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Pipeline Embolization Device for intracranial aneurysms presenting with mass effect:a large Chinese cohort

Stroke & Vascular Neurology 2024年第1期9卷 50-58页

作者： Yang Zhao Junlin Lu Hongqi Zhang Tianxiao LI Donglei Song Sheng Guan aisha maimaitili Yunyan Wang Wenfeng Feng Yang Wang Jieqing Wan Guohua Mao Huaizhang Shi Xinjian Yang Jianmin Liu Yuanli Zhao Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurosurgery Peking University International HospitalBeijingChina Department of Neurosurgery West China HospitalSichuan UniversityChengduSichuanChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Interventional Neuroradiology Zhengzhou University People's HospitalZhengzhouHenanChina Department of Neurosurgery Shanghai Donglei Brain HospitalShanghaiChina Department of Interventional Neuroradiology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanChina Department of Neurosurgery The First Affiliated Hospital of Xinjiang Medical UniversityUrumqiXinjiangChina Department of Neurosurgery Qilu Hospital of Shandong University QingdaoJinanShandongChina Department of Neurosurgery Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdongChina Department of Neurosurgery The First Affiliated Hospital of Nanchang UniversityNanchangJiangxiChina Department of Neurosurgery Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Neurosurgery The Second Affiliated Hospital of Nanchang UniversityNanchangJiangxiChina Department of Neurosurgery The First Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangChina Department of Neurosurgery Changhai HospitalNaval Medical UniversityShanghaiChina

Background Unruptured intracranial aneurysm treatment aims to reduce the risk of aneurysm rupture and bleeding,relieves symptoms and improve the quality of life for patients.This study aimed to assess the safety and efficacy of Pipeline Embolization Device(PED,Covidien/Medtronic,Irvine,CA)treatment for intracranial aneurysms presenting with mass effect in real-world settings.Methods We selected patients from the PED in China Post-Market Multi-Center Registry Study with mass effect presentation.The study endpoints included postoperative mass effect deterioration and mass effect relief at follow-up(3–36 months).We conducted multivariate analysis to identify factors associated with mass effect relief.Subgroup analyses by aneurysm location,size and form were also performed.Results This study included 218 patients with a mean age of 54.3±11.8 years and a female predominance of 74.0%(162/218).The postoperative mass effect deterioration rate was 9.6%(21/218).During a median follow-up period of 8.4 months,the mass effect relief rate was 71.6%(156/218).Notably,immediate aneurysm occlusion following treatment was significantly associated with mass effect relief(OR 0.392,95%CI,0.170 to 0.907,p=0.029).Subgroup analysis demonstrated that adjunctive coiling contributed to mass effect relief in cavernous aneurysms,while dense embolism impeded symptom relief in aneurysms<10mm and saccular aneurysms.Conclusions Our data confirmed the efficacy of PED in relieving mass effect.The findings of this study provide support for endovascular treatment to alleviate mass effect in unruptured intracranial aneurysms.Trial registration number NCT03831672.

关键词： aneurysm intracranial Irvine

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Comparison of the Pipeline embolisation device alone or combined with coiling for treatment of different sizes of intracranial aneurysms

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Stroke & Vascular Neurology 2022年第4期7卷 345-352,I0051-I0055页

作者： Chao Wang Bin Luo Tianxiao Li aisha maimaitili Guohua Mao Donglei Song Yunyan Wang Wenfeng Feng Yang Wang Huaizhang Shi Jieqing Wan Jianmin Liu Sheng Guan Yuanli Zhao Hongqi Zhang Department of Interventional Neuroradiology Beijing Neurosurgical Institute and Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Neurosurgery Departement Peking University International HospitalBeijingChina Zhengzhou University People′s Hospital ZhengzhouHenan ProvinceChina Department of Neurosurgery Xinjiang Medical University Affiliated First HospitalUrumqiXinjiangChina Department of Neurosurgery Nanchang University Second Affiliated HospitalNanchangJiangxiChina Department of Neurosurgery Shanghai Donglei Brain HospitalShanghaiChina Department of Neurosurgery Qilu Hospital of Shandong University QingdaoJinanShandongChina Department of Neurosurgery Southern Medical University Nanfang HospitalGuangzhouGuangdongChina Department of Neurosurgery First Affiliated Hospital of Nanchang UniversityNanchangJiangxiChina Department of Neurosurgery First Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangChina Department of Neurosurgery Shanghai Jiao Tong University School of Medicine Affiliated Renji HospitalShanghaiChina Department of Neurosurgery Changhai Hospital Affiliated to Naval Medical UniversityShanghaiChina Department of Neurointerventional Surgery First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina

Objectives The aim of this study was to compare complications and outcomes between intracranial aneurysms treated with the Pipeline embolisation device(PED)alone or with PED combined with coiling for different-sized aneurysms.Method Patients with aneurysms treated by PED were collected from the PED in China postmarket multicentre registry study.We performed a propensity match analysis to compare the efficacy and safety between PED alone and PED combined with coiling treatment,and then aneurysms were organised into three groups based on their size:small(≤7 mm),medium(≤15 mm to>7 mm)and large/giant(>15 mm).Complications and aneurysm occlusion rates in the aneurysm size groups were compared between PED alone and PED combined with coiling patients.Result A total of 1171 patients with 1322 aneurysms were included.All patients received clinical follow-up,while angiographic follow-up was available in 967 aneurysms.For small aneurysms,there was no difference in the aneurysm occlusion rate between two groups(79.1%vs 88.4%,respectively),while there was a significant increase in the ischaemic complication rate(8.3%vs 19.3%,respectively,p=0.0001).For medium and large/giant saccular aneurysms,PED combined with coiling significantly improved the occlusion rate(medium aneurysms:74.7%vs 88.8%,respectively,p<0.0001;large/giant saccular aneurysms:72.9%vs 86.9%,respectively,p=0.018),while there were no differences in the total complication rate.For large/giant non-saccular aneurysms,two groups showed no differences.Conclusion Use of the PED with adjunctive coils can significantly improve the occlusion rate of medium aneurysms,without increasing the total complication rate.

关键词： alone treatment sizes

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Highly selective adsorption of rhenium by amyloid-like protein material

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Science China(Technological Sciences) 2024年第5期67卷 1417-1430页

作者： MUHAMMAD Arif YANG QingMin KANWAL aisha ZHAO Jian NAWAZ Mohsan REN Hao YANG Peng Key Laboratory of Applied Surface and Colloid Chemistry Ministry of Education Xi’an Key Laboratory of Polymeric Soft Matter International Joint Research Center on Functional Fiber and Soft Smart TextileSchool of Chemistry and Chemical EngineeringShaanxi Normal UniversityXi’an710119China School of Chemistry and Chemical Engineering Northwestern Polytechnical UniversityXi’an710072China

Rhenium separation from molybdenum in molybdenite minerals and waste leachate has become an emerging challenge.Addressing this challenge,we prepared a set of protein-based alkylamine/alkylammonium salts complexes as extractants for selective uptake of rhenium from molybdenum,where the protein component turned into the insoluble amyloid-like structure when its internal disulfide bonds were reduced,namely phase-transition process.Among them,the phase-transited lysozyme and methyletrioctyleammonium chloride complex(PTL-N263)exhibited the most efficient adsorption at the alkaline condition for the electrostatic interaction between negatively charged metal ions with positively charged center(R_(4)N^(+))in N263,where negatively charged protein residues hindered the ion exchange of Cl^(-)in N263 for larger size Mo species(Mo_(7)O_(24)^(6-))than smaller size Re species(ReO^(4-)).The adsorption follows the Freundlich model and pseudo-second-order kinetics,which exhibits toplevel adsorption performance with a maximum adsorption capacity of 124 mg/g and a separation factor(β_(Re/Mo))of 2.78×10^(3)for Re.The adsorption capacity per unit area(57.2 mg/(g m^(2)))is 1.6–41 times higher than previously reported adsorbents,and the cost for adsorbing 1 g of Re(VII)is$1.07,indicating its industrial capability.This adsorption strategy can be applied to separating Re from Mo in binary solutions and industrial wastewater with other competing ions.

关键词： amyloid phase-transited lysozyme selective adsorption rhenium waste leachate solution

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Enhancing Patient Safety in the Operating Room: A Comprehensive Guide from a Nurse’s Perspective

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Open Journal of Nursing 2024年第6期14卷 252-266页

作者： aisha Mohamed Hussein Operating Room Nurse Dr. Sulaiman Al-Habib Medical Group Bone Joint and Spine Hospital Riyadh Saudi Arabia

Ensuring patient safety within the operating room is a paramount concern in contemporary healthcare, and this guide aims to provide an in-depth exploration of this crucial aspect from the perspective of nurses. Nurses play a pivotal role in supporting surgeons and maintaining a safe environment for patients undergoing various medical procedures.

关键词： Operating Room Patient Safety Nurses

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The Impact of Simulation Education on Self-Efficacy in Pre-Registration Nursing Students

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Open Journal of Nursing 2024年第1期14卷 51-76页

作者： Ahmed A. Hakami aisha Hussin Rabie Sultan Ghormallah M. Alzahrani Faisal Mohammed Alnakhilan Khalid Awaidhalharbi College of Nursing Umm Al-Qura University Makkah Saudi Arabia Al-Noor Specialist Hospital Makkah Saudi Arabia (MOH) Ministry of Health King Fahad Hospital Al Baha Saudi Arabia (MOH) Ministry of Health Eradah Complex Riyadh Saudi Arabia King Salman Medical City Al Madinah Saudi Arabia

This literature review primarily aims to explore and synthesise the previous studies in simulation education research conducted over the past five years related to the effects of simulation training on the self-efficacy of undergraduate pre-registration nursing students. The second aim of this study is to explore additional outcome variables that were examined in the previous studies. Five electronic databases were searched systematically. These databases were MEDLINE, CINAHL Plus, Scopus, Embase and PsycINFO. The PICO model was employed to identify the search terms, with a thesaurus being used to provide synonyms. Reference lists of relevant articles were examined and hand searches of journals were also undertaken. The quality of each study was assessed using the Simulation Research Rubric (SRR). A total of 11 studies were included. All studies explored the impact of simulation education on undergraduate pre-registration nursing. Six studies explored nursing students’ competence and performance and two papers examined their critical thinking. Problem solving, learning motivation, communication skills and knowledge acquisition were examined once. The majority of studies indicated that simulation training has a positive impact on pre-registration nursing students’ self-efficacy and other outcome variables. Furthermore, the study results indicate that simulation training is more dependable than traditional training, and students were extremely satisfied with the simulation training. However, most of the studies included in this review had several gaps, including study design, sample size and dissimilarities between the scales used. Further research with large samples, reliable and valid instruments, and outcomes measures (such as critical thinking and transferability of skills) is required to provide better insight into the effectiveness of simulation in undergraduate nursing education. .

关键词： Simulation Education Self-Efficacy Pre-Registration Nursing Students Clinical Skills Undergraduate Nursing Education Teaching Techniques Decision-Making

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员工在内部招揽投资令Meta陷入窘境

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商业周刊（中文版） 2024年第10期 17-19页

作者： aisha Counts 杜然(译) 不详

Meta长期以来一直允许员工投资外部初创公司,但员工在公司内部系统里招揽投资的情况却并不常见。在Meta公司内部通讯平台的众多频道中,有一个供员工讨论房地产投资的组群。2019年,Meta洛杉矶办公中心的工程人才招募员西夫·哈法吉(Sief ... 详细信息

Meta长期以来一直允许员工投资外部初创公司,但员工在公司内部系统里招揽投资的情况却并不常见。在Meta公司内部通讯平台的众多频道中,有一个供员工讨论房地产投资的组群。2019年,Meta洛杉矶办公中心的工程人才招募员西夫·哈法吉(Sief Khafagi)开始发布关于Scoutpads的信息,这是他建立的一项服务,在用户与开发商之间建立联系,以便将资金投人房地产。

关键词：资金投人房地产投资初创公司通讯平台洛杉矶开发商

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制造材料对血管支架性能的影响

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医疗装备 2024年第7期37卷 7-11,15页

作者：杨航宋喜艳木合塔尔·克力木买买提力·艾沙新疆理工学院机电工程学院新疆阿克苏843000 新疆大学机械工程学院新疆乌鲁木齐830017 新疆医科大学第一附属医院新疆乌鲁木齐830054

由于血管支架对心血管疾病患者的创伤小且治疗效果显著,近年来被广泛应用于临床。然而,支架在血管中长期遭受血流脉动压,可能会使其发生变形或疲劳失效。随着计算机技术的快速发展,有限元分析技术由于其高效及较低的成本被广泛应用于心... 详细信息

由于血管支架对心血管疾病患者的创伤小且治疗效果显著,近年来被广泛应用于临床。然而,支架在血管中长期遭受血流脉动压,可能会使其发生变形或疲劳失效。随着计算机技术的快速发展,有限元分析技术由于其高效及较低的成本被广泛应用于心血管疾病研究中。该研究通过计算机模拟技术对S型支架赋予3种材料属性,使用Goodman图表与动态安全系数评估支架制造材料对血管支架疲劳性能的影响。结果显示,支架在相同服役条件下,改变支架的材料可显著提高支架的疲劳强度。该研究结果可以帮助工程人员在临床治疗中根据具体应用场景选择合适的支架材料,获得满足使用要求的支架。

关键词：血管支架材料疲劳

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Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont aisha Khan George Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander J.P.Goldschmidt Damien D.Pearse W.Dalton Dietrich Allan D.Levi James D.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular junction.In amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be impaired.Recently,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been reported.This case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such treatment.An 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral sclerosis.After initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and taurursodiol.The patient volunteered to participate in an FDA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron function.We confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in vitro.After a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of Dulbecco’s phosphate-buffered saline.None of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or changes in vital signs.Clinical lab serum neuro

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

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计算机技术在数字图书馆中的创新应用

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电子技术（上海） 2024年第1期53卷 270-271页

作者：阿孜古·麦麦提力喀什大学图书馆新疆844000

阐述计算机技术与数字图书馆的创新应用策略,包括完善数字化图书馆的体系架构、创建数字图书馆智慧空间、搭建数字图书馆智慧平台、提升数字图书馆智慧服务水平,实现数字化、智能化管理。

关键词：计算机技术数字图书馆信息化智慧服务

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Clinical relevance of circulating non-coding RNAs in metabolic diseases:Emphasis on obesity,diabetes,cardiovascular diseases and metabolic syndrome

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Genes & Diseases 2023年第6期10卷 2393-2413页

作者： Abdullahi Dandare Muhammad Jawad Khan aisha Naeem Afrose Liaquat Department of Biosciences COMSATS University IslamabadIslamabad 45550Pakistan Department of Biochemistry Usmanu Danfodiyo UniversitySokoto 840104Nigeria Ministry of Public Health POB42DohaQatar Department of Oncology Lombardi Comprehensive Cancer CenterGeorgetown University Medical CenterWashingtonDC 20057USA Shifa College of Medicine Shifa Tameer-E-Millat UniversityIslamabad 45550Pakistan

Non-coding RNAs(ncRNAs)participate in the regulation of several cellular processes including transcription,RNA processing and genome rearrangement.The aberrant expression of ncRNAs is associated with several pathological conditions.In this review,we focused on recent information to elucidate the role of various regulatory ncRNAs i.e.,micro RNAs(miRNAs),circular RNAs(circRNAs)and long-chain non-coding RNAs(lncRNAs),in metabolic diseases,e.g.,obesity,diabetes mellitus(DM),cardiovascular diseases(CVD)and metabolic syndrome(MetS).The mechanisms by which ncRNAs participated in disease pathophysiology were also highlighted.miRNAs regulate the expression of genes at transcriptional and translational levels.circRNAs modulate the regulation of gene expression via miRNA sponging activity,interacting with RNA binding protein and polymerase II transcription regulation.lncRNAs regulate the expression of genes by acting as a protein decoy,miRNA sponging,miRNA host gene,binding to miRNA response elements(MRE)and the recruitment of transcriptional element or chromatin modifiers.We examined the role of ncRNAs in the disease pathogenesis and their potential role as molecular markers for diagnosis,prognosis and therapeutic targets.We showed the involvement of ncRNAs in the onset of obesity and its progression to MetS and CVD.miRNA-192,miRNA-122,and miRNA-221 were dysregulated in all these metabolic diseases.Other ncRNAs,implicated in at least three diseases include miRNA-15a,miRNA-26,miRNA-27a,miRNA-320,and miRNA-375.Dysregulation of ncRNAs increased the risk of development of DM and MetS and its progression to CVD in obese individuals.Hence,these molecules are potential targets to arrest or delay the progression of metabolic diseases.

关键词： Biomarkers CircRNAs LncRNAs Metabolic diseases miRNAs Non-coding RNAs Therapeutic targets

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