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Epidemic of non-alcoholic fatty liver disease and hepatocellular carcinoma

World Journal of Clinical Oncology 2017年第6期8卷 429-436页

作者： Adnan Said aiman Ghufran Division of Gastroenterology and Hepatology Department of Medicine William S. Middleton VAMC University of Wisconsin School of Medicine and Public Health Gastroenterology and Hepatology Medical College of Wisconsin

Non-alcoholic fatty liver disease(NAFLD) associated hepatocellular carcinoma(HCC) incidence is increasing worldwide, paralleling the obesity epidemic. Although most cases are associated with cirrhosis, HCC can occur without cirrhosis in NAFLD. Diabetes and obesity are associated risk factors for HCC in patients. Given the sheer magnitude of the underlying risk factors(diabetes, obesity, non-cirrhotic NAFLD) screening for HCC in the non-cirrhotic population is not recommended. Optimal screening strategies in NAFLD cirrhosis are not completely elucidated with Ultrasound having significant limitations in detection of liver lesions in the presence of obesity and steatosis. Consequently NAFLD-HCC is more often diagnosed at a later stage with larger tumors and reduced opportunities for curative treatments as opposed to HCC in other causes of cirrhosis. When HCC is found at a curative stage treatments including liver transplantation, resection and loco-regional therapies are associated with good results similar to that seen in HCV-HCC. Future strategies under study include the use of chemopreventive and antioxidant agents to reduce development of cirrhosis and non-alcoholic steatohepatitis(NASH). Strategies to reverse NASH via weight loss, control of associated conditions like diabetes are key strategies in reducing the increasing incidence of NASH-HCC. Novel therapeutic agents for NASH are in trials and if successful in achieving reversal of NASH will be an important strategy in reducing NAFLD-HCC.

关键词： Non-alcoholic fatty liver disease Hepatocellular carcinoma Screening Epidemiology Pathophysiology Diagnosis Liver transplant Resection Locoregional therapy Treatment

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Effect of Salicylic Acid on Salinity-induced Changes in Brassica juncea

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Journal of Integrative Plant Biology 2008年第9期50卷 1096-1102页

作者： Mohammad Yusuf Syed aiman Hasan Barket Ali Shamsul Hayat Qazi Fariduddin Aqil Ahmad Plant Physiology Section Department of Botany Aligarh Muslim University Department of Applied Sciences Higher College of Technology

Seeds of Indian mustard （Brassicajuncea （L.） Czern. et Coss.） were exposed to 0, 50, 100 and 150 mmol/L NaCI for 8 h and seeds were sown in an earthen pot. These stressed seedlings were subsequently sprayed with 10μmol/L salicylic acid （SA） at 30 d and were sampled at 60 d to assess the changes in growth, photosynthesis and antioxidant enzymes. The seedlings raised from the seeds treated with NaCI had significantly reduced growth and the activities of carbonic anhydrase, nitrate reductase and photosynthesis, and the decrease was proportional to the increase in NaCI concentration. However, the antioxidant enzymes （catalase, peroxidase and superoxide dismutase） and proline content was enhanced in response to NaCI and/or SA treatment, where their interaction had an additive effect. Moreover, the toxic effects generated by the lower concentration of NaCI （50 mmol/L） were completely overcome by the application of SA. It was, therefore, concluded that SA ameliorated the stress generated by NaCl through the alleviated antioxidant system.

关键词： carbonic anhydrase catalase mustard net photosynthetic rate nitrate reductase peroxidase salicylic acid salinity superoxidedismutase.

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一种基于DSM和DOM的地理信息数据采集方法

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北京测绘 2024年第4期38卷 502-508页

作者：梁爱曼张海涛左效刚周庆北京市测绘设计研究院北京100038 城市空间信息工程北京市重点实验室北京100038

针对航摄影像立体采集和人工外业测绘等方式的人员投入大、数据采集效率不高问题,本文通过数字正射影像图(DOM)数据、数字表面模型(DSM)数据及DOM数据生产过程中产生的辅助数据进行再利用,探索推扫式数据中高大地物的倒伏特点,解决数据... 详细信息

针对航摄影像立体采集和人工外业测绘等方式的人员投入大、数据采集效率不高问题,本文通过数字正射影像图(DOM)数据、数字表面模型(DSM)数据及DOM数据生产过程中产生的辅助数据进行再利用,探索推扫式数据中高大地物的倒伏特点,解决数据生产过程中产生的投影差问题,形成了一种新的数据采集技术,并通过生产验证。试验结果表明这种方法打破了传统采集方式的束缚,不受软硬件和人员技能的约束,不仅能够实现基本比例尺地形图测绘功能、新型基础测绘地理实体采编功能,还可以实现建模数据采编功能。

关键词：地理信息数据采集数字正射影像投影差投影纠正算法推扫式遥感影像

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Patients without hepatocellular carcinoma progression after transarterial chemoembolization benefit from liver transplantation

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World Journal of Gastroenterology 2007年第5期13卷 761-767页

作者： aiman Obed Alexander Beham Kerstin Püllmann Heinz Becker Hans J Schlitt Thomas Lorf Department of Surgery University of Regensburg Regensburg 93053Germany 不详 Department of Surgery University of Goettingen Goettingen 37073 Germany

AIM： To assess the outcome of patients, who underwent transarterial chemoembolization （TACE） for hepatocellular carcinoma （HCC） and subsequently liver transplantation （OLT） irrespective of tumor size when no tumor progression was observed. METHODS： Records, imaging studies and pathology of 84 patients with HCC were reviewed. Ten patients were not treated at all, 67 patients had TACE and 35 of them were listed for OLT. Tumor progression was monitored by ultrasound and AFP level every 6 wk. Fifteen patients showed signs of tumor progression without transplantation. The remaining 20 patients underwent OLT. Further records of 7 patients with HCC seen in histological examination after OLT were included. RESULTS： The patients after TACE without tumor progression underwent transplantation and had a median survival of 92.3 too. Patients, who did not qualify for liver transplantation or had signs of tumor progression had a median survival of 8.4 mo. The patients without treatment had a median survival of 3.8 mo. Independent of International Union Against Cancer （UICC） stages, the patients without tumor progression and subsequent OLT had longer median survival. No significant difference was seen in the OLT treated patients if they did not fulfill the Milan criteria. CONCLUSION： Selection of patients for OLT based on tumor progression results in good survival. The evaluation of HCC patients should not only be based on tumor size and number of foci but also on tumor progression and growth behavior under therapy.

关键词： Liver transplantation Hepatocellularcarcinoma

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Feasibility of Integrating Bimetallic Au-Ag Non-Alloys Nanoparticles Embedded in Reduced Graphene Oxide Photodetector

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Photonic Sensors 2023年第3期13卷 23-36页

作者： Nurul Syazwani ROHIZAT Muhammad Nur Syafiq MOHAMAD ISMAIL Muhammad aiman Saufi AHMAD FAHRI Chee Leong TAN Rozalina ZAKARIA Photonics Research Center Faculty of ScienceUniversity of MalayaKuala Lumpur 50603Malaysia Department of Physics Faculty of ScienceUniversity of MalayaKuala Lumpur 50603Malaysia School of Electronic and Optical Engineering and College of Microelectronics Nanjing University of Posts and TelecommunicationsNanjing 210023China

To coordinate the resonant wavelength of the plasmonic nanoparticles(NPs),the emission band of the reduced graphene oxide(rGO)photodetector at the NIR-region is crucial for the optimal plasmon-enhanced luminescence in the *** contrast to monometallic NPs,where limits the dimensions and extended resonant wavelength,we integrated an Au-Ag bimetallic NPs(BMNPs)to enable resonance tuning at the longer wavelength at the excitation source of 785 *** features showed an increase in radiative recombination rates as well as the quantum yield efficiency of the *** BMNPs were produced from the dewetting process of 600℃and 500℃,both at 1 min after the deposition thickness layer of Au(8 nm)and Ag(10 nm)on the Si substrate using the electron-beam evaporation *** BMNPs-rGO photodetector exhibited the responsivity of 2.25 A·W^(–1),Jones of specific detectivity of 2.45×10^(11)Jones,and external quantum efficiency(EQE)of 356%.The rise time and fall time for the photodetector were 32 ns and 186 ns,*** work provided an essential information to enable the versatile plasmon-enhanced application in 2-dimensional(2D)material optoelectronic devices.

关键词： Au-Ag bimetallic nanoparticles rGO photodetector

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Repurposed anti-cancer epidermal growth factor receptor inhibitors: mechanisms of neuroprotective effects in Alzheimer’s disease

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Neural Regeneration Research 2022年第9期17卷 1913-1918页

作者： Heba M.Mansour Hala M.Fawzy aiman S.El-Khatib Mahmoud M.Khattab Department of Pharmacology Egyptian Drug AuthorityEDAformerly NODCARGizaEgypt Department of Pharmacology and Toxicology Faculty of PharmacyCairo UniversityCairoEgypt

Numerous molecular mechanisms are being examined in an attempt to discover disease-modifying drugs to slow down the underlying neurodegeneration in Alzheimer’s *** studies have shown the beneficial effects of epidermal growth factor receptor inhibitors on the enhancement of behavioral and pathological sequelae in Alzheimer’s *** the promising effects of epidermal growth factor receptor inhibitors in Alzheimer’s disease,there is no irrefutable neuroprotective evidence in well-established animal models using epidermal growth factor receptor inhibitors due to many un-explored downstream signaling *** caused controversy about the potential involvement of epidermal growth factor receptor inhibitors in any prospective clinical *** this review,the mystery beyond the under-investigation of epidermal growth factor receptor in Alzheimer’s disease will be ***,their molecular mechanisms in neurodegeneration will be ***,we will shed light on SARS-COVID-19 induced neurological manifestations mediated by epidermal growth factor ***,we will discuss future perspectives and under-examined epidermal growth factor receptor downstream signaling pathways that warrant more *** conclude that epidermal growth factor receptor inhibitors are novel effective therapeutic approaches that require further research in attempts to be repositioned in the delay of Alzheimer’s disease progression.

关键词： Alzheimer’s disease autophagy drug re-positioning epidermal growth factor receptor human epidermal growth factor receptor-2 neurodegenerative diseases neuroinflammation oxidative stress tyrosine kinase inhibitors

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Role of biliary complications in chronic graft rejection after living donor liver transplantation

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World Journal of Hepatology 2022年第5期14卷 1050-1052页

作者： aiman Obed Abdalla Bashir Anwar Jarrad Laszlo Fuzesi Hepatobiliary and Liver Transplant Unit Jordan HospitalAmman 52112Jordan Department of General Surgery Jordan HospitalAmman 52112Jordan Department of Hepatology Jordan HospitalAmman 52112Jordan Department of Pathology Faculty of MedicineUniversity AugsburgAugsburg 86156Germany

Postoperative biliary complications remain a substantial challenge after living donor liver transplantation,especially due to its heterogeneous clinical presentation.

关键词： Chronic graft rejection Biliary complications Living donor liver transplantation Graft survival Cholangiopathy

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Blockchain Mobile Wallet with Secure Offline Transactions

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Computers, Materials & Continua 2023年第5期75卷 2905-2919页

作者： Raed Saeed Rasheed Khalil Hamdi Ateyeh Al-Shqeerat Ahmed Salah Ghorab Fuad Salama AbuOwaimer aiman Ahmed AbuSamra Faculty of Engineering Islamic University of GazaP.O.Box 108GazaPalestine Department of Computer Science College of ComputerQassim UniversityP.O.Box 52211BuraydahSaudi Arabia University College of Applied Sciences P.O.Box 1415GazaPalestine Palestine Technical College P.O.Box 6037Deir ElBalahPalestine

There has been an increase in the adoption of mobile payment systems worldwide in the past few ***,poor Internet connection in rural regions continues to be an obstacle to the widespread use of such *** top of that,there are significant problems with the currently available offline wallets;for instance,the payee cannot verify the number of coins received without access to the ***,it has been demonstrated that some existing systems are susceptible to false token generation,and some do not even permit the user to divide the offline token into smaller portions to be used as *** paper proposes a blockchainbased wallet system that provides a secure mobile payment service even if a user cannot access a reliable Internet *** approach relies on Bluetooth and digital signatures to establish and build a trust connection between the *** proposed solution overcomes the main limitations of existing systems that use offline transactions,such as the generation of fake offline tokens and the indivisibility of offline *** user buys Offline Tokens(OTs)from a server called an Offline Token Manager(OTM)to use them later to perform offline *** mobile device must store a single,signed offline token transaction to prevent fake *** the other hand,all offline transactions will be kept as a history in a particular local ***,when the receiver becomes online,it will send a convert request to the OTMto change the value of the OTs to the appropriate amount in real *** step requires a connection to the *** evaluate the effectiveness of the system,the Solidity programming language was used to develop a smart contract on the Ethereum blockchain with a backend application programming interface(API)and an android mobile *** proposed method has an advantage over other prominent wallets.

关键词： Mobile wallet blockchain smart contracts digital signature

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Adeno-associated virus-mediated heme oxygenase-1 gene transfer suppresses the progression of micronodular cirrhosis in rats

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World Journal of Gastroenterology 2006年第13期12卷 2016-2023页

作者： Tung-Yu Tsui Chi-Keung Lau Jian Ma Gabriel Glockzin aiman Obed Hans J Schlitt Sheung-Tat Fan Centre for the Study of Liver Disease and Department of Surgery the University of Hong Kong Pokfulam Hong Kong Department of Surgery University of Regensburg Medical Centre Regensburg Germany

AIM： To test the hypothesis that enhancement of the activity of heine oxygenase can interfere with processes of fibrogenesis associated with recurrent liver injury, we investigated the therapeutic potential of over-expression of heine oxygense-1 in a CCl4-induced micronodular cirrhosis model. METHODS： Recombinant adeno-associated viruses carrying rat HO-1 or GFP gene were generated, 1×10^12 vg of adeno-associated viruses were administered through portal injection at the time of the induction of liver fibrosis. RESULTS： Conditioning the rat liver with over-expression of HO-1 by rAAV/HO-1 significantly increased the HO enzymatic activities in a stable manner. The development of micronodular cirrhosis was significantly inhibited in rAAV/HO-1-transduced animals as compared to controls. Portal hypertension was markedly diminished in rAAV/HO-1-transduced animals as compared to controls, whereas there are no significant changes in systolic blood pressure. This finding was accompanied with improved liver biochemistry, less infiltrating macrophages and less activated hepatic stellate cells （HSCs） in rAAV/ HO-1-transduced livers. CONCLUSIONS： Enhancement of HO activity in the livers suppresses the development of cirrhosis.

关键词： Cirrhosis Portal hypertension Heme oxygenase Gene therapy Adeno-associated virus

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Thermal Properties of Ferrimagnetic Systems

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World Journal of Condensed Matter Physics 2011年第4期1卷 121-129页

作者： aiman Al-Omari 不详

The heat capacity of some ferrimagnets has additional structures like a shoulder in the Schottky-like peak, or emergence of a second peak when an external magnetic field is applied. It is shown here that the ferromagnetic and anti-ferromagnetic elementary excitation spectra give rise to two independent heat capacity peaks, one enveloped by the other, which add up to give the peak for the total system. Taking this into account helps understand the additional structures in the peaks. Moreover, the classification of ferrimagnets into predominantly antiferromagnetic, ferromagnetic, or a mixture of the two is shown to be validated by studying them under additional influences like dimerization and frustration. Because these two are shown to influence the ferromagnetic and antiferromagnetic dispersion rela tions—and hence the quantities like heat capacity and magnetic susceptibility—by different amounts, the characterization of ferrimagnetic systems (1,1/2), (3/2,1) and (3/2,1/2) is brought out more clearly. Both these influences enhance antiferromagnetic character. PACS numbers: ***, ***.

关键词： Ferrimagnet Alternat Spins Susceptibility Heat Capacity

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