bVP-VHH、pHEN1-5MVZ-VHH, 其中VHH为重链单域抗体, 4G6M-VHH、5bVP-VHH、5MVZ-VHH分别为3种抗IL-1β的纳米抗体), 将构建成功的质粒分别转入大肠杆菌Rosetta2(DE3)表达菌中进行诱导表达及镍柱纯化, 用十二烷基硫酸钠-聚丙烯酰胺凝胶电泳(SDS-PAGE)和Western印迹对表达产物及纯化产物进行鉴定, 并通过酶联免疫吸附试验(ELISA)测定其亲和力。将纯化所得亲和力最高的抗IL-1β纳米抗体(pHEN1-5MVZ-VHH)应用于小鼠HL-1心肌细胞缺氧模型(分为正常对照组、缺氧模型组、空白质粒组及12.5、25.0、50.0 μg/ml pHEN1-5MVZ-VHH处理组), 并检测细胞存活率及凋亡率。结果 SDS-PAGE和Western印迹结果显示, 成功得到相对分子质量约15 000的抗IL-1β纳米抗体;ELISA结果显示, 与pET-16b载体组相比, pHEN1载体组所表达的纳米抗体与IL-1β抗原的亲和力更高(4G6M-VHH组:3.20±0.03比1.20±0.03, PbVP-VHH组:3.18±0.06比1.21±0.02, Pb和pHEN1载体均能表达出抗IL-1β纳米抗体, 且pHEN1载体表达的纳米抗体具有更好的抗原亲和作用。此外, pHEN1-5MVZ-VHH治疗可减少缺氧小鼠心肌细胞凋亡。

关键词：缺氧心肌细胞细胞凋亡白细胞介素1β 纳米抗体原核表达

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black hole shadows in Einstein-bel-Robinson gravity

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Chinese Physics C 2024年第5期48卷 272-283页

作者： b.Hamil b.C.Lütfüoğlu Laboratoire de Physique Mathématique et Subatomique Facultédes Sciences ExactesUniversitéConstantine 1ConstantineAlgeria Department of Physics University of Hradec KrálovéRokitanského 6250003 Hradec KrálovéCzechia

Gravity models given by higher-order scalar curvature corrections are believed to bear important consequences. Einstein-bel-Robinson (EbR) gravity with quartic curvature modification motivated Sajadi et al. to explore static spherically symmetric black hole solutions using perturbative methods. In this study, inspired by their work, we investigate AdS black hole shadows in EbR gravity and demonstrate how the gravity parameter alters the energy emission rate. Finally, we address the same problem in the presence of plasma, because the black holes are thought to be surrounded by a medium that changes the geodesic of photons.

关键词： black hole shadows Einstein-bel-Robinson gravity plasma

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Soils in extraterrestrial space: Need for studies under microgravity

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Pedosphere 2024年第1期34卷 13-14页

作者： M.b.KIRKHAM Department of Agronomy Kansas State UniversityManhattan KS 66506USA

With the increased interest of plants in space, gravity cannot be ignored when studying soil-plant-water relations. Therefore, it is important to understand the water relations of soils under zero gravity in space or under reduced gravity on the Moon or Mars. This paper outlines the problems of moving water in soils under zero gravity or microgravity, as well as growing plants in these soils. It is suggested that microgravity experiments could be done on Earth using both soils and plants. Results from such experiments could be used to grow plants when mankind establishes bases on the Moon and Mars.

关键词： soils soil bases

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Water Vapor Information from Satellite and Its Applications

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Advances in Atmospheric Sciences 2024年第1期41卷 188-189页

作者： b.J.SOHN School of Earth and Environmental Sciences Seoul National UniversitySeoul 08826Korea

Water vapor is a critical component of the hydrological cycle because it plays a vital role in transporting water from one part of the cycle to *** vapor evaporated from surfaces such as oceans,lakes,and rivers conden... 详细信息

关键词： motion oceans lakes

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CompactChain:an efficient stateless chain for UTXO-model blockchain

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Frontiers of Computer Science 2024年第2期18卷 167-179页

作者： b Swaroopa REDDY T Uday Kiran REDDY Department of Electrical Engineering Indian Institute of Technology HyderabadHyderabadTelangana 502285India

In this work,we propose a stateless blockchain called CompactChain,which compacts the entire state of the UTXO(Unspent Transaction Output)based blockchain systems into two RSA *** first accumulator is called Transaction Output(TXO)commitment which represents the TXO *** second one is called Spent Transaction Output(STXO)commitment which represents the STXO *** this work,we discuss three algorithms:(i)To update the TXO and STXO commitments by the *** miner also provides the proofs for the correctness of the updated commitments;(ii)To prove the transaction’s validity by providing a membership witness in TXO commitment and non-membership witness against STXO commitment for a coin being spent by a user;(iii)To update the witness for the coin that is not yet spent;The experimental results evaluate the performance of the CompactChain in terms of time taken by a miner to update the commitments and time taken by a validator to verify the commitments and validate the *** compare the performance of CompactChain with the existing state-of-the-art works on stateless *** shows a reduction in commitments update complexity and transaction witness size which inturn reduces the mempool size and propagation latency without compromising the system throughput(Transactions per second(TPS)).

关键词： stateless blockchain RSA Accumulator STXO commitment TXO commitment UTXO Non-interactive Proof of Exponentiation(NI-PoE) Transactions per second(TPS)

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