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Acta Oceanologica Sinica 2023年第11期42卷 98-106页

作者： Zhiyong Li Yuan He Hongyan He Caiwei Fu Mengru Li aiming lu Dongren Zhang Tuanjie Che Songdong Shen School of Biology&Basic Medical Sciences Soochow UniversitySuzhou 215101China Key Laboratory of Functional Genomic and Molecular Diagnosis of Gansu Province Lanzhou 730030China

In this study,Ulva prolifera protein was used for preparing angiotensin-I converting enzyme(ACE)-inhibitory peptide via virtual gastrointestinal digestion and in silico *** parameters of the obtained peptide,such as inhibition kinetics,docking mechanism,stability,transport pathway,were explored by Lineweaver-Burk plots,molecular docking,in vitro stimulate gastrointestinal(GI)digestion and Caco-2 cells monolayer model,***,a novel anti-ACE peptide LDF(IC_(50),(1.66±0.34)μmol/L)was screened and synthesized by chemical *** was a no-competitive inhibitor and its anti-ACE inhibitory effect mainly attributable to four Conventional Hydrogen Bonds and Zn701 *** could keep activity during simulated GI digestion in vitro and was transported by peptide transporter PepT1 and passive-mediated ***,it could activate Endothelial nitric oxide synthase(eNOS)activity to promote the production of NO and reduce Endothelin-1(ET-1)secretion induced by AngiotensinⅡ(AngⅡ)in Human Umbilical Vein Endothelial Cells(HUVECs).Meanwhile,it could promote mice splenocytes proliferation in a concentration-dependent *** study indicated that this peptide was a potential ingredient functioning on vasodilation and enhancing immunity.

关键词： Ulva prolifera protein ACE-inhibitory peptide in vitro GI digestion vasodilation mechanism immunomodulation

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正负压共同作用加固软土路基应用探讨

现代交通技术 2009年第3期6卷 21-23页

作者：卢爱民江苏东南交通工程咨询监理有限公司江苏南京210018

文章从真空预压与路堤填筑的作用机理出发,对正负压共同作用时的固结特点进行介绍。在此基础上,根据某高速公路真空—路堤联合加载试验,介绍真空联合路堤堆载预压应用于高速公路的特点,分析土体在正负压共同作用下的固结特性和变形特点... 详细信息

文章从真空预压与路堤填筑的作用机理出发,对正负压共同作用时的固结特点进行介绍。在此基础上,根据某高速公路真空—路堤联合加载试验,介绍真空联合路堤堆载预压应用于高速公路的特点,分析土体在正负压共同作用下的固结特性和变形特点,并与现场实测对比,以验证理论分析的合理性。

关键词：软土路基真空预压联合加载加固侧向变形

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双能X射线骨密度测量中的X射线源

核电子学与探测技术 1999年第3期19卷 185-187页

作者：蔡建新卢爱明宋犀云北京大学重离子物理研究所

阐述了双能量Ｘ射线骨密度测量中使用的Ｘ射线源，介绍了产生双能量Ｘ线的两种方法，即Ｋ边过滤器法和高压切换法。重点介绍Ｋ边过滤器法的组成、特点和优点，并对这两种方法作了比较。

关键词： K边过滤器双能量X射线骨密度测量 X射线源

Fast measurement and prediction method for electromagnetic susceptibility of receiver

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Journal of Systems Engineering and Electronics 2024年第2期35卷 275-285页

作者： CHEN Yan lu Zhonghao LIU Yunxia State Key Laboratory of Complex Electromagnetic Environment Effects on Electronics and Information System College of Electronic Science and TechnologyNational University of Defense TechnologyChangsha 410073China State Key Laboratory of Astronautic Dynamics Xi’an 710043China

aiming at evaluating and predicting rapidly and accurately a high sensitivity receiver’s adaptability in complex electromagnetic environments,a novel testing and prediction method based on dual-channel multi-frequency is proposed to improve the traditional two-tone ***,two signal generators are used to generate signals at the radio frequency(RF)by frequency scanning,and then a rapid measurement at the intermediate frequency(IF)output port is carried out to obtain a huge amount of sample data for the subsequent ***,the IF output response data are modeled and analyzed to construct the linear and nonlinear response constraint equations in the frequency domain and prediction models in the power domain,which provide the theoretical criteria for interpreting and predicting electromagnetic susceptibility(EMS)of the *** experiment performed on a radar receiver confirms the reliability of the method proposed in this *** shows that the interference of each harmonic frequency and each order to the receiver can be identified and predicted with the sensitivity *** on this,fast and comprehensive evaluation and prediction of the receiver’s EMS in complex environment can be efficiently realized.

关键词： electromagnetic susceptibility(EMS) receiver dualchannel multi-frequency nonlinear response frequency domain power domain

Resolving aging dynamics of a 3D colloidal glass

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Science China(Physics,Mechanics & Astronomy) 2024年第3期67卷 110-118页

作者： XiaoJuan Wang Jun Duan Gan Ding YunZhuo lu Xing lu LanHong Dai MinQiang Jiang State Key Laboratory of Nonlinear Mechanics Institute of MechanicsChinese Academy of SciencesBeijing 100190China School of Materials Science and Engineering Dalian Jiaotong UniversityDalian 116028China School of Engineering Science University of Chinese Academy of SciencesBeijing 100049China

Physical aging is an inherent property of glassy matter, but understanding its microscopic mechanism remains a challenge particularly at the particle level. In this work, we use a confocal microscope to in-situ trace the particle trajectories in a 3D colloidal glass for 73000 s, aiming at resolving the aging dynamics. By calculating the mean square displacement of particle motions, we find that the glass aging with time can be divided into three stages: β relaxation, α relaxation and free diffusion. The system's mean square displacement at each aging state is quantitatively resolved into three contributions of particle dynamics modes: vibration within the nearest-neighbor cages, hopping between cages and cooperative rearrangement. We further calculate the particle's free volume and find that the β-to-α transition is accompanied by the temporary increase of the system-averaged free volume due to pronounced hops of particles. Nevertheless, the temporal autocorrelation of the free volume spatial distribution still obeys a monotonically stretched exponential decay with an exponent of 0.76, which is related to the sub-diffusion dynamics of cooperative rearrangements and hops mixed in α relaxation. According to the resolved vibrational displacements,we calculate the vibrational density of states of this 3D glass, and the characteristic boson peak is reproduced at low *** findings shed insight into the particle-level aging dynamics of a real glass under purely thermal activation.

关键词： colloidal glass physical aging particle dynamics free volume boson peak

Recent Advances in Biomass-derived Porous Carbon Materials:Synthesis,Composition and Applications

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Chemical Research in Chinese Universities 2024年第1期40卷 3-19页

作者： ZHAI Ziqi lu Yumiao LIU Guangyong DING Wei-lu CAO Bobo HE Hongyan CAS Key Laboratory of Green Process and Engineering State Key Laboratory of Mesoscience and EngineeringBeijing Key Laboratory of Ionic Liquids Clean ProcessInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190P.R.China University of Chinese Academy of Sciences Beijing 100049P.R.China Longzihu New Energy Laboratory Zhengzhou Institute of Emerging Industrial TechnologyZhengzhou 450000P.R.China

Porous carbon materials(PCMs)play a pivotal role in diverse applications,such as energy storage,adsorption,catalysis,environmental remediation,and microwave *** selection of carbon precursors,in particular,is crucial for tailoring porous structures with specific ***,with its rich carbon feedstock,abundant availability,renewability,and versatile structures,has emerged as a promising precursor for porous carbon material *** review comprehensively summarizes the recent advances in biomass-derived porous carbon materials(BPCMs)encompassing synthetic strategy,morphology,structural composition,and multiple *** first review synthetic approaches aiming at regulating porosity,followed by morphological and composition features of BPCMs,with a special emphasis on elucidating the dimensional clarification and heteroatom doping *** discussion then extends to the wide-ranging applications of BPCMs,covering energy-related applications and CO_(2) adsorption to environmental ***,the review outlines the existing challenges and prospects in the *** summary,this review systematically describes BPCMs and provides valuable guidance for researchers to select and synthesize BPCMs that meet specific functional requirements.

关键词： Biomass Porous carbon Pyrolysis Heteroatom-doping Supercapacitor CO_(2)adsorption

CBA: multi source fusion model for fast and intelligent target intention identification

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Journal of Systems Engineering and Electronics 2024年第2期35卷 406-416页

作者： WAN Shichang LI Qingshan WANG Xuhua lu Nanhua School of Computer Science and Technology Xidian UniversityXi’an 710071China School of Mathematics and Computer Application Shangluo UniversityShangluo 726000China

How to mine valuable information from massive multisource heterogeneous data and identify the intention of aerial targets is a major research focus at present. aiming at the longterm dependence of air target intention recognition, this paper deeply explores the potential attribute features from the spatiotemporal sequence data of the target. First, we build an intelligent dynamic intention recognition framework, including a series of specific processes such as data source, data preprocessing,target space-time, convolutional neural networks-bidirectional gated recurrent unit-atteneion (CBA) model and intention recognition. Then, we analyze and reason the designed CBA model in detail. Finally, through comparison and analysis with other recognition model experiments, our proposed method can effectively improve the accuracy of air target intention recognition,and is of significance to the commanders’ operational command and situation prediction.

关键词： intention massive data deep network artificial intelligence

Emerging role of regulated cell death in intestinal failure-associated liver disease

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 228-233页

作者： Si-Yang Cheng lu Jiang Ying Wang Wei Cai Department of Pediatric Surgery Xinhua HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200092China Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition Shanghai 200092China Shanghai Institute for Pediatric Research Shanghai 200092China Division of Pediatric Gastroenterology and Nutrition Xinhua HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200092China

Intestinal failure-associated liver disease(IFALD)is a common complication of long-term parenteral nutrition that is associated with significant morbidity and *** is mainly characterized by cholestasis in children and steatohepatitis in ***,there is no effective approach to prevent or reverse the *** cell death(RCD)represents a fundamental biological paradigm that determines the outcome of a variety of liver *** cell death is reclassified into several types,based on the mechanisms and morphological *** evidence has linked different modes of RCD,such as apoptosis,necroptosis,ferroptosis,and pyroptosis to the pathogenesis of liver *** studies have shown that different modes of RCD are present in animal models and patients with *** the pathogenic roles of cell death may help uncover the underlying mechanisms and develop novel therapeutic strategies in *** this review,we discuss the current knowledge on how RCD may link to the pathogenesis of *** highlight examples of cell death-targeted interventions aiming to attenuate the disease,and provide perspectives for future basic and translational research in the field.

关键词： Parenteral nutrition Apoptosis Necroptosis Cholestasis Steatosis

3D打印技术在肩关节骨性关节炎全肩关节置换术中的应用研究

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中华肩肘外科电子杂志 2018年第2期6卷 105-114页

作者：鲜爱明卢冰王跃刘攀四川省医学科学院四川省人民医院骨科成都610072

目的探讨3D打印技术在全肩关节置换术治疗肩关节骨性关节炎的应用价值。方法 2014年5月至2016年5月四川省人民医院骨科收治的肩关节骨关节炎患者12例,其中男4例,女8例;年龄48~81岁,平均(58.5±13.2)岁。累及侧别:左5例,右7例。其中原发... 详细信息

目的探讨3D打印技术在全肩关节置换术治疗肩关节骨性关节炎的应用价值。方法 2014年5月至2016年5月四川省人民医院骨科收治的肩关节骨关节炎患者12例,其中男4例,女8例;年龄48~81岁,平均(58.5±13.2)岁。累及侧别:左5例,右7例。其中原发性盂肱关节骨关节炎5例,肱骨头缺血性坏死继发盂肱关节骨关节炎4例,创伤性盂肱关节骨关节炎3例。术前应用3D打印技术制备患者双侧肩关节模型,在健侧模型上测定相关解剖学参数,用于假体型号的选择与置入。在患侧模型上观察病变情况,模拟手术过程。记录并与术中情况比较。比较末次随访与术前的肩关节活动度、Constant评分和视觉模拟评分(visual analogue scale,VAS)。采用SPSS 17.0软件对数据进行t检验分析。结果 12例患者均顺利完成人工全肩关节置换术手术,术中选取的假体型号、截骨平面均与模拟手术完全一致。术后影像学资料证实假体组件均按计划精确置入。12例患者术后获随访(16.0±3.8)个月,13~25个月,末次随访Constant评分和VAS与术前对比均有改善,差异具有统计学意义(P<0.05)。末次随访无神经血管损伤,无感染、假体松动,无假体肱骨头上移等严重并发症。结论 3D打印技术用于人工全肩关节置换术治疗原发性和继发性盂肱关节骨关节炎,有助于术前制定手术计划并模拟手术操作,降低手术难度,提高手术质量。

关键词： 3D打印骨关节炎肩关节置换人工关节

Tube-based robust reinforcement learning for autonomous maneuver decision for UCAVs

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Chinese Journal of Aeronautics 2024年第7期37卷 391-405页

作者： Lixin WANG Sizhuang ZHENG Haiyin PIAO Changqian lu Ting YUE Hailiang LIU School of Aeronautical Science and Engineering Beihang UniversityBeijing 100191China Shenyang Aircraft Design&Research Institute Shenyang 110035China

Reinforcement Learning(RL)algorithms enhance intelligence of air combat AutonomousManeuver Decision(AMD)policy,but they may underperform in target combat environmentswith *** enhance the robustness of the AMD strategy learned by RL,thisstudy proposes a Tube-based Robust RL(TRRL)***,this study introduces a tube todescribe reachable trajectories under disturbances,formulates a method for calculating tubes basedon sum-of-squares programming,and proposes the TRRL algorithm that enhances robustness byutilizing tube size as a quantitative ***,this study introduces offline techniques forregressing the tube size function and establishing a tube library before policy learning,aiming toeliminate complex online tube solving and reduce the computational burden during ***,an analysis of the tube library demonstrates that the mitigated AMD strategy achievesgreater robustness,as smaller tube sizes correspond to more cautious *** finding highlightsthat TRRL enhances robustness by promoting a conservative *** effectively balanceaggressiveness and robustness,the proposed TRRL algorithm introduces a“laziness factor”as aweight of ***,combat simulations in an environment with disturbances confirm thatthe AMD policy learned by the TRRL algorithm exhibits superior air combat performance comparedto selected robust RL baselines.

关键词： Air combat Autonomous maneuver decision Robust reinforcement learning Tube-based algorithm Combat simulation