检索结果-南通市图书馆

GROWTH AND MORPHOLOGY OF POLYMER-ACTIN COMPLEXES

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2007年第1期25卷 47-55页

作者： Hyuck Joon Kwon Kazuhiro Shikinaka akira Kakugo Hidemitsu furukawa Yoshihito Osada 龚剑萍 Graduate School of Science Hokkaido UniversitySapporo 060-0810Japan Graduate School of Science Hokkaido UniversitySapporo 060-0810Japan SORSTJSTSapporo 060-0810Japan

F-actins are semi-flexible polyelectrolytes and can be assembled into large polymer-actin complex with polymorphism through electrostatic interaction with polycations. This study investigates the structural phase behavior and the growth of polymer-actin complexes in terms of its longitudinal and lateral sizes. Our results show that formation of polymer-actin complexes is cooperative, and morphology and growth of polymer-actin complexes depend on polycation species and concentrations of polycation and salt in a constant actin concentration. We found that the longitudinal growth and lateral growth of polymer-actin complexes are dominated by different factors. This induces the structural polymorphism of polymer-actin complexes. Major factors to influence the polymorphism of polymer-actin complexes in polyelectrolytc system have been discussed. Our results indicate that the semi-flexible polyelectrolyte nature of F-actins is important for controlling the morphology and growth ofactin architectures in cell.

关键词： F-actin Polymer-actin complex Polycation concentration (Cp) KCl concentration (Cs) Fluorescence microscopy Transmission electron microscopy (TEM) Rod-like polyelectrolyte.

Elucidation of the relationship of BNIP3 expression to gemcitabine chemosensitivity and prognosis

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2007年第34期13卷 4593-4597页

作者： Masaharu Ishida Makoto Sunamura Toru furukawa Masanori Akada Hiroko Fujimura Emiko Shibuya Shinichi Egawa Michiaki Unno akira Horii Departments of Molecular Pathology Tohoku University School of Medicine 2-1 Seiryo-machi Aoba-ku Sendai 980-8575 Japan Department of Gastroenterological Surgery Tohoku University School of Medicine 1-1 Seiryo-machi Aoba-ku Sendai 980-8574 Japan Department of Gastroenterological Surgery Tohoku University School of Medicine 1-1 Seiryo-machi Aoba-ku Sendai 980-8574 Japan Cancer Surgery Section Hammersmith Hospital Imperial College Du Cane Road London W12 0NN United Kingdom Departments of Molecular Pathology Tohoku University School of Medicine 2-1 Seiryo-machi Aoba-ku Sendai 980-8575 Japan Department of Gastroenterological Surgery Tohoku University School of Medicine 1-1 Seiryo-machi Aoba-ku Sendai 980-8574 Japan

AIM: To evaluate the significance of BNIP3 in the pathogenesis of pancreatic cancer, we analyzed the relationship between the expression of BNIP3 and survival rate of the patients with pancreatic cancer, or chemosensitivities in pancreatic cancer cell lines, particularly for gemcitabine, the first-line anti-tumor drug for pancreatic cancer. METHODS: To compare the expression level of BNIP3 with the resistance to gemcitabine, eight pancreatic cancer cell lines were subjected to gemcitabine treatment and the quantitative real-time RT-PCR method was used to evaluate BNIP3 expression. Immunohistochemical analysis was also performed using 22 pancreatic cancer specimens to study relationship between BNIP3 expression and survival rate. RESULTS: Although no significantly positive association between BNIP3 mRNA level and gemcitabine chemosensitivity was observed, pancreatic cancer cell lines that were sensitive to gemcitabine treatment tended to show high levels of BNIP3 expression. The converse, an absence of BNIP3 expression, was not correlated with gemcitabine resistance. We further compared the BNIP3 expression profiles of resected primary pancreaticcancer specimens with the prognosis of the patients, and found a tendency of favorable prognosis and low BNIP3 expression. CONCLUSION: High levels of BNIP3 expression cannot be used as one of the predicting factors for gemcitabine chemosensitivity, and some yet to be known factors will have to fill the gap for the accurate prediction of pancreatic cancer chemosensitivity to gemcitabine. However, BNIP3 expression may have an impact on prediction of prognosis of patients with pancreatic cancer.

关键词： BNIP3 Chemosensitivity Gemcitabine Pancreatic cancer Prognosis

Management Agility Depends on Well-Renovated IT Infrastructure

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computer Technology and Application 2012年第8期3卷 564-577页

作者： Masaru furukawa akira Minami Department of Business Administration Faculty of Economics University of Toyama Toyama City 930-8555 Japan Toyama Prefectural University Imizu City 939-0398 Japan

Today management agility as an inter-corporate competitive advantage cannot be realized unless given all of the following quickness：（a） quick recognition of changes in the management environment, （b） quick decision-making on countermeasures against these changes, and （c） quick implementation of the countermeasures chosen. With a focus on （c） and assuming flexibility as a core property that an MIS （Management Information System） should have to make management agile, this study aims to clarify how MIS flexibility could be enhanced. With this aim in mind, the authors will first survey the sources and types of change demands on an MIS and consider in a structured way the flexibility characteristics of an MIS, enhancement of which will conduce to its efficiency in dealing with these change demands. With this groundwork laid, the authors will go on to discuss practical methods to enhance MIS flexibility, and wind up their discussion by presenting the evaluation procedure for this property.

关键词： IT (information technology) infrastructure MIS (management information system) flexibility MIS evaluation penalty of change.

Weyl points and Dirac lines protected by multiple screw rotations

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science Bulletin 2017年第11期62卷 788-794页

作者： akira Furusaki Condensed Matter Theory Laboratory RIKEN Wako Saitama 351-0198 Japan

In three-dimensional noncentrosymmetric materials two-fold screw rotation symmetry forces electron＇s energy bands to have Weyl points at which two bands touch. This is illustrated for space groups No. 19 （P212121 ） and No. 198 （P213）, which have three orthogonal screw rotation axes. In the case of space groups No. 61 （Pbca） and No. 205 （Pa-3） that have extra inversion symmetry, Weyl points are promoted to four-fold degenerate line nodes in glide-invariant planes. The three-fold rotation symmetry present in the space groups No. 198 and No. 205 allows Weyl and Dirac points, respectively, to appear along its rotation axes in the Brillouin zone and generates four-fold and six-fold degeneracy at the F point and R point, respectively.

关键词： Weyl points Dirac points Nodal lines Nonsymmorphic symmetry

Estimations of the Maximum Tangential Velocity V_(θm) in the Vortex Core Region and also the Mean Rotational Velocity V_(oi) near the Concave Wall Surface in the Returned Flow Type Cyclone Dust Collector

在线全文

学校读者我要写书评

暂无评论

Journal of Thermal Science 2010年第6期19卷 553-560页

作者： akira Ogawa T 110-0011. Minowa 2-14-7 Taitou-Ku Tokyo Japan

There are many types of cyclone dust collectors for separating the fine solid and dust particles from gases in the various industries and also in the home used purposes. For estimating the power loss and the collection efficiency, one of the most important factors is the maximum tangential velocity V0m in the vortex core region in the cyclone body. In order to determine V0~ by the simple method, it is useful to apply the mechanical balance of the angular momentum fluxes under the assumption of Ogawa combined vortex model which is composed of the quasi-forced vortex in the vortex core region and also the quasi-free vortex surrounded the vortex core region and also under the assumption of the introduction of equivalent length Heq corresponding to the cone spaces of the cyclone body and the dust bunker. On the other hand, the mean rotational velocity Voi near the concave wall surface is also estimated by the mechanical balance of angular momentum fluxes with the moment of viscous friction force. For confirming the general applications of the obtained equations, the returned flow types cyclones changed the throat diameter D3 are designed. The material of the cyclone is the transparent acrylic resin. Therefore the inner surface of the cyclone body can be regarded as smooth surface. The comparisons of the measured velocities V~ and Voi by a cylindrical Pitot tube are shown in good agreement with those of the proposed equations. The above stated results are described in detail.

关键词： Cyclone Dust Collector Maximum Tangential Velocity Mean Rotational Velocity Angular Momentum Flux Equivalent Length Surface Frictional Force Ogawa Combined Vortex Model Reynolds Number.

Comparison of generalized engine control and MPC based on maximum principle

在线全文

学校读者我要写书评

暂无评论

Control Theory and Technology 2017年第2期15卷 150-157页

作者： akira OHATA TECHNOVA Inc. The Imperial Hotel Tower 1-1 Uchisaiwai-cho 1 Chiyoda-ku Tokyo 100-0011 Japan

Automotive engine control has been continuously improved due to the strong demands from the society and the market since introducing electronic controls but not always following control theories. Therefore, it is not easy for researchers from academia and even engineers from the automotive industry to grasp the whole aspect of engine control. To encounter the issue, important features of engine control are extracted and generalized from the standpoint of control engineering. Comparisons of the control and model predictive control （MPC） showed an outstanding performance of the control generalized from engine controls and how to apply MPC in the framework.

关键词： Automotive engine history of engine control control design input constraints time delay model predictive control

Rifaximin ameliorates hepatic encephalopathy and endotoxemia without affecting the gut microbiome diversity

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2017年第47期23卷 8355-8366页

作者： Kosuke Kaji Hiroaki Takaya Soichiro Saikawa Masanori furukawa Shinya Sato Hideto Kawaratani Mitsuteru Kitade Kei Moriya Tadashi Namisaki Takemi Akahane akira Mitoro Hitoshi Yoshiji Third Department of Internal Medicine Nara Medical University

AIM To determine the efficacy of rifaximin for hepatic encephalopathy(HE) with the linkage of gut microbiome in decompensated cirrhotic *** Twenty patients(12 men and 8 women; median age, 66.8 years; range, 46-81 years) with decompensated cirrhosis(Child-pugh score > 7) underwent cognitive neuropsychological testing, endotoxin analysis, and fecal microbiome assessment at baseline and after 4 wk of treatment with rifaximin 400 mg thrice a day. HE was determined by serum ammonia level and number connection test(NCT)-A. Changes in whole blood endotoxin activity(EA) was analyzed by endotoxinactivity assay. Fecal microbiome was assessed by 16 S ribosome RNA(rR NA) gene *** Treatment with rifaximin for 4 wk improved hyperammonemia(from 90.6 ± 23.9 μg/d L to 73.1 ± 33.1 μg/dL; P < 0.05) and time required for NCT(from 68.2 ± 17.4 s to 54.9 ± 20.3 s; P < 0.05) in patients who had higher levels at baseline. Endotoxin activity was reduced(from 0.43 ± 0.03 to 0.32 ± 0.09; P < 0.05) in direct correlation with decrease in serum ammonia levels(r = 0.5886, P < 0.05). No statistically significant differences were observed in the diversity estimator(Shannon diversity index) and major components of the gut microbiome between the baseline and after treatment groups(3.948 ± 0.548 at baseline vs 3.980 ± 0.968 after treatment; P = 0.544), but the relative abundances of genus Veillonella and Streptococcus were *** Rifaximin significantly improved cognition and reduced endotoxin activity without significantly affecting the composition of the gut microbiome in patients with decompensated cirrhosis.

关键词： gut microbiome Hepatic encephalopathy Liver cirrhosis Endotoxin Rifaximin

Serum angiotensin-converting enzyme level for evaluating significant fibrosis in chronic hepatitis B

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2017年第36期23卷 6705-6714页

作者： Ryuichi Noguchi Kosuke Kaji Tadashi Namisaki Kei Moriya Mitsuteru Kitade Kosuke Takeda Hideto Kawaratani Yasushi Okura Yosuke Aihara Masanori furukawa akira Mitoro Hitoshi Yoshiji Third Department of Internal Medicine Nara Medical University

AIM To evaluate the diagnostic performance of angiotensinconverting enzyme(ACE)on significant liver fibrosis in patients with chronic hepatitis B(CHB). METHODS In total,100 patients with CHB who underwent liver biopsy in our hospital were enrolled,and 70 patients except for 30 patients with hypertension,fatty liver or habitual alcoholic consumption were *** compared histological liver fibrosis and serum ACE levels and evaluated the predictive potential to diagnose significant liver fibrosis by comparison with several biochemical marker-based indexes such as the aspartate aminotransferase(AST)-to-platelet ratio index(APRI),the fibrosis index based on four factors(FIB-4),the Mac-2 binding protein glycosylation isomer(M2BPGi)level and the number of platelets(Plt). RESULTS Serum ACE levels showed moderately positive correlation with liver fibrotic stages(R2=0.181).Patients with significant,advanced fibrosis and cirrhosis(F2-4)had significantly higher serum ACE levels than those with early-stage fibrosis and cirrhosis(F0-1).For significant fibrosis(≥F2),the 12.8 U/L cut-off value of ACE showed 91.7%sensitivity and 75.0%*** receiver-operating characteristic(ROC)curves analysis revealed that the area under the curve(AUC)value of ACE was 0.871,which was higher than that of APRI,FIB-4,M2BPGi and Plt. CONCLUSION The serum ACE level could be a novel noninvasive,easy,accurate,and inexpensive marker of significant fibrosis stage in patients with CHB.

关键词： Angiotensin-converting enzyme Hepatitis B virus Liver fibrosis Noninvasive fibrosis marker Aspartate aminotransferase-to-platelet ratio index Fibrosis index based on four factors Mac-2 binding protein glycosylation isomer

Control of Collection Efficiency for Axial Flow Cyclone Dust Collectors with Fixed Guide Vanes and with Funnel Shaped Exit Pipes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Thermal Science 2006年第3期15卷 240-250页

作者： akira Ogawa Masaru Arakawa T-110-0011 Minowa 2-14-7Taitou-KuTokyoJapan SHINWA RULES Co. Ltd.Sanjo-ShiNiigataJapan

The experimental result of the collection efficiency of the axial flow cyclone with the fixed guide vanes is lower than that with the tangential inlet pipe to the cyclone body due to the weak angular momentum transfer given by flowing through the guide vanes. However, one of the interesting points is the control of the collection efficiency depended on the funnel shaped exit pipes. The collection efficiencies for these funnel shaped exit pipes are depended on the Froude number. Then, in this paper, the experimental results of the pressure drop and also the collection efficiency using the fly-ash particles and also the comparison of the calculated results of the collection efficiency with the experimental results are described i~ detail.

关键词： Axial flow cyclone funnel shaped exit pipe fixed guide vanes pressure drop collection efficiency,Froude number cut-Size