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力敏感离子通道Piezo1分布与活性的力学调控及其与细胞转化态的关系

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医用生物力学 2021年第S1期36卷 88-88页

作者：姚明曦 ajay Tijore Charles d Cox Anushya Hariharan Guy Tran Van Nhieu Boris Martinac Michael Sheetz 南方科技大学生物医学工程系深圳518055 Mechanobiology Institute National University of Singapore Victor Chang Cardiac Research Institute NSW 2010Australia Equipe Communication Intercellulaire et Infections Microbiennes Centre de Recherche Interdisciplinaire en Biologie(CIRB)Collège de FranceFrance department of Biological Sciences National University of Singapore Molecular MechanoMedicine Program Dept.of Biochemistry and Molecular BiologyUniversity of Texas Medical BranchUSA

目的近十年来新发现广泛表达于多种组织细胞中的力敏感钙离子通道Piezo1在触觉/听觉感受,血压控制,免疫激活等生理过程中起到关键的力学感知作用。经典模型认为,Piezo1在细胞膜上扩散分布并在细胞膜局部表面张力起伏的作用下被激活,但... 详细信息

目的近十年来新发现广泛表达于多种组织细胞中的力敏感钙离子通道Piezo1在触觉/听觉感受,血压控制,免疫激活等生理过程中起到关键的力学感知作用。经典模型认为,Piezo1在细胞膜上扩散分布并在细胞膜局部表面张力起伏的作用下被激活,但其在细胞复杂生理过程中的调控还有很多未知问题尚待回答。方法通过一系列显微成像方法研究了Piezo1的时空分布与活性在不同种类细胞中的力学调控。

关键词：钙离子通道细胞转化力学调控免疫激活血压控制组织细胞经典模型未知问题

Versatile aza-BOdIPY-based low-bandgap conjugated small molecule for light harvesting and near-infrared photodetection

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InfoMat 2022年第12期4卷 112-127页

作者： Gurudutt Bhat Marcin Kielar Haixia Rao Mahnaz d.Gholami Isabel Mathers Astrid C.R.Larin Thomas Flanagan Enkhtur Erdenebileg Annalisa Bruno Amandeep Singh Pannu Kathryn E.Fairfull-Smith Emad L.Izake Pankaj Sah Yeng Ming Lam ajay K.Pandey Prashant Sonar School of Chemistry Physicsand Centre for Materials ScienceQueensland University of TechnologyBrisbaneQueenslandAustralia School of Electrical Engineering and Robotics Queensland University of TechnologyBrisbaneQueenslandAustralia Queensland Brain Institute The University of QueenslandSt LuciaQueenslandAustralia School of Materials Science and Engineering Nanyang Technological UniversitySingaporeSingapore Energy Research Institute@NTU(ERI@N) Nanyang Technological UniversitySingaporeSingapore

The versatile nature of organic conjugated materials renders their flawless integration into a diverse family of optoelectronic devices with light-harvesting,photodetection,or light-emitting *** of materials that offer the possibilities of two or more distinct optoelectronic functions are particularly attractive as they enable smart applications while providing the benefits of the ease of fabrication using low-cost ***,we develop a novel,multi-purpose conjugated small molecule by combining boron-azadipyrromethene(aza-BOdIPY)as electron acceptor with triphenylamine(TPA)as end-capping donor *** implemented donor–acceptor–donor(d–A–d)configuration,in the form of TPA-azaBOdIPY-TPA,preserves ideal charge transfer characteristics with appropriate excitation energy levels,with the additional ability to be used as either a charge transporting interlayer or light-sensing semiconducting layer in optoelectronic *** demonstrate its versatility,we first show that TPA-azaBOdIPY-TPA can act as an excellent hole transport layer in methylammonium lead triiodide(MAPbI3)-based perovskite solar cells with measured power conversion efficiencies exceeding 17%,outperforming control solar cells with PEdOT:PSS by nearly 60%.Furthermore,the optical bandgap of 1.49 eV is shown to provide significant photodetection in the wavelength range of up to 800 nm where TPA-azaBOdIPY-TPA functions as donor in near-infrared organic photodetectors(OPds)composed of fullerene ***,the established versatility of TPA-azaBOdIPY-TPA,combined with its robust thermal stability as well as excellent solubility and processability,provides a new guide for developing highly efficient multi-purpose electronic materials for the next-generation of smart optoelectronic devices.

关键词： BOdIPY multifunctionality organic photodetector perovskite solar cell TPA TPA-azaBOdIPY-TPA

Surface-Modified Metallic Ti3C2Tx MXene as Electron Transport Layer for Planar Heterojunction Perovskite Solar Cells

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Surface-Modified Metallic Ti3C2Tx MXene as Electron Transpor...

辛伐他汀对大鼠心肌缺血再灌注后细胞凋亡及线粒体融合素2表达的影响

第七届新型太阳能电池材料科学与技术学术研讨会

作者： Lin Yang Chunxiang dall’Agnese Yohan dall’Agnese Gang Chen Yu Gao Yoshitaka Sanehira ajay Kumar Jena Xiao-Feng Wang Yury Gogotsi Tsutomu Miyasaka Key Laboratory of Physics and Technology for Advanced Batteries(Ministry of Education) College of PhysicsJilin University

MXenes are a large and rapidly expanding family of two-dimensional(2 d) materials which,owing to their unique optoelectronic properties and tunable surface termination,find a wide range of applications including energy storage and energy *** this work,TiCT MXene nanosheets are applied as a novel type of electron transport layer(ETL) in low-temperature processed planar-structured perovskite solar cells(PSCs).Interestingly,simple UV-ozone treatment of the metallic TiCT that increases the surface Ti-O bonds without any change in its bulk properties like high electron mobility improves its suitability as an *** electron transfer and suppressed recombination at the ETL/perovskite interface results in augmentation of the power conversion efficiency(PCE) from 5.00% in the case of TiCT without UV-ozone treatment to the champion PCE of 17.17%,achieved using the TiCT film after 30 minutes of UV-ozone *** the first report on the use of pure MXene layer as an ETL in PSCs,this work shows great potential of MXenes to be used in PSCs and displays their promises for applications in photovoltaic technology in general.

关键词： UV-ozone treatment Ti3C2Tx MXene electron transport layers perovskite solar cells

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南通大学学报（医学版） 2016年第4期36卷 281-284页

作者： ajay Kumar Mishra 吴优 Shiv Kumar Yadav Akanand Singh Ram Narayan Mandal Sailendra Jha 重庆医科大学附属第二医院心血管内科重庆404100 南通大学附属医院泌尿外科上海和睦家医院外科重庆医科大学心血管内科新疆医科大学放射科

目的:探讨辛伐他汀对大鼠心肌缺血再灌注后细胞凋亡及线粒体融合素2(Mitofusin 2,Mfn2)表达的影响。方法:选取32只Sprague-dawley(Sd)大鼠,随机分为假手术组、缺血再灌注模型组(模型组)、5 mg辛伐他汀组、10 mg辛伐他汀组,每组8只。5 m... 详细信息

目的:探讨辛伐他汀对大鼠心肌缺血再灌注后细胞凋亡及线粒体融合素2(Mitofusin 2,Mfn2)表达的影响。方法:选取32只Sprague-dawley(Sd)大鼠,随机分为假手术组、缺血再灌注模型组(模型组)、5 mg辛伐他汀组、10 mg辛伐他汀组,每组8只。5 mg辛伐他汀组、10 mg辛伐他汀组分别于术前7 d开始给予5 mg/(kg·d)、10 mg/(kg·d)的辛伐他汀灌胃,假手术组、模型组均给予等量蒸馏水灌胃。采用结扎左前降支法建立大鼠心肌缺血再灌注损伤模型。各组于造模后3 h剪取心脏组织,采用TUNEL法检测心肌细胞凋亡,Western Blot法检测p-Akt的表达,免疫组织化学法检测Mfn2的表达。结果 :与假手术组相比较,模型组心肌细胞凋亡指数、Mfn2的表达明显升高,p-Akt的表达显著降低(均P<0.05);与模型组比较,5 mg辛伐他汀组、10 mg辛伐他汀组心肌细胞凋亡指数、Mfn2的表达显著降低,p-Akt的表达显著升高(均P<0.05),并显示出明显剂量依赖性(P<0.05)。结论:辛伐他汀可有效抑制心肌缺血再灌注损伤后的心肌细胞凋亡,抑制Mfn2表达是其可能作用机制。

关键词：辛伐他汀缺血再灌注心肌细胞细胞凋亡线粒体融合素2 大鼠

慢性肾衰竭患者继发甲状旁腺功能亢进的治疗进展

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赣南医学院学报 2020年第11期40卷 1174-1177页

作者：钟岸青李赞滨操凤郭莉 Pulusu ajay kumar Reddy 曾祥泰赣南医学院第一附属医院甲状腺外科江西赣州341000 赣南医学院第一附属医院肾内科江西赣州341000 赣南医学院第一附属医院内分泌科江西赣州341000 赣南医学院江西赣州341000

继发性甲状旁腺功能亢进(SHPT)是慢性肾衰竭的常见并发症之一,1,25-二羟维生素d3(1,25-dihydroxy vitamin d3,1,25-(OH)2-d3)和成纤维细胞生长因子23(fibroblast growth factor 23,FGF23)水平异常及其受体表达下调、钙磷代谢紊乱是SHPT的重要发病机制。鉴于上述发病机制,磷结合剂、活性维生素d和钙敏感受体激动剂等被广泛运用于治疗SHPT。近年来上述药物不断被深入研发并取得良好疗效,对于药物治疗效果不佳的SHPT,甲状旁腺切除术、超声引导下局部注射介入疗法成为有效的治疗手段。在SHPT的治疗过程中,血清钙、磷、全段甲状旁腺激素(iPTH)、25-羟维生素d[25(OH)d]、碱性磷酸酶(ALP)等的监测也非常重要,有利于指导用药及评估疗效。

关键词：甲状旁腺功能亢进,继发性肾衰竭,慢性治疗监测

An international delphi consensus statement on metabolic dysfunction-associated fatty liver disease and risk of chronic kidney disease

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Hepatobiliary Surgery and Nutrition 2023年第3期12卷 386-403,I0014-I0016页

作者： dan-Qin Sun Giovanni Targher Christopher d.Byrne david C.Wheeler Vincent Wai-Sun Wong Jian-Gao Fan Herbert Tilg Wei-Jie Yuan Christoph Wanner Xin Gao Michelle T.Long Mehmet Kanbay Mindie H.Nguyen Sankar d.Navaneethan Yusuf Yilmaz Yuli Huang Rino A.Gani Pierluigi Marzuillo Jérôme Boursier Huijie Zhang Chan-Young Jung Jin Chai Luca Valenti George Papatheodoridis Giovanni Musso Yu-Jun Wong Mohamed El-Kassas Nahum Méndez-Sánchez Silvia Sookoian Michael Pavlides ajay duseja Adriaan G.Holleboom Junping Shi Wah-Kheong Chan Yasser Fouad Junwei Yang Sombat Treeprasertsuk Helena Cortez-Pinto Masahide Hamaguchi Manuel Romero-Gomez Mamun Al Mahtab Ponsiano Ocama Atsushi Nakajima Chunsun dai Mohammed Eslam Lai Wei Jacob George Ming-Hua Zheng department of Nephrology Jiangnan University Medical CenterWuxiChina Affiliated Wuxi Clinical College of Nantong University WuxiChina Section of Endocrinology Diabetes and MetabolismDepartment of MedicineAzienda Ospedaliera Universitaria Integrata VeronaVeronaItaly Southampton National Institute for Health and Care Research Biomedical Research Centre University Hospital Southamptonand Southampton General HospitalUniversity of SouthamptonSouthamptonUK department of Renal Medicine University College LondonLondonUK department of Medicine and Therapeutics Chinese University of Hong KongHong KongChina Center for Fatty Liver Department of GastroenterologyXin Hua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina department of Internal Medicine I GastroenterologyEndocrinology&MetabolismMedical University InnsbruckInnsbruckAustria department of Nephrology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghaiChina division of Nephrology Department of MedicineWürzburg University ClinicWürzburgGermany department of Endocrinology and Metabolism Zhongshan HospitalFudan UniversityShanghaiChina Section of Gastroenterology Boston Medical CenterBoston University School of MedicineBostonMAUSA division of Nephrology Department of Medicine(M.K.)Koc University School of MedicineIstanbulTurkey division of Gastroenterology and Hepatology Department of MedicineStanford University Medical CenterPalo AltoCAUSA department of Epidemiology and Population Health Stanford University Medical CenterPalo AltoCAUSA Section of Nephrology and Institute of Clinical and Translational Research Baylor College of Medicineand Michael E.DeBakey VA Medical CenterHoustonTXUSA department of Gastroenterology School of MedicineMarmara UniversityIstanbulTurkey department of Gastroenterology School of MedicineRecep Tayyip Erdoğan UniversityRizeTurkey department of Cardiology Shunde HospitalSouthern Medical UniversityFoshanChina division of Hepat

Background:With the rising global prevalence of fatty liver disease related to metabolic dysfunction,the association of this common liver condition with chronic kidney disease(CKd)has become increasingly *** 2020,the more inclusive term metabolic dysfunction-associated fatty liver disease(MAFLd)was proposed to replace the term non-alcoholic fatty liver disease(NAFLd).The observed association between MAFLd and CKd and our understanding that CKd can be a consequence of underlying metabolic dysfunction support the notion that individuals with MAFLd are at higher risk of having and developing CKd compared with those without ***,to date,there is no appropriate guidance on CKd in individuals with ***,there has been little attention paid to the link between MAFLd and CKd in the Nephrology *** and Results:Using a delphi-based approach,a multidisciplinary panel of 50 international experts from 26 countries reached a consensus on some of the open research questions regarding the link between MAFLd and ***:This delphi-based consensus statement provided guidance on the epidemiology,mechanisms,management and treatment of MAFLd and CKd,as well as the relationship between the severity of MAFLd and risk of CKd,which establish a framework for the early prevention and management of these two common and interconnected diseases.

关键词： Metabolic dysfunction-associated fatty liver disease(MAFLd) non-alcoholic fatty liver disease(NAFLd) chronic kidney disease(CKd) consensus

在中国西藏边远地区和印度Haryana地区进行心血管高危人群简化规范管理:一项集群随机对照研究

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中华高血压杂志 2015年第7期23卷 607-607页

作者：李金凤叶鹏 Tian M ajay V dunzhu d Hameed S Li X Liu Z Li C Chen H Cho K Li R Zhao X Jindal d Rawal I Ali MK Peterson Ed Ji J Amarchand R Krishnan A Tandon N Xu LQ Wu Y Prab-hakaran d Yan L

在中国和印度边远地区，治疗心血管病的经济负担十分沉重，但是这些地区经济落后，医疗保健资源有限。该研究旨在设计和评估由社区医护人员（community health workers，CHW）实施，

关键词：边远地区心血管病随机对照研究高危人群印度中国集群管理

Unusual complication of amebic liver abscess: Hepatogastric fistula

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World Journal of Gastrointestinal Endoscopy 2015年第9期7卷 916-919页

作者： Sunil V Pawar Vinay G Zanwar Pravir A Gambhire Ashok R Mohite ajay S Choksey Pravin M Rathi dileep S Asgaonkar department of Gastroenterology 7th floor OPD building Topiwala National Medical College and Bai Yamunabai Laxman Nair HospitalMumbai Central department of Medicine 1st floor College buildingTopiwala National Medical College and Bai Yamunabai Laxman Nair HospitalMumbai Central

Amebic liver abscess is a parasitic disease which is often encountered in tropical countries. A hepatogastric fistula secondary to an amebic liver abscess is a rare complication of this disease and there are only a handful of reported cases in literature. Here we present a case of an amebic liver abscess which was complicated with the development of a hepatogastric fistula. The patient presented with the Jaundice, pain and distension of abdomen. The Jaundice and pain improved partially after he had an episode of brownish black colored increase in frequency of stools for 5 to 6 d. Patient also had ascites and anemia. He was a chronic alcohol drinker. Esophagogastroduodenoscopy performed in view of the above findings. It showed a fistulous opening with bilious secretions along the lesser curvature of the stomach. On imaging multiple liver abscesses seen including one in sub capsular location. The patient was managed conservatively with antiamebic medications along with proton pump inhibitors. The pigtail drainage of the sub capsular abscess was done. The patient improved significantly. The repeat endoscopy performed after about two months showed reduction in fistula size. A review of the literature shows that hepatogastric fistulas can be managed conservatively with medications and drainage, endoscopically with biliary stenting or with surgical excision.

关键词： Amebic liver abscess Hepatogastric fistula Esophagogastroduodenoscopy Entaameba histolytica Ultrasonography Computed tomography

Fungal diversity notes 1387-1511:taxonomic and phylogenetic contributions on genera and species of fungal taxa

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Fungal diversity 2021年第6期111卷 1-335页

作者： Saranyaphat Boonmee dhanushka N.Wanasinghe Mark S.Calabon Naruemon Huanraluek Sajini K.U.Chandrasiri Gareth E.B.Jones Walter Rossi Marco Leonardi Sanjay K.Singh Shiwali Rana Paras N.Singh deepak K.Maurya ajay C.Lagashetti deepika Choudhary Yu-Cheng dai Chang-Lin Zhao Yan-Hong Mu Hai-Sheng Yuan Shuang-Hui He Rungtiwa Phookamsak Hong-Bo Jiang María P.Martín Margarita dueñas MTeresa Telleria Izabela L.Kałucka Andrzej M.Jagodziński Kare Liimatainen diana S.Pereira Alan J.L.Phillips Nakarin Suwannarach Jaturong Kumla Surapong Khuna Saisamorn Lumyong Tarynn B.Potter Roger G.Shivas Adam H.Sparks Niloofar Vaghefi Mohamed A.Abdel-Wahab Faten A.Abdel-Aziz Guo-Jie Li Wen-Fei Lin Upendra Singh Rajendra P.Bhatt Hyang Burm Lee Thuong T.T.Nguyen Paul M.Kirk Arun Kumar dutta Krishnendu Acharya VVenkateswara Sarma M.Niranjan Kunhiraman C.Rajeshkumar Nikhil Ashtekar Sneha Lad Nalin N.Wijayawardene darbe J.Bhat Rong-Ju Xu Subodini N.Wijesinghe Hong-Wei Shen Zong-Long Luo Jing-Yi Zhang Phongeun Sysouphanthong Naritsada Thongklang dan-Feng Bao Janith V.S.Aluthmuhandiram Jafar Abdollahzadeh Alireza Javadi Francesco dovana Muhammad Usman Abdul Nasir Khalid Asha J.dissanayake Anusha Telagathoti Maraike Probst Ursula Peintner Isaac Garrido-Benavent Lilla Bóna Zsolt Merényi Lajos Boros Bratek Zoltán JBenjamin Stielow Ning Jiang Cheng-Ming Tian Esmaeil Shams Farzaneh dehghanizadeh Adel Pordel Mohammad Javan-Nikkhah Teodor T.denchev Cvetomir M.denchev Martin Kemler dominik Begerow Chun-Ying deng Emma Harrower Tohir Bozorov Tutigul Kholmuradova Yusufjon Gafforov Aziz Abdurazakov Jian-Chu Xu Peter E.Mortimer Guang-Cong Ren Rajesh Jeewon Sajeewa S.N.Maharachchikumbura Chayanard Phukhamsakda Ausana Mapook Kevin d.Hyde Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand CAS Key Laboratory for Plant Biodiversity and Biogeography of East Asia(KLPB) Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China CIFOR-ICRAF China Program World Agroforestry(ICRAF)Kunming 650201YunnanPeople’s Republic of China Honghe Center for Mountain Futures Kunming Institute of BotanyHonghe CountyKunming 654400YunnanPeople’s Republic of China department of Botany and Microbiology College of ScienceKing Saud UniversityP.O.Box 2455Riyadh 11451Saudi Arabia Section Environmental Sciences Department MeSVAUniversity of L’Aquila67100 CoppitoAQItaly National Fungal Culture Collection of India(NFCCI) Biodiversity and Palaeobiology GroupMACS Agharkar Research InstituteG.G.Agarkar RoadPune 411004India Institute of Microbiology School of Ecology and Nature ConservationBeijing Forestry UniversityBeijing 100083People’s Republic of China College of Biodiversity Conservation Southwest Forestry UniversityKunming 650224People’s Republic of China CAS Key Laboratory of Forest Ecology and Management Institute of Applied EcologyChinese Academy of SciencesShenyang 110164People’s Republic of China University of the Chinese Academy of Sciences Beijing 100049People’s Republic of China Centre for Mountain Futures(CMF) Kunming Institute of BotanyKunming 650201YunnanPeople’s Republic of China department of Mycology Real Jardín Botánico-CSICPlaza de Murillo 228014 MadridSpain department of Algology and Mycology Faculty of Biology and Environmental ProtectionUniversity of LodzBanacha 12/1690-237ŁódźPoland Institute of dendrology Polish Academy of SciencesParkowa 562-035 KórnikPoland Jodrell Laboratory Royal Botanic GardensKewRichmond TW93DSSurreyUK Faculdade de Ciências Biosystems and Integrative Sciences Institute(BioISI)Universidade de LisboaCampo Grande1749-016 LisbonPortugal dep

This article is the 13th contribution in the Fungal diversity Notes series,wherein 125 taxa from four phyla,ten classes,31 orders,69 families,92 genera and three genera incertae sedis are treated,demonstrating worldwide and geographic *** taxa described and illustrated in the present study include three new genera,69 new species,one new com-bination,one reference specimen and 51 new records on new hosts and new geographical *** new genera,Cylindrotorula(Torulaceae),Scolecoleotia(Leotiales genus incertae sedis)and Xenovaginatispora(Lindomycetaceae)are introduced based on distinct phylogenetic lineages and unique *** described species are Aspergillus lan-naensis,Cercophora dulciaquae,Cladophialophora aquatica,Coprinellus punjabensis,Cortinarius alutarius,***-latus,***,Coryneum fagi,Cruentomycena uttarakhandina,Cryptocoryneum rosae,Cyathus uniperidiolus,Cylindrotorula indica,diaporthe chamaeropicola,didymella azollae,diplodia alanphillipsii,dothiora coronicola,Efibula rodriguezarmasiae,Erysiphe salicicola,Fusarium queenslandicum,Geastrum gorgonicum,***,Helicosporium sexualis,Helminthosporium chiangraiensis,Hongkongmyces kokensis,Hydrophilomyces hydraenae,Hygrocybe boertmannii,Hyphoderma australosetigerum,Hyphodontia yunnanensis,Khaleijomyces umikazeana,Laboulbenia divisa,Laboulbenia triarthronis,Laccaria populina,Lactarius pallidozonarius,Lepidosphaeria strobelii,Longipedicellata megafusiformis,Lophiotrema lincangensis,Marasmius benghalensis,***,***,Mariannaea camelliae,Mel-anographium smilaxii,Microbotryum polycnemoides,Mimeomyces digitatus,Minutisphaera thailandensis,Mortierella solitaria,Mucor harpali,Nigrograna jinghongensis,Odontia huanrenensis,***,Paraconiothyrium ajrekarii,Par-afuscosporella niloticus,Phaeocytostroma yomensis,Phaeoisaria synnematicus,Phanerochaete hainanensis,Pleopunctum thailandicum,Pleurotheciella dimorphospora,Pseudochaetosphaeronema

关键词： 72 new taxa One new combination One reference specimen 51 new records Agaricomycetes Ascomycota Bartheletiomycetes Basidiomycota dothideomycetes Eurotiomycetes Exobasidiomycetes Laboulbeniomycetes Leotiomycetes Mortierellomycetes Mortierellomycota Mucoromycetes Mucoromycota Phylogeny Sordariomycetes Taxonomy