3D-printed bioactive scaffolds from nanosilicates and PEOT/PBT for bone tissue engineering

作     者：James K.Carrow Andrea Di Luca Alireza Dolatshahi-Pirouz Lorenzo Moroni Akhilesh K.Gaharwar 

作者机构：Department of Biomedical EngineeringTexas A&M UniversityCollege StationTX 77843USA Tissue Regeneration DepartmentMIRA Institute for Biomedical Technology and Technical MedicineUniversity of TwenteEnschedeThe Netherlands DTU NanotechCenter for Intestinal Absorption and Transport of BiopharmaceuticalsTechnical University of Denmark2800 KgsLyngbyDenmark Department of Complex Tissue RegenerationMERLN Institute for Technology-Inspired Regenerative MedicineMaastricht UniversityUniversiteitsingel 406229ER MaastrichtThe Netherlands Department of Materials ScienceTexas A&M UniversityCollege StationTX 77843USA Center for Remote Health Technologies and SystemsTexas A&M UniversityCollege StationTX 77843USA 

出 版 物：《Regenerative Biomaterials》 (再生生物材料（英文版）)

年 卷 期：2019年第6卷第1期

页      面：29-37页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 081702[工学-化学工艺] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070305[理学-高分子化学与物理] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 

基　　金：from National Science Foundation(CBET 1705852) National Institute of Health(EB026265,EB023454).A.D.L.and L.M.are grateful to the Dutch Technology Foundation(Grant no.11135) 

主　　题：3D printing nanocomposites two dimensional(2D)nanoparticles copolymer tissue engineering 

摘      要：Additive manufacturing(AM)has shown promise in designing 3D scaffold for regenerative ***,many synthetic biomaterials used for AM are ***,we report synthesis of bioactive nanocomposites from a poly(ethylene oxide terephthalate)(PEOT)/poly(butylene terephthalate)(PBT)(PEOT/PBT)copolymer and 2D nanosilicates for fabricating 3D scaffolds for bone tissue ***/PBT have been shown to support calcification and bone bonding ability in vivo,while 2D nanosilicates induce osteogenic differentiation of human mesenchymal stem cells(hMSCs)in absence of osteoinductive *** effect of nanosilicates addition to PEOT/PBT on structural,mechanical and biological properties is ***,the addition of nanosilicate to PEOT/PBT improves the stability of nanocomposites in physiological conditions,as nanosilicate suppressed the degradation rate of ***,no significant increase in the mechanical stiffness of scaffold due to the addition of nanosilicates is *** addition of nanosilicates to PEOT/PBT improves the bioactive properties of AM nanocomposites as demonstrated in *** readily proliferated on the scaffolds containing nanosilicates and resulted in significant upregulation of osteo-related proteins and production of mineralized *** synergistic ability of nanosilicates and PEOT/PBT can be utilized for designing bioactive scaffolds for bone tissue engineering.