Activity Screening Study on the Anti-tumor Effects of Extracts from Mahoniae caulis

作     者：Xin XIE Liyuan LI Aipeng LI Zhidong LEI Suoyi HUANG 

作者机构：School of Basic Medical SciencesYoujiang Medical University for NationalitiesBaise 533000China School of PharmacyYoujiang Medical University for NationalitiesBaise 533000China Key Laboratory of Characteristic Ethnic Medicine Research in Youjiang BasinYoujiang Medical University for NationalitiesBaise 533000China 

出 版 物：《Medicinal Plant》 (药用植物：英文版)

年 卷 期：2023年第14卷第6期

页      面：19-21,26页

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Supported by Guangxi Key Research and Development Plan Project(Gui Ke AB18221095) 2023 Innovation Project of Youjiang Medical University for Nationalities Graduate Education(YXCXJH2023009) Scientific Research Project of High-level Talents of Youjiang Medical University for Nationalities(01002018079) 

主　　题：Mahoniae caulis Tumor cells Anti-tumor effects Activity screening 

摘      要：[Objectives]To explore the anti-tumor activity of the extracts of petroleum ether,ethyl acetate,n-butanol and aqueous solution from Mahoniae caulis.[Methods]The extracts were extracted with petroleum ether,ethyl acetate,n-butanol and aqueous solution respectively,and then *** inhibitory effects of these extracts on the growth of three tumor cell lines in vitro were detected by CCK-8 method,and the IC 50 value was calculated.[Results]The four extracts inhibited the growth of the three tumor cell lines in vitro,among which the n-butanol extract had the best anti-tumor *** IC 50 values of the n-butanol extract on human gastric cancer(SGC-7901),human breast cancer(MCF-7)and human liver cancer(BEL-7404)cell lines were 0.23,0.25 and 0.58 mg/mL,respectively.[Conclusions]The ethanol extract of Mahoniae caulis under petroleum ether,ethyl acetate,n-butanol and aqueous solution had certain anti-tumor effect,and n-butanol extract had the best anti-tumor activity.