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Human umbilical cord-derived mesenchymal stromal cells promote sensory recovery in a spinal cord injury rat model

Stem Cell Discovery 2013年第3期3卷 155-163页

作者： Sachiko Takikawa akihito yamamoto Kiyoshi Sakai Ryutaro Shohara Akira Iwase Fumitaka Kikkawa Minoru Ueda Department of Oral and Maxillofacial Surgery Nagoya University Graduate School of Medicine Nagoya Japan

While paralysis is widely appreciated to impact the quality-of-life after spinal cord injuries (SCIs), neuropathic chronic pain may also occur in many cases. In this study, we investigated whether human umbilical cord-derived mesenchymal stromal cells (hUCMSCs) possess the therapeutic potential to reduce neuropathic pain following SCI in rats. Spinal cord hemitransection, which was used as a rat SCI pain model, induced tactile hypersensitivity in the hind paw and hyperexcitability of wild dynamic range neurons in response to natural cutaneous stimuli. Following hemitransection, we transplanted hUCMSCs into the spinal cord. Attenuation of neuronal hyperexcitability was observed in the hUCMSC-treated group compared with that observed in the vehicle-treated group. Immunohistochemistry showed that the transplanted hUCMSCs retained the expression of gammaamino butyric acid (GABA). The results suggest that transplanted hUCMSCs ameliorate GABAergic inhibition in the spinal cord. In summary, the production of GABA plays a critical role in the plasticity of neuropathic pain after implantation of hUCMSCs.

关键词： Human Umbilical Cord Mesenchymal Stromal Cell Mesenchymal Stem Cell GABA

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Immunotherapy for esophageal cancer:Where are we now and where can we go

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World Journal of Gastroenterology 2024年第19期30卷 2496-2501页

作者： Yoshiaki Shoji Kazuo Koyanagi Kohei Kanamori Kohei Tajima Mika Ogimi Yamato Ninomiya Miho yamamoto akihito Kazuno Kazuhito Nabeshima Takayuki Nishi Masaki Mori Department of Gastroenterological Surgery Tokai University School of MedicineKanagawa 259-1193Japan

Immune checkpoint inhibitor therapy has dramatically improved patient prognosis,and thereby transformed the treatment in various cancer types including esophageal squamous cell carcinoma(ESCC)in the past *** antibodies that selectively inhibit programmed cell death-1(PD-1)activity has now become standard of care in the treatment of ESCC in metastatic settings,and has a high expectation to provide clinical benefit during perioperative ***,anti-cytotoxic T-lymphocyte–associated protein 4(CTLA-4)monoclonal antibody has also been approved in the treatment of recurrent/metastatic ESCC in combination with anti-PD-1 *** understanding of the existing evidence of immune-based treatments for ESCC,as well as recent clinical trials on various combinations with chemotherapy for different clinical settings including neoadjuvant,adjuvant,and metastatic diseases,may provide future prospects of ESCC treatment for better patient outcomes.

关键词： Esophageal cancer Immunotherapy Immune checkpoint inhibitor Programmed cell death-1 Anti-cytotoxic T-lymphocyte-associated protein 4 Neoadjuvant therapy Adjuvant therapy Clinical trials Combination therapy

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Current status and future perspectives for the treatment of resectable locally advanced esophagogastric junction cancer:A narrative review

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World Journal of Gastroenterology 2023年第24期29卷 3758-3769页

作者： Yoshiaki Shoji Kazuo Koyanagi Kohei Kanamori Kohei Tajima Mika Ogimi Kentaro Yatabe Miho yamamoto akihito Kazuno Kazuhito Nabeshima Kenji Nakamura Takayuki Nishi Masaki Mori Department of Gastroenterological Surgery Tokai University School of MedicineIsehara 259-1193Japan

Incidence rates for esophagogastric junction cancer are rising rapidly worldwide possibly due to the economic development and demographic ***,increased attention has been paid to the prevention,diagnosis,and the treatment of esophagogastric junction *** there are discrepancies in the treatment strategy between Asian and Western countries,surgery remains the mainstay of treatment for esophagogastric junction *** developments of perioperative multidisciplinary treatment may lead to better therapeutic effect,higher complete resection rate,and better control of the residual diseases,thus result in prolonged *** this review,we will focus on the treatment of locally advanced resectable esophagogastric junction cancer,and discuss the current status and future perspectives of the perioperative treatment including chemotherapy,radiation therapy,and immunotherapy,as well as the surgical *** understanding of the latest treatment strategy and future overlook may enable to standardize and individualize the treatment for esophagogastric junction cancer,thus leading to better prognosis for those patients.

关键词： Esophagogastric junction cancer Perioperative therapy Neoadjuvant therapy Surgery Multidisciplinary treatment

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Metabolropic glutamale receptors negatively regulate melatonin synthesis in rat pinealocytes

Metabolropic glutamale receptors negatively regulate melaton...

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Third Congress of the Asian-Pacific Organization for Cell Biology

作者： Hiroshi Yamada Shouki Yatsushiro Mitsuko Hayashi Akitsugu yamamoto akihito Yamaguchi Yoshinori Moriyama Institute of Scientific and Industrial Research (ISIR) Osaka UniversityIbarakiOsaka 567JAPAN Kansai Medical University MoriguchiOsaka 570JAPAN

Rat pinealocytes are neuroendocrine cells that synthesize and secrete melatonin. Besides melatonin, pinealocytes accumulate L-glutamate in microvesicles and secrete it through Ca2+ regulated exocytosis (1,2). Extracellular glutamate is sequestered through a GLT-1 type Na+-dependent glutamate transporter at the plasma membrane (3). Thus pinealocyte may also

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