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Diagnostic performance of C-reactive protein level and its role as a potential biomarker of severe dengue in adults

Asian Pacific Journal of Tropical Medicine 2020年第8期13卷 358-365页

作者： Raghavendra Rao Snehal Nayak akhilesh k pandey Shobha U kamath Department of Medicine Kasturba Medical CollegeManipalIndia Manipal Academy of Higher Education ManipalIndia Department of Biochemistry Kasturba Medical CollegeManipalIndia Department of Community Medicine Kasturba Medical CollegeManipalIndia

Objective: To determine the relationship between C-reactive protein(CRP) level and the severity of dengue and the potential use of CRP in predicting acute dengue ***: A prospective observational study was performed on dengue patients admitted to a tertiary care hospital in southern India. All patients of age above 18 years, diagnosed with dengue were included in the study. The detailed laboratory parameters pertaining to dengue were recorded. CRP levels were estimated and compared between groups i.e. severe and non-severe dengue. CRP cut-off value was detected using the receiver-operator ***: Totally 98 patients with a mean age of 40 years were included. Among them, 11.2% of the patients suffered from severe dengue, 54.1% of the cases had non-severe dengue without warning signs, and 34.7% had non-severe dengue with warning signs. The median CRP was significantly higher in patients with severe dengue compared to patients with non-severe dengue(96.2 mg/d L vs. 5.3 mg/d L). Univariate logistic regression analysis showed that the odd’s ratio(OR) of CRP was 1.053(P≤0.001, 95% CI=1.029-1.078). CRP at a cutoff value of 21.6 mg/L(0.929 AUC) had excellent sensitivity(100%) and specificity(81.6%) in predicting severe dengue infection. Multivariate logistic regression analysis showed that CRP(OR=1.089, P=0.013) and ALT(OR=1.010, P=0.034) were statistically significant independent predictors of dengue ***: CRP level could be used as a potential biomarker to predict severity of dengue in adults.

关键词： Vector-borne Arbovirus Inflammation Biochemical Tropical disease

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A Pair of Pseudo-differential Operators Involving Index Whittaker Transform in L_(2)^(a) (R_(+);m_(a)(x)dx)

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Acta Mathematica Sinica,English Series 2024年第6期40卷 1420-1430页

作者： Jeetendrasingh MAAN akhilesh PRASAD Department of Mathematics and Computing Indian Institute of Technology(Indian School of Mines)Dhanbad-826004India

Pseudo-differential operators(PDO)Q(x,L_(a,x))and Q(x,L_(a,x))involving the index Whittaker transform are *** for these operators in Hilbert space L_(2)^(a)(R+;m_(a)(x)dx)are obtained.A symbol classΩis *** product an... 详细信息

关键词： Pseudo-differential operator index Whittaker transform confluent hypergeometric functions Hilbert space

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Perianal Crohn’s disease:Still more questions than answers

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World Journal of Gastroenterology 2024年第39期30卷 4260-4266页

作者： akhilesh Swaminathan Miles P Sparrow Department of Medicine University of OtagoChristchurch 8011CanterburyNew Zealand Department of Gastroenterology Alfred HealthMelbourne 3004VictoriaAustralia Department of Gastroenterology The Alfred HospitalMelbourne 3004VictoriaAustralia Department of Gastroenterology Alfred Health and School of Translational MedicineMonash UniversityMelbourne 3004VictoriaAustralia

In this editorial we comment on the article by Pacheco et al published in a recent issue of the World Journal of *** focus specifically on the burden of illness associated with perianal fistulizing Crohn’s disease(PFCD)and the diagnostic and therapeutic challenges in the management of this ***-ving evidence has shifted the diagnostic framework for PFCD from anatomical classification systems,to one that is more nuanced and patient-focused to drive ongoing decision *** editorial aims to reflect on these aspects to help clinicians face the challenge of PFCD in day-to-day clinical practice.

关键词： Perianal Crohn’s disease Crohn’s disease classification Disease severity Crohn’s disease treatment Anorectal malignancy

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Spin squeezing in Dicke-class of states with non-orthogonal spinors

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Chinese Physics B 2019年第6期28卷 66-71页

作者： k S akhilesh k S Mallesh Sudha Praveen G Hegde Department of Physics University of MysoreManasagangotriMysuru-570006KarnatakaIndia Department of Physics Kuvempu UniversityShankaraghattaShimoga-577451India Inspire Institute Inc. AlexandriaVirginia 22303USA

The celebrated Majorana representation is exploited to investigate spin squeezing in different classes of pure symmetric states of N qubits with two distinct spinors, namely the Dicke-class of states. On obtaining a general expression for spin squeezing parameter, the variation of squeezing for different configurations is studied in detail. It is shown that the states in the Dicke-class, characterized by two-distinct non-orthogonal spinors, exhibit squeezing.

关键词： Majorana representation of pure symmetric multiqubit states spin squeezing Dicke states

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Fractional Wavelet Packet Transformations Involving Hankel–Clifford Integral Transformations

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Acta Mathematica Sinica,English Series 2016年第7期32卷 783-796页

作者： akhilesh PRASAD Sumant kUMAR Department of Applied Mathematics Indian School of Mines

In this paper, we introduce the fractional wavelet transformations （FrWT） involving Han- kel-Clifford integral transformation （HCIIT） on the positive half line and studied some of its basic properties. Also we obtain Parseval＇s relation and an inversion formula. Examples of fractional powers of Hankel-Clifford integral transformation （FrHClIT） and FrWT are given. Then, we introduce the concept of fractional wavelet packet transformations FrBWPT and FrWPIT, and investigate their properties.

关键词： Wavelet packet transformation fractional Hankel-Clifford integral transformation frac-tional Hankel-Clifford integral convolution wavelet

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Synthetic and biological studies on a cyclopolypeptide of plant origin

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第5期9卷 391-400页

作者： Rajiv DAHIYA akhilesh kUMAR Department of Pharmaceutical Chemistry Rajiv Academy for Pharmacy

Objective:A natural cyclic peptide previously isolated from Citrus medica was synthesized by coupling of tetrapep-tide units Boc-Leu-Pro-Trp-Leu-OMe and Boc-Ile-Ala-Ala-Gly-OMe after proper deprotection at carboxyl and amino terminals followed by cyclization of linear octapeptide segment. Methods:Solution phase technique was adopted for the synthesis of cyclooctapeptide-sarcodactylamide. Required tetrapeptide units were prepared by coupling of Boc-protected dipeptides viz. Boc-Leu-Pro-OH and Boc-Ile-Ala-OH with respective dipeptide methyl esters Trp-Leu-OMe and Ala-Gly-OMe. Cyclization of linear octapeptide unit was done by p-nitrophenyl ester method. The structure of synthesized cyclopolypeptide was elucidated by FTIR,1H NMR,13C NMR,FABMS spectral data and elemental analysis. The newly synthesized peptide was evaluated for dif-ferent pharmacological activities including antimicrobial,anthelmintic and cytotoxic activities. Results:Synthesis of sarcodac-tylamide was accomplished with >78% yield utilizing dicyclohexylcarbodiimide(DCC) as coupling agent. Newly synthesized peptide possessed potent cytotoxic activity against Dalton's lymphoma ascites(DLA) and Ehrlich's ascites carcinoma(EAC) cell lines,in addition to moderate anthelmintic activity against earthworms Megascoplex konkanensis,Pontoscotex corethruses and Eudrilus sp. Moreover,cyclopolypeptide displayed good antimicrobial activity against pathogenic fungi Candida albicans and Gram-negative bacteria Pseudomonas aeruginosa,in comparison to standard drugs griseofulvin and ciprofloxacin. Conclusion:Solution phase technique employing DCC and triethylamine(TEA) as base proved to be effective for the synthesis of natural cyclooctapeptide. N-methyl morpholine(NMM) was found to be a better base for the cyclization of linear octapeptide unit in comparison to TEA and pyridine.

关键词： Cyclic octapeptide Citrus medica var. sarcodactylis Sarcodactylamide Peptide synthesis Anthelmintic activity Antimicrobial activity Cytotoxicity

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Long noncoding RNA: TRIMming the viral load

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Cellular & Molecular Immunology 2019年第11期16卷 843-845页

作者： akhilesh kumar Himanshu kumar Laboratory of Immunology and Infectious Disease Biology Department of Biological SciencesIndian Institute of Science Education and Research BhopalBhopal By-pass roadBhauriBhopalMadhya Pradesh 462066India Laboratory of Host Defense WPI Immunology Frontier Research CenterOsaka University3-1 Yamada-okaSuitaOsaka 565-0871Japan

Viruses are obligate intracellular entities that require a living host and its machinery for *** replication,viral components known as pathogen-associated molecular patterns(PAMPs)are sensed by a family of innate immune sensors or pattern recognition receptors(PRRs)and promote an antiviral *** nucleic acids are one of the key PAMPs sensed by cytosolic RIG-I-like receptors(RLRs),Cyclic GMP-AMP Synthase(cGAS),Absent In Melanoma 2(AIM2),Interferon Gamma Inducible Protein 16(IFI16),and Z-DNA Binding Protein 1(ZBP1 or DAI)and endosome-localized Toll-like receptors(TLR3,7,8,and 9).1 Recognition of viral RNA by Retinoic acid-inducible gene I(RIG-I),Melanoma differentiation associated gene 5(MDA5),and TLR3,7,and 8 or viral DNA by TLR9,cGAS,AIM2,IFI16,and DAI triggers a cascade of signaling events to recruit transcription factors,interferon regulatory factors and NF-κ*** IRF3/7 and NF-κB translocate to the nucleus and induce expression of type I and III interferons and proinflammatory cytokines,respectively.1 The production of these interferons is further enhanced in an autocrine and paracrine manner through the JAk-STAT signaling *** I and III interferons further induce interferoninducible genes,and together with proinflammatory cytokines,they develop an antiviral *** antiviral state is characterized by by apoptosis of virally infected cells and inhibition of the cellular protein synthesis machinery,making the uninfected cells resistant to viral infection and initiates virus-specific adaptive immune responses(Fig.1a).

关键词： interferon load viral

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On the Sobolev Boundedness Results of the Product of Pseudo-differential Operators Involving a Couple of Fractional Hankel Transforms

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Acta Mathematica Sinica,English Series 2018年第2期34卷 221-232页

作者： akhilesh PRASAD kanailal MAHATO Department of Applied Mathematics Indian Institute of Technology (Indian School of Mines) Dhanbad-826004 India Department of Mathematics Institute of Science Banaras Hindu University Varanasi-221005 India

This article is concerned with the study of pseudo-differential operators associated with fractional Hankel transform. The product of two fractional pseudo-differential operators is defined and investigated its basic properties on some function space. It is shown that the pseudo-differential operators and their products are bounded in Sobolev type spaces. Particular cases are discussed.

关键词： Pseudo-differential operators Bessel operator fractional Hankel convolution fractional Hankel integral transform Sobolev type space

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3D-printed bioactive scaffolds from nanosilicates and PEOT/PBT for bone tissue engineering

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Regenerative Biomaterials 2019年第1期6卷 29-37页

作者： James k.Carrow Andrea Di Luca Alireza Dolatshahi-Pirouz Lorenzo Moroni akhilesh k.Gaharwar Department of Biomedical Engineering Texas A&M UniversityCollege StationTX 77843USA Tissue Regeneration Department MIRA Institute for Biomedical Technology and Technical MedicineUniversity of TwenteEnschedeThe Netherlands DTU Nanotech Center for Intestinal Absorption and Transport of BiopharmaceuticalsTechnical University of Denmark2800 KgsLyngbyDenmark Department of Complex Tissue Regeneration MERLN Institute for Technology-Inspired Regenerative MedicineMaastricht UniversityUniversiteitsingel 406229ER MaastrichtThe Netherlands Department of Materials Science Texas A&M UniversityCollege StationTX 77843USA Center for Remote Health Technologies and Systems Texas A&M UniversityCollege StationTX 77843USA

Additive manufacturing(AM)has shown promise in designing 3D scaffold for regenerative ***,many synthetic biomaterials used for AM are ***,we report synthesis of bioactive nanocomposites from a poly(ethylene oxide terephthalate)(PEOT)/poly(butylene terephthalate)(PBT)(PEOT/PBT)copolymer and 2D nanosilicates for fabricating 3D scaffolds for bone tissue ***/PBT have been shown to support calcification and bone bonding ability in vivo,while 2D nanosilicates induce osteogenic differentiation of human mesenchymal stem cells(hMSCs)in absence of osteoinductive *** effect of nanosilicates addition to PEOT/PBT on structural,mechanical and biological properties is ***,the addition of nanosilicate to PEOT/PBT improves the stability of nanocomposites in physiological conditions,as nanosilicate suppressed the degradation rate of ***,no significant increase in the mechanical stiffness of scaffold due to the addition of nanosilicates is *** addition of nanosilicates to PEOT/PBT improves the bioactive properties of AM nanocomposites as demonstrated in *** readily proliferated on the scaffolds containing nanosilicates and resulted in significant upregulation of osteo-related proteins and production of mineralized *** synergistic ability of nanosilicates and PEOT/PBT can be utilized for designing bioactive scaffolds for bone tissue engineering.

关键词： 3D printing nanocomposites two dimensional(2D)nanoparticles copolymer tissue engineering

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Potential of roots and shoots of Napier grass for arresting soil erosion and runoff of mollisols soils of Himalayas

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International Soil and Water Conservation Research 2023年第3期11卷 538-548页

作者： Sushma Tamta akhilesh kumar Daniel Prakash kushwaha krishi Vigyan kendra Khodawandpur848202BegusaraiBiharIndia Department of Soiland Water Conservation Engineering G.B.Pant University of Agriculture and TechnologyPantnagar263145India

In this study, a soil filled Hydraulic Tilting Flume (HTF) was used as a test plot under simulated rainfallconditions. This flume was flled with mollisols soils (sandy loam in texture) collected from tarai regionof Himalayas. The effects of root and shoot characteristics of Napier grass in terms of leaf area index (LAI),shoot length (SL), number of leaves (NL), number of tillers (NT), shoot biomass (SB), root density (RD),root length (RL), root biomass (RB), and total biomass (TB) were investigated on runoff and sedimentoutflow at 90, 120 and 150 days after planting (DAP). Four simulated rainfall intensities namely 4.0, 6.5,8.3 and 9.4 cm/h over three land slopes of 1, 2 and 3% were selected. Runoff samples collected fromwhole plant plot and only root plot were analyzed for runoff and sediment outflow. Findings revealedthat Napier grasses were very effective to reduce runoff and sediment outflow and its efficacy increasedwith the extended growth stages. The reduction in runoff and sediment outflow at 90, 120 and 150 DAPwas obtained as 56% and 85%, 68% and 90%, and 74% and 96%, respectively, as compared to bare plotconditions. It was observed that the comparative contribution of shoots in runoff rate reduction washigher than the roots. On the contrary, the root part of the plant showed more contribution in sedimentrate reduction as compared to the shoot part. Step wise regression was attempted for the selection ofeffective input parameters to establish authentic runoff and sediment outflow models. Power form ofmultiple non-linear regression (MNLR) showed very satisfactory results for predicting runoff and sedimentoutflow with coefficient of determination (R^(2)) as 97.4% and 99.0%, respectively, root mean squareerror (RMSE) as 38.8 cc/m^(2)/min and 0.126 g/m^(2)/min, respectively, and coefficient of efficiency (CE) as93.9% and 96.7%, respectively, during testing period.

关键词： Rootand shoot characteristics Runoff and sedimentreduction Simulated rainfall conditions Hydraulic tilting flume Step wise regression analysis

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