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3D-printed bioactive scaffolds from nanosilicates and PEOT/PBT for bone tissue engineering

Regenerative Biomaterials 2019年第1期6卷 29-37页

作者： James k.Carrow Andrea Di Luca Alireza Dolatshahi-Pirouz Lorenzo Moroni ak.ilesh k.gaharwar Department of Biomedical Engineering Texas A&M UniversityCollege StationTX 77843USA Tissue Regeneration Department MIRA Institute for Biomedical Technology and Technical MedicineUniversity of TwenteEnschedeThe Netherlands DTU Nanotech Center for Intestinal Absorption and Transport of BiopharmaceuticalsTechnical University of Denmark2800 KgsLyngbyDenmark Department of Complex Tissue Regeneration MERLN Institute for Technology-Inspired Regenerative MedicineMaastricht UniversityUniversiteitsingel 406229ER MaastrichtThe Netherlands Department of Materials Science Texas A&M UniversityCollege StationTX 77843USA Center for Remote Health Technologies and Systems Texas A&M UniversityCollege StationTX 77843USA

Additive manufacturing(AM)has shown promise in designing 3D scaffold for regenerative ***,many synthetic biomaterials used for AM are ***,we report synthesis of bioactive nanocomposites from a poly(ethylene oxide terephthalate)(PEOT)/poly(butylene terephthalate)(PBT)(PEOT/PBT)copolymer and 2D nanosilicates for fabricating 3D scaffolds for bone tissue ***/PBT have been shown to support calcification and bone bonding ability in vivo,while 2D nanosilicates induce osteogenic differentiation of human mesenchymal stem cells(hMSCs)in absence of osteoinductive *** effect of nanosilicates addition to PEOT/PBT on structural,mechanical and biological properties is ***,the addition of nanosilicate to PEOT/PBT improves the stability of nanocomposites in physiological conditions,as nanosilicate suppressed the degradation rate of ***,no significant increase in the mechanical stiffness of scaffold due to the addition of nanosilicates is *** addition of nanosilicates to PEOT/PBT improves the bioactive properties of AM nanocomposites as demonstrated in *** readily proliferated on the scaffolds containing nanosilicates and resulted in significant upregulation of osteo-related proteins and production of mineralized *** synergistic ability of nanosilicates and PEOT/PBT can be utilized for designing bioactive scaffolds for bone tissue engineering.

关键词： 3D printing nanocomposites two dimensional(2D)nanoparticles copolymer tissue engineering

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Iron Oxide Nanoparticles Induced Oxidative Damage in Peripheral Blood Cells of Rat

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Journal of Biomedical Science and Engineering 2015年第4期8卷 274-286页

作者： Usha Singh gaharwar Paulraj R School of Environmental Sciences Jawaharlal Nehru University New Delhi India

Nanotechnology is a rapidly growing field that has elicited much concern due to a variety of applications in different fields such as industry, medicine, and cosmetics. These developments increase the concern among the general population. Hence, there is an urgent need to explore the possible human health effects of these nanomaterials. The present study is aimed to evaluate the cytotoxic and genotoxic effects of iron oxide nanoparticles (IONPs) in-vivo. In order to study the toxic effects, Wistar rats were administered intravenously with various doses of IONPs (Fe2O3) through caudal vein once in a week for 28 days, and various biochemical assays such as antioxidant enzymes activity (SOD, CAT, and GSH), lipid peroxidation, DNA damage and hematological parameters were evaluated. Genotoxicity was evaluated by comet assay and oxidative stress was measured by anti-oxidant enzymes. The results reveal that IONPs alter hematological factor such as RBC counts, WBC counts, neutrophils, monocytes and hemoglobin. A dose-dependent inhibition (p < 0.05) of antioxidant enzymes was found, and meanwhile the level of MDA elevated significantly (p < 0.05) in IONPs treated groups in dose-dependent manner;however comet assay results indicate that IONPs did not induce any significant DNA damage. The present study concluded that IONP affects inflammatory response, which induces the oxidative stress and may adversely affect the cellular function.

关键词： Oxidative Stress Iron Oxide Nanoparticles Antioxidant Enzymes Genotoxicity Peripheral Blood Cells

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Identification, Quantification and <i>In-Vitro</i>Genotoxicity of Major Polyaromatic Hydrocarbons Produced by Sugarcane Fly Ash Emitted from Sugarmill

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Journal of Environmental Protection 2019年第10期10卷 1244-1261页

作者： akanksha Verma Ramovatar Meena Anurag Maurya Usha Singh gaharwar Paulraj Rajamani School of Environmental Sciences Jawaharlal Nehru University New Delhi India

Sugarcane burning during harvest and non-harvest season emits various pollutants like volatile organic compounds (VOCs), alkanes, and PAHs (Polyaromatic hydrocarbons) in the surrounding environment. Among these pollutants, PAHs are of uttermost concern due to their high level of toxicity. Burning of sugarcane bagase in sugar mill results in the production of fly ash. Fly ash is produced as a result of sugarcane bagasse burning in sugar mills. In present study, fly ash that comes out from the sugar mill chimney was collected from Western Uttar Pradesh, India and used for further analysis. High temperature and incomplete combustion inside chimney lead to the formation of PAHs. Extraction of PAHs present in fly ash samples was done by ultrasonication method and was identified with GC-FID (gas chromatography-flame ionization detector). Results exhibit the presence of eight PAHs in fly ash samples where the Benzo(a)pyrene and Naphthalene were found to be in high concentration. Furthermore, we have evaluated toxic effects of fly ash and Polyaromatic hydrocarbons (Standard of BaP & Nap) through different methods i.e. MTT, ROS and comet assay. Significant reduction (p < 0.001) in cell viability was noted in cells treated with fly ash as compared to control. Fly ash samples were also found to induce significant oxidative stress in HeLa cells, which ultimately causes DNA damage. Therefore, it may be concluded that the fly ash samples are toxic to the environment due to the presence of PAHs. Hence, the present study plays an important role in determining the harmful effects of PAHs and their source of occurrence.

关键词： Sugarcane Fly Ash Polyaromatic Hydrocarbons Reactive Oxygen Species (ROS) DNA Damage Environmental Toxicity

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