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Study on Styrene Grafting onto Per-fluorinated Polymers Effects of Irradiated and Reaction Conditions

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Study on Styrene Grafting onto Per-fluorinated Polymers Effe...

The Impact of Second-Order Analytical Derivatives on Regularized Direct Multiple Shooting Method for Impulsive Spacecraft Trajectory Optimization

第6届辐射研究与辐射工艺学术年会

作者： Akio Matsuura Tomoyuki Kakigi Saneto Asano Fumihiro Mutou akihiro oshima Masakazu Washio Advanced Research Institute for Science and Engineering Waseda University 3-4-1 Okubo Shinjuku Tokyo 169-8555 JAPAN

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Guidance, Navigation and Control 2024年第1期4卷 62-85页

作者： Kenta oshima Hiroshima Institute of Technology 2-1-1 Miyake Hiroshima 731-5193Japan

While thefirst-order derivatives of an objective function and constraints have often been analytically provided in the gradient-based optimization algorithms,the joint use of the secondorder derivatives can further improve the computational e±ciency and *** paper implements thefirst-and second-order analytical derivatives in the direct multiple shootingbased,regularized method of minimizing the fuel expenditure for impulsive space *** high-order dynamical information expresses the Hessian matrix of the Lagrange function in the nonlinear programming *** result is an e±cient tool for robustly computing fueloptimal,multi-impulse trajectories in the regularized framework of removing singularities associated with null thrust impulses from the derivatives of the objective *** computational performance is compared for the cases of optimizing impulsive transfers between cislunar periodic orbits within the regularized framework implementing the analytical derivatives in different ways over various initial guess trajectories and computational *** results indicate the superiority of adopting both thefirst-and second-order analytical derivatives in terms of the e±ciency and robustness.

关键词： Spacecraft trajectory optimization analytical derivatives regularization

Solid-State NMR Analysis of Irradiated Fluoropolymers

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Solid-State NMR Analysis of Irradiated Fluoropolymers

Study on styrene grafting onto per-fluorinated polymers——effects of irradiation and reaction conditions

RadTech Asia 2005

作者： Yukari Numata akihiro oshima Keitaro Aimi Shinji Ando Katsuyoshi Murata Hiroyuki Kono Masakazu Washio Etsuko Katoh Department of Biochemistry National Institute of Agrobiological Science （NIAS） 2-1-2 Kannondai Tsukuba Ibaraki 305-8602Japan Advanced Research Institute for Science and Engineering Waseda University 3-4-1 Okubo Shinjuku-ku Tokyo 169-8555Japan Department of Organic and polymeric Materials Tokyo Institute of Technology 2-12-1 Ookayama Meguro-ku Tokyo152-8552 Japan Department of Organic and polymeric Materials Tokyo Institute of Technology 2-12-1 Ookayama Meguro-ku Tokyo152-8552 Japan Department of Biochemistry National Institute of Agrobiological Science （NIAS） 2-1-2 Kannondai Tsukuba Ibaraki 305-8602 Japan Bruker BioSpin Company Ltd. Ninomiya 3-21-5 Tsukuba Ibaraki 305-0051 Japan Advanced Research Institute for Science and Engineering Waseda University 3-4-1 Okubo Shinjuku-ku Tokyo 169-8555Japan Department of Biochemistry National Institute of Agrobiological Science （NIAS） 2-1-2 Kannondai Tsukuba Ibaraki 305-8602Japan

＜正＞ We have investigated changes in chemical structures and molecular dynamics for electron beam（EB）-irradiated MPE/PTFE polymer-blend using solid-state NMR spectroscopy. Although 13the 13C MAS NMR spectra did not yield useful information regarding changes in the chemical structure of MPE/PTFE by the EB- irradiation, it was possible to obtain detailed structural information from the 19F MAS NMR spectra. The results indicate that 19F signals at -215 （-CFH- and/or -CFH2） and -140 ppm （-CF2H） for EB-irradiated MPE/PTFE are characteristic signals, which are not observed in independently irradiated PTFE. Furthermore, relaxation times for these samples were measured, and the results indicate that the molecular motion of the crystalline components of PTFE and MPE is altered by EB-irradiation. These NMR experimental results indicate that a chemical reaction occurred between MPE and PTFE, and that their molecular motion was significantly changed by irradiation.

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辐射研究与辐射工艺学报 2005年第2期23卷 103-103页

作者： Akio Matsuura Tomoyuki Kakigi Saneto Asano Fumihiro Mutou akihiro oshima Masakazu Washio Advanced Research Institute for Science and Engineering Waseda University Shinjuku Tokyo 169-8555 JapanAdvanced Research Institute for Science and Engineering Waseda University Shinjuku Tokyo 169-8555 JapanAdvanced Research Institute for Science and Engineering Waseda University Shinjuku Tokyo 169-8555 JapanAdvanced Research Institute for Science and Engineering Waseda University Shinjuku Tokyo 169-8555 JapanAdvanced Research Institute for Science and Engineering Waseda University Shinjuku Tokyo 169-8555 JapanAdvanced Research Institute for Science and Engineering Waseda University Shinjuku Tokyo 169-8555 Japan

Fuel cell is in focus as a very low exhaust new dynamo system. Especially polymer electrolyte fuel cells (PEFC) using proton exchange membranes (PEM) have attracted much attention for the electrical vehicle and other mobile applications such as cellar phone and personal computer. Conventional perfluoro-sulfonic acid membranes such as Nation() (DuPont de Nemours LTD.) have been the popular PEM used in PFEC. However, there are still several problems such as insufficient gas barrier properties, low thermal resistance, and their high *** this study, hawse have studied the partially fluorinated PEM for PEFC by radiation grafting onto per-fluorinated polymers such as PFA, FEP and ETFE with reactive styrene monomers using pre-irradiation grafting method in gas and in liquid phase, respectively, and successive sulfonation. Characteristic properties of the grafted and sulfonated materials have been discussed and optimized fabricating conditions were *** properties of the obtained materials have been measured by differential scanning calorimetry,thermogravimetric analysis and FT-IR spectroscopy, *** the case of irradiation in air, glass transition temperatures (Tg) of the grafted materials depend on the yields of styrene grafting onto the materials. That is higher yields of grafting give lower thermal stability. On the other hand, when the peroxy radicals were converted trapped radicals by exposure in air after irradiation under oxygen-free atmosphere, Tg of the grafted materials hardly depends on the grafting ***, the yields of grafting in gas phase were higher than that of liquid phase. However, the sample form of grafting in gas phase has been greatly changed, whereas the sample form of grafting in liquid phase has kept its original ***, it is suggested that the fabricating conditions for PEFC membranes were preferred to irradiation under oxygen-free atmosphere and grafting in liquid *** exchange capacities of t

关键词： polymers effects and

利用探针跳跃式扫描离子电导显微镜技术揭示结直肠癌单细胞层面对H_(2)O_(2)良性应激的动态响应

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Science Bulletin 2024年第12期69卷 1909-1919页

作者：王东 Emily Woodcock 杨羲 Hiromi Nishikawa Elena V.Sviderskaya Masanobu oshima Christopher Edwards 张彦军 Yuri Korchev WPI Nano Life Science Institute(WPI-Nano LSI) Kanazawa UniversityKanazawa 920-1192Japan Department of Medicine Imperial College LondonLondon W120NNUnited Kingdom Cell Biology Research Centre Molecular and Clinical Sciences Research InstituteSt George’sUniversity of LondonLondon SW170REUnited Kingdom

Colorectal cancer(CRC),a widespread malignancy,is closely associated with tumor microenvironmental hydrogen peroxide(H_(2)O_(2))*** clinical trials targeting H_(2)O_(2)for cancer treatment have revealed its paradoxical role as a promoter of cancer *** the dynamics of cancer cell H_(2)O_(2)eustress at the single–cell level is *** this study,non–contact hopping probe mode scanning ion conductance microscopy(HPICM)with high-sensitive Pt–functionalized nanoelectrodes was employed to measure dynamic extracellular to intracellular H_(2)O_(2)gradients in individual colorectal cancer Caco–*** explored the relationship between cellular mechanical properties and H_(2)O_(2)*** to 0.1 or 1 mmol/L H_(2)O_(2)eustress increased the extracellular to intracellular H_(2)O_(2)gradient from 0.3 to 1.91 or 3.04,***,cellular F–actin–dependent stiffness increased at 0.1 mmol/L but decreased at 1 mmol/L H_(2)O_(2)*** H_(2)O_(2)–induced stiffness modulated AKT activation positively and glutathione peroxidase 2(GPX2)expression *** findings unveil the failure of some H_(2)O_(2)-targeted therapies due to their ineffectiveness in generating H_(2)O_(2),which instead acts eustress to promote cancer cell *** research also reveals the complex interplay between physical properties and biochemical signaling in cancer cells'antioxidant defense,illuminating the exploitation of H_(2)O_(2)eustress for survival at the single–cell *** GPX and/or catalase(CAT)enhances the cytotoxic activity of H_(2)O_(2)eustress against CRC cells,which holds significant promise for developing innovative therapies targeting cancer and other H_(2)O_(2)-related inflammatory diseases.

关键词： SPM Nanoprobe Nanobiology SECM ROS Stiffness

Emotion Measurement Using Biometric Signal

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Health 2024年第5期16卷 395-404页

作者： Yukina Miyagi Saori Gocho Yuka Miyachi Chika Nakayama Shoshiro Okada Kenta Maruyama Taeyuki oshima College of Pharmacy Kinjo Gakuin University Nagoya Japan Graduate School of Medicine Aichi Medical University Nagakute Japan Department of Pharmacy Nagoya Ekisaikai Hospital Nagoya Japan Department of Pharmacy Gifu University of Medical Science Kani Japan

In recent years, research on the estimation of human emotions has been active, and its application is expected in various fields. Biological reactions, such as electroencephalography (EEG) and root mean square successive difference (RMSSD), are indicators that are less influenced by individual arbitrariness. The present study used EEG and RMSSD signals to assess the emotions aroused by emotion-stimulating images in order to investigate whether various emotions are associated with characteristic biometric signal fluctuations. The participants underwent EEG and RMSSD while viewing emotionally stimulating images and answering the questionnaires. The emotions aroused by emotionally stimulating images were assessed by measuring the EEG signals and RMSSD values to determine whether different emotions are associated with characteristic biometric signal variations. Real-time emotion analysis software was used to identify the evoked emotions by describing them in the Circumplex Model of Affect based on the EEG signals and RMSSD values. Emotions other than happiness did not follow the Circumplex Model of Affect in this study. However, ventral attentional activity may have increased the RMSSD value for disgust as the β/θ value increased in right-sided brain waves. Therefore, the right-sided brain wave results are necessary when measuring disgust. Happiness can be assessed easily using the Circumplex Model of Affect for positive scene analysis. Improving the current analysis methods may facilitate the investigation of face-to-face communication in the future using biometric signals.

关键词： Biometric Signals Electroencephalogram Electrocardiogram Emotion Communication

SEPARATION OF METAL IONS AS CHELATES OF 1N2,7O3,6S IN THE PRESENCE OR ABSSENCE OF TBA^+ BY CAPILLARY ELECTROPHORESIS

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Journal of Wuhan University of Technology(Materials Science) 1999年第2期14卷 40-45页

作者： Mitsuko oshima Okayama University

Separation and determination of metal ions based on the formation of chelate anions with 1-Nitroso-2, 7-dihydrexynaphthalene-3, 6-disulfonic acid (1N2, 7O3, 6S) was studied by rising HPCE of the nine metal ions examined, the ions that can be detected sensitively with 1-Nitroso-2, 7-dihydrexynaphthalene-3, 6-disulfonic acid were Fe2+, Co2+, Cu2+, Ni2+, Zn2+ and Pd2+. The cobalt chelate could exist in two oxidation states of cobalt. When TBA(+) were added in electrophoretic solutions, the drastic changes in elertrophoretic mobilities of chelate were observed, which was due to the ion association between chelates anions and TBA(+). The ion association constants of chelate anions with TBA(+) were determined by using the change in electrophoretic mobilities of chelates, metal ions tested were separated within 10 min using 30cm silica capillary (50 m i. d).

关键词： high-performance capillary electrophoresis 1-Nitroso-2,7-dihydrozynaphthalene-3,6-disulfonic acid metal ions

Mutant p53 in colon cancer

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Journal of Molecular Cell Biology 2019年第4期11卷 267-276页

作者： Mizuho Nakayama Masanobu oshima Division of Genetics Cancer Research Institute Kanazawa University Kanazawa 920-1192 Japan WPI-Nano Life Science Institute Kanazawa University Kanazawa 920-1192 Japan

The accumulation of genetic alterations in driver genes is responsible for the development and malignant progression of colorectal cancer. Comprehensive genome analyses have revealed the driver genes, including APC, KRAS, TGFBR2, and TP53, whose mutations are frequently found in human colorectal cancers. Among them, the p53 mutation is found in ~60% of colorectal cancers, and a majority of mutations are missense-type at ‘hot spots’, suggesting an oncogenic role of mutant p53 by ‘gain-of-function’ mechanisms. Mouse model studies have shown that one of these missense-type mutations, p53 R270H (corresponding to human R273H), causes submucosal invasion of intestinal tumors, while the loss of wild-type p53 has a limited effect on the invasion process. Furthermore, the same mutant p53 promotes metastasis when combined with Kras activation and TGF-β suppression. Importantly, either missense-type p53 mutation or loss of wild-type p53 induces NF-κB activation by a variety of mechanisms, such as increasing promoter accessibility by chromatin remodeling, which may contribute to progression to epithelial–mesenchymal transition. These results indicate that missense-type p53 mutations together with loss of wild-type p53 accelerate the late stage of colorectal cancer progression through the activation of both oncogenic and inflammatory pathways. Accordingly, the suppression of the mutant p53 function via the inhibition of nuclear accumulation is expected to be an effective strategy against malignant progression of colorectal cancer.

关键词： colon cancer missense-type mutant p53 gain-of-function mouse model NF-κB multistep tumorigenesis organoids

Performance analysis for power generating system by using matrix method

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Science China(Technological Sciences) 2011年第7期54卷 1689-1696页

作者： Kanji oshima Yohji UCHIYAMA Department of Risk Engineering Graduate School of Systems and Information Engineering University of Tsukuba

We verified that the matrix method, a process analysis method used mainly for life cycle inventory analysis, has several advantages in the analysis of power systems, which have recently become more complex to enhance efficiency and to reduce C02 emissions. While designing a conceptual thermodynamic model of a complex power system, the matrix method provides a definite procedure and facilitates calculations, even if there is a recttrsive loop between the upstream and downstream processes. Similarly, in the case of partial modification to the constructed model, the matrix method can potentially reduce the time and effort required to calculate the thermodynamic balances, even if the constructed model is designed by others. In this study, we obtained mass flow and energy balances of example model power systems by the matrix method from the common thermodynamic conditions including temperatures and pressures which are set on the basis of an existing industrial steam power system. While analyzing the environmental impact of complex multiproduct power systems, such as carbon emissions, the matrix method can be used to easily derive the environmental impact of each final product. We could verify the efficacy of the matrix method in accurately deriving that of an example model power system.

关键词： power system matrix method efficiency environmental impact hybrid power generation conceptual design