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Effects of Polygala fallax Hemsl Water Extract on a Mouse Model of Gastric Motility Disorders

Medicinal Plant 2024年第4期15卷 101-106页

作者： liangyin ZHU Xiaofeng HAO liuqi HUANG Zongyuan CHEN Wenfeng CHEN liu YANG Bingchen HUANG liyuan li aipeng li Suoyi HUANG Xiuzhen SU School of Clinical Medicine Youjiang Medical University for NationalitiesBaise 533000China Key Laboratory of Guangxi Universities on National Medicine in Youjiang River Youjiang Medical University for NationalitiesBaise 533000China School of Pharmacy Youjiang Medical University for NationalitiesBaise 533000China Institute of life Sciences Youjiang Medical University for NationalitiesBaise 533000China

[Objectives]To explore the effects of Polygona fallax Hemsl water extract on gastrointestinal motility in normal mice and gastric motility disorder model mice and approximate mechanism.[Methods]Using normal mice and mice with gastric motility disorders(modeled with atropine),the effects of different mass concentration groups of *** Hemsl water extract(0.125,0.250,0.500 g/mL)and domperidone groups on gastric residual rate,small intestine propulsion rate,serum motilin(MLT),vasoactive intestinal peptide(VIP),and tissue morphology were studied.[Results]There was a highly significant difference(Pliquid in normal mice among the different concentration groups of *** Hemsl water extract compared to the blank *** small intestine propulsion rate and gastric residue rate of semi-solid paste were statistically significant compared to the blank group(Pliquid and semi-solid paste in mice with gastric motility disorders were statistically significant compared to the atropine group,with extremely significant differences(Plity in normal mice may be related to the content of MLT in mouse *** mechanism of action in atropine induced gastric paresis mice may be related to the reactivation of M receptors,and the action mechanism of *** Hemsl d

关键词： Polygala fallax Hemsl Gastric motility Mouse model Gastric emptying Gastric paresis Motilin Vasoactive intestinal peptide

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Screening for Anti-tumor Activity of Fractions from Buddleja officinalis Maxim

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Medicinal Plant 2024年第2期15卷 48-50,56页

作者： Tong li Xin XIE liyuan li aipeng li Zhidong LEI Tingting HE Sirui MO Shangfeng HUANG Yao liN Suoyi HUANG lixiang LU Shiyou ZHOU School of Basic Medical Sciences Youjiang Medical University for NationalitiesBaise 533000China Key Laboratory of Characteristic Ethnic Medicine Research in Youjiang Basin Youjiang Medical University for NationalitiesBaise 533000China School of Pharmacy Youjiang Medical University for NationalitiesBaise 533000China School of Clinical Medicine Youjiang Medical University for NationalitiesBaise 533000China

[Objectives]The anti-tumor activity of fractions from Buddleja officinalis *** petroleum ether,ethyl acetate,n-butanol and water solvent was studied.[Methods]The ethanol extract from *** *** extracted and then concentrated with petroleum ether,ethyl acetate,n-butanol and water,respectively,and the extracts were *** inhibitory effects of the four different fractions on the growth of three tumor cell lines in vitro were detected by CCK-8 method,and the median inhibitory concentration(IC 50 value)was calculated.[Results]The four fractions inhibited the growth of the three tumor cell lines in vitro,among which the n-butanol fraction had the best anti-tumor *** IC 50 values of the n-butanol fraction on human gastric cancer(SGC-7901),human breast cancer(MCF-7)and human liver cancer(BEL-7404)cell lines were 0.08,1.58 and 0.12 mg/mL,respectively.[Conclusions]Petroleum ether,ethyl acetate,n-butanol and water fractions from the ethanol extract of *** *** certain anti-tumor effects,and the n-butanol fraction had the best anti-tumor activity.

关键词： Buddleja officinalis Maxim. Tumor cells Anti-tumor Activity screening

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Redesign of a short-chain dehydrogenase/reductase for asymmetric synthesis of ethyl (R)-2-hydroxy-4-phenylbutanoate based on per-residue free energy decomposition and sequence conservatism analysis

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Green Synthesis and Catalysis 2020年第2期1卷 150-159页

作者： Bingmei Su lian Xu Xinqi Xu lichao Wang aipeng li Juan lin lidan Ye Hongwei Yu College of Chemical Engineering Fuzhou UniversityFuzhou 350116China College of Biological Science and Engineering Fuzhou UniversityFuzhou 350116China Institute of Bioengineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027China School of life Sciences Northwestern Polytechnical UniversityXi’an 710072China

As an important building block for the synthesis of angiotensin-converting enzyme inhibitors,ethyl(R)-2-hy-droxyl-4-phenylbutanoate[(R)-HPBE]has attracted increasing *** key to industrial biosynthesis of(R)-HPBE is a biocatalyst that efficiently reduces ethyl 2-oxo-4-phenylbutanoate(OPBE)with high *** paper proposed a strategy for identifying key residues involved in enantioselectivity control based on per-residue free energy decomposition and sequence conservatism *** this strategy,4 noncon-servative sites with high energy contribution to binding of OPBE were chosen as engineering targets,generating variant Mu27 with 99%conversion and 98%(R)ee value at substrate loading of up to 500 mmol/*** simu-lations suggested the higher stability and formation probability of Mu27-OPBEproR prereaction state as key rea-sons for the excellent R-enantioselectivity of Mu27 towards *** success in this study provides a viable approach for rational design of alcohol dehydrogenases with high enantioselectivity towards unnatural substrates.

关键词： Ethyl(R)-2-hydroxy-4-phenylbutanoate Rational design Enantioselectivity Short-chain dehydrogenase/reductase Per-residue free energy decomposition Sequence conservatism analysis

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Activity Screening Study on the Anti-tumor Effects of Extracts from Mahoniae caulis

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Medicinal Plant 2023年第6期14卷 19-21,26页

作者： Xin XIE liyuan li aipeng li Zhidong LEI Suoyi HUANG School of Basic Medical Sciences Youjiang Medical University for NationalitiesBaise 533000China School of Pharmacy Youjiang Medical University for NationalitiesBaise 533000China Key Laboratory of Characteristic Ethnic Medicine Research in Youjiang Basin Youjiang Medical University for NationalitiesBaise 533000China

[Objectives]To explore the anti-tumor activity of the extracts of petroleum ether,ethyl acetate,n-butanol and aqueous solution from Mahoniae caulis.[Methods]The extracts were extracted with petroleum ether,ethyl acetate,n-butanol and aqueous solution respectively,and then *** inhibitory effects of these extracts on the growth of three tumor cell lines in vitro were detected by CCK-8 method,and the IC 50 value was calculated.[Results]The four extracts inhibited the growth of the three tumor cell lines in vitro,among which the n-butanol extract had the best anti-tumor *** IC 50 values of the n-butanol extract on human gastric cancer(SGC-7901),human breast cancer(MCF-7)and human liver cancer(BEL-7404)cell lines were 0.23,0.25 and 0.58 mg/mL,respectively.[Conclusions]The ethanol extract of Mahoniae caulis under petroleum ether,ethyl acetate,n-butanol and aqueous solution had certain anti-tumor effect,and n-butanol extract had the best anti-tumor activity.

关键词： Mahoniae caulis Tumor cells Anti-tumor effects Activity screening

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Environmental Change and Human Occupation during Late Pleistocene in Hunan Province， South China

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Journal of Earth Science 2024年

作者： aipeng Guo Longjiang Mao Yiyuan li Haicheng Lai Jiafu Zhang Duowen Mo School of Marine Science， Nanjing University of Information Science and Technology Hunan Institute of Archaeology Institute of Scientific and Technical History， Nanjing University of Information Science and Technology College of Urban and Environmental Sciences， Peking University

The Paleolithic sites in South China have caused controversy regarding human behaviors in response to the rapidly shifting environment of the late Pleistocene. However， chronometric and high-resolution proxies are absent from interpreting the paleoenvironmental evolution. Here we present the chronology， grain size parameters， and geochemical elements records from the Hejialing (HJL) site in South China to reveal the crucial aspects of environmental evolution， and human occupation. The geochemical record shows that during MIS 5e–5a， northern Hunan experienced the influence of summer monsoon and maintained a warm and humid climate. The laterite layer began to develop. During MIS 4， the climate transitioned to dry and cold state， leading to the attraction of hominins to the HJL area due to the abundant water and lithic raw material resources， resulting in their establishment of a short-term camp. The HJL site was primarily inhabited by hunter-gatherer societies within a forested environment. From MIS 4 to MIS 2， Hunan experienced a prolonged period of dry and cold climatic conditions， with a brief rainfall recovery occurring in late MIS 3. Diminished vegetation and resource availability compelled human populations to broaden their activities and undertake migrations. The HJL site was abandoned amid the arid phase of MIS 2. The HJL area gradually became buried beneath eolian dust deposition (EM1) from distant sources and riverine dust from nearby sources (EM2)， and the site was informed. In MIS 1， During MIS 1， the climate shifted to a warm and humid state， marking the emergence of early agricultural practices. As an essential part of South China， the environmental evolution process and diverse survival strategies employed by hominins in Hunan are vital for explaining how the paleoenvironment drove human occupation during the Late Pleistocene.

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Additives strategies to improving cycling stability of li metal batteries by modifying electrode electrolyte interphases

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Progress in Natural Science:Materials International 2024年第2期34卷 338-344页

作者： Yuan li Pengfei Huang Chunyu Cui Xiaoyuan Ma li Chen Zekun li linhai li Yuhong Tian School of Biological and Chemical Engineering Guangxi University of Science and Technology School of College of Chemistry and Chemical Engineering Hunan University Isky Future Energy Institute

li metal batteries（LMBs） have attracted much attention due to the ultra-high theoretical capacity of the li metal anode（LMA）.However,the uncontrollable dendrites growth and low coulombic efficiency hinder their practical ***,we explore 3,5-difluoropyridine（2F-BD） as a novel electrolyte additive to enable highperformance *** 2F-BD additive participates in and modifies the solvation structure of li ions by reducing the coordinated number of PF6-at the electrode surface,leading to the formation of a liF and li3N-rich solid electrolyte interphase（SEI）.The liF component increases the robustness of SEI and suppresses the formation of li dendrites,while the li3N component facilitates the transportation and reaction kinetics of li *** a result,the li‖li symmetric cell presents a stable cycling performance of up to 500 h at a current density of 1 mA *** coupling with liFePO4cathode,the obtained full cell achieves high specific capacities of 106.06 mA h g-1and 84.98 mA h g-1at 2.55 mA cm-2and 5.10 mA cm-2,respectively,and maintains a high capacity retention of84.0% after 1000 cycles at 0.13 mA cm-2,with an average cycling CE of 99.58%.

关键词： Electrolyte additive li dendrites li metal batteries liF and li3N-Rich electrode-electrolyte interphase liFePO4 cathode

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Leaching kinetics of fluorine during the aluminum removal from spent li-ion battery cathode materials

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Journal of Environmental Sciences 2024年第4期138卷 312-325页

作者： Shengjie li Jianxin Zhu Research Center for Eco-Environmental Sciences Chinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China

The high content of aluminum(Al)impurity in the recycled cathode powder seriously affects the extraction efficiency of Nickel,Cobalt,Manganese,and lithium resources and the actual commercial value of recycled materials,so Al removal is crucially important to conform to the industrial standard of spent li-ion battery cathode *** this work,we systematically investigated the leaching process and optimum conditions associated with Al removal from the cathode powder materials collected in a wet cathode-powder peeling and recycling production line of spent li-ion batteries(liBs).Moreover,we specifically studied the leaching of fluorine(F)synergistically happened along with the removal process of Al,which was not concerned about in other studies,but one of the key factors affecting pollution prevention in the recovery *** mechanism of the whole process including the leaching of Al and F from the cathode powder was indicated by using NMR,FTIR,and XPS,and a defluoridation process was preliminarily investigated in this *** leaching kinetics of Al could be successfully described by the shrinking core model,controlled by the diffusion process and the activation energy was 11.14 kJ/***,the leaching of F was attributed to the dissolution of liPF6and decomposition of PVDF,and the kinetics associated was described by Avrami *** interaction of Al and F is advantageous to realize the defluoridation to some *** is expected that our investigation will provide theoretical support for the large-scale recycling of spent liBs.

关键词： Al removal F leaching Cathode powder Heating alkali leaching Leaching kinetics

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SEI/dead li-turning capacity loss for high-performance anode-free solid-state lithium batteries

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Journal of Energy Chemistry 2024年第9期96卷 145-152页

作者： Qianwen Yin Tianyu li Hongzhang Zhang Guiming Zhong Xiaofei Yang Xianfeng li Division of Energy Storage Dalian National Laboratory for Clean EnergyDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Long-Duration and Large-Scale Energy Storage Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina Laboratory of Advanced Spectro-Electrochemistry and lithium-Ion Batteries Dalian National Laboratory for Clean EnergyDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina

Anode-free solid-state lithium metal batteries(AF-SSLBs)have the potential to deliver higher energy density and improved safety beyond lithium-metal ***,the unclear mechanism for the fast capacity decay in AF-SSLBs,either determined by dead li or solid electrolyte interface(SEI),limits the proposal of effective strategies to prolong cycling *** clarify the underlying mechanism,herein,the evolution of SEI and dead li is quantitatively analyzed by a solid-state nuclear magnetic resonance(ss-NMR)technology in a typical liPF6-based polymer *** results show that the initial capacity loss is attributed to the formation of SEI,while the dead li dominates the following capacity loss and the growth rate is 0.141 mA h cm^(−2)cycle−*** reduce the active li loss,the combination of inorganic-rich SEI and self-healing electrostatic shield effect is proposed to improve the reversibility of li deposition/dissolution behavior,which reduces the capacity loss rate for the initial SEI and following dead li generation by 2.3 and 20.1 folds,*** a result,the initial Coulombic efficiency(ICE)and stable CE increase by 15.1%and 15.3%in li-Cu cells,which guides the rational design of high-performance AF-SSLBs.

关键词： Solid-state lithium batteries Solid-state NMR Anode-free SEI Dead li

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Theoretical Design of Defects as a Driving Force for Ion Transport in li_(3)OBr Solid Electrolyte

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Energy & Environmental Materials 2024年第3期7卷 143-153页

作者： Xingyun Luo Yanlu li Xian Zhao State Key Lab of Crystal Materials and Institute of Crystal Materials Shandong UniversityJinan 250100China Center for Optics Research and Engineering Shandong UniversityQingdao 266237China

Due to ever-increasing concerns about safety issues in using li ionic batteries,solid electrolytes have extensively *** li-rich antiperovskite li_(3)OBr has been considered as a promising solid electrolyte candidate,but it still suffers challenges to achieve a high ionic conductivity owing to the high intrinsic symmetry of the crystal ***,we presented a design strategy that introduces various point defects and grain boundaries to break the high lattice symmetry of li_(3)OBr crystal,and their effect and microscopic mechanism of promoting the migration of li-ion were explored *** has been found that li_(i)are the dominant defects responsible for the fast li-ion diffusion in bulk li_(3)OBr and its surface,but they are easily trapped by the grain boundaries,leading to the annihilating of the Frenkel defect pair V'_(li)+li_(i),and thus limits the V'_(li)diffusion at the grain *** V_(Br)defect near the grain boundaries can effectively drive V'_(li)across the grain boundary,thereby converting the carrier of li^(+)migration from li,in the bulk and surface to V'_(li)at the grain boundary,and thus improving the ionic conductivity in the whole li_(3)OBr *** work provides a comprehensive insight into the li^(+)transport and conduction mechanism in the li_(3)OBr *** opens a new way of improving the conductivity for all-solid-state li electrolyte material through the defect design.

关键词： defects density functional theory ionic migration solid electrolyte

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Highly polar CoP/Co_(2)P heterojunction composite as efficient cathode electrocatalyst for li-air battery

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Chinese Chemical Letters 2024年第9期35卷 486-490页

作者： Miaomiao li Mengwei Yuan Xingzi Zheng Kunyu Han Genban Sun Fujun li Huifeng li Beijing Key Laboratory of Energy Conversion and Storage Materials College of ChemistryBeijing Normal UniversityBeijing 100875China Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) College of ChemistryNankai UniversityTianjin 300071China Center for Advanced Materials Research Beijing Normal UniversityZhuhai 519087China

In order to advance the commercialization of rechargeable li-air batteries,it is of importance to explore cathode catalyst with efficient catalytic *** metal oxides have poor electrical conductivity,while cobalt phosphide has excellent electrical conductivity and large specific surface ***,its application in organic li-air batteries has been much less studied,and the electrocatalytic activity desires to be further ***,CoP/Co_(2)P heterojunction composite with higher polarity was *** discharge product of high-polarity CoP/Co_(2)P had a new porous box-like morphology,which was easy to be decomposed and exposed more active *** highly polar CoP/Co_(2)P heterostructure composite had homogeneous pores,the synergistic effect existed between CoP and Co_(2)P,and the discharge product was porous box mixed with li_(2)O_(2)and liOH,which made CoP/Co_(2)P achieve high specific capacity of14632 m Ah/g and cycle stably 161 times when used as air electrode cathode *** work furnished a thought for the construction of cathode catalysts with efficient catalytic activity for li-air batteries.

关键词： li-air battery Cathode catalyst CoP/Co_(2)P Heterojunction structure High polarity

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