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Journal of Biosciences and Medicines 2015年第11期3卷 128-135页

作者： Sangeeta singh ajit singh yadav Priyanka Bharti Applied Science Department Indian Institute of Information Technology Allahabad India Food Microbiology Lab Post Harvest Technology Division Central Avian Research Institute Bareilly India

Most methods used by food industries to decontaminate eggs involve washing of egg surface with various chemicals. In this study, the effectiveness of two organic decontaminants viz., acidified sodium chlorite (ASC) and cell free culture supernatant (CFCS) of two lactic acid bacteria (Lactobacillus plantarum and Pediococcus cerevisiae) was evaluated for the decontamination of spiked Salmonella Typhimurium on chicken egg shell surface. Acidified sodium chlorite at 100 μl/L concentration with the contact time of 20 min completely inhibited S. Typhimurium on egg shell surface while at 50 μl/L concentration 1 - 2 log10 units reduction was observed in counts of S. Typhimurium as compared to control group. Likewise, CFCS of P. cerevisiae completely inhibited the growth of S. Typhimurium on 30 min contact, whereas L. plantarum and combination of both were revealed significant reduction in the counts of S. Typhimurium counts.

关键词： Acidified Sodium Chlorite Eggs Lactobacillus plantarum and Pediococcus cerevisiae and Salmonella Typhimurium

Geochemical and petrological studies of high sulfur coal and overburden from Makum coalfield (Northeast India) towards understanding and mitigation of acid mine drainage

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International Journal of Coal Science & Technology 2024年第1期11卷 133-147页

作者： Angana Mahanta Debashis Sarmah Nilotpol Bhuyan Monikankana Saikia Sarat Phukan K.S.V.Subramanyam ajit singh Prasenjit Saikia Binoy K.Saikia Coal and Energy Division CSIR-North East Institute of Science and TechnologyJorhatAssam785006India Academy of Scientific&Innovative Research(AcSIR) Ghaziabad201002India Department of Geological Sciences Gauhati UniversityGuwahatiAssam781014India Geochemistry Division CSIR-National Geophysical Research InstituteUppal RoadHyderabad500007India

Opencast coal mining produces trash of soil and rock containing various minerals,that are usually dumped nearby the abandoned sites which causes severe environmental concern including the production of acid mine drainage(AMD)through oxidation pyrite *** current study entailed assessing the potential production of AMD from an opencast coal mining region in Northeast part of *** order to have a comprehensive overview of the AMD problem in Makum coalfield,the physico-chemical,geochemical,and petrological characteristics of the coal and overburden(OB)samples collected from the Makum coalfield(Northeast India)were thoroughly *** maceral compositions reveal that coal features all three groups of macerals(liptinite,vitrinite,and inertinite),with a high concentration of liptinite indicating the coal of perhydrous,thereby rendering it more ***(FeS_(2))oxidation kinetics were studied by conducting the aqueous leaching experiments of coal and(OB)samples to interpret the chemical weathering under controlled laboratory conditions of various temperature and time periods,and to replicate the actual mine site *** coupled plasma-optical emission spectroscopy(ICP-OES)was operated to detect the disposal of some precarious elements from coal and OB samples to the leachates during our controlled leaching *** Rare earth element(REE)enrichment in the samples shows the anthropogenic incorporation of the REE in the coal and *** experiments reveal the change in conductivity,acid producing tendency,total dissolved solid(TDS),total Iron(Fe)and dissolved Sulfate(SO_(4)^(2−))ions on progress of the leaching ***,the discharge of FeS_(2) via atmospheric oxidation in laboratory condition undergoes a significant growth with the rise of temperature of the reaction systems in the environment and follows pseudo first order kinetics.A bio-remediative strategies is also reported in this paper to mitigate AMD water by

关键词： Opencast mining Pyrite oxidation Coal geochemistry Coal petrology Rare earth elements AMD remediation

Cardiovascular risk factors among older persons with cognitive frailty in middle income country

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World Journal of Clinical Cases 2024年第17期12卷 3076-3085页

作者： Azianah Mohamad Ibrahim Devinder Kaur ajit singh Arimi Fitri Mat Ludin Noor Ibrahim Mohamed Sakian Nurul Fatin Malek Rivan Suzana Shahar Centre for Healthy Ageing and Wellness Faculty of Health SciencesUniversiti Kebangsaan MalaysiaWilayah Persekutuan Kuala Lumpur 50300Malaysia Basic Medical Sciences University of CyberjayaSelangor Darul EhsanMalaysia 63000Malaysia

BACKGROUND Cognitive frailty,characterized by the coexistence of cognitive impairment and physical frailty,represents a multifaceted challenge in the aging *** role of cardiovascular risk factors in this complex interplay is not yet fully *** To investigate the relationships between cardiovascular risk factors and older persons with cognitive frailty by pooling data from two cohorts of studies in *** A comprehensive approach was employed,with a total of 512 communitydwelling older persons aged 60 years and above,involving two cohorts of older persons from previous *** related to cardiovascular risks,namely sociodemographic factors,and cardiovascular risk factors,including hypertension,diabetes,hypercholesterolemia,anthropometric characteristics and biochemical profiles,were pooled for *** frailty was defined based on the Clinical Dementia Rating scale and Fried frailty *** risk was determined using Framingham risk *** analyses were conducted using SPSS version *** Of the study participants,46.3%exhibited cognitive *** risk factors including hypertension(OR:1.60;95%CI:1.12-2.30),low fat-free mass(OR:0.96;95%CI:0.94-0.98),high percentage body fat(OR:1.04;95%CI:1.02-1.06),high waist circumference(OR:1.02;95%CI:1.01-1.04),high fasting blood glucose(OR:1.64;95%CI:1.11-2.43),high Framingham risk score(OR:1.65;95%CI:1.17-2.31),together with sociodemographic factors,i.e.,being single(OR 3.38;95%CI:2.26-5.05)and low household income(OR 2.18;95%CI:1.44-3.30)were found to be associated with cognitive *** Cardiovascular-risk specific risk factors and sociodemographic factors were associated with risk of cognitive frailty,a prodromal stage of *** identification and management of cardiovascular risk factors,particularly among specific group of the population might mitigate the risk of cognitive frailty,hence preventing dementia.

关键词： Cognitive frailty Older persons Cardiovascular risk factors Frailty Mild cognitive impairment

Cardiovascular implications of inflammatory bowel disease: An updated review

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World Journal of Cardiology 2023年第11期15卷 553-570页

作者： Arshia Bhardwaj Arshdeep singh Vandana Midha ajit Sood Gurpreet singh Wander Bishav Mohan Akash Batta Department of Gastroenterology Dayanand Medical College and HospitalPunjabLudhiana 141001India Department of Internal Medicine Dayanand Medical College and HospitalPunjabLudhiana 141001India Department of Cardiology Dayanand Medical College and HospitalPunjabLudhiana 141001India

Emerging data highlights the heightened risk of atherosclerotic cardiovascular diseases(ASCVD)in patients with chronic inflammatory disorders,particularly those afflicted with inflammatory bowel disease(IBD).This review delves into the epidemiological connections between IBD and ASCVD,elucidating potential underlying ***,it discusses the impact of current IBD treatments on cardiovascular ***,the cardiovascular adverse effects of novel small molecule drugs used in moderate-to-severe IBD are investigated,drawing parallels with observations in patients with rheumatoid *** article aims to comprehensively evaluate the existing evidence supporting these *** achieve this,we conducted a meticulous search of PubMed,spanning from inception to August 2023,using a carefully selected set of *** search encompassed topics related to IBD,such as Crohn’s disease and ulcerative colitis,as well as ASCVD,including coronary artery disease,cardiovascular disease,atrial fibrillation,heart failure,conduction abnormalities,heart blocks,and premature coronary artery *** review encompasses various types of literature,including retrospective and prospective cohort studies,clinical trials,meta-analyses,and relevant guidelines,with the objective of providing a comprehensive overview of this critical intersection of inflammatory bowel disease and cardiovascular health.

关键词： Inflammatory bowel diseases Cardiovascular disorders Pericarditis myocarditis Thromboembolism Chronic inflammation Oxidative stress Endothelial dysfunction

Clinical outcomes and gut microbiota analysis of severe alcohol-associated hepatitis patients undergoing healthy donor fecal transplant or pentoxifylline therapy:single-center experience from Kerala

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Gastroenterology Report 2022年第1期10卷 566-574页

作者： Cyriac Abby Philips Rizwan Ahamed Sasidharan Rajesh Shobhit singh ajit Tharakan Jinsha K.Abduljaleel Philip Augustine Clinical and Translational Hepatology The Liver InstituteCenter of Excellence in GI SciencesRajagiri HospitalChunangamvelyAluvaErnakulamKeralaIndia Monarch Liver Laboratory The Liver InstituteCenter of Excellence in GI SciencesRajagiri HospitalChunangamvelyAluvaErnakulamKeralaIndia Department of Gastroenterology and Advanced GI Endoscopy Center of Excellence in GI SciencesRajagiri HospitalChunangamvelyAluvaErnakulamKeralaIndia Diagnostic and Interventional Radiology Center of Excellence in GI SciencesRajagiri HospitalChunangamvelyAluvaErnakulamKeralaIndia

Background Severe alcohol-associated hepatitis(SAH)patients with infections have a high short-term mortality *** microbiota dysbiosis plays an important role in the pathogenesis of *** studies have demonstrated long-term benefits with healthy donor fecal microbiota transplantation(FMT).Data on FMT compared with pentoxifylline for SAH and relevant gut microbial changes are lacking in *** From January 2019 to February 2021,retrospective analysis of a single hospital’s records revealed 47 SAH patients undergoing FMT(100mL/day via nasoduodenal tube for 7days)and 25matched patients receiving pentoxifylline(400mg/8 h for 28days).The primary end point was a 6-month survival *** end points included incidence of ascites,hepatic encephalopathy,infections,acute kidney injury,and gutmicrobiota changes between post-therapy *** discovery and network analysis were also performed to identify significant taxa of gutmicrobiota in post-treatment groups in retrospectively stored stool *** All were *** 6-month survival rate was higher in the patients undergoing FMT than in patients receiving pentoxifylline(83.0%vs 56.0%,P=0.012).At the end of 6-month follow-up,the incidences of clinically significant ascites(56.0%vs 25.5%,P=0.011),hepatic encephalopathy(40.0%vs 10.6%,P=0.003),and critical infections(52.0%vs 14.9%,P<0.001)in patients administered pentoxifylline were significantly higher than those in patients treated with *** 3 months,biomarker analysis revealed a significant abundance of Bifidobacterium and Eggerthella in the FMT group and the pentoxifylline group,*** 6 months,Bifidobacterium in the FMT group and pathogenic Aerococcaceae in the pentoxifylline group were *** analysis showed beneficial taxa(Bifidobacterium)as a central influencer in those undergoing FMT at 6 *** Healthy donor FMT improved survival rate and reduced liver-related complications compared with pe

关键词： fecal microbiota stool transplant alcoholic hepatitis liver transplant dysbiosis

Staphylococcus aureusβ-hemolysin-neutralizing single-domain antibody isolated from phage display library of Indian desert camel

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Asian Pacific Journal of Tropical Medicine 2010年第1期3卷 1-7页

作者： Jangra Pooja singh ajit Immunology Section Department of Veterinary MicrobiologyCh.Charan Singh Haryana Agricultural University

Objective:To isolate and characterize Staphylococcus aureus(***)β-hemolysinneutralizing dAbs from phage display library of Indian desert ***:Phage display library of 5×10 dAb clones of LPS-immunized Indian desert camel constructed in our laboratory was used for selection of *** exotoxin-specific clones by panning *** of Ag-specific clones in successive rounds of panning was assessed by phage-ELISA and phage *** dAb clones binding to *** exotoxin Ags were expressed with C-terminal 6×His tag in *** and purified by Ni-chelate *** expression was verified by SDS-PAGE and western *** purified clones were tested for inhibition of ’hot-cold’ hemolytic activity in *** to thermal inactivation of the dAb clones was studied by observing the effect of heat treatment from 50℃to 99℃for 30 min on the ’hot-cold’ hemolytic activity in ***:Several dAb clones binding to *** exotoxins were isolated and enriched by three rounds of *** soluble dAb clones were approximately～16 kDa in size and reacted with 6×His tag specific murine monoclonal antibody in western *** of the Ni-chelate affinity purified dAb.6×His clones,inhibited ***β-hemolysin activity in vitro and resisted thermal inactivation upto ***:An ***β-hemolysinneutralizing dAb clone of possible therapeutic potential has been isolated.

关键词： Staphylococcus aureus β-hemolysin neutralization Single domain antibodies Phage display library Indian desert camel

Effect of climate change on seasonal monsoon in Asia and its impact on the variability of monsoon rainfall in Southeast Asia

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Geoscience Frontiers 2015年第6期6卷 817-823页

作者： Yen Yi Loo Lawal Billa ajit singh School of Bioscience University of Nottingham Malaysia Campus School of Geography University of Nottingham Malaysia Campus

Global warming and climate change is one of the most extensively researched and discussed topical issues affecting the *** there are enough historical evidence to support the theory that climate change is a natural phenomenon,many research scientists are widely in agreement that the increase in temperature in the 20 th century is anthropologically *** associated effects are the variability of rainfall and cyclonic patterns that are being observed *** Southeast Asia the link between global warming and the seasonal atmospheric flow during the monsoon seasons shows varying degree of *** study investigates the impact of climate change on the seasonality of monsoon Asia and its effect on the variability of monsoon rainfall in Southeast *** comparison of decadal variation of precipitation and temperature anomalies before the 1970 s found general increases which were mostly *** beyond the 1970 s,global precipitation anomalous showed increases that almost corresponded with increases in global temperature anomalies for the same *** are frequent changes and a shift westward of the Indian summer *** precipitation is observed to be 70%below normal levels,in some areas the topography affects the intensity of *** shifting phenomenon of other monsoon season in the region are impacting on the variability of rainfall and the onset of monsoons in Southeast Asia and is predicted to delay for 15 days the onset of the monsoon in the *** variability of monsoon rainfall in the SEA region is observed to be decadal and the frequency and intensity of intermittent flooding of some areas during the monsoon season have serious consequences on the human,financial,infrastructure and food security of the region.

关键词： Climate change Temperature anomalies Precipitation anomalies Seasonal monsoons Rainfall variability Southeast Asia

Composition, structure and diversity characterization of dry tropical forest of Chhattisgarh using satellite data

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Journal of Forestry Research 2014年第4期25卷 819-825页

作者： Tarun Thakur S.L. Swamy ajit singh Nain Department of Forestry Indira Gandhi Agricultural University (IGAU) Raipur Chhattisgarh India

The purpose of this study was to characterize the land use, vegetation structure, and diversity in the Barnowpara Sanctuary, Raipur district, Chhattisgarh, India through the use of satellite remote sensing and GIS. Land cover and vegetation were spatially analyzed by digitally classifying IRS 1D LISS III satellite data using a maximum likelihood algorithm. Later, the variations in structure and diversity in different forest types and classes were quantified by adopting quadratic sampling proce- dures. Nine land-cover types were delineated： teak forest, dense mixed forest, degraded mixed forest, Sal mixed forest, open mixed forest, young teak plantation, grasslands, agriculture, habitation, and water bodies. The classification accuracy for different land-use classes ranged from 71.23% to 100%. The highest accuracy was observed in water bodies and grass- land, followed by habitation and agriculture, teak forest, degraded mixed forest, and dense mixed forest. The accuracy was lower in open mixed forest, and sal mixed forest. Results revealed that density of different forest types varied from 324 to 733 trees ha-l, basal area from 8.13 to 28.87 ***-1 and number of species from 20 to 40. Similarly, the diversity ranged from 1.36 to 2.98, concentration of dominance from 0.06 to 0.49, species richness from 3.88 to 6.86, and beta diversity from 1.29 to 2.21. The sal mixed forest type recorded the highest basal area, diversity was highest in the dense mixed forest, and the teak forest recorded maximum density, which was poor in degraded mixed forests. The study also showed that Normalized Difference Vegetation Index （NDVI） was strongly cor- related to with the Shannon Index and species richness.

关键词： forest Shannon Index species richness RS and GIS landuse NDVI

Ethnobotanical survey of medicinal plants used in the management of cancer and diabetes

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Journal of Traditional Chinese Medicine 2020年第6期40卷 1007-1017页

作者： Garima singh ajit Kumar Passari Marcy D Momin Sakthivel Ravi Bhim Pratap singh Nachimuthu Senthil Kumar Department of Biotechnology Mizoram UniversityAizawl 796004India Department of Botany Pachhunga University CollegeAizawl 796001India Departamento de Biologia Molecular y Biotecnologia Instituto de Investigaciones BiomedicasUniversidad Nacional Autonoma de Mexico(UNAM)Ciudad de Mexico-04510Mexico Department of Agriculture&Environmental Sciences(AES) National Institute of Food Technology Entrepreneurship&Management(NIFTEM)SonepatHaryanaIndia

OBJECTIVE:To conduct an ethnobotanical survey and document the traditional anticancer and antidiabetic plants used by the local tribes of Mizoram,Northeast ***:A systematic survey was conducted in rural and urban areas of Mizoram by interviewing traditional practitioners,and cancer and diabetes patients.A detailed literature search was carried out using MEDLINE and SCOPUS and available literatures were selected and included in the *** use value(UV)of the selected plants was calculated based on the number of citations per species given by ***:Data was obtained for 201 traditional medicinal plants from Mizoram,Northeast *** plants were from 72 different families and belonged to 140 *** these,103 plants were reported for the first time as possessing either anticancer or antidiabetic potential,and 105 plants were identified that were used for the treatment of both *** plants(Phlogacanthus thysiformis,Solanum gilo and Lobelia angulata)with antidiabetic potential,and six plants(Dillenia scabrella,Circium sinesis,Eupatorium nodiflorum,Pratia begonifolia,Vernonia teres and Plantago erosa)with both as anticancer and antidiabetic potential were documented for the first ***:In this study,we documented several explored and unexplored medicinal plants that may be useful for the management of cancer and *** study suggests that there is a broad scope fordeveloping potent anticancer and antidiabetic agent from the flora of Mizoram,Northeast India.

关键词： Plants medicinal Antineoplastic agents Hypoglycemic agents Ethanobotanical survey Traditional knowledge

Implementing Augmented Reality in Learning

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Psychology Research 2019年第4期9卷 172-177页

作者： ajit singh Patna Women’s College BiharIndia

Technologies are changing and ever *** of the newest developing technologies is augmented reality(AR),which can be applied to many different existing technologies,such as computers,tablets,and *** technology can also be utilized through wearable components,for example,*** this paper review on AR,the following aspects are discussed at length:research explored,theoretical foundations,applications in education,challenges,reactions,and *** different types of AR devices and applications are discussed at length,and an in-depth analysis is done on several studies that have implemented AR technology in an educational setting.

关键词： augmented reality learning and development educator flow theory just-in-time learning